Silica nanoparticles induce NLRP3 inflammasome activation in human primary immune cells

Differential cytotoxic and inflammatory potency of amorphous silicon dioxide nanoparticles of similar size in multiple cell lines

(2017) Dalibor Breznan et al.   Nanotoxicology

SR-B1 Is a Silica Receptor that Mediates Canonical Inflammasome Activation

(2017) Misato Tsugita et al.   Cell Reports

Assessment of Pain Associated with Insertion Torque of Dental Implants. A Prospective, Randomized-Controlled Study

(2017) A. Scarano et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Effects of silver nanoparticles and gold nanoparticles on IL-2, IL-6, and TNF-α production via MAPK pathway in leukemic cell lines

(2015) C. Parnsamut et al.   GENETICS AND MOLECULAR RESEARCH

HIV-1–neutrophil interactions trigger neutrophil activation and Toll-like receptor expression

(2015) Diana Marcela Giraldo et al.   IMMUNOLOGIC RESEARCH

HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status?

(2015) Juan C. Hernandez et al.   IMMUNOLOGIC RESEARCH

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Cytotoxicity and Cellular Uptake of Amorphous Silica Nanoparticles in Human Cancer Cells

(2015) Yuequn Wu et al.   PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION

The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine

(2015) L Baron et al.   Cell Death & Disease

Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

(2015) Philipp Kruger et al.   PLoS Pathogens

Metal-Based Nanoparticles and the Immune System: Activation, Inflammation, and Potential Applications

(2015) Yueh-Hsia Luo et al.   Biomed Research International

Involvement of Neutrophil Hyporesponse and the Role of Toll-Like Receptors in Human Immunodeficiency Virus 1 Protection

(2015) Juan C. Hernandez et al.   PLoS One

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Nanotoxicity: Oxidative Stress Mediated Toxicity of Metal and Metal Oxide Nanoparticles

(2014) Abhijit Sarkar et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Effect of Silica Particle Size on Macrophage Inflammatory Responses

(2014) Toshimasa Kusaka et al.   PLoS One

Purinergic signaling via P2X7 receptor mediates IL-1β production in Kupffer cells exposed to silica nanoparticle

(2014) Shuji Kojima et al.   TOXICOLOGY

Activation of NLRP3 inflammasome by crystalline structures via cell surface contact

(2014) Aswin Hari et al.   Scientific Reports

Immunomodulation of Nanoparticles in Nanomedicine Applications

(2014) Qing Jiao et al.   Biomed Research International

Short Communication Transient increase in IL-1β, IL-6 and TNF-α gene expression in rat liver exposed to gold nanoparticles

(2013) H.A. Khan et al.   GENETICS AND MOLECULAR RESEARCH

HIV-1 Induces the First Signal to Activate the NLRP3 Inflammasome in Monocyte-Derived Macrophages

(2013) Juan C. Hernandez et al.   INTERVIROLOGY

Toxicity screenings of nanomaterials: challenges due to interference with assay processes and components of classicin vitrotests

(2013) Rina Guadagnini et al.   Nanotoxicology

Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity

(2013) Amruta Manke et al.   Biomed Research International

Immunostimulatory Effects of Silica Nanoparticles in Human Monocytes

(2013) Eun-Jeoung Yang et al.   Immune Network

Biodegradable nanoparticles for drug and gene delivery to cells and tissue

(2012) Jayanth Panyam et al.   ADVANCED DRUG DELIVERY REVIEWS

HIV Type 1 Infection Up-Regulates TLR2 and TLR4 Expression and Function in Vivo and in Vitro

(2012) Juan C. Hernández et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Comparison of non-crystalline silica nanoparticles in IL-1β release from macrophages

(2012) Wiggo J Sandberg et al.   Particle and Fibre Toxicology

The comparative effects of mesoporous silica nanoparticles and colloidal silica on inflammation and apoptosis

(2011) Soyoung Lee et al.   BIOMATERIALS

Multifunctional silica nanoparticles with potentials of imaging and gene delivery

(2011) Gajadhar Bhakta et al.   Nanomedicine-Nanotechnology Biology and Medicine

Particle size affects the cellular response in macrophages

(2010) Hua Yue et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Regulation of adaptive immunity by the NLRP3 inflammasome

(2010) Mingkuan Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Molecular Mechanism of NLRP3 Inflammasome Activation

(2010) Chengcheng Jin et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1  and IL-1 

(2010) A. S. Yazdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Activation of human neutrophils by titanium dioxide (TiO2) nanoparticles

(2009) D.M. Gonçalves et al.   TOXICOLOGY IN VITRO

Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers☆

(2008) I SLOWING et al.   ADVANCED DRUG DELIVERY REVIEWS

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE