Review
Biochemistry & Molecular Biology
Christopher Lotz, Johannes Herrmann, Quirin Notz, Patrick Meybohm, Franz Kehl
Summary: Mitochondria play a crucial role in myocardial ischemia/reperfusion injury and pharmacological cardiac conditioning, including maintaining cellular function, regulating calcium balance and cell death, participating in aging and mitochondrial regeneration, etc.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Michael Mallouppas, Robin Chung, Arjun K. Ghosh, Alison Macklin, Derek M. Yellon, J. Malcolm Walker
Summary: This study aimed to investigate the effect of remote ischemic conditioning (RIC) on cardiac biomarkers and function during anthracycline chemotherapy. The results showed that both troponin T (TnT) and cardiac myosin-binding-protein C (cMyC) levels significantly increased during chemotherapy, and RIC did not affect this rise. Additionally, there were more cancer deaths in the RIC group, possibly due to the higher proportion of patients with metastatic disease in this group.
JACC: CARDIOONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Edoardo Alfi, Cecilia Thairi, Saveria Femmino, Giuseppe Alloatti, Francesco Moccia, Maria F. Brizzi, Pasquale Pagliaro, Claudia Penna
Summary: Myocardial ischemia-reperfusion injury is a common complication in heart diseases, and ischemic conditioning along with remote ischemic conditioning can protect the myocardium from such damages. Studies suggest that extracellular vesicles may play a crucial role in the process of remote ischemic conditioning, particularly in angiogenesis and organ remodeling.
VASCULAR PHARMACOLOGY
(2021)
Article
Cell Biology
Martin Donato, Eliana P. Bin, Veronica D'Annunzio, Ricardo J. Gelpi
Summary: Remote ischemic preconditioning (rIPC) can protect the heart from ischemia/reperfusion injury by activating different signaling pathways. Factors such as age, comorbidities, medication, and anesthetic protocol may weaken the subcellular mechanisms of rIPC in patients. Further carefully designed studies are necessary to develop a clearer understanding of the pathways and mechanisms of early and late rIPC.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Thomas Ravn Lassen, Jesper Just, Marie Vognstoft Hjortbak, Nichlas Riise Jespersen, Katrine Tang Stenz, Tingting Gu, Yan Yan, Junyi Su, Jakob Hansen, Rikke Baek, Malene Moller Jorgensen, Jens Randel Nyengaard, Steen Buus Kristiansen, Kim Ryun Drasbek, Jorgen Kjems, Hans Erik Botker
Summary: The study demonstrates that cardioprotection by RIC may be mediated by circulating EVs that accumulate in the injured myocardium. The EV miRNAs may promote cell survival during reperfusion, suggesting a potential mechanism for the protective effect.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Article
Biology
Claudia Penna, Matteo Sorge, Francesca Tullio, Stefano Comita, Saveria Femmino, Mara Brancaccio, Pasquale Pagliaro
Summary: Remote ischemic conditioning is a simple cardioprotective practice that involves brief intermittent ischemia applied to a limb. Keeping the limb warm during intermittent ischemia can enhance the efficacy of remote ischemic conditioning. Using a thermal blanket around the ischemic limb could be a simple and safe approach to test in humans.
Review
Neurosciences
Bin Jiang, Xiaojie Wang, Jianping Ma, Aminah Fayyaz, Li Wang, Pei Qin, Yuchuan Ding, Xunming Ji, Sijie Li
Summary: Stroke is a major global health concern, and remote ischemic conditioning (RIC) has emerged as a convenient, simple, non-intrusive, and effective method for treating stroke. RIC improves brain tolerance to ischemia, increases cerebral blood perfusion, and reduces the risk of brain tissue damage.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Cardiac & Cardiovascular Systems
Helmut Raphael Lieder, Maria Tsoumani, Ioanna Andreadou, Karsten Schroer, Gerd Heusch, Petra Kleinbongard
Summary: The role of platelets during myocardial ischemia/reperfusion (I/R) is ambivalent. Remote ischemic conditioning (RIC) reduces myocardial I/R injury and platelet activation. This study found that platelets serve as carriers for RIC's cardioprotective signal and aspirin-sensitive mechanism plays a role in this process.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Ashraf Hamarneh, Andrew Fu Wah Ho, Heerajnarain Bulluck, Vivek Sivaraman, Federico Ricciardi, Jennifer Nicholas, Hilary Shanahan, Elizabeth A. Hardman, Peter Wicks, Manish Ramlall, Robin Chung, John McGowan, Roger Cordery, David Lawrence, Tim Clayton, Bonnie Kyle, Maria Xenou, Cono Ariti, Derek M. Yellon, Derek J. Hausenloy
Summary: Remote ischaemic preconditioning (RIPC) using transient limb ischaemia did not improve clinical outcomes following cardiac surgery, and the presence of nitrates abrogated the cardioprotective effect of RIPC.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Article
Clinical Neurology
Yu Cui, Yi-Ning Chen, Thanh N. Nguyen, Hui-Sheng Chen
Summary: The study found that early remote ischemic conditioning (RIC) treatment may be associated with better clinical outcomes in patients with acute moderate ischemic stroke.
ANNALS OF NEUROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Helmut Raphael Lieder, Andreas Skyschally, Michael Sturek, Gerd Heusch, Petra Kleinbongard
Summary: Ischemic preconditioning (IPC) reduces infarct size through trigger molecule release and activation of STAT3. However, IPC failed to protect Ossabaw minipigs from infarction, while remote ischemic conditioning (RIC) induced the release of cardioprotective triggers and reduced infarct size.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Shaomin Chen, Shijia Li, Xinheng Feng, Guisong Wang
Summary: This study investigated the effect of repeated remote ischemic conditioning (RIC) started early after primary percutaneous coronary intervention (PCI) on left ventricular (LV) function in patients with ST-segment elevation myocardial infarction (STEMI). The results showed that repeated RIC can improve LV function and reduce plasma NT proBNP levels in patients with STEMI.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Critical Care Medicine
Martin Cour, Kada Klouche, Bertrand Souweine, Jean-Pierre Quenot, Carole Schwebel, Sophie Perinel, Camille Amaz, Marielle Buisson, Michel Ovize, Nathan Mewton, Laurent Argaud
Summary: The study did not find that remote ischemic conditioning (RECO) reduces the severity of organ failure in patients with septic shock, but the cumulative mortality within 90 days was slightly lower in the RECO group compared to the control group.
INTENSIVE CARE MEDICINE
(2022)
Article
Neurosciences
Yu Cui, Jing Zhang, Hui-Sheng Chen
Summary: This study aimed to evaluate the relationship between patient age and functional outcomes. The analysis of different age groups showed that the effect of remote ischemic conditioning (RIC) on functional recovery decreased with increasing age. This is the first report to demonstrate the age-related impact of RIC on functional outcomes in patients with acute moderate ischemic stroke.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Clinical Neurology
Line Fuglsang Hansen, Nicholine S. K. Nielsen, Laura Cathrine Christoffersen, Christina Kruuse
Summary: The study found differences in the application methods and results of remote ischemic conditioning (RIC) between preclinical and clinical studies, mainly in the choice and design of treatment methods. Clinical trials also face challenges, such as not completing the expected treatment cycles or issues in data analysis. Consistency and consensus on RIC procedures between preclinical and clinical studies are crucial for understanding the potential beneficial effects of RIC treatment in stroke.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Karam Nam, Yunseok Jeon, Tae Kyong Kim, Ki-Bong Kim, Ho Young Hwang, Youn Joung Cho
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2020)
Article
Hematology
Tae Kyong Kim, Karam Nam, Youn Joung Cho, Seungeun Choi, Hyung Sang Row, Yunseok Jeon
THROMBOSIS RESEARCH
(2020)
Article
Cardiac & Cardiovascular Systems
Jimi Oh, In-Kyung Song, Jae-Sik Nam, Sang-Wook Lee, Eun-Ho Lee, In-Cheol Choi
JOURNAL OF CARDIOLOGY
(2020)
Article
Anesthesiology
Hyun-Kyu Yoon, Hyung-Chul Lee, Pyoyoon Kang, Jung-Man Lee, Hee-Pyoung Park, Youn Joung Cho
BMC ANESTHESIOLOGY
(2020)
Article
Anesthesiology
Susie Yoon, Jung-bin Park, Jaehun Lee, Hyung-Chul Lee, Jae-Hyon Bahk, Youn Joung Cho
Summary: This study evaluated the relationship between performance measurement of mean arterial pressure during cardiac surgery and postoperative mortality. Intraoperative hypotension measured by performance measurement variables was independently associated with 30-day and overall mortality after cardiac surgery requiring cardiopulmonary bypass. Performance measurement variables were proposed to be useful for quantifying intraoperative hypotension and predicting survival following cardiac surgery.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2021)
Article
Medicine, General & Internal
Jae-Woo Ju, Yoomin Oh, Hyo Jun Yang, Seohee Lee, Jinyoung Bae, Karam Nam, Youn Joung Cho, Yunseok Jeon, Tae Kyong Kim
Summary: The study found that hemodialysis is an independent risk factor for lower right internal jugular vein stenosis in patients undergoing cardiac surgery, and preoperative hemodialysis is significantly associated with lower right internal jugular vein stenosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Anesthesiology
Youn Joung Cho, Dhong-Eun Jung, Yoomin Oh, Karam Nam, Hyung-Chul Lee, Yunseok Jeon, Young Dae Cho, Tae Kyong Kim
Summary: Cardiorespiratory compromise has been reported in pediatric patients with retinoblastoma during ophthalmic arterial chemotherapy, and heart rate variability differs between patients with and without events. Events were associated with lower end-tidal carbon dioxide, higher peak inspiratory pressure, increased heart rate variability parameters, and lower oxygen reserve index.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2022)
Article
Medicine, General & Internal
Jaeyeon Chung, Min Hur, Hyeyeon Cho, Jinyoung Bae, Hyun-Kyu Yoon, Ho-Jin Lee, Young Hyun Jeong, Youn Joung Cho, Ja Hyeon Ku, Won Ho Kim
Summary: The study investigated the impact of RIPC on renal injury after partial nephrectomy, but found no significant difference in serum creatinine levels or urinary biomarkers between the RIPC group and the control group. Further larger randomized trials are needed to determine the efficacy of RIPC in improving postoperative renal function.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Sang-Mee An, Jae-Sik Nam, Ho Jin Kim, Hyeun Joon Bae, Ji-Hyun Chin, Eun-Ho Lee, In-Cheol Choi
Summary: Postoperative left ventricular systolic function in patients with rheumatic heart disease can either stabilize or decrease over time, depending on the preoperative left ventricular ejection fraction.
JOURNAL OF CARDIAC SURGERY
(2021)
Article
Medicine, Research & Experimental
Gene Huh, Se-Hee Min, Sung-Dong Cho, Youn Joung Cho, Seong Keun Kwon
Summary: THRIVE is reliable for maintaining oxygenation during LMS and is efficient in reducing operation and emergence times, leading to shorter anesthesia time, especially for lesions at the glottis. However, caution is required when using THRIVE for lesions involving multiple subsites and prolonged operation time.
Article
Nutrition & Dietetics
Jung-Pil Yoon, Jae-Sik Nam, Mohd Fitry Bin Zainal Abidin, Seon-Ok Kim, Eun-Ho Lee, In-Cheol Choi, Ji-Hyun Chin
Summary: In patients undergoing esophagectomy for esophageal squamous cell carcinoma, poorer nutritional status, as indicated by CONUT, PNI, or GNRI, was associated with worse 5-year overall survival rates. The trend in survival rates decreased as nutritional status worsened, indicating that malnutrition is an independent prognostic factor for postoperative survival.
Article
Medicine, General & Internal
Sang-Wook Lee, Jae-Sik Nam, Ye-Jee Kim, Min-Ju Kim, Jeong-Hyun Choi, Eun-Ho Lee, Kyoung-Woon Joung, In-Cheol Choi
Summary: Developing and validating a predictive model for pre-operative frailty risk of elderly patients through diagnostic and operation codes can assist in evaluating peri-operative frailty risk before emergency surgery efficiently. The Operation Frailty Risk Score (OFRS) showed robust performance in both the temporal validation cohort and two external validation cohorts.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Seohee Lee, Jae -Woo Ju, Susie Yoon, Ho -Jin Lee, Jeong Hyun Ha, Ki Yong Hong, Ung Sik Jin, Hak Chang, Youn Joung Cho
Summary: This study compared the effects of norepinephrine and phenylephrine on blood flow during free flap breast reconstruction surgery. The results showed that norepinephrine preserved flap perfusion better than phenylephrine. This study has clinical significance, but further validation studies are needed.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Article
Infectious Diseases
Moonsuk Bae, Sang-Oh Lee, Kyung-Wook Jo, Sehoon Choi, Jina Lee, Eun Jin Chae, Kyung-Hyun Do, Dae-Kee Choi, In-Cheol Choi, Sang-Bum Hong, Tae Sun Shim, Hyeong Ryul Kim, Dong Kwan Kim, Seung-Il Park
INFECTION AND CHEMOTHERAPY
(2020)