Article
Immunology
Mei-Chun Yeh, Ben J. Wu, Yue Li, Mina Elahy, Leonel Prado-Lourenco, Jim Sockler, Herman Lau, Ric O. Day, Levon M. Khachigian
Summary: BT2 is a novel small molecule inhibitor that effectively suppresses joint inflammation, bone erosion, pro-inflammatory cytokines, and adhesion molecule expression, showing potential clinical utility as a new anti-inflammatory agent.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Immunology
Taiichiro Shirai, Akiko Nakai, Emiko Ando, Jun Fujimoto, Sarah Leach, Takao Arimori, Daisuke Higo, Floris J. van Eerden, Janyerkye Tulyeu, Yu-Chen Liu, Daisuke Okuzaki, Masanori A. Murayama, Haruhiko Miyata, Kazuto Nunomura, Bangzhong Lin, Akiyoshi Tani, Atsushi Kumanogoh, Masahito Ikawa, James B. Wing, Daron M. Standley, Junichi Takagi, Kazuhiro Suzuki
Summary: Celastrol can suppress humoral immune responses and autoimmunity by disabling the COMMD3/8 complex, a protein complex involved in chemotaxis and inflammation. Celastrol's immunosuppressive activity suggests that the COMMD3/8 complex could be a potential target for treating autoimmune diseases.
SCIENCE IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Daichi Akasaka, Satoru Iguchi, Ryusuke Kaneko, Yohei Yoshiga, Daisuke Kajiwara, Yoshinori Nakachi, Naruto Noma, Kenji Tanaka, Atsushi Shimizu, Fumihito Hosoi
Summary: The study investigated the potential of a Bruton's tyrosine kinase inhibitor, TAS5315, in treating rheumatoid arthritis. The results showed that TAS5315 suppressed immune-related signaling pathways, reduced inflammation, improved bone density, and ameliorated pathological changes in arthritis models, suggesting its promising therapeutic effects.
Article
Immunology
Junnan Zhou, Yuhang Mao, Xiaotian Shi, Yudie Zhang, Xiaolu Yu, Xuan Liu, Li Diao, Xue Yang, Changze Liu, Dan Liu, Xin Tan, Mei Liu
Summary: This study demonstrates the potential therapeutic effect of peimine on rheumatoid arthritis (RA), including the inhibition of destructive behaviors and over-expression of pro-inflammatory cytokines. It also provides insights into the molecular mechanism of action of peimine on RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Zhang Yan, Tang Li-Dong, Wang Jian-Ying, Wang Hao, Chen Xiao-Yun, Zhang Lei, Yuan Ying
Summary: In this study, the researchers investigated the anti-inflammatory effects and mechanisms of aucubin (AU) in rheumatoid arthritis (RA). They found that AU effectively inhibited cell migration and invasion, promoted apoptosis, and inhibited osteoclast differentiation. In addition, AU reduced the expression of inflammatory and bone metabolism-related genes and inhibited the NF-Kappa B signaling pathway. The results suggest that AU could be potentially used to treat synovial inflammation and bone destruction in RA.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Article
Plant Sciences
Mijin Kim, Bongjun Sur, Thea Villa, Seung Yeol Nah, Seikwan Oh
Summary: The study showed that Gintonin has anti-arthritic effects by inhibiting the expression of inflammatory mediators and preventing the nuclear translocation of NF-kappa B/p65. Additionally, it suppressed arthritis symptoms in a mice model of collagen-induced arthritis.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Immunology
Kane Langdon, Geraldine Buitrago, Darren Pickering, Paul Giacomin, Alex Loukas, Nagaraja Haleagrahara
Summary: This study assessed the effects of a helminthic protein Na-AIP-1 as monotherapy and in combination with MTX in the treatment of rheumatoid arthritis (RA). The results showed that Na-AIP-1, either as monotherapy or in combination with MTX, significantly reduced joint pathology in a mouse model of RA. This suggests that Na-AIP-1 could be a potential new candidate for drug development in the treatment of RA.
INFLAMMOPHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Wen Ye, Yachao Cui, Jian Rong, Wenlin Huang, Zhousan Zheng, Anqi Li, Yingchang Li
Summary: The expression of MCPIP1 is reduced in colorectal cancer tissues and is associated with poor prognosis. MCPIP1 exerts its anti-cancer effect by suppressing the NF-κB signaling pathway, making it a potential treatment option.
CANCER GENE THERAPY
(2023)
Article
Multidisciplinary Sciences
Nourihan Abdalla, Dina M. Abo-ElMatty, Sami Saleh, Maivel H. Ghattas, Nesreen Nabil Omar
Summary: In this study, the antifibrotic effect of Empa was examined by modulating the activity of hepatic stellate cells through the hedgehog pathway. The results showed that Empa suppressed CCl4-induced hedgehog signaling and proinflammatory response, while also mitigating endoplasmic reticulum stress in hepatic tissues, providing hepatoprotection.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Kaja Kasarello, Iwona Koehling, Anna Kosowska, Katarzyna Pucia, Anna Lukasik, Agnieszka Cudnoch-Jedrzejewska, Leszek Paczek, Urszula Zielenkiewicz, Piotr Zielenkiewicz
Summary: Cross-kingdom gene expression regulation by xenomiRs, particularly from plants, has been found to have potential scientific significance. In this study, miR172a derived from Brassica oleracea was shown to decrease the levels of FAN protein in human and mouse cells. Furthermore, treatment with miR172a was found to mitigate inflammation in a mouse model of rheumatoid arthritis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Ewan R. A. Ross, Andrew Devitt, Jill R. R. Johnson
Summary: Macrophages play critical roles in sterile inflammation and autoimmune diseases, particularly in the pathophysiology of diseases like rheumatoid arthritis. Imbalance in macrophage homeostasis contributes to chronic inflammation, and therapeutic strategies targeting macrophage plasticity are being explored. Apoptotic cell-derived extracellular vesicles may play a role in regulating macrophage phenotype and are a potential target for new therapeutic approaches.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Frideriki Poutoglidou, Chryssa Pourzitaki, Maria Eleni Manthou, Efthimios Samoladas, Athanasios Saitis, Foteini Malliou, Dimitrios Kouvelas
Summary: The study demonstrated that chronic treatment with infliximab had positive effects on bone mineral density and tendon inflammation in an animal model of inflammatory arthritis. Infliximab was more effective than methotrexate in improving joint inflammation and bone microarchitecture in the model.
INFLAMMOPHARMACOLOGY
(2021)
Review
Immunology
Yixin Zheng, Jianan Zhao, Yu Shan, Shicheng Guo, Steven J. Schrodi, Dongyi He
Summary: Rheumatoid arthritis (RA) is a complex autoimmune disease characterized by chronic inflammation in synovial tissues. Granzymes (Gzms) are serine proteases that enter target cells to induce programmed cell death. Increased levels of Gzms have been found in RA patients and they may contribute to inflammation by degrading extracellular matrix and promoting cytokine release. Although their exact role is yet to be fully understood, Gzms have the potential to be used as biomarkers for RA diagnosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Richard Ainsworth, Deepa Hammaker, Gyrid Nygaard, Cecilia Ansalone, Camilla Machado, Kai Zhang, Lina Zheng, Lucy Carrillo, Andre Wildberg, Amanda Kuhs, Mattias N. D. Svensson, David L. Boyle, Gary S. Firestein, Wei Wang
Summary: This study characterizes clusters of RA cell lines with distinctive TF biology by integrating transcriptomic and epigenomic data and validates the predicted differences.
NATURE COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Xiaolu Yu, Junnan Zhou, Fuli Zhao, Xuan Liu, Yuhang Mao, Li Diao, Chuanjun Wen, Mei Liu
Summary: Tomatidine (Td) shows inhibitory effects on inflammatory responses in arthritis and therapeutic effects on synovial inflammation and joint destruction in rats. Td can significantly suppress the production of pro-inflammatory cytokines and may act by reducing the activation of MAPKs and NF-κB.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
B. Williams, F. Lees, H. Tsangari, M. R. Hutchinson, E. Perilli, T. N. Crotti
MEDIATORS OF INFLAMMATION
(2020)
Article
Endocrinology & Metabolism
Dominic Thewlis, Andrew Waters, Lucian B. Solomon, Egon Perilli
Summary: The study found significant correlations between joint loading during walking and subchondral volumetric bone mineral density (vBMD) measured by pQCT in healthy young individuals, providing new insights into joint mechanics research.
Article
Engineering, Biomedical
Saulo Martelli, Mario Giorgi, Enrico Dall'Ara, Egon Perilli
Summary: Analysis of microstructural deformation and fracture behavior of elderly femora revealed that cortical elastic instability promotes bone fracture behavior, enhancing load bearing capacity, toughness, and damage tolerance. These findings will contribute to the advancement of current methods for predicting hip fragility.
ACTA BIOMATERIALIA
(2021)
Article
Orthopedics
Sophie Rapagna, Bryant C. Roberts, Lucian B. Solomon, Karen J. Reynolds, Dominic Thewlis, Egon Perilli
Summary: This study quantified the cartilage thickness, subchondral bone plate thickness, and subchondral trabecular bone microarchitecture in knees with varus- or valgus-malalignment and end-stage knee osteoarthritis. The results showed significant differences in cartilage and bone structures between varus-OA, valgus-OA, and controls, suggesting variations in load distribution and overall joint response to daily stimuli in OA patients.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Orthopedics
Thomas M. Grace, Dermot O'Rourke, Thomas Robertson, Egon Perilli, Stuart Callary, Mark Taylor, Gerald J. Atkins, Lucian B. Solomon, Dominic Thewlis
Summary: The study aimed to develop a semi-automated method to obtain lesion volume and bone mineral density from pelvic CT scans and assess its accuracy and reliability. Results showed that accuracy and reliability of lesion volume and BMD measurements decreased with decreasing CT clarity.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Cell Biology
Bonnie Williams, Florence Lees, Helen Tsangari, Mark R. Hutchinson, Egon Perilli, Tania N. Crotti
Summary: This study aimed to compare macroscopic and microscopic changes in the paws, along with central nervous system activation between a mild and moderate CAIA model. The moderate CAIA dose induced significantly greater local paw inflammation, inflammatory cell infiltration, and glial reactivity within the brain compared to the mild CAIA model. These findings support the use of a moderate CAIA model to induce more consistent histopathological features without excessive joint destruction.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2021)
Article
Orthopedics
Sophie Rapagna, Bryant C. Roberts, Lucian B. Solomon, Karen J. Reynolds, Dominic Thewlis, Egon Perilli
Summary: This study found significant correlations between joint loading indices and regional cartilage thickness values in end-stage knee OA subjects. Higher regional loads corresponded to thinner cartilage, suggesting a complementary bone-cartilage interplay in response to loading.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Multidisciplinary Sciences
Alice M. Clement, Richard Cloutier, Jing Lu, Egon Perilli, Anton Maksimenko, John Long
Summary: The megalichthyids are an extinct clade of tetrapodomorph fish that lived in freshwater environments during the Devonian-Permian periods. The diagnosis of this family remains controversial and the anatomy of certain species, such as Cladarosymblema narrienense, is not fully described. New anatomical details of C. narrienense have been revealed through 3D scanning and modeling, shedding light on the early neural adaptations of this group. Phylogenetic analysis confirms the relationships of megalichthyids and suggests further research is needed to fully understand their interrelationships.
Article
Engineering, Mechanical
Yanting Yin, Raihan Rumman, Madjid Sarvghad, Stuart Bell, Geoffrey Will, Richard E. Clegg, Egon Perilli, Sophie Rapagna, David A. Lewis, Theodore A. Steinberg, Gunther G. Andersson
Summary: This study conducted a systematic forensic analysis on a low-pressure CO2 receiver and found that grain boundary oxidation damage was the cause of failure in the adjacent stainless-steel tube.
ENGINEERING FAILURE ANALYSIS
(2022)
Article
Engineering, Biomedical
Lauren S. Wearne, Sophie Rapagna, Mark Taylor, Egon Perilli
Summary: This study assessed the accuracy and precision of DVC analysis on a cadaveric human tibia implanted with a titanium press-fit tray using a micro-CT system, and discussed the impact of experimental configurations and X-ray source settings.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Andrew Sales, Andrei Kotousov, Egon Perilli, Ling Yin
Summary: This study aimed to improve the fatigue properties of WAAM-produced SDSS by changing the interpass temperatures. It was found that an increase in the interpass temperature led to a reduction in the ferrite phase balance, resulting in an increased fatigue limit in the transverse direction. However, there was no significant effect on fatigue resistance in the longitudinal direction.
Review
Health Care Sciences & Services
Ming Min, David G. Hancock, Edoardo Aromataris, Tania Crotti, Christina Boros
Summary: The objective of this review was to investigate the experiences of children and young adults living with juvenile idiopathic arthritis, and their carers, in order to enhance understanding of their condition. Despite effective treatments, patients may experience persistent pain, growth retardation, physical disability, and psychological problems, which can negatively affect their quality of life.
JBI EVIDENCE SYNTHESIS
(2022)
Article
Orthopedics
Jetske Viveen, Egon Perilli, Ruurd L. Jaarsma, Job N. Doornberg, Denise Eygengaal, Gregory I. Bain
Summary: This study used micro-CT to describe the bone microstructure of the radial head and found that the lateral side has weaker bone microstructure compared to the medial side, which may explain commonly observed fracture patterns of the radial head. Surgeons should take advantage of the stronger bone microstructure on the medial side when dealing with radial head fractures.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2022)
Article
Engineering, Biomedical
Marco Palanca, Egon Perilli, Saulo Martelli
Summary: This study found that the risk of osteoporotic hip fractures in a sideways fall depends on both variations of body anthropometry and bone strength. The overlapping ranges of hip impact energy and fracture energy showed relatively small differences. Evaluating factors such as fracture patterns, force, and energy can help in correctly classifying fracture cases.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Review
Health Care Sciences & Services
Ming Min, David G. Hancock, Edoardo Aromataris, Tania Crotti, Christina Boros
JBI EVIDENCE SYNTHESIS
(2020)