uPA/uPAR system activation drives a glycolytic phenotype in melanoma cells

Metabolic reprogramming supports the invasive phenotype in malignant melanoma

(2015) Ingrid J. Bettum et al.   CANCER LETTERS

Inhibition of uPAR-TGFβ crosstalk blocks MSC-dependent EMT in melanoma cells

(2015) Anna Laurenzana et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The receptor for urokinase-plasminogen activator (uPAR) controls plasticity of cancer cell movement in mesenchymal and amoeboid migration style

(2015) Francesca Margheri et al.   Oncotarget

Extracellular acidity, a “reappreciated” trait of tumor environment driving malignancy: perspectives in diagnosis and therapy

(2014) Silvia Peppicelli et al.   CANCER AND METASTASIS REVIEWS

Proliferation-Independent Control of Tumor Glycolysis by PDGFR-Mediated AKT Activation

(2013) C. Ran et al.   CANCER RESEARCH

Role of monocarboxylate transporters in human cancers: state of the art

(2012) Céline Pinheiro et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Cell Surface Remodeling by Plasmin: A New Function for an Old Enzyme

(2012) Elena I. Deryugina et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Endothelial progenitor cell-dependent angiogenesis requires localization of the full-length form of uPAR in caveolae

(2011) F. Margheri et al.   BLOOD

Lactate: A Metabolic Key Player in Cancer

(2011) F. Hirschhaeuser et al.   CANCER RESEARCH

Downregulation of uPAR inhibits migration, invasion, proliferation, FAK/PI3K/Akt signaling and induces senescence in papillary thyroid carcinoma cells

(2011) Theodore S. Nowicki et al.   CELL CYCLE

The Urokinase Receptor Interactome

(2011) Gabriele Eden et al.   CURRENT PHARMACEUTICAL DESIGN

Clinical utility of level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1

(2010) Manfred Schmitt et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Characteristics of the level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1

(2010) Karin Mengele et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

18F-FDG Uptake in Lung, Breast, and Colon Cancers: Molecular Biology Correlates and Disease Characterization

(2009) H. Jadvar et al.   JOURNAL OF NUCLEAR MEDICINE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH

(2008) J. Chiche et al.   CANCER RESEARCH

Hepatocyte Growth Factor Is a Novel Stimulator of Glucose Uptake and Metabolism in Skeletal Muscle Cells

(2008) German Perdomo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Apigenin Inhibits the GLUT-1 Glucose Transporter and the Phosphoinositide 3-Kinase/Akt Pathway in Human Pancreatic Cancer Cells

(2008) Laleh G. Melstrom et al.   PANCREAS