The guanylate cyclase-C signaling pathway is down-regulated in inflammatory bowel disease

Guanylate Cyclase C Agonists: Emerging Gastrointestinal Therapies and Actions

(2015) Michael Camilleri   GASTROENTEROLOGY

The Paracrine Hormone for the GUCY2C Tumor Suppressor, Guanylin, Is Universally Lost in Colorectal Cancer

(2014) C. Wilson et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Linaclotide Inhibits Colonic Nociceptors and Relieves Abdominal Pain via Guanylate Cyclase-C and Extracellular Cyclic Guanosine 3′,5′-Monophosphate

(2013) Joel Castro et al.   GASTROENTEROLOGY

Intestinal Cell Proliferation and Senescence Are Regulated by Receptor Guanylyl Cyclase C and p21

(2013) Nirmalya Basu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gastrointestinal pain: Unraveling a novel endogenous pathway through uroguanylin/guanylate cyclase-C/cGMP activation

(2013) Inmaculada Silos-Santiago et al.   PAIN

Relevance of TNBS-Colitis in Rats: A Methodological Study with Endoscopic, Histologic and Transcriptomic Characterization and Correlation to IBD

(2013) Øystein Brenna et al.   PLoS One

Whole Genome Gene Expression Meta-Analysis of Inflammatory Bowel Disease Colon Mucosa Demonstrates Lack of Major Differences between Crohn's Disease and Ulcerative Colitis

(2013) Atle van Beelen Granlund et al.   PLoS One

Guanylate Cyclase C Deficiency Causes Severe Inflammation in a Murine Model of Spontaneous Colitis

(2013) Eleana Harmel-Laws et al.   PLoS One

Pharmacology and clinical potential of guanylyl cyclase C agonists in the treatment of ulcerative colitis

(2013) Giovanni Pitari   Drug Design Development and Therapy

Meconium Ileus Caused by Mutations in GUCY2C, Encoding the CFTR-Activating Guanylate Cyclase 2C

(2012) Hila Romi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

TNF-α-induced down-regulation of CDX2 suppresses MEP1A expression in colitis

(2012) Mehmet Coskun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Immunoreactivity Score Using an Anti-sst2A Receptor Monoclonal Antibody Strongly Predicts the Biochemical Response to Adjuvant Treatment with Somatostatin Analogs in Acromegaly

(2012) Federico Gatto et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Ulcerative colitis

(2012) Ingrid Ordás et al.   LANCET

Crohn's disease

(2012) Daniel C Baumgart et al.   LANCET

Familial Diarrhea Syndrome Caused by an ActivatingGUCY2CMutation

(2012) Torunn Fiskerstrand et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of the tumor suppressor homeogene Cdx2 by HNF4α in intestinal cancer

(2012) T Saandi et al.   ONCOGENE

GUCY2C Opposes Systemic Genotoxic Tumorigenesis by Regulating AKT-Dependent Intestinal Barrier Integrity

(2012) Jieru Egeria Lin et al.   PLoS One

Murine Guanylate Cyclase C Regulates Colonic Injury and Inflammation

(2011) K. A. Steinbrecher et al.   JOURNAL OF IMMUNOLOGY

Activation of REG family proteins in colitis

(2011) Atle Van Beelen Granlund et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

The role of CDX2 in intestinal homeostasis and inflammation

(2010) Mehmet Coskun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mechanisms of Diarrhea in Inflammatory Bowel Diseases

(2009) Henry J. Binder   Annals of the New York Academy of Sciences

The Hormone Receptor GUCY2C Suppresses Intestinal Tumor Formation by Inhibiting AKT Signaling

(2009) Jieru Egeria Lin et al.   GASTROENTEROLOGY

Receptor guanylyl cyclase C (GC-C): regulation and signal transduction

(2009) Nirmalya Basu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Enterotoxin preconditioning restores calcium-sensing receptor-mediated cytostasis in colon cancer cells

(2008) Giovanni M. Pitari et al.   CARCINOGENESIS

Hepatocyte nuclear factor 4α in the intestinal epithelial cells protects against inflammatory bowel disease

(2008) Sung-Hoon Ahn et al.   INFLAMMATORY BOWEL DISEASES

Intestinal barrier dysfunction in inflammatory bowel diseases

(2008) Michael A. McGuckin et al.   INFLAMMATORY BOWEL DISEASES