Dacomitinib-induced diarrhea: Targeting chloride secretion with crofelemer

Dacomitinib-induced diarrhoea is associated with altered gastrointestinal permeability and disruption in ileal histology in rats

(2017) Ysabella Z.A. Van Sebille et al.   INTERNATIONAL JOURNAL OF CANCER

Impact of a planned dose interruption of dacomitinib in the treatment of advanced non-small-cell lung cancer (ARCHER 1042)

(2017) Dong-Wan Kim et al.   LUNG CANCER

A novel in vitro platform for the study of SN38-induced mucosal damage and the development of Toll-like receptor 4-targeted therapeutic options

(2016) Hannah R Wardill et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Irinotecan-Induced Gastrointestinal Dysfunction and Pain Are Mediated by Common TLR4-Dependent Mechanisms

(2016) Hannah R. Wardill et al.   MOLECULAR CANCER THERAPEUTICS

TLR4-Dependent Claudin-1 Internalization and Secretagogue-Mediated Chloride Secretion Regulate Irinotecan-Induced Diarrhea

(2016) H. R. Wardill et al.   MOLECULAR CANCER THERAPEUTICS

Gastrointestinal toxicities of first and second-generation small molecule human epidermal growth factor receptor tyrosine kinase inhibitors in advanced nonsmall cell lung cancer

(2016) Ysabella Z.A. Van Sebille et al.   Current Opinion in Supportive and Palliative Care

ErbB small molecule tyrosine kinase inhibitor (TKI) induced diarrhoea: Chloride secretion as a mechanistic hypothesis

(2015) Ysabella Z.A. Van Sebille et al.   CANCER TREATMENT REVIEWS

Transcriptional Regulators of Claudins in Epithelial Tight Junctions

(2015) Niamat Khan et al.   MEDIATORS OF INFLAMMATION

Tight junction defects are seen in the buccal mucosa of patients receiving standard dose chemotherapy for cancer

(2015) Hannah R. Wardill et al.   SUPPORTIVE CARE IN CANCER

Management of diarrhea induced by epidermal growth factor receptor tyrosine kinase inhibitors

(2014) V. Hirsh et al.   Current Oncology

Guidance on the management of diarrhoea during cancer chemotherapy

(2014) Jervoise Andreyev et al.   LANCET ONCOLOGY

Irinotecan disrupts tight junction proteins within the gut

(2013) Hannah R Wardill et al.   CANCER BIOLOGY & THERAPY

Safety and efficacy of neratinib in combination with weekly paclitaxel and trastuzumab in women with metastatic HER2-positive breast cancer: an NSABP Foundation Research Program phase I study

(2013) Rachel C. Jankowitz et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Discovery and Development of Antisecretory Drugs for Treating Diarrheal Diseases

(2013) Jay R. Thiagarajah et al.   Clinical Gastroenterology and Hepatology

Targeted therapy-induced diarrhea: A review of the literature

(2013) M.A. Pessi et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Chloride channel inhibition by a red wine extract and a synthetic small molecule prevents rotaviral secretory diarrhoea in neonatal mice

(2013) Eun-A Ko et al.   GUT

Convective washout reduces the antidiarrheal efficacy of enterocyte surface–targeted antisecretory drugs

(2013) Byung-Ju Jin et al.   JOURNAL OF GENERAL PHYSIOLOGY

Dacomitinib, an Irreversible Pan-ErbB Inhibitor Significantly Abrogates Growth in Head and Neck Cancer Models That Exhibit Low Response to Cetuximab

(2013) Ferdows Ather et al.   PLoS One

A phase II trial of dacomitinib, an oral pan-human EGF receptor (HER) inhibitor, as first-line treatment in recurrent and/or metastatic squamous-cell carcinoma of the head and neck

(2012) A. R. Abdul Razak et al.   ANNALS OF ONCOLOGY

Intracellular mediators of JAM-A-dependent epithelial barrier function

(2012) Ana C. Monteiro et al.   Annals of the New York Academy of Sciences

Development of a rat model of oral small molecule receptor tyrosine kinase inhibitor-induced diarrhea

(2012) Joanne M. Bowen et al.   CANCER BIOLOGY & THERAPY

A double-blind, randomized, multiple-dose, parallel-group study to characterize the occurrence of diarrhea following two different dosing regimens of neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor

(2012) Richat Abbas et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Irinotecan Injures Tight Junction and Causes Bacterial Translocation in Rat

(2010) Toshihiro Nakao et al.   JOURNAL OF SURGICAL RESEARCH

Intestinal Damage Determines the Inflammatory Response and Early Complications in Patients Receiving Conditioning for a Stem Cell Transplantation

(2010) Walter J. F. M. van der Velden et al.   PLoS One

Epithelial Tight Junctions in Intestinal Inflammation

(2009) Joerg D. Schulzke et al.   Annals of the New York Academy of Sciences

Crofelemer, an Antisecretory Antidiarrheal Proanthocyanidin Oligomer Extracted from Croton lechleri, Targets Two Distinct Intestinal Chloride Channels

(2009) L. Tradtrantip et al.   MOLECULAR PHARMACOLOGY

Evidence for direct CFTR inhibition by CFTRinh-172 based on Arg347mutagenesis

(2008) Emanuela Caci et al.   BIOCHEMICAL JOURNAL

Evaluation of Crofelemer in the Treatment of Diarrhea-Predominant Irritable Bowel Syndrome Patients

(2008) Allen W. Mangel et al.   DIGESTION

Crosstalk of tight junction components with signaling pathways

(2007) Lorenza González-Mariscal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES