Negative Regulators of JAK/STAT Signaling in Rheumatoid Arthritis and Osteoarthritis

SOCS3 revisited: a broad regulator of disease, now ready for therapeutic use?

(2016) R. Mahony et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Understanding the role of cytokines in the pathogenesis of rheumatoid arthritis

(2016) Somaiya Mateen et al.   CLINICA CHIMICA ACTA

Janus kinase inhibitors for rheumatoid arthritis

(2016) Kunihiro Yamaoka   CURRENT OPINION IN CHEMICAL BIOLOGY

Anti cytokine therapy in chronic inflammatory arthritis

(2016) Charlotte Thompson et al.   CYTOKINE

STAT5 in Cancer and Immunity

(2016) Aradhana Rani et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The Activity of JAK/STAT and NF-κB in Patients with Rheumatoid Arthritis

(2016) Jerzy Świerkot et al.   Advances in Clinical and Experimental Medicine

Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis

(2015) D A Rodriguez et al.   CELL DEATH AND DIFFERENTIATION

Biologic basis of osteoarthritis

(2015) Charles J. Malemud   CURRENT OPINION IN RHEUMATOLOGY

SOCS3 and its role in associated diseases

(2015) Yanlin Yin et al.   HUMAN IMMUNOLOGY

Linear ubiquitination signals in adaptive immune responses

(2015) Fumiyo Ikeda   IMMUNOLOGICAL REVIEWS

Protein Inhibitor of Activated STAT3 Regulates Migration, Invasion, and Activation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis

(2015) Minxi Lao et al.   JOURNAL OF IMMUNOLOGY

The X-Linked Inhibitor of Apoptosis Protein Inhibitor Embelin Suppresses Inflammation and Bone Erosion in Collagen Antibody Induced Arthritis Mice

(2015) Anak A. S. S. K. Dharmapatni et al.   MEDIATORS OF INFLAMMATION

The diverse role of RIP kinases in necroptosis and inflammation

(2015) John Silke et al.   NATURE IMMUNOLOGY

Cytokines in rheumatoid arthritis — shaping the immunological landscape

(2015) Iain B. McInnes et al.   Nature Reviews Rheumatology

RIPK1 and RIPK3: critical regulators of inflammation and cell death

(2015) Kim Newton   TRENDS IN CELL BIOLOGY

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

(2015) Kate E. Lawlor et al.   Nature Communications

Programmed necrosis and necroptosis signalling

(2014) Maria Feoktistova et al.   FEBS Journal

Kinase inhibitors: The next generation of therapies in the treatment of rheumatoid arthritis

(2014) Lindsey A. MacFarlane et al.   International Journal of Rheumatic Diseases

mTOR Signaling in T Cell Immunity and Autoimmunity

(2014) Yu Liu et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation

(2014) Monica Yabal et al.   Cell Reports

Therapeutic Targeting of the JAK/STAT Pathway

(2013) Saara Aittomäki et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Targeting the JAK-STAT pathway in lymphoma: a focus on pacritinib

(2013) Enrico Derenzini et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Investigational Janus kinase inhibitors

(2013) Constantine S Tam et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

STAT inhibitors for cancer therapy

(2013) Muhammad Furqan et al.   Journal of Hematology & Oncology

SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition

(2013) Nadia J Kershaw et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulatory effect of calcineurin inhibitor, tacrolimus, on IL-6/sIL-6R-mediated RANKL expression through JAK2-STAT3-SOCS3 signaling pathway in fibroblast-like synoviocytes

(2013) Jung-Yoon Choe et al.   ARTHRITIS RESEARCH & THERAPY

Targeted drug development for arthritis

(2012) Charles J Malemud   Future Medicinal Chemistry

The JAK-STAT Pathway at Twenty

(2012) George R. Stark et al.   IMMUNITY

NFκB and ubiquitination: partners in disarming RIPK1-mediated cell death

(2012) Marie Anne O’Donnell et al.   IMMUNOLOGIC RESEARCH

Elevated expression of caspase-3 inhibitors, survivin and xIAP correlates with low levels of apoptosis in active rheumatoid synovium

(2012) Anak ASSK Dharmapatni et al.   ARTHRITIS RESEARCH & THERAPY

Matrix metalloproteinase-13 expression in IL-1β-treated chondrocytes by activation of the p38 MAPK/c-Fos/AP-1 and JAK/STAT pathways

(2011) Hyun Lim et al.   ARCHIVES OF PHARMACAL RESEARCH

Suppressors of cytokine signalling (SOCS) are reduced in osteoarthritis

(2011) María C. de Andrés et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Cytokine-Centric View of the Pathogenesis and Treatment of Autoimmune Arthritis

(2011) Brian Astry et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Osteoarthritis: can anti-cytokine therapy play a role in treatment?

(2010) Ana Luisa G. Calich et al.   CLINICAL RHEUMATOLOGY

Macrophage signaling in HIV-1 infection

(2010) Georges Herbein et al.   Retrovirology

Treating inflammation with the Janus Kinase inhibitor CP-690,550

(2010) Lalitha Vijayakrishnan et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Emerging from the shadows: Follicular helper T cells in autoimmunity

(2009) Leah D. DiPlacido et al.   ARTHRITIS AND RHEUMATISM

Targeting JAK/STAT Signaling Pathway in Inflammatory Diseases

(2009) Charles Malemud et al.   Current Signal Transduction Therapy

XIAP regulates bi-phasic NF-κB induction involving physical interaction and ubiquitination of MEKK2

(2008) Gabriele Winsauer et al.   CELLULAR SIGNALLING

A Mechanistic Insight into SMAC Peptide Interference with XIAP-Bir2 Inhibition of Executioner Caspases

(2008) Behnaz Ahangarian Abhari et al.   JOURNAL OF MOLECULAR BIOLOGY