Article
Immunology
Ebru Yuce
Summary: The role of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in predicting spontaneous preterm birth was investigated. Retrospective data collected from hospital records between February 2018 and November 2022 showed that NLR and PLR values can predict preterm birth with high sensitivity and specificity. Predicting preterm birth allows for sensitive and smooth management of the pregnancy process.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Immunology
E. Weijian, Zhixin Wang, Mingquan Pang, Yongliang Lu, Haining Fan
Summary: The NLR and PLR of AE patients were higher than those of CE patients, and the high inflammation of CE patients may be correlated to the reproductive mode of Echinococcus multilocularis. PLR and NLR have certain diagnostic values for disease classification, but PLR has higher specificity when compared with NLR.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Health Care Sciences & Services
Georgios Tzikos, Ioannis Alexiou, Sokratis Tsagkaropoulos, Alexandra-Eleftheria Menni, Georgios Chatziantoniou, Soultana Doutsini, Theodosios Papavramidis, Vasilios Grosomanidis, George Stavrou, Katerina Kotzampassi
Summary: In this study, the researchers investigated whether NLR and PLR could predict mortality and length of hospital stay after cardiac surgery. The results showed that NLR and PLR are efficient predictive factors for 90-day mortality and length of stay in cardiac surgery patients. Monitoring NLR and PLR postoperatively could provide a reliable predictor of patients' outcomes.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Pediatrics
Spyridoula Gysi, Michael Doulberis, Corinne Legeret, Henrik Kohler
Summary: This retrospective analysis explored the utilization of PYMS as a screening tool for malnutrition in pediatric inpatients and investigated the correlation between PYMS and NLR and PLR. The study found a potential value of PLR as a predictive marker for moderate to severe malnutrition in hospitalized children.
Article
Medicine, General & Internal
Milena-Adina Man, Lavinia Davidescu, Nicoleta-Stefania Motoc, Ruxandra-Mioara Rajnoveanu, Cosmina-Ioana Bondor, Carmen-Monica Pop, Claudia Toma
Summary: The study showed that NLR and PLR had limited ability to differentiate between various respiratory diseases and were not suitable for making the differential diagnosis.
Article
Immunology
Pauline Jacob, Julie Bonnefoy, Stephanie Ghislin, Jean-Pol Frippiat
Summary: This study evaluated the relevance of two easily-implemented biomarkers for monitoring immune system in astronauts and suggested using neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) to assess long-lasting immune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Bowen Xu, Zhiqiang Chen, Jing Zhang, Jianhua Chang, Wei Zhao, Zhaoru Dong, Xuting Zhi, Tao Li
Summary: The study confirmed the importance of whole blood cell count-derived indexes including NLR, MLR/LMR, and PLR as prognostic parameters for GBC patients, and can be used to predict survival outcomes, helping to improve risk stratification and patient selection.
FRONTIERS IN ONCOLOGY
(2021)
Article
Psychiatry
Qi Zheng, Jin Liu, YaJuan Ji, Yan Zhang, XinChao Chen, BangShan Liu
Summary: This study compared the levels of inflammatory indicators derived from blood routine tests between adolescents with and without non-suicidal self-injury (NSSI). The results showed that adolescents with NSSI had significantly higher MLR and PLR compared to those without NSSI. MLR and PLR were independently associated with NSSI. ROC curve analysis demonstrated that MLR and PLR can be used to differentiate NSSI from non-NSSI.
Article
Endocrinology & Metabolism
Wenwen Chen, Kun Chen, Zhixiao Xu, Yepeng Hu, Yiying Liu, Wenyue Liu, Xiang Hu, Tingting Ye, Jing Hong, Hong Zhu, Feixia Shen
Summary: The study found that elevated platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) were associated with higher all-cause mortality in patients with diabetic foot ulcers (DFU) following amputations. Multivariate analysis identified age, Wagner classification, PLR, NLR, creatinine, and direct bilirubin as independent predictors of mortality after amputation.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Cieszymierz Gawinski, Andrzej Mroz, Katarzyna Roszkowska-Purska, Iwona Sosnowska, Edyta Derezinska-Wolek, Wojciech Michalski, Lucjan Wyrwicz
Summary: This study investigated the role of systemic inflammatory response (SIR) markers in locally advanced rectal cancer (LARC). The results showed a significant positive correlation between lymphocyte-to-monocyte ratio (LMR) and cancer-related inflammatory infiltrate, as well as PD-L1 expression. Platelet-to-lymphocyte ratio (PLR) was correlated with nodal involvement. However, these markers demonstrated only moderate reproducibility and had no significant prognostic value. Further research is needed to establish their effectiveness as biomarkers in LARC.
Article
Medicine, General & Internal
Yingjie Duan, Zhong Peng, Shuzhu Zhong, Hong Huang, Zhangxiu He
Summary: This study investigated the relationship between monocyte-to-lymphocyte ratio (MLR) and left ventricular ejection fraction (LVEF) in patients with peritoneal dialysis (PD), and found that platelet-to-lymphocyte ratio (PLR) was more reliable than neutrophil-to-lymphocyte ratio (NLR), MLR, and albumin in predicting left ventricular systolic dysfunction (LVSD) in PD patients.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Marina Sagud, Zoran Madzarac, Gordana Nedic Erjavec, Ivona Simunovic Filipcic, Filip Luka Mikulic, Dunja Rogic, Zoran Bradas, Maja Bajs Janovic, Nela Pivac
Summary: Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR) and systemic immune-inflammation index (SII index) are commonly used to indicate inflammation. Their relationship with negative symptoms, including anhedonia, in patients with schizophrenia is not well understood. This study found that there were weak to moderate positive correlations between various negative symptoms and blood cell inflammatory ratios in male patients, and weaker correlations in female patients. However, social anhedonia showed a negative correlation with the SII index in females, suggesting a possible different mechanism. Further exploration is needed to understand the relationship between anhedonia and inflammatory markers.
Article
Emergency Medicine
Murat Seyit, Esin Avci, Rukiye Nar, Hande Senol, Atakan Yilmaz, Mert Ozen, Alten Oskay, Hulya Aybek
Summary: The study revealed that levels of CRP, LDH, PLR, and NLR were significantly higher in COVID-19 positive patients, while levels of eosinophil, lymphocyte, and platelets were significantly elevated in COVID-19 negative patients.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Medicine, General & Internal
Sho Yasui, Tomoaki Takata, Yu Kamitani, Yukari Mae, Hiroki Kurumi, Yuichiro Ikebuchi, Akira Yoshida, Koichiro Kawaguchi, Kazuo Yashima, Hajime Isomoto
Summary: The study demonstrates an association between NLR and PLR with the histological diagnosis of gastric cancer, suggesting that NLR could be a useful marker for assessing early gastric cancer.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biology
Cieszymierz Gawinski, Wojciech Michalski, Andrzej Mroz, Lucjan Wyrwicz
Summary: Colorectal cancer is a leading cause of cancer-related mortality worldwide, requiring novel markers for patient risk assessment and treatment adjustments. Peripheral and local markers of cancer-related inflammation have been extensively studied and found to be highly prognostic. Despite the initial hypothesis, peripheral blood-based markers showed no correlation with tissue-based markers of tumor-infiltrating lymphocytes.
Article
Oncology
Zhang Yang, Shun-Qing Liang, Liang Zhao, Haitang Yang, Thomas M. Marti, Balazs Hegedus, Yanyun Gao, Bin Zheng, Chun Chen, Wenxiang Wang, Patrick Dorn, Gregor J. Kocher, Ralph A. Schmid, Ren-Wang Peng
Summary: This study reveals the metabolic dependency induced by mutant KRAS and identifies nucleolar protein 5A (NOP56) and mTOR as potential targets for the treatment of KRAS-mutant cancers. The depletion of NOP56 leads to synthetic lethal susceptibility to mTOR inhibition due to the regulation of ROS homeostasis. Co-targeting NOP56 and mTOR significantly enhances cell death in KRAS-mutant tumor cells.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Medicine, Research & Experimental
Haitang Yang, Sabina Berezowska, Patrick Dorn, Philipp Zens, Peiru Chen, Ren-Wang Peng, Thomas M. Marti, Gregor J. Kocher, Ralph A. Schmid, Sean R. R. Hall
Summary: This study investigates the relationship between the tumor microenvironment (TME) and tumor-infiltrating lymphocytes (TILs) in malignant pleural mesothelioma (MPM). The results suggest that targeting the TME can potentially redirect the fate of TILs and restore anti-tumor immunity in MPM.
Article
Oncology
Jesse J. Lipp, Limei Wang, Haitang Yang, Feng Yao, Nathalie Harrer, Stefan Muller, Sabina Berezowska, Patrick Dorn, Thomas M. Marti, Ralph A. Schmid, Belazs Hegedus, Abdallah Souabni, Sebastian Carotta, Mark A. Pearson, Wolfgang Sommergruber, Greg J. Kocher, Sean R. R. Hall
Summary: This study investigates the effect of PD1 expression on the functional and molecular profiles of tumor-resident T cells in non-small cell lung cancer patients. They find that PD1+ CD8+ T cells have elevated expression of the transcriptional regulator ID3 and that knocking down ID3 improves the cytotoxic potential of these cells. Additionally, PD1+ CD4+ memory T cells can facilitate B cell activation and expansion. Restoring WNT signaling by blocking GSK3 beta improves the effector function of PD1+ CD8+ T cells.
Letter
Oncology
Haitang Yang, Wenyan Ma, Feng Yao
TRANSLATIONAL LUNG CANCER RESEARCH
(2022)
Article
Respiratory System
Wenbin Fan, Haitang Yang, Jie Ma, Zhexin Wang, Heng Zhao, Feng Yao
Summary: The present study compares the short-term outcomes of indocyanine green fluorescence (ICGF) versus the traditional inflation-deflation method for uniportal video-assisted thoracoscopic surgery (VATS) segmentectomy. The results show that the ICGF-based navigation approach is a simple and effective technique that can greatly facilitate the uniportal VATS segmentectomy.
JOURNAL OF THORACIC DISEASE
(2022)
Letter
Oncology
Haitang Yang, Feng Yao, Ren-Wang Peng
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Physics, Particles & Fields
Guangzhou Guo, Peng Wang, Houwen Wu, Haitang Yang
Summary: This study investigates the waveforms of time signals produced by scalar perturbations in static hairy black holes. The waveforms are influenced by a double-peak effective potential. When the distance between the peaks is large, a series of decaying echo pulses are generated. However, when the peaks are close, fewer echo signals and a slowly decaying sinusoid tail are observed.
JOURNAL OF HIGH ENERGY PHYSICS
(2022)
Article
Medicine, General & Internal
Haitang Yang, Beibei Sun, Wenyan Ma, Liwen Fan, Ke Xu, Yunxuan Jia, Jianlin Xu, Zhexin Wang, Feng Yao
Summary: By studying the response of metastatic lymph nodes and primary tumors in lung cancer patients treated with immune checkpoint inhibitors, we found significant differences in radiological, metabolic, and pathological changes between the two. The presence of invaded lymph nodes was associated with poor pathological responses in primary tumors and predicted rapid tumor relapse after treatment.
Review
Medicine, Research & Experimental
Ke Xu, Jie Ma, Sean R. R. Hall, Ren-Wang Peng, Haitang Yang, Feng Yao
Summary: The hyperactivation of the KEAP1/NRF2 pathway in non-small cell lung cancer leads to metabolic reprogramming and immune remodeling, contributing to the aggressiveness, treatment resistance, and susceptibility to metastases of the cancer cells.
Article
Chemistry, Multidisciplinary
Ke Xu, Meiqi Chang, Zeyu Wang, Haitang Yang, Yunxuan Jia, Weijiao Xu, Baicheng Zhao, Yu Chen, Feng Yao
Summary: In this study, LaCoO3 (LCO) lanthanide-based nanocrystals were designed to trigger lung cancer cell pyroptosis by generating cytotoxic reactive oxygen species (ROS) and releasing lanthanum ions. The LCO nanoenzyme exhibited peroxidase- and oxidase-mimicking activities, producing ROS in the tumor microenvironment. It also reversed the hypoxic environment, destroying the antioxidant system of tumor cells and increasing their sensitivity to ROS. LCO-induced pyroptotic cell death effectively restrained lung cancer growth and metastasis.
ADVANCED MATERIALS
(2023)
Article
Cell Biology
Haitang Yang, Yanyun Gao, Duo Xu, Ke Xu, Shun-Qing Liang, Zhang Yang, Amina Scherz, Sean R. R. Hall, Stefan Forster, Sabina Berezowska, Feng Yao, Adrian F. F. Ochsenbein, Thomas M. M. Marti, Gregor J. J. Kocher, Ralph A. A. Schmid, Patrick Dorn, Ren-Wang Peng
Summary: Malignant pleural mesothelioma (MPM) is a lethal malignancy caused by asbestos exposure. In this study, we found that the hyperactive MAPK pathway is a molecular driver of MPM, and blocking this pathway induces cell apoptosis. Additionally, the MAPK pathway cooperates with PARP1 to regulate ROS levels, and combining MEK inhibitors with PARP inhibitors enhances cell apoptosis.
CELL DEATH DISCOVERY
(2023)
Article
Engineering, Biomedical
Jiamin Sun, Kai Jiang, Yifan Wang, Yuqing Liu, Ting Wang, Shiyue Ding, Xianzhi Zhang, Weiwei Xiong, Fenfen Zheng, Haitang Yang, Jun-Jie Zhu
Summary: An easy-synthesized and biodegradable nanoflower-medicine that effectively suppresses tumor growth and reactivates antitumor immunity through tumor microenvironment (TME)-responsive sequential multimodal synergistic cancer therapy is designed. The proposed TME-responsive degradable nanoflower-medicine can be excreted through kidneys after implementing multimodal therapy, which is highly desirable in clinical precision oncology.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Chenxi Zhong, Guosheng Xiong, Haitang Yang, Xiaohua Du, Jiankui Du, Feng Yao, Wentao Fang, Yuezhen Deng
Summary: This study found that the downregulation of 3-hydroxy-3-methylglutaryl-CoA lyase (HMGCL) in lung cancer was associated with larger tumor size and shorter overall survival time. Overexpression of HMGCL increased the content of 8-hydroxybutyrate (8-HB) and inhibited the tumorigenicity of lung cancer cells. Mechanistically, TNF alpha treatment decreased HMGCL protein level by phosphorylating it at Ser258 through IKK8, and NEDD4 promoted the degradation of HMGCL. These findings demonstrate a link between TNF alpha-mediated inflammation and cancer metabolism.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Medicine, Research & Experimental
Yunfei He, Wenqian Luo, Yingjie Liu, Yuan Wang, Chengxin Ma, Qiuyao Wu, Pu Tian, Dasa He, Zhenchang Jia, Xianzhe Lv, Yu-Shui Ma, Haitang Yang, Ke Xu, Xue Zhang, Yansen Xiao, Peiyuan Zhang, Yajun Liang, Da Fu, Feng Yao, Guohong Hu
Summary: This study revealed the role of IL-20RB in promoting bone metastasis of lung cancer. IL-20RB facilitated the growth of lung cancer cells in the bone by activating JAK1/STAT3 signaling. Blocking IL-20RB significantly suppressed the bone metastasis of lung cancer.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Medicine, Research & Experimental
Haitang Yang, Beibei Sun, Liwen Fan, Wenyan Ma, Ke Xu, Sean R. R. Hall, Zhexin Wang, Ralph A. Schmid, Ren-Wang Peng, Thomas M. Marti, Wen Gao, Jianlin Xu, Weiwei Yang, Feng Yao
Summary: In this study, we identified a specific cancer-associated fibroblast subset in lung adenocarcinoma patients that promotes an aggressive phenotype. We found that THBS2 is a biomarker that can predict post-surgical survival and is exclusively derived from this fibroblast subset.