Quercetin Has Antimetastatic Effects on Gastric Cancer Cells via the Interruption of uPA/uPAR Function by Modulating NF-κb, PKC-δ, ERK1/2, and AMPKα

Polyphenol compounds and PKC signaling

(2016) Joydip Das et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Prolactin-induced PAK1 tyrosyl phosphorylation promotes FAK dephosphorylation, breast cancer cell motility, invasion and metastasis

(2016) Alan Hammer et al.   BMC CELL BIOLOGY

Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization

(2016) An Liu et al.   JOURNAL OF CELL BIOLOGY

Inhibitory Effects of Quercetin on Progression of Human Choriocarcinoma Cells Are Mediated Through PI3K/AKT and MAPK Signal Transduction Cascades

(2016) Whasun Lim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Enhanced anti-inflammatory effects of DHA and quercetin in lipopolysaccharide-induced RAW264.7 macrophages by inhibiting NF-κB and MAPK activation

(2016) TIAN-LEI SI et al.   Molecular Medicine Reports

Quercetin-3-O-glucoside suppresses pancreatic cancer cell migration induced by tumor-deteriorated growth factors in vitro

(2016) JUNGWHOI LEE et al.   ONCOLOGY REPORTS

Allium cepaExtract and Quercetin Protect Neuronal Cells from Oxidative Stress via PKC-εInactivation/ERK1/2 Activation

(2016) Bo Kyung Lee et al.   Oxidative Medicine and Cellular Longevity

Effect of urokinase-type plasminogen activator system in gastric cancer with peritoneal metastasis

(2016) YOUCHENG DING et al.   Oncology Letters

MiR-320a inhibits gastric carcinoma by targeting activity in the FoxM1-P27KIP1 axis

(2016) Yangyang Wang et al.   Oncotarget

Anti-Breast Cancer Potential of Quercetin via the Akt/AMPK/Mammalian Target of Rapamycin (mTOR) Signaling Cascade

(2016) Amilcar Rivera Rivera et al.   PLoS One

Quercetin inhibits HGF/c-Met signaling and HGF-stimulated melanoma cell migration and invasion

(2015) Hui-Hui Cao et al.   Molecular Cancer

S-Nitrosylation of Cofilin-1 Mediates Estradiol-17β-Stimulated Endothelial Cytoskeleton Remodeling

(2015) Hong-hai Zhang et al.   MOLECULAR ENDOCRINOLOGY

Quercetin promotes cell apoptosis and inhibits the expression of MMP-9 and fibronectin via the AKT and ERK signalling pathways in human glioma cells

(2015) Hong-Chao Pan et al.   NEUROCHEMISTRY INTERNATIONAL

Berberine and Curcumin Target Survivin and STAT3 in Gastric Cancer Cells and Synergize Actions of Standard Chemotherapeutic 5-Fluorouracil

(2015) Arvind Pandey et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Quercetin-induced apoptosis prevents EBV infection

(2015) Minjung Lee et al.   Oncotarget

Plant polyphenols as inhibitors of NF-κB induced cytokine production—a potential anti-inflammatory treatment for Alzheimer's disease?

(2015) Niloo Karunaweera et al.   Frontiers in Molecular Neuroscience

Computer-Based Identification of a Novel LIMK1/2 Inhibitor that Synergizes with Salirasib to Destabilize the Actin Cytoskeleton

(2015) Efrat Mashiach Farkash et al.   Oncotarget

uPA-uPAR molecular complex is involved in cell signaling during neuronal migration and neuritogenesis

(2014) Noelia Lino et al.   DEVELOPMENTAL DYNAMICS

Protein kinase C-δ mediates sepsis-induced activation of complement 5a and urokinase-type plasminogen activator signaling in macrophages

(2014) Xiao-song Yang et al.   INFLAMMATION RESEARCH

Quercetin induces apoptosis by inhibiting MAPKs and TRPM7 channels in AGS cells

(2014) MIN CHUL KIM et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Quercetin reverses EGF-induced epithelial to mesenchymal transition and invasiveness in prostate cancer (PC-3) cell line via EGFR/PI3K/Akt pathway

(2014) Firdous Ahmad Bhat et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Characterization of the Interaction between Heterodimeric αvβ6 Integrin and Urokinase Plasminogen Activator Receptor (uPAR) Using Functional Proteomics

(2014) Seong Beom Ahn et al.   JOURNAL OF PROTEOME RESEARCH

Quercetin suppresses invasion and migration of H-Ras-transformed MCF10A human epithelial cells by inhibiting phosphatidylinositol 3-kinase

(2013) Nu Ry Song et al.   FOOD CHEMISTRY

Integrin-binding Protein Nischarin Interacts with Tumor Suppressor Liver Kinase B1 (LKB1) to Regulate Cell Migration of Breast Epithelial Cells

(2013) Prachi Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quercetin Suppresses Intracellular ROS Formation, MMP Activation, and Cell Motility in Human Fibrosarcoma Cells

(2013) Dong Eun Lee et al.   JOURNAL OF FOOD SCIENCE

uPAR

(2013) Pavel Uhrin et al.   Cell Adhesion & Migration

Role of Urokinase Receptor in Tumor Progression and Development

(2013) Hyangsoon Noh et al.   Theranostics

In vitro effect of quercetin on human gastric carcinoma: Targeting cancer cells death and MDR

(2012) Sylwia Borska et al.   FOOD AND CHEMICAL TOXICOLOGY

PKD2 and PKD3 promote prostate cancer cell invasion by modulating NF- B- and HDAC1-mediated expression and activation of uPA

(2012) Z. Zou et al.   JOURNAL OF CELL SCIENCE

Quercetin Inhibits Angiogenesis Mediated Human Prostate Tumor Growth by Targeting VEGFR- 2 Regulated AKT/mTOR/P70S6K Signaling Pathways

(2012) Poyil Pratheeshkumar et al.   PLoS One

Quercetin induces protective autophagy in gastric cancer cells: Involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling

(2011) Kui Wang et al.   Autophagy

Quercetin inhibits invasion, migration and signalling molecules involved in cell survival and proliferation of prostate cancer cell line (PC-3)

(2011) Kalimuthu Senthilkumar et al.   CELL BIOCHEMISTRY AND FUNCTION

Binding of Anti-SSA Antibodies to Apoptotic Fetal Cardiocytes Stimulates Urokinase Plasminogen Activator (uPA)/uPA Receptor-Dependent Activation of TGF-β and Potentiates Fibrosis

(2011) Paraskevi Briassouli et al.   JOURNAL OF IMMUNOLOGY

Effects of quercetin on the apoptosis of the human gastric carcinoma cells

(2011) Ping Wang et al.   TOXICOLOGY IN VITRO

Dietary quercetin intake and risk of gastric cancer: results from a population-based study in Sweden

(2010) A. M. Ekstrom et al.   ANNALS OF ONCOLOGY

Suppression of urokinase plasminogen activator receptor inhibits proliferation and migration of pancreatic adenocarcinoma cells via regulation of ERK/p38 signaling

(2009) Aiqun Xue et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Activation of phosphatidylinositol 3-kinase is required for tumor necrosis factor-α-induced upregulation of matrix metalloproteinase-9: Its direct inhibition by quercetin

(2009) Mun Kyung Hwang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Reactive oxygen species regulate urokinase plasminogen activator expression and cell invasion via mitogen-activated protein kinase pathways after treatment with hepatocyte growth factor in stomach cancer cells

(2009) Kyung Lee et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Urokinase mediates endothelial cell survival via induction of the X-linked inhibitor of apoptosis protein

(2008) G. W. Prager et al.   BLOOD