Article
Biochemistry & Molecular Biology
G. M. Leggio, S. A. Torrisi, R. Mastrogiacomo, D. Mauro, M. Chisari, C. Devroye, D. Scheggia, M. Nigro, F. Geraci, N. Pintori, G. Giurdanella, L. Costa, C. Bucolo, V. Ferretti, M. A. Sortino, L. Ciranna, M. A. De Luca, M. Mereu, F. Manago, S. Salomone, F. Drago, F. Papaleo
Summary: The dopamine D2 and D3 receptors are associated with schizophrenia and its treatment; a genetic interaction between D3 and Dys suggests that reducing D3 and Dys functionality can improve cognitive abilities; Dys interference with the D3 receptor subtype mechanism needs further investigation.
MOLECULAR PSYCHIATRY
(2021)
Article
Biology
Allison E. Hamilos, Giulia Spedicato, Ye Hong, Fangmiao Sun, Yulong Li, John A. Assad
Summary: The study revealed that dopamine signals play a crucial role in the timing of reward-related movements in animals, with the signals gradually increasing over time to predict movement/reward timing. The dynamics of dopamine signals can modulate the probability of movement initiation, providing important insights into the decision of when to move.
Article
Biology
Deetje Iggena, Sein Jeung, Patrizia Maier, Christoph Ploner, Klaus Gramann, Carsten Finke
Summary: This study investigates the role of multisensory information in memory-guided spatial navigation. The results show that the availability of multisensory input improves spatial navigation in both individuals with hippocampal lesions and those without. It has a significant impact on navigational behavior, with greater improvement in spatial memory performance observed in patients. The study concludes that congruent multisensory information shifts computations to extrahippocampal areas that support spatial navigation and compensates for spatial navigation deficits.
COMMUNICATIONS BIOLOGY
(2023)
Article
Behavioral Sciences
Marisa Alves de Oliveira-Higa, Paula da Silva Rodrigues, Ana Claudia Silva Sampaio, Alex de Camargo Coque, Thiago Berti Kirsten, Silvia Maria Gomes Massironi, Sandra Regina Alexandre-Ribeiro, Claudia Madalena Cabrera Mori, Rodrigo Augusto da Silva, Maria Martha Bernardi
Summary: The mutant bate-palmas (claps; symbol - bapa) mice induced by the mutagenic chemical ENU present motor incoordination and postural alterations. A previous study showed that bapa mice present increased motor/exploratory behaviors during the prepubertal period due to increased striatal tyrosine hydroxylase expression, suggesting striatal dopaminergic system hyperactivity. This study aimed to evaluate the involvement of striatal dopaminergic receptors in the hyperactivity of bapa mice.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Immunology
S. Vancassel, H. Fanet, N. Castanon, C. Moncheaux De Oliveira, S. Cussotto, L. Capuron
Summary: This study aimed to investigate the response of the brain BH4 pathway to inflammatory stimulus and found that BH4 supply can help maintain or restore dopaminergic neurotransmission under inflammatory conditions. Experimental results indicated that BH4 activity may decrease in inflammation, but BH4 supply can effectively increase BH4 levels, restore dopamine levels, and dampen inflammatory cytokine expression.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Endocrinology & Metabolism
Stephanie Kullmann, Dominik Blum, Benjamin Assad Jaghutriz, Christoph Gassenmaier, Benjamin Bender, Hans-Ulrich Haering, Gerald Reischl, Hubert Preissl, Christian la Fougere, Andreas Fritsche, Matthias Reimold, Martin Heni
Summary: This study demonstrates that central administration of insulin can impact dopaminergic activity in the striatum, which in turn affects regional brain activity and connectivity. The interaction between insulin and dopamine and the regulation of whole-body metabolism through a complex network are further elucidated by our findings.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biology
Laifu Li, Li-Zi Zhang, Zhi-Xiong He, Huan Ma, Yu-Ting Zhang, Yu-Feng Xun, Wei Yuan, Wen-Juan Hou, Yi-Tong Li, Zi-Jian Lv, Rui Jia, Fa-Dao Tai
Summary: This study using socially monogamous mandarin voles found that neural circuits involving 5-HTergic neurons in the dorsal raphe nucleus and serotonin terminals in the anterior cingulate cortex play a crucial role in consolation-like behaviors and sociability. The release of 5-HT in the ACC and activity of DR neurons were significantly increased during comforting behaviors and social interactions. Activation of 5-HT1A receptors in the ACC was able to reverse deficits in consolation and sociability induced by inhibition of 5-HTergic neurons in the DR.
Article
Biochemistry & Molecular Biology
Olivier Rampin, Audrey Saint Albin Deliot, Christian Ouali, Jasmine Burguet, Elisa Gry, Gaelle Champeil Potokar, Nathalie Jerome, Olga Davidenko, Nicolas Darcel, Vincent Bombail, Philippe Andrey, Isabelle Denis
Summary: Food odour coding is crucial for food intake, and dopamine plays a regulatory role in food odour information processing in the ventral striatum.
Article
Biology
Alexander Soutschek, Susanna C. Weber, Thorsten Kahnt, Boris B. Quednow, Philippe N. Tobler
Summary: The study found that pharmacological manipulations can affect human desires for rewards rather than preferences, with stronger neural connectivity. Opioid receptors impact reward motivation, whereas dopamine receptors do not affect behavior or neural activity.
Article
Multidisciplinary Sciences
Charles W. Lu, Daniel E. Harper, Asra Askari, Matthew S. Willsey, Philip P. Vu, Andrew D. Schrepf, Steven E. Harte, Parag G. Patil
Summary: Stimulation of the zona incerta can reduce heat pain perception, but does not affect warmth perception or pressure pain. These findings provide a mechanistic explanation for sensory changes observed in Parkinsonian patients undergoing subthalamic deep brain stimulation and identify the zona incerta as a potential target for neuromodulation of pain.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Kyoungjune Pak, Seongho Seo, Myung Jun Lee, Keunyoung Kim, Sunghwan Suh, Jeehyun Lee, Seong-Jang Kim, In Joo Kim
Summary: This study investigated the association between hedonic value and striatal dopamine transporter availability, revealing an increase of DAT in dorsal striatum after glucose loading, with different association patterns among the striatal sub-regions.
NEUROENDOCRINOLOGY
(2022)
Article
Neurosciences
Eve Privman Champaloux, Nathan Donelson, Poojan Pyakurel, Danielle Wolin, Leah Ostendorf, Madelaine Denno, Ryan Borman, Chris Burke, Jonah C. Short-Miller, Maria R. Yoder, Jeffrey M. Copeland, Subhabrata Sanyal, B. Jill Venton
Summary: Recent research shows that RNF11 plays a critical role in dopamine neurotransmission, with RNF11 knockdown significantly increasing dopamine release and overexpression having no effect on dopamine levels. This study demonstrates for the first time that RNF11 affects both dopamine release and uptake.
Article
Clinical Neurology
Joline M. Fan, A. Moses Lee, Kristin K. Sellers, Kai Woodworth, Ghassan S. Makhoul, Tony X. Liu, Catherine Henderson, Daniela A. Astudillo Maya, Rebecca Martinez, Hashem Zamanian, Benjamin A. Speidel, Ankit N. Khambhati, Vikram R. Rao, Leo P. Sugrue, Katherine W. Scangos, Edward F. Chang, Andrew D. Krystal
Summary: This study investigated the effects of direct electrical stimulation on the corticolimbic network in humans and found that stimulation of the orbitofrontal cortex, subgenual cingulate, and ventral capsule modulated sleep-wake levels. Stimulation at 100Hz increased wakefulness, while 1Hz stimulation increased sleepiness. Sleep-wake levels were correlated with gamma activity in various brain regions.
Article
Multidisciplinary Sciences
Sukesh Narayan Sinha, Rajesh Kumar Kumpati, Pandu Naik Ramavath, Rajendra Sangaraju, Balaji Gouda, Priyanka Chougule
Summary: The aim of this study was to investigate the sociodemographic characteristics of patients based on the poison chosen and different types of organophosphorus compounds. The study found that serotonin levels significantly decreased and dopamine levels slightly increased in patients with organophosphate poisoning compared to the control group.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Xinjian Zhang, Daisuke Tsuboi, Yasuhiro Funahashi, Yukie Yamahashi, Kozo Kaibuchi, Taku Nagai
Summary: Dopamine regulates emotional behaviors, including rewarding and aversive behaviors, through the mesolimbic dopaminergic pathway. Protein phosphorylation plays a critical role in intracellular signaling pathways and physiological functions, and dopamine regulates neuronal excitability and synaptic plasticity through phosphorylation of intracellular substrates. Understanding the mechanisms by which dopamine controls emotional behaviors is crucial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Kenneth T. Kishida, Ignacio Saez, Terry Lohrenz, Mark R. Witcher, Adrian W. Laxton, Stephen B. Tatter, Jason P. White, Thomas L. Ellis, Paul E. M. Phillips, P. Read Montague
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Neurosciences
Sebastien Hetu, Yi Luo, Ignacio Saez, Kimberlee D'Ardenne, Terry Lohrenz, P. Read Montague
HUMAN BRAIN MAPPING
(2016)
Article
Multidisciplinary Sciences
Ignacio Saez, Michael J. Friedlander
Article
Biochemical Research Methods
Arjen Stolk, Sandon Griffin, Roemer van der Meij, Callum Dewar, Ignacio Saez, Jack J. Lin, Giovanni Piantoni, Jan-Mathijs Schoffelen, Robert T. Knight, Robert Oostenveld
Article
Neurosciences
Rosalyn J. Moran, Kenneth T. Kishida, Terry Lohrenz, Ignacio Saez, Adrian W. Laxton, Mark R. Witcher, Stephen B. Tatter, Thomas L. Ellis, Paul E. M. Phillips, Peter Dayan, P. Read Montague
NEUROPSYCHOPHARMACOLOGY
(2018)
Review
Neurosciences
Ignacio Saez, Michael J. Friedlander
JOURNAL OF NEUROSCIENCE
(2009)
Article
Neurosciences
Ignacio Saez, Michael J. Friedlander
JOURNAL OF NEUROSCIENCE
(2009)
Article
Multidisciplinary Sciences
Kenneth T. Kishida, Stefan G. Sandberg, Terry Lohrenz, Youssef G. Comair, Ignacio Saez, Paul E. M. Phillips, P. Read Montague
Article
Multidisciplinary Sciences
Eric Set, Ignacio Saez, Lusha Zhu, Daniel E. Houser, Noah Myung, Songfa Zhong, Richard P. Ebstein, Soo Hong Chew, Ming Hsu
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Article
Multidisciplinary Sciences
Xiaoxue Gao, Hongbo Yu, Ignacio Saez, Philip R. Blue, Lusha Zhu, Ming Hsu, Xiaolin Zhou
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Neurosciences
Ignacio Saez, Eric Set, Ming Hsu
FRONTIERS IN NEUROSCIENCE
(2014)
Editorial Material
Neurosciences
Ignacio Saez, Anne S. Berry, Julie E. Elie, Samantha R. Santacruz
EUROPEAN JOURNAL OF NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Elizabeth L. Johnson, Jack J. Lin, David King-Stephens, Peter B. Weber, Kenneth D. Laxer, Ignacio Saez, Fady Girgis, Mark D'Esposito, Robert T. Knight, David Badre
Summary: Flexible behavior relies on gating mechanisms that selectively encode task-relevant information in working memory. This study identifies rapid changes in regional and inter-regional activities in patients with intracranial EEG, highlighting the role of neocortical gating mechanisms in predicting behavioral output. The results demonstrate information accumulation and filtering processes in neocortical networks, providing evidence for a rapid neocortical theta network mechanism for flexible information encoding.
NATURE COMMUNICATIONS
(2023)