Fascaplysin Exerts Anti-Cancer Effects through the Downregulation of Survivin and HIF-1α and Inhibition of VEGFR2 and TRKA

Targeting TRK family proteins in cancer

(2017) Yekaterina B. Khotskaya et al.   PHARMACOLOGY & THERAPEUTICS

Loss of FOXO1 promotes gastric tumour growth and metastasis through upregulation of human epidermal growth factor receptor 2/neu expression

(2015) Young San Ko et al.   BRITISH JOURNAL OF CANCER

Fascaplysin Induces Caspase Mediated Crosstalk Between Apoptosis and Autophagy Through the Inhibition of PI3K/AKT/mTOR Signaling Cascade in Human Leukemia HL-60 Cells

(2015) Suresh Kumar et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Targeting the translation machinery in cancer

(2015) Mamatha Bhat et al.   NATURE REVIEWS DRUG DISCOVERY

Tubeimoside-1 suppresses tumor angiogenesis by stimulation of proteasomal VEGFR2 and Tie2 degradation in a non-small cell lung cancer xenograft model

(2015) Yuan Gu et al.   Oncotarget

PRMT5 is essential for the eIF4E-mediated 5′-cap dependent translation

(2014) Ji-Hong Lim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting Mitochondrial Oxidative Metabolism in Melanoma Causes Metabolic Compensation through Glucose and Glutamine Utilization

(2014) J.-H. Lim et al.   CANCER RESEARCH

Anti-cancer effect of HS-345, a new tropomyosin-related kinase A inhibitor, on human pancreatic cancer

(2013) Ju Hyeon Seo et al.   CANCER LETTERS

VEGFR and Type-V RTK Activation and Signaling

(2013) M. Shibuya   Cold Spring Harbor Perspectives in Biology

FASCAPLYSIN as a Specific Inhibitor for CDK4: Insights from Molecular Modelling

(2012) Muhammad Imtiaz Shafiq et al.   PLoS One

Fascaplysin exert anti-tumor effects through apoptotic and anti-angiogenesis pathways in sarcoma mice model

(2011) Xiaojun Yan et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Survivin and IAP proteins in cell-death mechanisms

(2010) Dario C. Altieri   BIOCHEMICAL JOURNAL

Targeting Eukaryotic Translation Initiation Factor 4E (eIF4E) in Cancer

(2010) A. C. Hsieh et al.   CLINICAL CANCER RESEARCH

Direct effects of fascaplysin on human umbilical vein endothelial cells attributing the anti-angiogenesis activity

(2009) Y.L. Zheng et al.   BIOMEDICINE & PHARMACOTHERAPY

Fascaplysin-inspired diindolyls as selective inhibitors of CDK4/cyclin D1

(2009) Carine Aubry et al.   BIOORGANIC & MEDICINAL CHEMISTRY

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Aspirin Sensitizes Cancer Cells to TRAIL-Induced Apoptosis by Reducing Survivin Levels

(2008) M. Lu et al.   CLINICAL CANCER RESEARCH