Silencing c-Rel in macrophages dampens Th1 and Th17 immune responses and alleviates experimental autoimmune encephalomyelitis in mice

The natural dual cyclooxygenase and 5-lipoxygenase inhibitor flavocoxid is protective in EAE through effects on Th1/Th17 differentiation and macrophage/microglia activation

(2016) Weimin Kong et al.   BRAIN BEHAVIOR AND IMMUNITY

Treating psoriasis by targeting its susceptibility gene Rel

(2016) Tingting Fan et al.   CLINICAL IMMUNOLOGY

AMP-Activated Protein Kinase Suppresses Autoimmune Central Nervous System Disease by Regulating M1-Type Macrophage–Th17 Axis

(2016) Ashutosh K. Mangalam et al.   JOURNAL OF IMMUNOLOGY

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

c-Rel Is Essential for the Development of Innate and T Cell-Induced Colitis

(2014) Y. Wang et al.   JOURNAL OF IMMUNOLOGY

Transcription factor c-Rel plays a crucial role in driving anti-CD40-mediated innate colitis

(2014) A Visekruna et al.   Mucosal Immunology

Cationic polypeptide micelle-based antigen delivery system: A simple and robust adjuvant to improve vaccine efficacy

(2013) Zichao Luo et al.   JOURNAL OF CONTROLLED RELEASE

Increased expression of T cell immunoglobulin and mucin domain 3 aggravates brain inflammation via regulation of the function of microglia/macrophages after intracerebral hemorrhage in mice

(2013) ChangJun Xu et al.   Journal of Neuroinflammation

Self-Assembled Cationic Micelles Based on PEG-PLL-PLLeu Hybrid Polypeptides as Highly Effective Gene Vectors

(2012) Jizhe Deng et al.   BIOMACROMOLECULES

A Key Role for NF-κB Transcription Factor c-Rel in T-Lymphocyte-Differentiation and Effector Functions

(2012) Alexander Visekruna et al.   Clinical & Developmental Immunology

Roles of c-Rel signalling in inflammation and disease

(2012) Nicola Fullard et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

siRNA-optimized Modifications for Enhanced In Vivo Activity

(2012) Denise M Kenski et al.   Molecular Therapy-Nucleic Acids

The Th17 immune response is controlled by the Rel–RORγ–RORγT transcriptional axis

(2011) Qingguo Ruan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The NF- B Transcription Factor c-Rel Is Required for Th17 Effector Cell Development in Experimental Autoimmune Encephalomyelitis

(2011) G. Chen et al.   JOURNAL OF IMMUNOLOGY

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

RTL551 Treatment of EAE Reduces CD226 and T-bet+ CD4 T Cells in Periphery and Prevents Infiltration of T-bet+ IL-17, IFN-γ Producing T Cells into CNS

(2011) Sushmita Sinha et al.   PLoS One

Stimuli-Sensitive Synthetic Polypeptide-Based Materials for Drug and Gene Delivery

(2011) Chaoliang He et al.   Advanced Healthcare Materials

T-cell-specific deletion of STIM1 and STIM2 protects mice from EAE by impairing the effector functions of Th1 and Th17 cells

(2010) Jian Ma et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Nanomicellar formulations for sustained drug delivery: strategies and underlying principles

(2010) Ruchit Trivedi et al.   Nanomedicine

Small silencing RNAs: State-of-the-art

(2009) Dirk Grimm   ADVANCED DRUG DELIVERY REVIEWS

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease

(2009) I. L. King et al.   BLOOD

Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling

(2009) Yeonseok Chung et al.   IMMUNITY

T-bet is essential for encephalitogenicity of both Th1 and Th17 cells

(2009) Yuhong Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation

(2009) S. Z. Ben-Sasson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA