The mechanisms shaping the repertoire of CD4+  Foxp3+ regulatory T cells

Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage

(2016) Sven Malchow et al.   IMMUNITY

Thymus-Derived Regulatory T Cells Are Positively Selected on Natural Self-Antigen through Cognate Interactions of High Functional Avidity

(2016) Elisa Kieback et al.   IMMUNITY

CD4 + T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion

(2015) Francois P. Legoux et al.   IMMUNITY

Immune homeostasis enforced by co-localized effector and regulatory T cells

(2015) Zhiduo Liu et al.   NATURE

Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance

(2015) S. Yang et al.   SCIENCE

Role of the Microbiota in Immunity and Inflammation

(2014) Yasmine Belkaid et al.   CELL

Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool

(2014) J. Christoph Vahl et al.   IMMUNITY

Affinity-Based Selection of Regulatory T Cells Occurs Independent of Agonist-Mediated Induction of Foxp3 Expression

(2014) L. M. Relland et al.   JOURNAL OF IMMUNOLOGY

TCR Signaling Events Are Required for Maintaining CD4 Regulatory T Cell Numbers and Suppressive Capacities in the Periphery

(2014) Arnaud Delpoux et al.   JOURNAL OF IMMUNOLOGY

The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function

(2014) Kristin A Hogquist et al.   NATURE IMMUNOLOGY

Continuous requirement for the TCR in regulatory T cell function

(2014) Andrew G Levine et al.   NATURE IMMUNOLOGY

Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC

(2014) Stephen P Persaud et al.   NATURE IMMUNOLOGY

The same self-peptide selects conventional and regulatory CD4+ T cells with identical antigen receptors

(2014) Lukasz Wojciech et al.   Nature Communications

T Cell-Positive Selection Uses Self-Ligand Binding Strength to Optimize Repertoire Recognition of Foreign Antigens

(2013) Judith N. Mandl et al.   IMMUNITY

Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota

(2013) Anna Cebula et al.   NATURE

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

(2013) Koji Atarashi et al.   NATURE

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

A Broad Range of Self-Reactivity Drives Thymic Regulatory T Cell Selection to Limit Responses to Self

(2012) Hyang-Mi Lee et al.   IMMUNITY

Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease

(2012) SuJin Hwang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

(2012) Steven Z. Josefowicz et al.   NATURE

T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

(2011) Amy E. Moran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Response to self antigen imprints regulatory memory in tissues

(2011) Michael D. Rosenblum et al.   NATURE

Peripheral education of the immune system by colonic commensal microbiota

(2011) Stephanie K. Lathrop et al.   NATURE

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

(2010) Ye Zheng et al.   NATURE

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

(2010) J. L. Round et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

TCR-dependent differentiation of thymic Foxp3+cells is limited to small clonal sizes

(2009) Monica W.L. Leung et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Feedback control of regulatory T cell homeostasis by dendritic cells in vivo

(2009) Guillaume Darrasse-Jèze et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intraclonal competition limits the fate determination of regulatory T cells in the thymus

(2009) Jhoanne L Bautista et al.   NATURE IMMUNOLOGY

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Linked T Cell Receptor and Cytokine Signaling Govern the Development of the Regulatory T Cell Repertoire

(2008) Matthew A. Burchill et al.   IMMUNITY

A Two-Step Process for Thymic Regulatory T Cell Development

(2008) Chan-Wang Joaquim Lio et al.   IMMUNITY

Antigen-specific peripheral shaping of the natural regulatory T cell population

(2008) Stephanie K. Lathrop et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology