Sweet SIGNs: IgG glycosylation leads the way in IVIG-mediated resolution of inflammation

Peripherally Generated Foxp3+Regulatory T Cells Mediate the Immunomodulatory Effects of IVIg in Allergic Airways Disease

(2017) Amir H. Massoud et al.   JOURNAL OF IMMUNOLOGY

Differential antibody glycosylation in autoimmunity: sweet biomarker or modulator of disease activity?

(2017) Michaela Seeling et al.   Nature Reviews Rheumatology

Mechanisms of Autoantibody-Induced Pathology

(2017) Ralf J. Ludwig et al.   Frontiers in Immunology

Galactosylation and Sialylation Levels of IgG Predict Relapse in Patients With PR3-ANCA Associated Vasculitis

(2017) Michael J. Kemna et al.   EBioMedicine

Sialylated intravenous immunoglobulin suppress anti-ganglioside antibody mediated nerve injury

(2016) Gang Zhang et al.   EXPERIMENTAL NEUROLOGY

Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis

(2016) Yuhsuke Ohmi et al.   Nature Communications

Anti-HA Glycoforms Drive B Cell Affinity Selection and Determine Influenza Vaccine Efficacy

(2015) Taia T. Wang et al.   CELL

Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation

(2015) Ari B. Molofsky et al.   IMMUNITY

Effects of Intravenous Immunoglobulins on Mice with Experimental Epidermolysis Bullosa Acquisita

(2015) Misa Hirose et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Pro-inflammatory pattern of IgG1 Fc glycosylation in multiple sclerosis cerebrospinal fluid

(2015) Manfred Wuhrer et al.   Journal of Neuroinflammation

Skewed Fc Glycosylation Profiles of Anti-proteinase 3 Immunoglobulin G1 Autoantibodies from Granulomatosis with Polyangiitis Patients Show Low Levels of Bisection, Galactosylation, and Sialylation

(2015) Manfred Wuhrer et al.   JOURNAL OF PROTEOME RESEARCH

Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity

(2015) Nathaniel Washburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protection in antibody- and T cell-mediated autoimmune diseases by antiinflammatory IgG Fcs requires type II FcRs

(2015) Benjamin M. Fiebiger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathways Responsible for Human Autoantibody and Therapeutic Intravenous IgG Activity in Humanized Mice

(2015) Inessa Schwab et al.   Cell Reports

Broad requirement for terminal sialic acid residues and FcγRIIB for the preventive and therapeutic activity of intravenous immunoglobulins in vivo

(2014) Inessa Schwab et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tregitope: Immunomodulation Powerhouse

(2014) Leslie Cousens et al.   HUMAN IMMUNOLOGY

Intravenous immunoglobulin exerts reciprocal regulation of Th1/Th17 cells and regulatory T cells in Guillain–Barré syndrome patients

(2014) Mohan S. Maddur et al.   IMMUNOLOGIC RESEARCH

CD8+CD205+ Splenic Dendritic Cells Are Specialized to Induce Foxp3+ Regulatory T Cells

(2014) S. Yamazaki et al.   JOURNAL OF IMMUNOLOGY

Therapeutic Effect of IVIG on Inflammatory Arthritis in Mice Is Dependent on the Fc Portion and Independent of Sialylation or Basophils

(2014) I. K. Campbell et al.   JOURNAL OF IMMUNOLOGY

IL-33 Is an Unconventional Alarmin That Stimulates IL-2 Secretion by Dendritic Cells To Selectively Expand IL-33R/ST2+Regulatory T Cells

(2014) Benjamin M. Matta et al.   JOURNAL OF IMMUNOLOGY

The alarmin IL-33 promotes regulatory T-cell function in the intestine

(2014) Chris Schiering et al.   NATURE

Type I and type II Fc receptors regulate innate and adaptive immunity

(2014) Andrew Pincetic et al.   NATURE IMMUNOLOGY

Optimal Attenuation of Experimental Autoimmune Encephalomyelitis by Intravenous Immunoglobulin Requires an Intact Interleukin-11 Receptor

(2014) Carlyn A. Figueiredo et al.   PLoS One

Cytokine profiles in mouse models of experimental immune thrombocytopenia reveal a lack of inflammation and differences in response to intravenous immunoglobulin depending on the mouse strain

(2014) Danila Leontyev et al.   TRANSFUSION

A prominent lack of IgG1-Fc fucosylation of platelet alloantibodies in pregnancy

(2013) R. Kapur et al.   BLOOD

Dendritic cell immunoreceptor: A novel receptor for intravenous immunoglobulin mediates induction of regulatory T cells

(2013) Amir H. Massoud et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

T cell–independent B cell activation induces immunosuppressive sialylated IgG antibodies

(2013) Constanze Hess et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact of Immune Complex Size and Glycosylation on IgG Binding to Human Fc Rs

(2013) A. Lux et al.   JOURNAL OF IMMUNOLOGY

Dissecting the Molecular Mechanism of IVIg Therapy: The Interaction between Serum IgG and DC-SIGN is Independent of Antibody Glycoform or Fc Domain

(2013) Xiaojie Yu et al.   JOURNAL OF MOLECULAR BIOLOGY

IgG autoantibody subclass analysis as a tool to differentiate epidermolysis bullosa acquisita with overlapping features of bullous systemic lupus erythematosus

(2013) Adrià Gual et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Treatment Response in Kawasaki Disease Is Associated with Sialylation Levels of Endogenous but Not Therapeutic Intravenous Immunoglobulin G

(2013) Shohei Ogata et al.   PLoS One

B cells are critical for autoimmune pathology in Scurfy mice

(2013) S. Aschermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammatory monocytes and Fc  receptor IV on osteoclasts are critical for bone destruction during inflammatory arthritis in mice

(2013) M. Seeling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute inflammation primes myeloid effector cells for anti-inflammatory STAT6 signaling

(2013) F. Wermeling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of sialylated IgG Fc: Implications for the mechanism of intravenous immunoglobulin therapy

(2013) M. Crispin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasmacytoid Dendritic Cells, Interferon Signaling, and FcγR Contribute to Pathogenesis and Therapeutic Response in Childhood Immune Thrombocytopenia

(2013) Kartik Sehgal et al.   Science Translational Medicine

Mouse background and IVIG dosage are critical in establishing the role of inhibitory Fc  receptor for the amelioration of experimental ITP

(2012) D. Leontyev et al.   BLOOD

B cells and CD22 are dispensable for the immediate antiinflammatory activity of intravenous immunoglobulins in vivo

(2012) Inessa Schwab et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IVIg-mediated amelioration of ITP in mice is dependent on sialic acid and SIGNR1

(2012) Inessa Schwab et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tolerance induction with T cell–dependent protein antigens induces regulatory sialylated IgGs

(2012) Carolin M. Oefner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Intravenous Immunoglobulin Expands Regulatory T Cells in Autoimmune Rheumatic Disease

(2012) J. BAYRY et al.   JOURNAL OF RHEUMATOLOGY

Intravenous Immunoglobulin Prevents Murine Antibody-Mediated Acute Lung Injury at the Level of Neutrophil Reactive Oxygen Species (ROS) Production

(2012) John W. Semple et al.   PLoS One

Sialylation-independent mechanism involved in the amelioration of murine immune thrombocytopenia using intravenous gammaglobulin

(2012) Danila Leontyev et al.   TRANSFUSION

Epidermolysis bullosa acquisita

(2011) Rishu Gupta et al.   CLINICS IN DERMATOLOGY

Current therapy of the pemphigus group

(2011) Michael Kasperkiewicz et al.   CLINICS IN DERMATOLOGY

Monocyte Subsets Responsible for Immunoglobulin G-Dependent Effector Functions In Vivo

(2011) Markus Biburger et al.   IMMUNITY

IL-33 Expands Suppressive CD11b+ Gr-1int and Regulatory T Cells, including ST2L+ Foxp3+ Cells, and Mediates Regulatory T Cell-Dependent Promotion of Cardiac Allograft Survival

(2011) H. R. Turnquist et al.   JOURNAL OF IMMUNOLOGY

Intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway

(2011) Robert M. Anthony et al.   NATURE

Intravenous immunoglobulin therapy in rheumatic diseases

(2011) Jagadeesh Bayry et al.   Nature Reviews Rheumatology

Enrichment of Sialylated IgG by Lectin Fractionation Does Not Enhance the Efficacy of Immunoglobulin G in a Murine Model of Immune Thrombocytopenia

(2011) Theresa Guhr et al.   PLoS One

IVIg modulates BCR signaling through CD22 and promotes apoptosis in mature human B lymphocytes

(2010) J.-F. Seite et al.   BLOOD

Fc RIV deletion reveals its central role for IgG2a and IgG2b activity in vivo

(2010) F. Nimmerjahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Dose Intravenous Immunoglobulin (IVIG) Therapy in Autoimmune Skin Blistering Diseases

(2009) Norito Ishii et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Low-affinity Fcγ receptors, autoimmunity and infection

(2009) Lisa C. Willcocks et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Pathogenicity of IgG subclass autoantibodies to type VII collagen: Induction of dermal–epidermal separation

(2009) Andreas Recke et al.   JOURNAL OF AUTOIMMUNITY

A randomized double-blind trial of intravenous immunoglobulin for pemphigus

(2009) Masayuki Amagai et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Impaired inhibitory Fc  receptor IIB expression on B cells in chronic inflammatory demyelinating polyneuropathy

(2009) B. Tackenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-Inflammatory Actions of Intravenous Immunoglobulin

(2008) Falk Nimmerjahn et al.   Annual Review of Immunology

Of mice and men: an open-label pilot study for treatment of immune thrombocytopenic purpura by an inhibitor of Syk

(2008) A. Podolanczuk et al.   BLOOD

Activation of natural regulatory T cells by IgG Fc-derived peptide "Tregitopes"

(2008) A. S. De Groot et al.   BLOOD

Specificity and affinity of human Fc  receptors and their polymorphic variants for human IgG subclasses

(2008) P. Bruhns et al.   BLOOD

Regulated Glycosylation Patterns of IgG during Alloimmune Responses against Human Platelet Antigens

(2008) Manfred Wuhrer et al.   JOURNAL OF PROTEOME RESEARCH

Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells

(2008) Noriyuki Fujikado et al.   NATURE MEDICINE

Identification of a receptor required for the anti-inflammatory activity of IVIG

(2008) R. M. Anthony et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc

(2008) R. M. Anthony et al.   SCIENCE

The Mechanisms of Action of Intravenous Immunoglobulin and Polyclonal Anti-D Immunoglobulin in the Amelioration of Immune Thrombocytopenic Purpura: What Do We Really Know?

(2008) Andrew R. Crow et al.   TRANSFUSION MEDICINE REVIEWS

Expansion of CD4+CD25+ regulatory T cells by intravenous immunoglobulin: a critical factor in controlling experimental autoimmune encephalomyelitis

(2007) A. Ephrem et al.   BLOOD