Revisiting the Metabolism and Bioactivation of Ketoconazole in Human and Mouse Using Liquid Chromatography–Mass Spectrometry-Based Metabolomics

Profiling Reactive Metabolites via Chemical Trapping and Targeted Mass Spectrometry

(2016) Jae Won Chang et al.   ANALYTICAL CHEMISTRY

Characterization of chemical-induced sterile inflammation in vitro: application of the model compound ketoconazole in a human hepatic co-culture system

(2016) Franziska Wewering et al.   ARCHIVES OF TOXICOLOGY

Reactive Metabolites: Current and Emerging Risk and Hazard Assessments

(2016) Richard A. Thompson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Predicting Toxicities of Reactive Metabolite–Positive Drug Candidates

(2015) Amit S. Kalgutkar et al.   Annual Review of Pharmacology and Toxicology

Transgenic mice and metabolomics for study of hepatic xenobiotic metabolism and toxicity

(2015) Frank J Gonzalez et al.   Expert Opinion on Drug Metabolism & Toxicology

RUCAM in Drug and Herb Induced Liver Injury: The Update

(2015) Gaby Danan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metabolic activation and drug-induced liver injury:in vitroapproaches for the safety risk assessment of new drugs

(2015) M. José Gómez-Lechón et al.   JOURNAL OF APPLIED TOXICOLOGY

Minimizing DILI risk in drug discovery — A screening tool for drug candidates

(2015) S. Schadt et al.   TOXICOLOGY IN VITRO

LC–MS-based metabolomics: an update

(2014) Zhong-Ze Fang et al.   ARCHIVES OF TOXICOLOGY

Metabolic profiling of praziquantel enantiomers

(2014) Haina Wang et al.   BIOCHEMICAL PHARMACOLOGY

Practical approaches to resolving reactive metabolite liabilities in early discovery

(2014) Deepak Dalvie et al.   DRUG METABOLISM REVIEWS

Drug safety assessment of oral formulations of ketoconazole

(2014) Aditya K Gupta et al.   Expert Opinion On Drug Safety

Risk of oral antifungal agent-induced liver injury in Taiwanese

(2013) Wei-Yu Kao et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

LC-MS-BASED METABOLOMICS OF XENOBIOTIC-INDUCED TOXICITIES

(2013) Chi Chen et al.   Computational and Structural Biotechnology Journal

Metabolic map and bioactivation of the anti-tumour drug noscapine

(2012) Zhong-Ze Fang et al.   BRITISH JOURNAL OF PHARMACOLOGY

LC–MS-based metabolomics in profiling of drug metabolism and bioactivation

(2012) Feng Li et al.   Acta Pharmaceutica Sinica B

Metabolomic Screening and Identification of the Bioactivation Pathways of Ritonavir

(2011) Feng Li et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Profiling the Reactive Metabolites of Xenobiotics Using Metabolomic Technologies

(2011) Feng Li et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Current Concepts in Antifungal Pharmacology

(2011) Russell E. Lewis   MAYO CLINIC PROCEEDINGS

Managing the challenge of chemically reactive metabolites in drug development

(2011) B. Kevin Park et al.   NATURE REVIEWS DRUG DISCOVERY

MZmine 2: Modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data

(2010) Tomáš Pluskal et al.   BMC BIOINFORMATICS

Investigation into UDP-Glucuronosyltransferase (UGT) Enzyme Kinetics of Imidazole- and Triazole-Containing Antifungal Drugs in Human Liver Microsomes and Recombinant UGT Enzymes

(2010) K. Bourcier et al.   DRUG METABOLISM AND DISPOSITION

Rapid detection and characterization of reactive drug metabolitesin vitrousing several isotope-labeled trapping agents and ultra-performance liquid chromatography/time-of-flight mass spectrometry

(2009) Timo Rousu et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Comparison of the Bioactivation Potential of the Antidepressant and Hepatotoxin Nefazodone with Aripiprazole, a Structural Analog and Marketed Drug

(2008) J. N. Bauman et al.   DRUG METABOLISM AND DISPOSITION