Article
Oncology
Yuanliu Nie, Guangyue Yao, Liang Li, Alei Feng, Wentao Zhang, Xiaoying Xu, Qiang Li, Zhe Yang
Summary: This study assessed the effects of immunotherapy plus radiotherapy on survival outcomes in patients with advanced esophageal cancer and established a prognostic nomogram based on independent prognostic factors. The results showed that immunotherapy plus radiotherapy resulted in significantly longer progression-free survival and overall survival compared to immunotherapy alone. The nomogram based on prognostic factors can guide personalized treatment and monitoring of prognosis.
CANCER MANAGEMENT AND RESEARCH
(2022)
Review
Oncology
Mate Naszai, Alina Kurjan, Timothy S. Maughan
Summary: Inflammation is closely related to cancer, and NLR from routine blood testing serves as an easily accessible prognostic biomarker, aiding in assessing clinical outcomes in colorectal cancer patients. Combining results from numerous studies, high NLR was found to be associated with poor clinical outcomes, despite limitations in some studies, it should be routinely collected in clinical trials.
Article
Oncology
Jun-Qiang Du, Fan Zhang, Chao-Qun Wang, Ju-Fan Zhu, Li-Xia Xu, Yi-Heng Yang, Meng-Fei Han, Yan Hu
Summary: This study analyzed the levels of peripheral blood NLR in 203 patients with early cervical cancer and evaluated the relationship between NLR changes, clinicopathological characteristics, and patient prognosis. The study found that high preoperative NLR was associated with shorter overall survival and high postoperative NLR was associated with lower progression-free survival. Postmenopausal patients and those without vascular infiltration had higher rates of NLR increase. Further multicenter studies are needed to verify the effect of NLR changes on the prognosis of cervical cancer patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Health Care Sciences & Services
Yi Liu, Chuandong Wang, Huan Wang, Changshun Yang, Xuefei Cheng, Weihua Li
Summary: This study developed a new prognostic scoring system combining preoperative inflammatory factors and clinicopathologic features for predicting the prognosis of gastric cancer patients after distal radical gastrectomy. The results showed that tumor stage, pathological type, and neutrophil to lymphocyte ratio (NLR) were independent risk factors for the prognosis of gastric cancer patients. The nomogram based on these factors was more accurate in prognostic prediction compared to the current AJCC TNM staging.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Immunology
Qian Song, Song-Xiao Xu, Jun-Zhou Wu, Lin Ling, Sheng Wang, Xin-Hua Shu, Dan-Ni Ying, Wang-Wei Pei, Yu-Chen Wu, Su-Fang Sun, Yi-Ning Zhang, Si-Hang Zhou, Zhu-Yan Shao
Summary: This study analyzed data from 991 ovarian cancer patients and found that the lymphocyte to monocyte ratio (LMR) and platelet to neutrophil ratio (PNR) were independent prognostic indicators of ovarian cancer. In contrast, the platelet to lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) had limited prognostic value. In conclusion, LMR and PNR are superior prognostic indicators in ovarian cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Otorhinolaryngology
Xianyang Hu, Tengfei Tian, Xueyan Zhang, Qin Sun, Yanyang Chen, Wenxiu Jiang
Summary: This meta-analysis aims to clarify the effect of neutrophil-to-lymphocyte ratio (NLR) on the prognosis of hypopharyngeal cancer. The results show that high NLR is associated with poor overall survival and progression-free survival in patients with hypopharyngeal cancer. Pretreatment NLR can be used as an effective serological indicator to assess the prognosis of these patients.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Oncology
Wentao Wang, Yilin Tong, Shulan Sun, Yuen Tan, Zexing Shan, Fan Sun, Chengyao Jiang, Yanmei Zhu, Jianjun Zhang
Summary: This study found that pretreatment neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) can independently predict tumor regression grade (TRG) after neoadjuvant chemotherapy in patients with locally advanced gastric cancer. Patients with high NLR and PLR values may benefit from alternative treatments.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jia-ming Zhao, Qi An, Chao-nan Sun, Yu-bing Li, Zi-lan Qin, Hong Guo, Xue Zeng, Yao-tian Zhang, Lin-lin Wei, Ning Han, Shi-chen Sun, Na Zhang
Summary: This study identified tumor size, ER/PR status, preoperative NLR, and NMR as independent predictors of recurrence risk in breast cancer patients. PMRT was found to significantly improve locoregional control even in the low-risk subgroup of patients with T1-2 tumors and 1-3 positive lymph nodes.
Article
Oncology
Chunji Chen, Haitang Yang, Deng Cai, Lujie Xiang, Wentao Fang, Rui Wang
Summary: The study aimed to establish NLR and PLR related nomograms based on clinical data and peripheral blood markers to predict the survival of LS-SCLC patients. Elevated NLR and PLR were found to predict poor prognosis in their respective nomograms, showing better accuracy and stability compared to the TNM staging system. The models had a better effect in predicting prognosis as indicated by C-index and calibration curves.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Review
Oncology
Kian Heshmat-Ghahdarijani, Vida Sarmadi, Afshin Heidari, Alireza Falahati Marvasti, Sina Neshat, Sina Raeisi
Summary: This article evaluates the prognostic potential of the neutrophil-to-lymphocyte ratio (NLR) in cancer. By reviewing recent studies, the association between NLR and various malignancies is identified. These findings contribute to a better understanding of the role of NLR in cancer prognosis and provide guidance for future research directions.
FRONTIERS IN ONCOLOGY
(2023)
Article
Infectious Diseases
Zhihan Gu, Bofu Liu, Xiaomin Yu, Tao Cheng, Tianyong Han, Le Tong, Yu Cao
Summary: This study investigated the role of the neutrophil lymphocyte ratio (NLR) in the short-term prognosis and severity of tuberculosis meningitis (TBM) patients without HIV infection. The results showed that NLR, peripheral neurological deficit, and hydrocephalus were independent risk factors for 28-day mortality. NLR can predict the short-term prognosis of TBM patients without HIV infection and is significantly correlated with the severity of the disease.
BMC INFECTIOUS DISEASES
(2023)
Article
Oncology
Xinran Li, Jiamin Zheng, Min Yan, Ye Lu, Xiangtao Pan
Summary: The combination of fibrinogen and neutrophil to lymphocyte ratio significantly improves the accuracy of predicting prognosis in patients with gastric cancer, with differences in levels of fibrinogen and NLR showing statistical significance between survival and death groups.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Oncology
Zhifeng Yang, Yongjing Li, Ke Zhang, Xuejie Deng, Shaoqi Yang, Zhen Wang
Summary: This study suggests that the combination of neutrophil to lymphocyte ratio (NLR) and interleukin-6 (IL-6) has a stronger predictive value for non-metastatic colorectal cancer (CRC) prognosis compared to using NLR or IL-6 alone. High NLR and IL-6 levels are significantly correlated with tumor differentiation and staging in CRC patients, and a high NLR + IL-6 value is associated with a worse overall survival and disease-free survival.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Surgery
Worapat Attawettayanon, Teeranop Choorit, Virote Chalieopanyarwong, Choosak Pripatnanont
Summary: NLR and PLR are useful in assessing survival outcomes of nonmetastatic RCC patients, with high PLR being an independent prognostic factor; Elevated NLR and anemia were significantly associated with cancer-specific survival.
ASIAN JOURNAL OF SURGERY
(2021)
Review
Clinical Neurology
Miguel Cabanillas-Lazo, Carlos Quispe-Vicuna, Claudia Cruzalegui-Bazan, Milagros Pascual-Guevara, Nicanor Mori-Quispe, Carlos Alva-Diaz
Summary: A systematic review and meta-analysis found that the neutrophil-lymphocyte ratio (NLR) may serve as a potential biomarker for Guillain-Barre syndrome (GBS). The study revealed a significant increase in NLR values in GBS patients compared to healthy controls. Furthermore, NLR showed potential as a prognostic factor for disability and respiratory failure in GBS patients. However, more research is needed to confirm these findings.
FRONTIERS IN NEUROLOGY
(2023)
Article
Surgery
Naoya Yoshida, Keisuke Kosumi, Ryuma Tokunaga, Baba Yoshifumi, Yohei Nagai, Yuji Miyamoto, Shiro Iwagami, Masaaki Iwatsuki, Yukiharu Hiyoshi, Takatsugu Ishimoto, Kojiro Eto, Yu Imamura, Masayuki Watanabe, Hideo Baba
Article
Oncology
Masayo Tsukamoto, Katsunori Imai, Takatsugu Ishimoto, Yoshihiro Komohara, Yo-ichi Yamashita, Shigeki Nakagawa, Naoki Umezaki, Takanobu Yamao, Yuki Kitano, Tatsunori Miyata, Kota Arima, Hirohisa Okabe, Yoshifumi Baba, Akira Chikamoto, Takatoshi Ishiko, Masahiko Hirota, Hideo Baba
Article
Cell Biology
Daisuke Izumi, Shusuke Toden, Elsie Ureta, Takatsugu Ishimoto, Hideo Baba, Ajay Goel
CELL DEATH & DISEASE
(2019)
Article
Gastroenterology & Hepatology
Yohei Nagai, Naoya Yoshida, Yoshifumi Baba, Kazuto Harada, Katsunori Imai, Masaaki Iwatsuki, Ryuichi Karashima, Yuki Koga, Daichi Nomoto, Kazuo Okadome, Takatsugu Ishimoto, Yu Imamura, Masayuki Watanabe, Hideo Baba
DIGESTIVE ENDOSCOPY
(2020)
Article
Oncology
Kohei Yamashita, Masaaki Iwatsuki, Kazuto Harada, Kojiro Eto, Yukiharu Hiyoshi, Takatsugu Ishimoto, Yohei Nagai, Shiro Iwagami, Yuji Miyamoto, Naoya Yoshida, Yoshihiro Komohara, Jaffer A. Ajani, Hideo Baba
Article
Oncology
Rebecca Kalikawe, Yoshifumi Baba, Daichi Nomoto, Kazuo Okadome, Keisuke Miyake, Kojiro Eto, Yukiharu Hiyoshi, Youhei Nagai, Masaaki Iwatsuki, Takatsugu Ishimoto, Shiro Iwagami, Yuji Miyamoto, Naoya Yoshida, Masayuki Watanabe, Hideo Baba
Article
Oncology
Kosuke Mima, Yuki Sakamoto, Keisuke Kosumi, Yoko Ogata, Keisuke Miyake, Yukiharu Hiyoshi, Takatsugu Ishimoto, Masaaki Iwatsuki, Yoshifumi Baba, Shiro Iwagami, Yuji Miyamoto, Naoya Yoshida, Shuji Ogino, Hideo Baba
SURGICAL ONCOLOGY-OXFORD
(2020)
Article
Oncology
Naoya Yoshida, Yuki Adachi, Takeshi Morinaga, Kojiro Eto, Ryuma Tokunaga, Kazuto Harada, Yukiharu Hiyoshi, Yohei Nagai, Masaaki Iwatsuki, Takatsugu Ishimoto, Yoshifumi Baba, Shiro Iwagami, Yuji Miyamoto, Yu Imamura, Masayuki Watanabe, Hideo Baba
ANNALS OF SURGICAL ONCOLOGY
(2020)
Article
Oncology
Kazuo Okadome, Yoshifumi Baba, Daichi Nomoto, Taisuke Yagi, Rebecca Kalikawe, Kazuto Harada, Yukiharu Hiyoshi, Yohei Nagai, Takatsugu Ishimoto, Masaaki Iwatsuki, Shiro Iwagami, Yuji Miyamoto, Naoya Yoshida, Masayuki Watanabe, Yoshihiro Komohara, Takashi Shono, Yutaka Sasaki, Hideo Baba
BRITISH JOURNAL OF CANCER
(2020)
Review
Biochemistry & Molecular Biology
Sana Hibino, Tetsuro Kawazoe, Hidenori Kasahara, Shinji Itoh, Takatsugu Ishimoto, Mamiko Sakata-Yanagimoto, Koji Taniguchi
Summary: Inflammation plays a pivotal role in tumorigenesis and metastasis by suppressing anti-tumor immunity. Different types of tumors may have diverse responses to inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Surgery
Tadahito Yasuda, Kojiro Eto, Naoya Yoshida, Shiro Iwagami, Yukiharu Hiyoshi, Youhei Nagai, Masaaki Iwatsuki, Takatsugu Ishimoto, Yoshifumi Baba, Yuji Miyamoto, Takuya Shiota, Yoshiki Mikami, Hideo Baba
SURGICAL CASE REPORTS
(2020)
Review
Biochemistry & Molecular Biology
Lingfeng Fu, Luke Bu, Tadahito Yasuda, Mayu Koiwa, Takahiko Akiyama, Tomoyuki Uchihara, Hideo Baba, Takatsugu Ishimoto
Meeting Abstract
Oncology
Kazuo Okadome, Yoshifumi Baba, Taisuke Yagi, Yuki Kiyozumi, Kojiro Eto, Yukiharu Hiyoshi, Yohei Nagai, Takatsugu Ishimoto, Masaaki Iwatsuki, Shiro Iwagami, Yuji Miyamoto, Naoya Yoshida, Hideo Baba
Meeting Abstract
Oncology
Yuki Sakamoto, Kosuke Mima, Nobuya Daitoku, Yukiharu Hiyoshi, Katsunori Imai, Masaaki Iwatsuki, Takatsugu Ishimoto, Yoshifumi Baba, Shiro Iwagami, Yuji Miyamoto, Yoichi Yamashita, Naoya Yoshida, Hideo Baba
Meeting Abstract
Oncology
Takatsugu Ishimoto, Kota Arima, Tomoyuki Uchihara, Keisuke Miyake, Atsuko Yonemura, Tadahito Yasuda, Rumi Itoyama, Masaaki Iwatsuki, Yoshifumi Baba, Naoya Yoshida, Hideo Baba
