Cytokine profiles in mouse models of experimental immune thrombocytopenia reveal a lack of inflammation and differences in response to intravenous immunoglobulin depending on the mouse strain

Differences in gene expression and cytokine levels between newly diagnosed and chronic pediatric ITP

(2013) M. Jernas et al.   BLOOD

Immune thrombocytopenia – what are the new treatment options?

(2013) Simon Hallam et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Pathophysiology and management of primary immune thrombocytopenia

(2013) Hirokazu Kashiwagi et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

The serum levels of the cytokines involved in the Th17 and Th1 cell commitment are increased in individuals with borderline thrombocytopenia

(2013) Andreia Maria Camargos Rocha et al.   Journal of Hematology & Oncology

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasmacytoid Dendritic Cells, Interferon Signaling, and FcγR Contribute to Pathogenesis and Therapeutic Response in Childhood Immune Thrombocytopenia

(2013) Kartik Sehgal et al.   Science Translational Medicine

Involvement of levels of Toll like receptor-4 in monocytes, CD4+ T-lymphocyte subsets, and cytokines in patients with immune thrombocytopenic purpura

(2013) Hongyun Liu et al.   THROMBOSIS RESEARCH

Unraveling the IVIG mystique

(2013) Donald R. Branch   TRANSFUSION

Mouse background and IVIG dosage are critical in establishing the role of inhibitory Fc  receptor for the amelioration of experimental ITP

(2012) D. Leontyev et al.   BLOOD

Elevated profiles of Th22 cells and correlations with Th17 cells in patients with immune thrombocytopenia

(2012) Yu Hu et al.   HUMAN IMMUNOLOGY

Inhibitory Effect of IVIG on IL-17 Production by Th17 Cells is Independent of Anti-IL-17 Antibodies in the Immunoglobulin Preparations

(2012) Mohan S. Maddur et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Sialylation-independent mechanism involved in the amelioration of murine immune thrombocytopenia using intravenous gammaglobulin

(2012) Danila Leontyev et al.   TRANSFUSION

Technical approaches for mouse models of human disease

(2011) M. J. Justice et al.   Disease Models & Mechanisms

Intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway

(2011) Robert M. Anthony et al.   NATURE

Investigation of TNF-alpha, TGF-beta 1, IL-10, IL-6, IFN-gamma, MBL, GPIA, and IL1A gene polymorphisms in patients with idiopathic thrombocytopenic purpura

(2011) M. Pehlivan et al.   PLATELETS

Enrichment of Sialylated IgG by Lectin Fractionation Does Not Enhance the Efficacy of Immunoglobulin G in a Murine Model of Immune Thrombocytopenia

(2011) Theresa Guhr et al.   PLoS One

Passively Administered Pooled Human Immunoglobulins Exert IL-10 Dependent Anti-Inflammatory Effects that Protect against Fatal HSV Encephalitis

(2011) Chandran Ramakrishna et al.   PLoS Pathogens

Improved mouse models for the study of treatment modalities for immune-mediated platelet destruction

(2010) Yulia Katsman et al.   TRANSFUSION

Can Animal Models of Disease Reliably Inform Human Studies?

(2010) H. Bart van der Worp et al.   PLOS MEDICINE

A murine model of severe immune thrombocytopenia is induced by antibody- and CD8+ T cell-mediated responses that are differentially sensitive to therapy

(2009) L. Chow et al.   BLOOD

Elevated profile of Th17, Th1 and Tc1 cells in patients with immune thrombocytopenic purpura

(2009) J. Zhang et al.   HAEMATOLOGICA