Review
Pharmacology & Pharmacy
Mahmoud Zaki El-Readi, Ahmed M. Al-Abd, Mohammad A. Althubiti, Riyad A. Almaimani, Hiba Saeed Al-Amoodi, Mohamed Lotfy Ashour, Michael Wink, Safaa Yehia Eid
Summary: Plant secondary metabolites are commonly used in pharmaceutical agents, especially in cancer therapy, to reduce the doses of chemotherapeutic drugs, enhance cell growth inhibition, avoid side effects, and increase cancer cell sensitivity to chemotherapy. They interact with membrane proteins and nucleic acids, inducing apoptosis to overcome multidrug resistance. Consuming dietary supplements containing secondary metabolites may affect the bioavailability, efficacy, and safety of drugs that are substrates of P-glycoprotein.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Ke Liu, Jun Huang, Jiao Liu, Daniel J. Klionsky, Rui Kang, Daolin Tang
Summary: Carboplatin-resistant RB cells exhibit higher autophagy activity compared to parent cells, leading to multi-drug resistance. This study introduces a new strategy of inducing autophagy-dependent ferroptosis to eliminate drug-resistant RB cells. The effectiveness and safety of a cell-permeable derivative of itaconate in inducing ferritinophagy-dependent ferroptosis were evaluated.
CELL DEATH & DISEASE
(2022)
Review
Pharmacology & Pharmacy
Bowen Qing, Song Wang, Yingan Du, Can Liu, Wei Li
Summary: Endoplasmic reticulum stress is a cell response to stress and its abnormal activation can influence tumor development and treatment efficacy. Investigating the molecular mechanism of ERS can help solve drug resistance in tumors and provide a novel strategy for treating refractory tumors.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Chengyuan Zhang, Xuemei Zhou, Hanyi Zhang, Xuanliang Han, Baijun Li, Ran Yang, Xing Zhou
Summary: Multidrug resistance (MDR) is a major reason for chemotherapy failure, and developing nano-delivery systems for MDR tumors has become important. This review systematically summarizes recent advances in nanotechnology targeting different mechanisms of MDR. However, there are still issues with nano-delivery systems for MDR tumors, such as excessive use of carrier materials, low drug-loading capacity, and limited targeting mechanisms.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tiantian Tan, Jie Li, Ruhua Luo, Rongrong Wang, Liyan Yin, Mengmeng Liu, Yiying Zeng, Zhaowu Zeng, Tian Xie
Summary: The research reviewed in the article shows that elemene has the potential to reverse drug resistance in tumor cells and enhance the sensitivity of cancer cells to chemotherapy.
Article
Biochemistry & Molecular Biology
Xingkai Cheng, Junting Zhang, Zhengya Liang, Zhaochen Wu, Pengfei Liu, Jianjun Hao, Xili Liu
Summary: This study found that plant pathogens can develop multidrug resistance (MDR) through metabolomic and efflux activities. The genes encoding ABC and MFS transporters were identified to be associated with MDR in Rhizoctonia solani, and their expression levels were higher in MDR mutant compared to the wild-type strain. Two of these transporters were found to be related to MDR and their roles were confirmed by detecting their protein products and high accumulation of an antifungal compound. These findings contribute to our understanding of fungicide resistance and the development of MDR.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Environmental Sciences
Ruixuan Wang, Xiaozhi Lin, Guangcai Zha, Juan Wang, Wei Huang, Jiangyong Wang, Yuee Hou, Hongli Mou, Ting Zhang, Hui Zhu, Jun Wang
Summary: Vibrio harveyi infection in aquaculture has caused significant economic losses. This study found that a pathogenic strain of V. harveyi could be induced to become a multiple-resistant strain by enrofloxacin, and the mechanism of multidrug resistance was mainly related to the upregulation of the efflux and SOS systems. This research is important for addressing the issue of drug resistance in V. harveyi.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Multidisciplinary Sciences
Yagmur Demircan Yalcin, Taylan Berkin Toral, Sertan Sukas, Ender Yildirim, Ozge Zorlu, Ufuk Gunduz, Haluk Kulah
Summary: The development of a lab-on-a-chip system enabled the investigation of drug resistance in leukemia cells using coupled dielectrophoretic detection (DEP-D) and impedimetric counting (IM-C) techniques. Conductivity matching and frequency values allowed for successful discrimination between drug resistant and wild type cells.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Dima W. Alhamad, Sara M. Elgendy, Fatema Hersi, Hesham R. El-Seedi, Hany A. Omar
Summary: The study found differences in autophagy regulation in resistant hepatocellular carcinoma cells, and demonstrated that the combination of an autophagy inhibitor and a chemotherapeutic agent can promote cell death, reduce drug resistance, and increase reactive oxygen species production and apoptosis induction.
Article
Biochemistry & Molecular Biology
Eric Chekwube Aniogo, Blassan P. George, Heidi Abrahamse
Summary: The study utilized photodynamic therapy to treat MCF-7 cells overexpressed with P-glycoprotein, resulting in cell apoptosis with increased externalisation of phosphatidylserine protein and changes in apoptotic protein expression.
Article
Chemistry, Analytical
Han Li, Jiaojiao Li, Meng Wang, Weiyue Feng, Fuping Gao, Ying Han, Yijie Shi, Zhongying Du, Qing Yuan, Peng Cao, Xiayan Wang, Xueyun Gao, Kai Cao, Liang Gao
Summary: Identifying effective reversal agents to overcome multidrug resistance is crucial for improving tumor chemotherapy. In this study, a metal cluster-based probe called clusterbody was developed for flow sorting-assisted single-cell mass spectrometry analysis. The clusterbody, synthesized through biomimetic mineralization, selectively recognizes an efflux pump protein and enables high-throughput cell sorting based on fluorescence emitted by the probe. Protein abundance at the single-cell level is determined through precise signal amplification using laser ablation inductively coupled plasma mass spectrometry, allowing quantitative evaluation of reversal agent treatment. This work provides a new approach to identify reversal agents and sheds light on developing combined or synergetic tumor therapy.
ANALYTICAL CHEMISTRY
(2023)
Article
Cell Biology
Xiaofang Chen, Xianling Chen, Yiping Huang, Jia Lin, Yong Wu, Yuanzhong Chen
Summary: In this study, it was found that elevated expression of TCP1 in acute myeloid leukemia patients was associated with low complete response rate and poor overall survival. Further investigations revealed that TCP1 contributes to drug resistance by inhibiting autophagy and activating the AKT/mTOR signaling pathway. Targeting the TCP1/AKT/mTOR signaling pathway provides a new strategy for overcoming drug resistance in AML.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Nikoletta Szemeredi, Simona Dobiasova, Noemi Salardon-Jimenez, Annamaria Kincses, Marta Nove, Giyaullah Habibullah, Clotilde Sevilla-Hernandez, Miguel Benito-Lama, Francisco-Javier Alonso-Martinez, Jitka Viktorova, Gabriella Spengler, Enrique Dominguez-Alvarez
Summary: The research team designed, synthesized, and evaluated 15 novel selenoesters, some of which showed significant cytotoxicity and selectivity, indicating potential for use in the treatment of resistant cancer cells.
Article
Oncology
Lucia Pavlikova, Mario Seres, Albert Breier, Zdena Sulova
Summary: This paper provides an overview of the possible role of miRNAs in the molecular mechanisms that lead to multidrug resistance (MDR). miRNAs regulate post-transcriptional processes in the proteosynthetic pathway and may serve as specific effectors or interesting targets for cancer therapy.
Review
Pharmacology & Pharmacy
Shaojie Yang, Wanlin Dai, Jingnan Wang, Xiaolin Zhang, Yuting Zheng, Shiyuan Bi, Liwei Pang, Tengqi Ren, Ye Yang, Yang Sun, Zhuyuan Zheng, Shuodong Wu, Jing Kong
Summary: Cancer is a global health problem with high incidence and mortality rates. Osthole, a coumarin compound extracted from Cnidium monnieri (L.) Cuss., has shown promising anticancer effects. Studies have revealed that osthole inhibits cancer cell proliferation, induces apoptosis, suppresses migration and invasion, inhibits angiogenesis, enhances sensitivity to chemotherapy drugs, and reverses multidrug resistance.
FRONTIERS IN PHARMACOLOGY
(2022)
