Article
Infectious Diseases
Kamrul Islam, Fekade B. Sime, Steven C. Wallis, Michelle J. Bauer, Brian M. Forde, Patrick Harris, Tahmina Shirin, Zakir H. Habib, Meerjady S. Flora, Jason A. Roberts
Summary: This study compared the pharmacodynamics of piperacillin/tazobactam and meropenem against ESBL-producing and non-producing E. coli. The results suggest that piperacillin/tazobactam may be a potential alternative to carbapenems in treating urosepsis caused by ESBL-producing E. coli.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Elisabeth Krogsgaard Petersen, Pelle Hanberg, Martin Knudsen, Sara Kousgaard Tostesen, Andrea Rene Jorgensen, Kristina Obrink-Hansen, Kjeld Soballe, Maiken Stilling, Mats Bue
Summary: This study compared the effects of continuous infusion (CI) and short-term intermittent infusion (STI) of piperacillin on the minimal inhibitory concentration time (fT > MIC) in porcine cervical spine tissue. The results showed that CI resulted in a significantly higher fT > MIC, indicating that CI should be considered for the treatment of spondylodiscitis cases requiring piperacillin.
Article
Infectious Diseases
Chandra Datta Sumi, Aaron J. Heffernan, Saiyuri Naicker, Kyra Cottrell, Steven C. Wallis, Jeffrey Lipman, Patrick N. A. Harris, Fekade B. Sime, Jason A. Roberts
Summary: The study compared different infusion regimens of piperacillin/tazobactam on bacterial killing and resistance emergence. Results showed that for non-ESBL-producing E. coli, intermittent or prolonged infusions may suppress resistant subpopulations, while for AmpC- and ESBL-producing E. coli, these regimens may not be effective.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Jessica R. Tait, Timothy C. Barnett, Kate E. Rogers, Wee Leng Lee, Madhu Page-Sharp, Laurens Manning, Ben J. Boyd, Jonathan R. Carapetis, Roger L. Nation, Cornelia B. Landersdorfer
Summary: This study evaluates the penicillin G concentrations required to suppress the growth of Group A Streptococcus (Streptococcus pyogenes; Strep A) and provides guidance for the development of new penicillin formulations. Mathematical modeling was used to describe the effect of penicillin G on different strains of Strep A.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Microbiology
Xiao-jing Ma, Tong Wang, Hui-min Zhang, Jun-qian Shao, Mei Jiang, Huai Wang, Hui-xia Zhu, Dong Zhou
Summary: This study investigated the antibacterial effects and mechanisms of lactonic sophorolipid (LSL) on pathogenic bacteria and found that LSL had the best inhibitory effect against Staphylococcus aureus, followed by Pseudomonas aeruginosa. The study also provided a better understanding of the relationship between LSL and different bacterial cell structures, suggesting that LSL may be used for targeted treatment of special pathogens.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
O. Yetis, S. Ali, K. Karia, P. Wilson
Summary: This study evaluated the effectiveness of POU filter head (polysulfone; hollow-fibre matrix) shower filters in preventing the exposure of high-risk patient groups to P. aeruginosa. The results suggest that POU filter showerhead units may not be effective in preventing the exposure of vulnerable patients to P. aeruginosa in hospital water due to retrograde contamination or failure of the hollow-fibre filter matrix.
JOURNAL OF HOSPITAL INFECTION
(2022)
Article
Infectious Diseases
Jose Manuel Ortiz de la Rosa, Angel Rodriguez-Villodres, Guillermo Martin-Gutierrez, Carmen Cintora Mairal, Jose Luis Garcia Escobar, Lydia Galvez-Benitez, Jose Miguel Cisneros, Jose Antonio Lepe
Summary: A selective medium, BIChromET, has been developed for detecting piperacillin-tazobactam (TZP) and cefepime (FEP) resistant Pseudomonas aeruginosa. This medium showed excellent performance in terms of sensitivity and specificity, and demonstrated high agreements with results obtained through other detection methods.
Article
Biotechnology & Applied Microbiology
Jingjing Zhang, Feng Qu, Taobo Liang, Sidi Lv, Wen Li, Qixiu You, Bolu Chen, Hengyi Xu
Summary: Synthesized Ag NPs coated with ε-polylysine and poly-ethyleneimine showed strong anti-P. aeruginosa capacity at low concentrations, inhibiting drug-resistant clinical strains and biofilm formation. The antibacterial mechanism was found to be primarily through induction of oxidative stress by increasing levels of ROS, which was neutralized by the ROS scavenger N-acetyl-L-cysteine.
BIOCHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Applied
Shanshan Zhuang, Yao Bao, Yaxin Zhang, Huangyou Zhang, Jianliang Liu, Huifan Liu
Summary: DDDY from Dendrobium aphyllum has been found to possess antibacterial activity against Pseudomonas aeruginosa, and metabolomic and transcriptomic analyses provided insights into its mechanism. Molecular dynamics simulation revealed the specific interaction between DDDY and membranes, and its potential as an inhibitor of food microorganisms was also demonstrated.
Article
Fisheries
Alianet Rodriguez, Janet Velazquez, Luis Gonzalez, Tania Rodriguez-Ramos, Brian Dixon, Fidel Herrera Miyares, Antonio Morales, Osmany Gonzalez, Mario Pablo Estrada, Yamila Carpio
Summary: PACAP-38 from African catfish enhances antibacterial activity and modulates gene expression of immune-related molecules, suggesting its potential as an antimicrobial agent in aquaculture.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Infectious Diseases
Jessica R. Tait, Hajira Bilal, Kate E. Rogers, Yinzhi Lang, Tae-Hwan Kim, Jieqiang Zhou, Steven C. Wallis, Juergen B. Bulitta, Carl M. J. Kirkpatrick, David L. Paterson, Jeffrey Lipman, Phillip J. Bergen, Jason A. Roberts, Roger L. Nation, Cornelia B. Landersdorfer
Summary: This study evaluated different drug therapies for Pseudomonas aeruginosa infections in critically ill patients. The results showed that the combination regimen including intermittent piperacillin-tazobactam did not provide an advantage over tobramycin monotherapy. However, the combination regimen with continuous infusion of piperacillin-tazobactam achieved synergistic killing of Pseudomonas aeruginosa.
Article
Critical Care Medicine
Sterling C. Torian, Arek J. Wiktor, Sara E. Roper, Kate E. Laramie, Matthew A. Miller, Scott W. Mueller
Summary: This case report describes the unique findings of ARC in a non-critically ill burn patient and emphasizes the need for further research to classify the incidence, risk factors, and appropriate antimicrobial regimens for burn patients with ARC.
JOURNAL OF BURN CARE & RESEARCH
(2023)
Article
Food Science & Technology
Yuansong Li, Fei Ren, Da Chen, Haiming Chen, Wenxue Chen
Summary: The antibacterial mechanism of linalool against Pseudomonas fragi includes disruption of lipopolysaccharide synthesis, activation of fatty acid metabolism and ribosomal function, and disturbance of energy metabolism. Multiple ATP synthases and ATP transporters are overexpressed but fail to consume ATP, while the overexpression of ribosomal functional proteins and transporters may burden the cells and cause them to collapse.
Article
Chemistry, Inorganic & Nuclear
Sreekanth Rajagopalachar, Jayadev Pattar, Sikandar Mulla
Summary: In this work, high surface area MgO nanoparticles were successfully synthesized without using any directing agent or capping agent. The experimental conditions required to achieve high surface area MgO nanoparticles were investigated. The optical, structural, and morphological properties of the MgO nanoparticles were characterized using various techniques. The MgO nanoparticles exhibited good antibacterial activity against different bacteria.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Yuansong Li, Rongrong He, Haiming Chen, Da Chen, Wenxue Chen
Summary: The study revealed the antimicrobial activity and mechanism of linalool against P. fragi through altering intracellular metabolism, leading to disturbances in energy, amino acid, and nucleic acid metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medical Laboratory Technology
Lucy Sharrock, Melissa J. Ankravs, Adam M. Deane, Thomas Rechnitzer, Steven C. Wallis, Jason A. Roberts, Rinaldo Bellomo
Summary: This study measured the clearance of piperacillin-tazobactam and vancomycin in patients receiving CVVHDF with regional citrate anticoagulation, and found that both drugs have high clearance, providing key information for optimal dosing.
THERAPEUTIC DRUG MONITORING
(2023)
Article
Pharmacology & Pharmacy
Paul Williams, Menino Osbert Cotta, Mohd H. H. Abdul-Aziz, Kathryn Wilks, Andras Farkas, Jason A. A. Roberts
Summary: This study aimed to compare the achievement of therapeutic PK-PD exposure targets for beta-lactam antibiotics using product information dosing or guideline-based dosing for serious infections. In silico simulations were performed, and the results showed that guideline-based dosing had significantly higher probability of target attainment at 48 and 96 hours compared to product information dosing. The study also found that eGFR was significantly associated with the %PTA by guideline-based dosing.
Article
Urology & Nephrology
Carla E. Scuderi, Suzanne L. Parker, Margaret Jacks, George T. John, Brett McWhinney, Jacobus Ungerer, Andrew J. Mallett, Helen G. Healy, Jason A. Roberts, Christine E. Staatz
Summary: This study aimed to assess the diagnostic accuracy of using volumetric absorptive microsamplers (VAMS) to measure tacrolimus and creatinine in kidney transplant recipients. The results showed that VAMS can reliably measure tacrolimus and creatinine, providing a less invasive and more frequent sampling method for patients.
Article
Microbiology
Silvia Lopez-Argueello, Maria Montaner, Alaa R. M. Sayed, Antonio Oliver, Jurgen B. Bulitta, Bartolome Moya
Summary: Beta-lactam antibiotics have been effective against susceptible Pseudomonas aeruginosa, but their penetration ability and binding to penicillin-binding proteins (PBPs) in intact bacteria have not been well studied. This research investigated the time course of PBP binding and target site penetration of 15 compounds in P. aeruginosa PAO1. The results showed that PBPs 1-4 were considerably bound in lysed bacteria, but the binding was attenuated in intact bacteria for slow penetrating beta-lactams. Imipenem showed the highest killing effect, while other drugs had lower killing rates. The study also found a correlation between PBP5/6 binding and the rate of net influx and PBP access.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Microbiology
Pier Giorgio Cojutti, Aaron J. Heffernan, Thomas Tangden, Paola Della Siega, Carlo Tascini, Jason A. Roberts, Federico Pea
Summary: This study aimed to develop a population pharmacokinetic/pharmacodynamic (PK/PD) model of valganciclovir for preemptive therapy of cytomegalovirus (CMV) infection in kidney transplant patients. Ganciclovir concentrations and CMV viral loads were retrospectively obtained from kidney transplant patients. Monte Carlo simulations were conducted to assess the probability of attaining viral load targets, and a PK/PD model was devised.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Eko Setiawan, Menino Osbert Cotta, Mohd-Hafiz Abdul-Aziz, Doddy Widjanarko, Hernycane Sosilya, Dwi Lily Lukas, Steven C. Wallis, Suzanne Parker, Jason A. Roberts
Summary: This study investigated the pharmacokinetics of ampicillin-sulbactam in patients with a wide range of renal functions and found that serum creatinine was closely associated with drug clearance. Furthermore, a 4-hour infusion was found to enhance the probability of target attainment and fractional target attainment, especially at higher minimum inhibitory concentrations.
CLINICAL PHARMACOKINETICS
(2023)
Review
Pharmacology & Pharmacy
Haifa Lyster, Kiran Shekar, Kevin Watt, Anna Reed, Jason A. A. Roberts, Mohd-Hafiz Abdul-Aziz
Summary: Extracorporeal membrane oxygenation (ECMO) is an advanced life support system that provides temporary cardiac and/or respiratory support for critically ill patients. Fungal infections are associated with higher mortality rates in patients on ECMO. The pharmacokinetics of antifungal drugs can be affected by critical illness and ECMO, making dosing challenging. Current literature on antifungal dosing in critically ill patients on ECMO is limited and inconsistent, making it necessary to consider therapeutic drug monitoring.
CLINICAL PHARMACOKINETICS
(2023)
Review
Infectious Diseases
Jason A. Roberts, Katherine Croom, Nicholas Adomakoh
Summary: Continuous infusion of beta-lactam antibiotics may be beneficial in some patients, especially those with severe infections. However, the existing studies have been small-scale and have yielded conflicting results. The best evidence on the clinical outcomes of beta-lactam continuous infusion comes from systematic reviews/meta-analyses.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2023)
Review
Pharmacology & Pharmacy
Gavin Matthew Joynt, Lowell Ling, Wai Tat Wong, Jeffrey Lipman
Summary: The importance of antibiotic treatment for sepsis in critically ill septic patients is well known. However, achieving the correct dosage of antibiotics is a challenge. Understanding the pharmacokinetic and pharmacodynamic characteristics of antibiotics in critically ill patients is reshaping how they are dosed.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2023)
Review
Infectious Diseases
Eko Setiawan, Menino Osbert Cotta, Jason A. Roberts, Mohd Hafiz Abdul-Aziz
Summary: While inter-ethnic differences in the pharmacokinetic variabilities of antimicrobials have been studied among healthy subjects, further investigation is needed to understand the differences in antimicrobial pharmacokinetics between Asian and non-Asian patients with severe pathologic conditions. A systematic review was conducted to explore the potential variations in antimicrobial pharmacokinetics between Asian and non-Asian populations, with the inclusion of thirty studies on different antimicrobial agents. Inconsistent differences in pharmacokinetic parameters were observed between Asian and non-Asian patients, suggesting that ethnicity may not be a significant predictor in characterizing these differences, and dosing regimens should be adjusted based on demographic or clinical characteristics.
Review
Infectious Diseases
Amy Legg, Sinead Carmichael, Ming G. Chai, Jason A. Roberts, Menino O. Cotta
Summary: Beta-lactam antibiotics are commonly used in critically ill patients to treat infections, but the optimal exposure targets for these drugs are still debated. Overcoming pharmacokinetic and pharmacodynamic challenges in the intensive care unit is necessary to achieve desired exposures. Therapeutic drug monitoring has shown promise for determining if the desired exposures are reached, but more research is needed to determine its impact on infection-related outcomes. Improving the efficiency of sampling and reporting results in at-risk patients is important for an ideal beta-lactam TDM service.
Article
Infectious Diseases
Francisco Beraldi-Magalhaes, Suzanne L. L. Parker, Cristina Sanches, Leandro Sousa Garcia, Brenda Karoline Souza Carvalho, Amanda Araujo Costa, Mariana Millan Fachi, Marcus Vinicius de Liz, Alexandra Brito de Souza, Izabella Picinin Safe, Roberto Pontarolo, Steven Wallis, Jeffrey Lipman, Jason A. A. Roberts, Marcelo Cordeiro-Santos
Summary: This study compared the pharmacokinetics of oral rifampin, isoniazid, pyrazinamide, and ethambutol in tuberculosis patients in intensive care units (ICU) and outpatients, and evaluated drug serum concentrations as a potential cause of mortality. The results showed that ICU patients had a lower clearance and volume of distribution for these drugs, and the 30-day mortality rate was 77% compared to an 89% cure rate in outpatients. These differences may reflect changes in organ function, absorption, and distribution to the site of infection in ICU patients, which could impact clinical outcomes.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Hematology
John Coutsouvelis, Carl M. Kirkpatrick, Michael Dooley, Andrew Spencer, Glen Kennedy, Maggie Chau, Gillian Huang, Richard Doocey, Tandy-Sue Copeland, Louis Do, Peter Bardy, Ian Kerridge, Theresa Cole, Chris Fraser, Travis Perera, Stephen R. Larsen, Kate Mason, Tracey A. O'Brien, Peter J. Shaw, Lochie Teague, Andrew Butler, Anne-Marie Watson, Shanti Ramachandran, Jodie Marsh, Zulekha Khan, Nada Hamad
Summary: This study aimed to describe the incidence of SOS/VOD and patterns of defibrotide use from 2016 to 2020 based on data from the Australasian Bone Marrow Transplant Recipient Registry. The incidence of SOS/VOD was 4.1% in adult centers and 11.5% in pediatric centers. Defibrotide was administered to 74.8% of adult patients and 97.3% of pediatric patients with SOS/VOD. The 100-day survival rate was 51.8% for adults and 90.4% for pediatric patients.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Article
Surgery
Steven Ivulich, Miranda Paraskeva, Eldho Paul, Carl Kirkpatrick, Michael Dooley, Gregory Snell
Summary: Everolimus in lung transplant recipients does not increase the risk of death or accelerate the progression to chronic lung allograft dysfunction compared to calcineurin inhibitor-based immunosuppression. The emergence of chronic lung allograft dysfunction, obstructive or restrictive phenotypes, and death rates showed no significant difference between the two groups. There is a lack of long-term evidence for survival and progression to chronic lung allograft dysfunction with Everolimus-based immunosuppression.
TRANSPLANT INTERNATIONAL
(2023)
Article
Anesthesiology
Ming G. Chai, Jason A. Roberts, Christina F. Kelly, Jacobus P. J. Ungerer, Brett C. Mcwhinney, Jeffrey Lipman, Andras Farkas, Menino O. Cotta
Summary: This study aimed to evaluate the efficiency of dosing software for achieving target antibiotic exposures in critically ill patients. The results showed that the use of therapeutic drug monitoring combined with Bayesian forecasting dosing software increased the chances of achieving target exposures in patients, and no antibiotic exposure-related adverse events were reported.
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2023)