GH/IGF-1 Signaling and Current Knowledge of Epigenetics; a Review and Considerations on Possible Therapeutic Options

Attenuation of epidermal growth factor (EGF) signaling by growth hormone (GH)

(2017) Lorena González et al.   JOURNAL OF ENDOCRINOLOGY

Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader–Willi syndrome

(2016) Yuna Kim et al.   NATURE MEDICINE

Screening out irrelevant cell-based models of disease

(2016) Peter Horvath et al.   NATURE REVIEWS DRUG DISCOVERY

Epigenetic drugs: from chemistry via biology to medicine and back

(2016) Lucia Altucci et al.   Clinical Epigenetics

Intrauterine growth restriction disrupts developmental epigenetics around distal growth hormone response elements on the rat hepatic IGF-1 gene

(2015) Qi Fu et al.   FASEB JOURNAL

Locus-specific editing of histone modifications at endogenous enhancers

(2013) Eric M Mendenhall et al.   NATURE BIOTECHNOLOGY

The Regulation of IGF-1 Gene Transcription and Splicing during Development and Aging

(2013) A. M. Oberbauer   Frontiers in Endocrinology

Combinatorial complexity in chromatin structure and function: revisiting the histone code

(2012) Oliver J Rando   CURRENT OPINION IN GENETICS & DEVELOPMENT

Mapping the growth hormone–Stat5b–IGF-I transcriptional circuit

(2012) Peter Rotwein   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Intrauterine Growth Restriction as a Potential Risk Factor for Disease Onset in Adulthood

(2011) A.A. Varvarigou   JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non-Small Cell Lung Cancer

(2011) R. A. Juergens et al.   Cancer Discovery

Minireview: Mechano-Growth Factor: A Putative Product of IGF-I Gene Expression Involved in Tissue Repair and Regeneration

(2010) Ronald W. Matheny et al.   ENDOCRINOLOGY

Dispersed Chromosomal Stat5b-binding Elements Mediate Growth Hormone-activated Insulin-like Growth Factor-I Gene Transcription

(2010) Dennis J. Chia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defining the Epigenetic Actions of Growth Hormone: Acute Chromatin Changes Accompany GH-Activated Gene Transcription

(2010) Dennis J. Chia et al.   MOLECULAR ENDOCRINOLOGY

Orphan CpG Islands Identify Numerous Conserved Promoters in the Mammalian Genome

(2010) Robert S. Illingworth et al.   PLoS Genetics

Computational and Functional Analysis of Growth Hormone (GH)-Regulated Genes Identifies the Transcriptional Repressor B-Cell Lymphoma 6 (Bc16) as a Participant in GH-Regulated Transcription

(2009) Yili Chen et al.   ENDOCRINOLOGY

Epigenetics: intrauterine growth retardation (IUGR) modifies the histone code along the rat hepatic IGF-1 gene

(2009) Qi Fu et al.   FASEB JOURNAL

Growth hormone-induced production of cytokines in murine peritoneal macrophages in vitro: Role of JAK/STAT, PI3K, PKC and MAP kinases

(2009) Anurag Tripathi et al.   IMMUNOBIOLOGY

The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells

(2009) C Flotho et al.   LEUKEMIA

Male-Specific Hepatic Bcl6: Growth Hormone-Induced Block of Transcription Elongation in Females and Binding to Target Genes Inversely Coordinated with STAT5

(2009) Rosana D. Meyer et al.   MOLECULAR ENDOCRINOLOGY

Histone modifications at human enhancers reflect global cell-type-specific gene expression

(2009) Nathaniel D. Heintzman et al.   NATURE

Growth Hormone Regulation of Insulin-Like Growth Factor-I Gene Expression May Be Mediated by Multiple Distal Signal Transducer and Activator of Transcription 5 Binding Sites

(2008) Satyanaryana Eleswarapu et al.   ENDOCRINOLOGY

Genome-wide relationship between histone H3 lysine 4 mono- and tri-methylation and transcription factor binding

(2008) A. G. Robertson et al.   GENOME RESEARCH

Adult Sequelae of Intrauterine Growth Restriction

(2008) Michael G. Ross et al.   SEMINARS IN PERINATOLOGY