Guanylate Cyclase C Activation Shapes the Intestinal Microbiota in Patients with Familial Diarrhea and Increased Susceptibility for Crohnʼs Disease

Role of epithelial ion transports in inflammatory bowel disease

(2016) Diogo Magalhães et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Modulation of the human gut microbiota by dietary fibres occurs at the species level

(2016) Wing Sun Faith Chung et al.   BMC BIOLOGY

Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin–GUCY2C Paracrine Signaling Axis

(2016) Jieru E. Lin et al.   CANCER RESEARCH

Genetic Determinants of the Gut Microbiome in UK Twins

(2016) Julia K. Goodrich et al.   Cell Host & Microbe

A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn’s Disease and Human Gut Microbiome Composition

(2016) Dalin Li et al.   GASTROENTEROLOGY

The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls

(2016) Martin Kummen et al.   GUT

Microbiome Survey of the Inflamed and Noninflamed Gut at Different Compartments Within the Gastrointestinal Tract of Inflammatory Bowel Disease Patients

(2016) Jessica D. Forbes et al.   INFLAMMATORY BOWEL DISEASES

Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation

(2016) S F Jørgensen et al.   Mucosal Immunology

Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota

(2016) Jun Wang et al.   NATURE GENETICS

The effect of host genetics on the gut microbiome

(2016) Marc Jan Bonder et al.   NATURE GENETICS

Association of host genome with intestinal microbial composition in a large healthy cohort

(2016) Williams Turpin et al.   NATURE GENETICS

An activatinggucy2cmutation causes impaired contractility and fluid stagnation in the small bowel

(2016) Hilde Løland von Volkmann et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Population-level analysis of gut microbiome variation

(2016) Gwen Falony et al.   SCIENCE

Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents

(2016) R. Alan Harris et al.   Journal of Immunology Research

Intestinal Microbiota And Diet in IBS: Causes, Consequences, or Epiphenomena?

(2015) Mirjana Rajilić-Stojanović et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Congenital secretory diarrhoea caused by activating germline mutations inGUCY2C

(2015) Thomas Müller et al.   GUT

Siblings of patients with Crohn’s disease exhibit a biologically relevant dysbiosis in mucosal microbial metacommunities

(2015) Charlotte Hedin et al.   GUT

Stool consistency is strongly associated with gut microbiota richness and composition, enterotypes and bacterial growth rates

(2015) Doris Vandeputte et al.   GUT

Reduced sodium/proton exchanger NHE3 activity causes congenital sodium diarrhea

(2015) Andreas R. Janecke et al.   HUMAN MOLECULAR GENETICS

Inhibition of Heat-Stable Toxin–Induced Intestinal Salt and Water Secretion by a Novel Class of Guanylyl Cyclase C Inhibitors

(2015) Marcel J. C. Bijvelds et al.   JOURNAL OF INFECTIOUS DISEASES

The guanylate cyclase-C signaling pathway is down-regulated in inflammatory bowel disease

(2015) Øystein Brenna et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Probiotic Bifidobacterium species stimulate human SLC26A3 gene function and expression in intestinal epithelial cells

(2014) Anoop Kumar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The Treatment-Naive Microbiome in New-Onset Crohn’s Disease

(2014) Dirk Gevers et al.   Cell Host & Microbe

Reduced colonic microbial diversity is associated with colitis in NHE3-deficient mice

(2013) Claire B. Larmonier et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Development of a Dual-Index Sequencing Strategy and Curation Pipeline for Analyzing Amplicon Sequence Data on the MiSeq Illumina Sequencing Platform

(2013) James J. Kozich et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Guanylate cyclase C limits systemic dissemination of a murine enteric pathogen

(2013) Elizabeth A Mann et al.   BMC GASTROENTEROLOGY

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Linaclotide for Irritable Bowel Syndrome With Constipation: A 26-Week, Randomized, Double-blind, Placebo-Controlled Trial to Evaluate Efficacy and Safety

(2012) William D Chey et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms

(2012) J Gregory Caporaso et al.   ISME Journal

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Familial Diarrhea Syndrome Caused by an ActivatingGUCY2CMutation

(2012) Torunn Fiskerstrand et al.   NEW ENGLAND JOURNAL OF MEDICINE

GUCY2C Opposes Systemic Genotoxic Tumorigenesis by Regulating AKT-Dependent Intestinal Barrier Integrity

(2012) Jieru Egeria Lin et al.   PLoS One

PCR Biases Distort Bacterial and Archaeal Community Structure in Pyrosequencing Datasets

(2012) Ameet J. Pinto et al.   PLoS One

Bifidobacterial surface-exopolysaccharide facilitates commensal-host interaction through immune modulation and pathogen protection

(2012) S. Fanning et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment

(2012) Xochitl C Morgan et al.   GENOME BIOLOGY

FLASH: fast length adjustment of short reads to improve genome assemblies

(2011) T. Magoc et al.   BIOINFORMATICS

An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea

(2011) Daniel McDonald et al.   ISME Journal

Murine Guanylate Cyclase C Regulates Colonic Injury and Inflammation

(2011) K. A. Steinbrecher et al.   JOURNAL OF IMMUNOLOGY

Metagenomic biomarker discovery and explanation

(2011) Nicola Segata et al.   GENOME BIOLOGY

An optimised sample preparation method for NMR-based faecal metabonomic analysis

(2010) Junfang Wu et al.   ANALYST

Search and clustering orders of magnitude faster than BLAST

(2010) Robert C. Edgar   BIOINFORMATICS

QIIME allows analysis of high-throughput community sequencing data

(2010) J Gregory Caporaso et al.   NATURE METHODS

Crohn's disease-associated adherent-invasiveE. coliare selectively favoured by impaired autophagy to replicate intracellularly

(2009) Pierre Lapaquette et al.   CELLULAR MICROBIOLOGY

The role of pH in determining the species composition of the human colonic microbiota

(2009) Sylvia H. Duncan et al.   ENVIRONMENTAL MICROBIOLOGY

Changes in Mucosal Homeostasis Predispose NHE3 Knockout Mice to Increased Susceptibility to DSS-Induced Epithelial Injury

(2009) Pawel R. Kiela et al.   GASTROENTEROLOGY

Receptor guanylyl cyclase C (GC-C): regulation and signal transduction

(2009) Nirmalya Basu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Microbial Influences in Inflammatory Bowel Diseases

(2008) R. Balfour Sartor   GASTROENTEROLOGY

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

(2008) H. Sokol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active Crohnʼs disease and ulcerative colitis can be specifically diagnosed and monitored based on the biostructure of the fecal flora

(2007) Alexander Swidsinski et al.   INFLAMMATORY BOWEL DISEASES