Article
Urology & Nephrology
Tuna Till Mut, Omer Acar, Ayse Armutlu, Said Incir, Annemarie Uhlig, Lale A. Ertuglu, Melis Ozel, Ali Cihan Taskin, Dilek Ertoy Baydar, Mehmet Kanbay, Tarik Esen
Summary: The study found that while RIPC failed to mitigate the detrimental effects of PN under warm ischemia on renal function in a solitary kidney animal model, there were marginal histological findings supportive of RIPC's renoprotective potential.
Article
Biology
Sahra Pajenda, Ludwig Wagner, Daniela Gerges, Harald Herkner, Tamar Tevdoradze, Karl Mechtler, Alice Schmidt, Wolfgang Winnicki
Summary: Acute kidney injury (AKI) is a leading complication in hospitalized patients, and urinary collectrin may serve as a biomarker for early detection of AKI.
Review
Cardiac & Cardiovascular Systems
Zigang Liu, Yongmei Zhao, Ming Lei, Guancong Zhao, Dongcheng Li, Rong Sun, Xian Liu
Summary: A meta-analysis evaluating the efficacy of remote ischemic preconditioning (RIPC) in preventing acute kidney injury (AKI) after cardiac surgery showed that RIPC significantly reduced the incidence of AKI, particularly for mild-to-moderate cases that did not require renal replacement therapy. The results suggest that RIPC is an effective strategy for AKI prevention after cardiac surgery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Oncology
Min Suk Chae, Jung-Woo Shim, Hoon Choi, Sung Hoo Hong, Ji Youl Lee, Woohyung Jeong, Bongsung Lee, Eunji Kim, Sang Hyun Hong
Summary: Robot-assisted laparoscopic partial nephrectomy (RALPN) may provide benefits in preserving renal function and minimizing postoperative complications in patients with renal cell carcinoma (RCC). Combining remote ischemic preconditioning (RIPC) and intrathecal morphine block (ITMB) as a bundle strategy can enhance the preservation of renal function. Swift adjustment of modifiable variables postoperatively is crucial for renal recovery. The combined RIPC and ITMB bundle therapy may serve as a safe and efficient method for improving renal outcomes in RCC patients undergoing RALPN.
Article
Medicine, General & Internal
Izumi Nagayama, Akito Maeshima, Daisuke Nagata
Summary: This study found that urinary activin A levels were significantly increased in human acute kidney injury (AKI) and correlated with the severity of the disease and the need for renal replacement therapy (RRT). Urinary activin A may serve as a novel non-invasive biomarker for assessing the severity of AKI.
Article
Urology & Nephrology
Cagri Akpinar, Ozlem Dogan, Eralp Kubilay, Mehmet Ilker Gokce, Evren Suer, Omer Gulpinar, Sumer Baltaci
Summary: Urinary neutrophil gelatinase-induced lipocalin (uNGAL) measurement plays an important role in the early diagnosis of ischemic acute kidney injury after partial nephrectomy. In patients with intraoperative ischemia, uNGAL levels significantly increased, serving as an early indicator of acute kidney injury. Additionally, the expression of uNGAL was detected before a rise in serum creatinine levels.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2021)
Article
Multidisciplinary Sciences
Usman Khalid, Robert H. Jenkins, Robert Andrews, Gilda Pino-Chavez, Benjamin C. Cossins, Rafael Chavez, Timothy Bowen, Donald J. Fraser
Summary: Ischemic preconditioning (IPC) provides optimal protection against subsequent ischemic acute kidney injury through short, repetitive sequences of preconditioning insult. Molecular analysis identified a unique profile of microRNA changes related to ischemia-reperfusion injury (IRI), predominantly localized in glomeruli and proximal tubules in the rat kidney. Pulsatile IPC reduces kidney damage post-IRI and attenuates the microRNA signal, highlighting potential candidate microRNAs as biomarkers and therapeutic targets.
SCIENTIFIC REPORTS
(2021)
Article
Critical Care Medicine
Thanawat Phulkerd, Tanat Lertussavavivat, Umaporn Limothai, Sadudee Peerapornratana, Win Kulvichit, Nuttha Lumlertgul, Kriang Tungsanga, Somchai Eiam-Ong, Yingyos Avihingsanon, Nattachai Srisawat
Summary: This study discovered that the microtranscriptome profiles of severe AKI patients with renal recovery were different from those of the non-recovery group. Urine miR-556-3p had the potential to improve the prediction of renal recovery from severe AKI.
JOURNAL OF INTENSIVE CARE
(2022)
Article
Biochemistry & Molecular Biology
Cristina Cuesta, Isabel Fuentes-Calvo, Sandra M. Sancho-Martinez, Floris A. Valentijn, Annette Duwel, Omar A. Hidalgo-Thomas, Consuelo Agueros-Blanco, Adalberto Benito-Hernandez, Maria A. Ramos-Barron, Carlos Gomez-Alamillo, Manuel Arias, Tri Q. Nguyen, Roel Goldschmeding, Carlos Martinez-Salgado, Francisco J. Lopez-Hernandez
Summary: After acute kidney injury, despite the normalization of standard markers of glomerular filtration and tubular function, the degree of persistent histological findings of tissue repair correlates with renal expression and urinary levels of KIM-1 in rats. Additionally, KIM-1 is elevated in the urine of a significant number of patients apparently recovered from AKI. This study suggests a potential utility of urinary KIM-1 in early and subclinical diagnosis of renal damage, as well as a new application in non-invasive follow-up of renal repair after AKI.
Article
Biochemistry & Molecular Biology
Marco Allinovi, Francesco Sessa, Gianluca Villa, Andrea Cocci, Samantha Innocenti, Maria Zanazzi, Lorenzo Tofani, Laura Paparella, Dritan Curi, Calogero Lino Cirami, Riccardo Campi, Andrea Mari, Agostino Ognibene, Maria Lorubbio, Alessandra Fanelli, Stefano Romagnoli, Paola Romagnani, Andrea Minervini
Summary: The study aimed to identify and compare serum and urinary predictors for predicting long-term decline in glomerular filtration rate (GFR) after robotic Nephron-Spearing Surgery (rNSS). The results showed that patients who developed clinical acute kidney injury (AKI) had a more pronounced decline in eGFR at 24 months. KineticGFR at 4 hours and NephroCheck at 10 hours were found to be efficient predictors of post-operative AKI and long-term eGFR decline. Combining these biomarkers could help identify high-risk patients as early as 10 hours after surgery.
Article
Biochemistry & Molecular Biology
Katharina Feige, Sebastian Roth, Rene M'Pembele, Anna Galow, Sarah Koenig, Martin Stroethoff, Annika Raupach, Giovanna Lurati Buse, Alexander M. Mathes, Markus W. Hollmann, Ragnar Huhn, Carolin Torregroza
Summary: The adverse impact of common diseases like diabetes mellitus and acute hyperglycemia on morbidity and mortality from myocardial infarction (MI) has been well documented. The relationship between blood glucose and mortality appears linear, and this seems to be independent of a diagnosis of diabetes. This study investigates the influence of acute and prolonged hyperglycemia on the protective effect of transferred human RIPC-plasma and suggests that hyperglycemia might obstruct translation into the clinical setting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pediatrics
Alexandra Franiek, Atul Sharma, Vedran Cockovski, David S. Wishart, Michael Zappitelli, Tom D. Blydt-Hansen
Summary: This study demonstrates the potential of a urine metabolite classifier to detect the risk of acute kidney injury in pediatric populations earlier than the current standard of diagnosis.
PEDIATRIC NEPHROLOGY
(2022)
Article
Infectious Diseases
Emanuela Locci, Jiajun Liu, Gwendolyn M. Pais, Alberto Chighine, Dariusc Andrea Kahnamoei, Theodoros Xanthos, Athanasios Chalkias, Andrew Lee, Alan R. Hauser, Jack Chang, Nathaniel J. Rhodes, Ernesto d'Aloja, Marc H. Scheetz
Summary: This study investigates the potential kidney injury caused by Polymyxin B treatment and aims to detect it early through the analysis of urinary metabolites. The study found that the concentration of urinary taurine significantly increased on the first day of treatment and then returned to baseline levels. Taurine may serve as an early indicator of acute kidney damage caused by Polymyxin B.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Veterinary Sciences
Hannah J. Harjen, Tove Nicolaysen, Tale Negard, Hege Lund, Bente K. Saevik, Kristin P. Anfinsen, Elena R. Moldal, Karin E. Zimmer, Runa Rortveit
Summary: Dogs envenomated by V. berus show mild, transient acute kidney injury, as indicated by urinary biomarker/creatinine ratios.
BMC VETERINARY RESEARCH
(2021)
Article
Urology & Nephrology
Maria Paniagua-Sancho, Yaremi Quiros, Alfredo G. Casanova, Victor Blanco-Gozalo, Consuelo Agueros-Blanco, Adalberto Benito-Hernandez, Maria A. Ramos-Barron, Carlos Gomez-Alamillo, Manuel Arias, Sandra M. Sancho-Martinez, Francisco J. Lopez-Hernandez
Summary: Acute kidney injury is a complex syndrome lacking specific diagnostic tools, leading to the search for new urinary biomarkers like urinary plasminogen activator inhibitor-1 (PAI-1). This study found that uPAI-1 is produced by damaged kidneys and provides complementary phenotypical information in AKI. Further investigation is needed to fully understand the pathophysiological significance of uPAI-1 in AKI.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)
Article
Anesthesiology
Hyun-Kyu Yoon, Hansu Bae, Seokha Yoo, Young-Won Kim, Jinyoung Bae, Sun-Kyung Park, Hansol Kim, Young-Jin Lim, Jin-Tae Kim
Summary: This study investigated the effects of pneumoperitoneum and the head-down tilt position on common carotid artery blood flow in surgical patients. The study found that anesthesia induction significantly decreased CCA blood flow, while pneumoperitoneum with or without the head-down tilt position did not further decrease blood flow if the cardiac index remained unchanged. CCA blood flow was significantly associated with cardiac index and stroke volume index.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Article
Anesthesiology
H. -K Yoon, Y. J. Kim, H. S. Lee, J. -H Seo, H. -S Kim
Summary: This study aimed to investigate the effect of the analgesia nociception index on postoperative pain in women undergoing gynaecological laparotomy. The results showed that maintaining analgesia nociception indices within a certain range did not significantly reduce the proportion of women with pain scores >= 5. There was also no significant difference in the doses of fentanyl administered during recovery and remifentanil doses during the operation between the two groups.
Article
Surgery
Jae-Woo Ju, Ho-Jin Lee, Min Jung Kim, Seung-Bum Ryoo, Won Ho Kim, Seung-Yong Jeong, Kyu Joo Park, Ji Won Park
Summary: This study aimed to investigate the association between early postoperative NSAID use and anastomotic leakage (AL) in patients who underwent colorectal cancer surgery. The findings showed a significant association between early postoperative NSAID use and AL.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Chemistry, Medicinal
Kwang Je Lee, Jae-Kean Ryu, Yun-Hyeong Cho, Won Yong Shin, Jeong Su Kim, Young Won Yoon, Ji Yong Jang, Won Ho Kim, Jong Wook Beom, Seok-Min Kang
Summary: This study aimed to assess the effectiveness and safety of a fixed-dose combination of rosuvastatin and valsartan (Rovatitan (R)) in Korean patients with concomitant hypertension and hyperlipidemia. The study drug was found to be effective and well tolerated, making it a good alternative for patients taking multiple medications.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Multidisciplinary Sciences
Woo-Seok Jung, Jae Hee Kuh, Leerang Lim, Hae Kyung Yoo, Jae-Woo Ju, Ho-Jin Lee, Won Ho Kim
Summary: Despite serious complications, such as infection and recurrence of diseases, corticosteroids are still widely used as immunosuppressive therapy for liver transplant recipients. This study compared the safety and efficacy of T-cell specific antibody induction with corticosteroid induction and found that T-cell specific antibody induction significantly reduced the risk of opportunistic infections and metabolic complications.
SCIENTIFIC REPORTS
(2023)
Article
Anesthesiology
Ho-Jin Lee, Hyo Bin Lee, Yoon Jung Kim, Hye-Yeon Cho, Won Ho Kim, Jeong-Hwa Seo
Summary: This study aimed to compare the reversal effect of flumazenil on the recovery of consciousness after remimazolam-based total intravenous anesthesia with the propofol recovery profile. The study found that the remimazolam group had significantly faster first eye opening time and extubation time compared to the propofol group. There were no significant differences in other postoperative outcomes.
BMC ANESTHESIOLOGY
(2023)
Article
Medicine, General & Internal
Jae-Woo Ju, Jiwon You, Hyunsook Hong, Chang Kyung Kang, Won Ho Kim, Ho-Jin Lee
Summary: The aim of this study was to examine the impact of enhanced in-hospital infection prevention during the COVID-19 pandemic on postoperative pneumonia in older surgical patients. A retrospective review of electronic medical records was conducted for patients aged ≥70 who underwent elective surgery between 2017 and 2021. The study found that although there was a decreasing trend in the monthly incidence rate of postoperative pneumonia during the COVID-19 pandemic, the difference was not statistically significant.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Anesthesiology
Yoon Jung Kim, Bo Rim Kim, Hee Won Kim, Ji-Yoon Jung, Hye-Yeon Cho, Jeoung-Hwa Seo, Won Ho Kim, Hee-Soo Kim, Suhyun Hwangbo, Hyun-Kyu Yoon
Summary: Driving pressure-guided PEEP did not decrease the incidence of pulmonary complications within 7 days of laparoscopic or robotic lower abdominal surgery, although uncertainty remains given the lower than anticipated event rate for the primary outcome.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Surgery
Seohee Lee, Jae -Woo Ju, Susie Yoon, Ho -Jin Lee, Jeong Hyun Ha, Ki Yong Hong, Ung Sik Jin, Hak Chang, Youn Joung Cho
Summary: This study compared the effects of norepinephrine and phenylephrine on blood flow during free flap breast reconstruction surgery. The results showed that norepinephrine preserved flap perfusion better than phenylephrine. This study has clinical significance, but further validation studies are needed.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Article
Anesthesiology
Pyoyoon Kang, Jung -bin Park, Hyun-Kyu Yoon, Sang-Hwan Ji, Young-Eun Jang, Eun-Hee Kim, Ji-Hyun Lee, Hyung Chul Lee, Jin-Tae Kim, Hee-Soo Kim
Summary: This study aimed to evaluate the association between intraoperative peripheral perfusion index (PPI) and postoperative acute kidney injury (AKI), and found that low intraoperative PPI was independently associated with AKI occurrence.
KOREAN JOURNAL OF ANESTHESIOLOGY
(2023)
Article
Clinical Neurology
Hye-Yeon Cho, In Eob Hwang, Mirang Lee, Wooil Kwon, Won Ho Kim, Ho-Jin Lee
Summary: This study compared the analgesic effect of M-TAPA and TAPB in patients undergoing LC and found no significant difference between the two techniques.
KOREAN JOURNAL OF PAIN
(2023)
Article
Multidisciplinary Sciences
Jae-Woo Ju, In Eob Hwang, Hye-Yeon Cho, Seong Mi Yang, Won Ho Kim, Ho-Jin Lee
Summary: This study aimed to compare the effect of sugammadex and neostigmine on postoperative nausea and vomiting (PONV) within the first 24 hours after general anesthesia. The retrospective cohort study included patients who underwent elective surgery in Seoul, South Korea. The results showed that sugammadex had a significantly lower incidence of PONV compared to neostigmine/glycopyrrolate. In conclusion, the use of sugammadex decreases the risk of PONV within the first 24 hours after general anesthesia.
SCIENTIFIC REPORTS
(2023)
Article
Anesthesiology
Jae-Woo Ju, Jina Kwon, Seokha Yoo, Ho-Jin Lee
Summary: This study investigated the incidence rate and predictors of postoperative nausea and vomiting (PONY) after spinal anesthesia in 6,610 patients undergoing orthopedic surgery. The results showed that 22.8% of patients experienced PONY within 24 hours after spinal anesthesia. Female sex, nonsmoker, history of PONY, prophylactic use of 5-hydroxytryptamine receptor antagonists and steroids, baseline heart rate >= 60 beats/min, and postoperative opioid use were significant predictors of PONY.
KOREAN JOURNAL OF ANESTHESIOLOGY
(2023)
Review
Clinical Neurology
Bo Rim Kim, Soo-Hyuk Yoon, Ho-Jin Lee
Summary: Chronic postsurgical pain (CPSP) is a complex condition that affects many patients undergoing surgery. Preventing and managing CPSP requires identifying preoperative risk factors and developing appropriate perioperative pain management plans to prevent its occurrence. Active postoperative pain management should be provided to prevent CPSP in patients with severe pain following surgery. These tasks have become increasingly important for perioperative team members.
KOREAN JOURNAL OF PAIN
(2023)