Article
Pharmacology & Pharmacy
Sweta Kar, Sandeep Kumar Singh
Summary: We improved the bioavailability of carvedilol (CVD) by fabricating intranasal administration of CVD-loaded cationic nanoliposomal (NLPs) in situ gel. The CVD NLPs in situ gel showed a 6.94-fold increase in Cmax and a 5-fold increase in relative bioavailability compared to an oral drug suspension, indicating the potential of cationic NLPs as an alternative carrier for intranasal administration.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ying Shen, Xinyu Wang, Binbin Li, Yajin Guo, Kuo Dong
Summary: This study incorporated nanoparticles into a scaffold to improve hemostatic properties and stimulate cell adhesion. The scaffold loaded with nanoparticles exhibited higher blood clotting index and promoted platelets adhesion. In addition, the scaffold loaded with nanoparticles showed stimulation effects on cell proliferation, migration, and adhesion. Therefore, the scaffold loaded with nanoparticles has great potential as a wound dressing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Arik Dahan, Daniel Porat, Milica Markovic, Moran Zur, Olga Kister, Peter Langguth
Summary: Experimental validation of the regional-dependent drug absorption changes after bariatric surgery provides important data for predicting drug absorption. It is crucial to consider the permeability of different intestinal segments post-surgery in simulation predictions to more accurately predict drug absorption after gastric bypass.
Article
Nanoscience & Nanotechnology
Alessandra Maria Bossi, Alessio Bucciarelli, Devid Maniglio
Summary: Nanosized biomimetics prepared by molecular imprinting are showing potential as plastic antibodies in medicine for cell imaging and targeted therapies. Utilizing natural polymer silk fibroin to synthesize biocompatible MIP SF-NPs demonstrates high affinity recognition sites and biocompatibility.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Applied
Li Wen, Lu Huang, Yiwei Li, Yanying Feng, Zhimeng Zhang, Zhou Xu, Mao-Long Chen, Yunhui Cheng
Summary: In this study, rice proteins were identified using LC-MS/MS and a strategy combining immuno-prediction and in silico simulation was used to screen for peptides with immunomodulatory activity. This approach may offer insights for identifying more food-derived immunopeptides.
Article
Biochemistry & Molecular Biology
Dengchao Xie, Xin Zhou, Bo Xiao, Lian Duan, Zhenhua Zhu
Summary: This study fabricated silk fibroin-based nanoparticles loaded with resveratrol (RSV) and functionalized with Pluronic F127 (PF-127) to enhance mucus-penetrating capacity and anti-inflammatory effects. The functionalized nanoparticles showed improved mucus-penetrating property and enhanced suppression of proinflammatory cytokine secretion. In a colitis model, the PF-127 functionalized nanoparticles demonstrated better therapeutic outcomes compared to other counterparts.
Article
Biochemistry & Molecular Biology
Xuemei Sun, Han Liang, Huiyan Wang, Na Meng, Suxing Jin, Ninglin Zhou
Summary: In this study, a nanocomposite film made of silk fibroin, polyvinyl alcohol, AgNP, and polydopamine-modified Montmorillonite was fabricated and characterized. The results showed that the nanocomposite film had enhanced thermal performance and excellent antibacterial activity. It also exhibited biocompatibility with cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Yuet Cheng, Gu Cheng, Congyong Xie, Chengcheng Yin, Xiangyang Dong, Zhi Li, Xue Zhou, Qun Wang, Hongbing Deng, Zubing Li
Summary: A silk fibroin hydrogel reinforced by short silica nanoparticles-distributed-silk fibroin nanofibers with superior osteoinductive properties was fabricated for treating bone defects. The composite scaffold mimics the extracellular matrix of native bone and enhances mechanical properties. In vivo studies confirmed successful bone repair using this composite hydrogel.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Polymer Science
Ahmed Al Saqr, Shahid Ud Din Wani, H. V. Gangadharappa, Mohammed F. Aldawsari, El-Sayed Khafagy, Amr S. Abu Lila
Summary: Despite the challenges in breast cancer therapy, the study successfully developed docetaxel (DXL)-loaded silk-fibroin-based nanoparticles (SF-NPs) with improved anticancer activity against breast cancer cell lines. The DXL-loaded SF-NPs showed enhanced cytotoxic potential and cellular uptake compared to free DXL, suggesting the potential of silk fibroin nanoparticles as a promising delivery vehicle for breast cancer treatment.
Article
Pharmacology & Pharmacy
Tanner Lehmann, Alyssa E. Vaughn, Sudipta Seal, Kenneth W. Liechty, Carlos Zgheib
Summary: Silk fibroin, as a promising treatment for impaired wound healing, promotes functional tissue regeneration. Its dynamic properties enable customizable nanoarchitectures that effectively address various wound healing impairments.
Article
Chemistry, Physical
Zhe Wang, Jingzhi Li, Changxiang Shao, Xiangyun Lin, Yanan Yang, Nan Chen, Ying Wang, Liangti Qu
Summary: The research and development of micro currents/potentials have led to the widespread use of tiny electrical signals in various fields. However, the potential of moisture power (MP) from water vapor has not been fully explored and utilized. By designing a flexible antibacterial MP membrane through electrospinning and synthesis of AgNPs, the membrane can generate moderate MP in a humid environment, exhibiting nearly 100% bactericidal rate compared to non-MP environments.
Article
Chemistry, Multidisciplinary
Jitao Li, Asma Khalid, Rajni Verma, Amanda Abraham, Farah Qazi, Xiuxiu Dong, Gaofeng Liang, Snjezana Tomljenovic-Hanic
Summary: Fluorescent nanoparticles coated with silk fibroin and containing optical defects showed enhanced emission efficiency, improved cellular uptake, and intracellular mobility in different cell lines, demonstrating their potential as bioimaging tools for in vivo imaging and drug delivery optimization.
Article
Materials Science, Multidisciplinary
Taeyoung Yoon, Wooboum Park, Yoonjung Kim, Hyunsung Choi, Soonchun Chung, Joonsong Park, Hyun Joon Chang, Sungsoo Na
Summary: This study proposes using silk procured from silkworms as a potential photoresist for extreme ultraviolet (EUV) lithography due to its organic, biocompatible, and ecofriendly nature, and excellent mechanical properties. The structural stability of silk was examined using multiscale in silico methods, and its photoreactivity was evaluated via quantum mechanical calculations. Molecular dynamics simulations were performed to observe the behavior of silk peptides after EUV lithography. The results show that photoionization cleaves the covalent bonds and destabilizes the assembled silk peptides. Despite its organic nature, the photoionized silk exhibits a 25% increase in its Young's modulus compared with other photoresists.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Nanoscience & Nanotechnology
Ya Wang, Giovanni Boero, Xiaosheng Zhang, Juergen Brugger
Summary: Researchers have demonstrated a fully biodegradable composite membrane made from silk fibroin and magnetic nanoparticles. The membrane's porosity can be remotely modified using an alternating magnetic field, allowing for controlled drug release.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Polymer Science
Jianjun Guo, Bo Yang, Qiang Ma, Sandra Senyo Fometu, Guohua Wu
Summary: The study prepared RSF/MoS2 nanoparticles hybrid fibers with different MoS2 nanoparticles contents by wet spinning, demonstrating that these fibers exhibit good thermal stability and excellent photothermal properties, showing great potential for multifunctional fiber applications.
Review
Pharmacology & Pharmacy
Sabya S. Das, Afzal Hussain, Priya R. Prasad Verma, Syed S. Imam, Mohammad A. Altamimi, Sultan Alshehri, Sandeep Kumar Singh
CURRENT DRUG DELIVERY
(2020)
Editorial Material
Chemistry, Medicinal
Sabya Sachi Das, Sandeep Kumar Singh, P. R. P. Verma, Niraj Kumar Jha, Piyush Kumar Gupta, Kamal Dua
FUTURE MEDICINAL CHEMISTRY
(2022)
Review
Oncology
Rahul Bhattacharjee, Sabya Sachi Das, Smruti Sudha Biswal, Arijit Nath, Debangshi Das, Asmita Basu, Sumira Malik, Lamha Kumar, Sulagna Kar, Sandeep Kumar Singh, Vijay Jagdish Upadhye, Danish Iqbal, Suliman Almojam, Shubhadeep Roychoudhury, Shreesh Ojha, Janne Ruokolainen, Niraj Kumar Jha, Kavindra Kumar Kesari
Summary: This article comprehensively discusses the structural organization and biological functions of all early proteins of human papilloma virus (HPV) and their contribution to the progression of cervical cancer (CC). The study reveals that E6 and E7 proteins are major causes of HPV-mediated CC progression, while E1, E2, and E5 proteins play supporting roles. The article also highlights the significance of targeting E6 and E7 proteins in therapeutic strategies for CC.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Neurosciences
Ankit Jana, Arkadyuti Bhattacharjee, Sabya Sachi Das, Avani Srivastava, Akshpita Choudhury, Rahul Bhattacharjee, Swagata De, Asma Perveen, Danish Iqbal, Piyush Kumar Gupta, Saurabh Kumar Jha, Shreesh Ojha, Sandeep Kumar Singh, Janne Ruokolainen, Niraj Kumar Jha, Kavindra Kumar Kesari, Ghulam Md Ashraf
Summary: Alzheimer's disease is a complex neurological disorder characterized by memory loss and cognitive dysfunction. Conventional therapies only provide symptomatic relief, while novel hybrid therapeutic compounds targeting multiple pathogenic pathways show promise for effective treatment.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sabya Sachi Das, Arunabh Sarkar, Siva Chander Chabattula, Priya Ranjan Prasad Verma, Aamir Nazir, Piyush Kumar Gupta, Janne Ruokolainen, Kavindra Kumar Kesari, Sandeep Kumar Singh
Summary: The developed nanoemulsion system loaded with nanosized food-grade quercetin (QNE) showed significant neuroprotective and cytotoxic effects against Parkinson's disease and human cancer cells, respectively.
Review
Medicine, Research & Experimental
Sabya Sachi Das, Sandeep Kumar Singh, P. R. P. Verma, Rekha Gahtori, Belay Zeleke Sibuh, Kavindra Kumar Kesari, Niraj Kumar Jha, Sugapriya Dhanasekaran, Vijay Kumar Thakur, Ling Shing Wong, Sinouvassane Djearamane, Piyush Kumar Gupta
Summary: Inflammations play a crucial role in the growth and treatment of cancer cells. Conventional chemotherapeutics have limitations, while nanotechnology offers potential benefits. Polyester-based nanoparticulate delivery systems have been extensively studied for targeting inflammation-mediated cancers.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Chemistry, Multidisciplinary
Pratik Chakraborty, Sabya Sachi Das, Abhijit Dey, Apala Chakraborty, Chiranjib Bhattacharyya, Ramesh Kandimalla, Biswajit Mukherjee, Abilash Valsala Gopalakrishnan, Sandeep Kumar Singh, Shubham Kant, Parma Nand, Shreesh Ojha, Pravir Kumar, Niraj Kumar Jha, Saurabh Kumar Jha, Saikat Dewanjee
Summary: Quantum dots (QDs) are semiconductor nanocrystals that can emit light energy of specific wavelengths when excited by photons. Due to their bio-imaging and targeted drug delivery capabilities, QDs have shown potential in delivering therapeutic agents into the brain, making them promising tools for future clinical applications.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Medicine, Research & Experimental
Sabya Sachi Das, Amit Kumar Dubey, Priya Ranjan Prasad Verma, Sandeep Kumar Singh, Shubhankar Kumar Singh
Summary: The study found that quercetin-loaded nanoemulsion (QTNE) has the potential antileishmanial activity against both promastigote and intracellular amastigote forms of Leishmania donovani. It achieves this by enhancing intracellular levels of reactive oxygen species and nitric oxide, affecting membrane integrity and phosphatidylserine release, disrupting parasite DNA, and modulating immune function. Additionally, QTNE demonstrates high biocompatibility with healthy cells.
MOLECULAR PHARMACEUTICS
(2022)
Correction
Chemistry, Multidisciplinary
Pratik Chakraborty, Sabya Sachi Das, Abhijit Dey, Apala Chakraborty, Chiranjib Bhattacharyya, Ramesh Kandimalla, Biswajit Mukherjee, Abilash Valsala Gopalakrishnan, Sandeep Kumar Singh, Shubham Kant, Parma Nand, Shreesh Ojha, Pravir Kumar, Niraj Kumar Jha, Saurabh Kumar Jha, Saikat Dewanjee
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Sweta Kar, Sandeep Kumar Singh
Summary: We improved the bioavailability of carvedilol (CVD) by fabricating intranasal administration of CVD-loaded cationic nanoliposomal (NLPs) in situ gel. The CVD NLPs in situ gel showed a 6.94-fold increase in Cmax and a 5-fold increase in relative bioavailability compared to an oral drug suspension, indicating the potential of cationic NLPs as an alternative carrier for intranasal administration.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Sabya Sachi Das, Srushti Tambe, Priya Ranjan Prasad Verma, Purnima Amin, Neeru Singh, Sandeep Kumar Singh, Piyush Kumar Gupta
Summary: Flavonoids, a major group of polyphenolic compounds, have shown significant potential in inhibiting tumor proliferation, cell cycle, angiogenesis, migration, and invasion in lung cancer. However, their clinical application is limited due to poor solubility, low permeability, and quick blood clearance. Nanoengineered systems such as liposomes, nanoparticles, micelles, dendrimers, and nanotubes can greatly enhance the targeted action of flavonoids with improved efficacy and pharmacokinetic properties, making them suitable for treating lung cancer. This review highlights the therapeutic potential of flavonoids and the cutting-edge progress in nanoengineered systems incorporating flavonoids for lung cancer treatment.
Review
Biotechnology & Applied Microbiology
Sabya Sachi Das, Srushti Tambe, Priya Ranjan Prasad Verma, Purnima Amin, Neeru Singh, Sandeep Kumar Singh, Piyush Kumar Gupta
Summary: Lung cancer is a major cause of cancer-related deaths worldwide, and non-small-cell lung cancer is the most common type. Nanotechnology-based drug-delivery systems show great potential in lung cancer therapy due to their unique characteristics. However, traditional chemotherapeutics have toxicity issues, so polyphenols from diet could be used as a replacement. Targeted nanotherapeutics based on polyphenols have shown interactions with protein targets and cellular signaling pathways, affecting key cellular processes. This review summarizes the molecular mechanisms and targeted therapeutic potentials of nanoengineered dietary polyphenols in lung cancer management.
Article
Chemistry, Multidisciplinary
Sabya Sachi Das, Priya Ranjan Prasad Verma, Viswanathan Sekarbabu, Satyajit Mohanty, Ashok Kumar Pattnaik, Janne Ruokolainen, Kavindra Kumar Kesari, Sandeep Kumar Singh
Summary: In this study, a liquid chromatography-electrospray ionization tandem mass spectrometry method was developed and validated for quantifying quercetin (QT) in rabbit plasma. The method showed high specificity, sensitivity, and reproducibility. Pharmacokinetic parameters and in vitro-in vivo correlation (IVIVC) of QTNE were analyzed and it was found that QTNE exhibited improved oral bioavailability compared to QTS. The Loo-Riegelman method was determined to be the best fitting model for establishing the IVIVC. Overall, this study suggests that QTNE is a potential carrier for enhancing the oral bioavailability of QT.
Review
Chemistry, Medicinal
Elham Assadpour, Atefe Rezaei, Sabya Sachi Das, Balaga Venkata Krishna Rao, Sandeep Kumar Singh, Mohammad Saeed Kharazmi, Niraj Kumar Jha, Saurabh Kumar Jha, Miguel A. A. Prieto, Seid Mahdi Jafari
Summary: Researchers have developed nanocarriers to enhance the oral bioavailability of Cannabidiol (CBD), improving its therapeutic efficacy and ability to treat various diseases.
Article
Food Science & Technology
Sweta Kar, Sabya Sachi Das, Sandeep Kumar Singh
Summary: In this study, QU-loaded magnetoliposomes (QMLs) were developed to overcome the challenges in the therapeutic efficacy of quercetin. By encapsulating QU in iron oxide nanoparticles and liposomes, the hydrophilicity and drug delivery potential of QU were enhanced. Comprehensive characterization and evaluation were conducted to optimize the formulations and assess their drug release and antioxidant activity. The developed QMLs hold promise in targeted drug delivery and have various practical applications.
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
