Article
Engineering, Electrical & Electronic
Morteza Teymoori, Arda Deniz Yalcinkaya
Summary: The microfluidic field has developed paper-based devices that offer fast and cost-effective testing options, particularly for regions with limited access to healthcare centers and laboratories. However, most paper-based devices are qualitative or semi-quantitative, highlighting the need for quantitative transduction methods. This study introduces a microwave paper-based metamaterial-inspired transduction method that relies on dielectric sensing, offering potential applications in the biosensing field.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Article
Chemistry, Analytical
Raquel Catalan-Carrio, Tugce Akyazi, Lourdes Basabe-Desmonts, Fernando Benito-Lopez
Summary: The main challenge for the expansion and mass production of microfluidic paper-based analytical devices lies in the lack of fluid flow control due to uncontrolled fabrication protocols. The key to addressing this issue is to generate uniform and reliable microfluidic channels and optimize the fabrication process. Wax printing is the most common method, which requires analysis and optimization of parameters such as device shape, wax barrier width, and internal area.
Article
Chemistry, Applied
Ana Carolina Rafanhin Sousa, Cleyton Nascimento Makara, Lais Canniatti Brazaca, Emanuel Carrilho
Summary: In order to detect sulfonamides in milk, a simple and portable microfluidic paper-based analytical device (mu PAD) was developed for precise analysis without the need for pretreatment. This device has good linearity and selectivity, potentially allowing for on-site monitoring of milk quality to reduce adverse conditions associated with high concentrations of sulfonamides.
Article
Chemistry, Analytical
Bao Thai Tran, Patsamon Rijiravanich, Nitipon Puttaraksa, Werasak Surareungchai
Summary: A hydrophobic wax barrier combined with surfactants was developed as a valving mechanism in paper-based microfluidic systems to control delays in reagent addition. The wax gate allowed the delay of reagent delivery and assisted multistep analysis. The integration of the triangle wax gate into prototype immunosensors enabled sensitive detection of mouse-IgG and SARS-CoV2 antibody.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Inmaculada Ortiz-Gomez, Almudena Rivadeneyra, Jose F. Salmeron, Ignacio de Orbe-Paya, Diego P. Morales, Luis Fermin Capitan-Vallvey, Alfonso Salinas-Castillo
Summary: In this study, a microfluidic paper-based analytical device (mu PAD) with an NFC tag was proposed as a portable, simple and fast colorimetric method for glutathione (GSH) determination. The method took advantage of the oxidizing property of Ag+ on 3,3';,5,5'-tetramethylbenzidine (TMB), which resulted in a blue color fading when GSH was present. By integrating electronic interfaces into the hardware of digital image capture, a smartphone was utilized for the colorimetric determination of GSH. Importantly, this new method exhibited a low detection limit of 1.0 mu M, offering high sensitivity and a simple, fast, portable and low-cost GSH determination within 20 minutes using a colorimetric signal.
Article
Chemistry, Physical
Prakash Rewatkar, Prasanth K. Enaganti, Manish Rishi, Subhas Mukhopadhyay, Sanket Goel
Summary: Microfluidic paper-based microbial fuel cells (mP-MFCs) have gained popularity for their compact, quick, and low-cost fluid manipulation. With customized electrode design and modification, these fuel cells have the potential for enhanced efficiency and applications in various fields.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Article
Chemistry, Analytical
Farshad Ardakani, Zahra Shojaeifard, Bahram Hemmateenejad
Summary: We present a three-dimensional origami paper-based analytical device (3D-muPAD) for ABO and Rh blood type detection using a three-dimensional origami microfluidic technology. By counting the number of paper layers through which blood moves in antibody channels, the blood type can be accurately determined. This device offers higher accuracy and efficiency compared to traditional methods.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Alexander Ritter Von Stockert, Anna Luongo, Markus Langhans, Thomas Brandstetter, Juergen Ruehe, Tobias Meckel, Markus Biesalski
Summary: Microfluidic paper combines low-cost pump-free water transport with high sustainability, making it an attractive candidate for point-of-care analytics and diagnostics. However, the nonspecific adsorption of protein analytes to paper fibers during lateral flow assay limits the overall sensitivity of microfluidic paper-based analytical devices. By modifying fibers in lab-made paper sheets and evaporating transport fluid through local heating, the nonspecific protein adsorption can be significantly reduced, leading to improved signal-to-noise ratio in paper-based lateral flow assays.
Article
Chemistry, Analytical
Jiali Huang, Xu Li, Mingzhen Xiu, Kang Huang, Kang Cui, Jing Zhang, Shenguang Ge, Shiji Hao, Jinghua Yu, Yizhong Huang
Summary: In this study, an ultrasensitive paper-based photoelectrochemical bioassay platform was developed for the detection of AFP targets, with great potential for application in POC testing and clinical disease diagnosis.
Article
Chemistry, Analytical
Maria M. P. Melo, Ana Machado, Antonio O. S. S. Rangel, Raquel B. R. Mesquita
Summary: A new microfluidic paper-based analytical device (muPAD) was developed for accurate creatinine quantification in urine samples. The paper device is accessible, portable, low-cost, and environmentally friendly. It uses a colorimetric reaction and digital image scanning for quantification and achieves similar results to traditional batch-wise procedures.
Article
Chemistry, Analytical
Jie Zheng, Min Zhu, Jiao Kong, Zimu Li, Jianming Jiang, Yachao Xi, Fang Li
Summary: A simple microfluidic paper-based analytical device using platinum nanoparticles as peroxidase mimic was developed for simultaneous determination of glucose and uric acid. The multi-layered structure improves color uniformity and intensity, leading to enhanced sensitivity in detection. The device showed satisfactory results in real serum samples and integrated with smartphone for easy and intelligent detection, making it suitable for simple and portable on-site analysis.
Article
Chemistry, Analytical
Kawin Khachornsakkul, Frank John Rybicki, Sameer Sonkusale
Summary: In this study, nanomaterials were integrated into microfluidic paper-based analytical devices (mu PADs) for enzyme-free glucose quantification and colorimetric readout. Gold and silver nanoparticles were used as a peroxidase-like nanozyme and colorimetric probe to detect glucose. The device achieved clinically relevant glucose monitoring with a linear range of 0.50-10.0 mmol L-1 and a detection limit of 340.0 mu mol L-1. The method is rapid (20 min), selective, and potentially suitable for point-of-care diagnostics in resource-limited settings.
Article
Biochemical Research Methods
Shaolong Feng, Marti Z. Hua, M. S. Roopesh, Xiaonan Lu
Summary: We have developed a competitive ELISA-based origami microfluidic paper-based analytical device (mu PAD) for the detection of mycotoxins in animal feed materials. The mu PAD was patterned using the wax printing technique, with a testing pad in the middle and absorption pads on the sides. By immobilizing anti-mycotoxin antibodies on chitosan-glutaraldehyde-modified sample reservoirs, we successfully achieved the quantification of zearalenone, deoxynivalenol, and T-2 toxin in corn flour in just 20 minutes. The mu PAD integrated with competitive ELISA shows potential for rapid, sensitive, and cost-effective detection of various mycotoxins in animal feed materials, which is important for the livestock industry.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Li-Xia Feng, Chao Tang, Xiao-Xuan Han, Hui-Chao Zhang, Feng-Na Guo, Ting Yang, Jian-Hua Wang
Summary: In this study, ZnO nanorods were hydrothermally grown on Whatman filter paper to fabricate a microfluidic paper-based device for simultaneous detection of glucose and uric acid. The presence of ZnO NRs promoted enzyme immobilization and overcame the coffee ring effect through uniform distribution and specialized design. Two color indicators provided complementary results for quantifying target analytes visually.
Article
Chemistry, Analytical
Manuel J. J. Arroyo, Ignacio de Orbe-Paya, Mariano Ortega-Munoz, Jose Vilar-Tenorio, David J. Gallego, Gerhard J. Mohr, Luis Fermain Captain-Vallvey, Miguel M. Erenas
Summary: A microfluidic paper-based analytical device has been developed to determine the sulfite content in wine without pretreatment. This device utilizes a chromoreactand that changes color in the presence of sulfite, allowing for a quick and accurate analysis. Two different devices were designed for white wine and red wine, respectively, to ensure optimal performance. The results obtained from this device have shown high sensitivity and selectivity.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
