Article
Environmental Sciences
Richelle D. Bjorvang, Ida Hallberg, Anne Pikki, Lars Berglund, Matteo Pedrelli, Hannu Kiviranta, Panu Rantakokko, Paivi Ruokojarvi, Christian H. Lindh, Matts Olovsson, Sara Persson, Jan Holte, Ylva Sjunnesson, Pauliina Damdimopoulou
Summary: This study examines the impact of persistent organic pollutants (POPs) on reproductive health and finds that age plays a crucial role in the transfer of chemicals from blood to follicular fluid. Moreover, exposure to POPs is significantly associated with assisted reproductive technology (ART) outcomes.
ENVIRONMENTAL RESEARCH
(2022)
Review
Plant Sciences
Kannan Maharajan, Qing Xia, Xiuying Duan, Pengfei Tu, Yun Zhang, Kechun Liu
Summary: Zishen Yutai Pill (ZYP) is a widely used Traditional Chinese Medicine in Assisted Reproductive Technology (ART) medications, and has shown potential therapeutic effects in improving fertility and pregnancy rates. Clinical studies have demonstrated its curative effects on various reproductive disorders by regulating reproductive functions such as ovulation, follicle development, and hormonal balance.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Aylin Nikshad, Afsoon Aghlmandi, Reza Safaralizadeh, Leili Aghebati-Maleki, Majid Ebrahimi Warkiani, Farhad Motavalli Khiavi, Mehdi Yousefi
Summary: According to the World Health Organization, approximately 70 million couples worldwide suffer from infertility. Research teams have integrated various scientific branches to develop therapeutic approaches, with Assisted Reproductive Technologies (ART) being a key solution. The use of microfluidic technology has shown significant progress in improving efficiency in assisted reproduction.
Article
Obstetrics & Gynecology
Summary: Building families through adoption of children is a long-standing practice supported by human society. The ethical appropriateness of patients donating embryos for family building or research has been affirmed. However, the term "adoption" should not be used to describe embryos, as it is inaccurate. This document supersedes the previous statement by ASRM Ethics Committee and is copyright protected by the American Society for Reproductive Medicine (c) 2023.
FERTILITY AND STERILITY
(2023)
Review
Biochemistry & Molecular Biology
Mustapha Benkhalifa, Fabien Joao, Cynthia Duval, Debbie Montjean, Molka Bouricha, Rosalie Cabry, Marie-Claire Belanger, Hatem Bahri, Pierre Miron, Moncef Benkhalifa
Summary: After more than four decades of assisted reproductive technology (ART) practice, the failure of in vitro fertilization (IVF) treatments and recurrent implantation failures (RIFs) and repeated pregnancy loss (RPL) remain significant issues. This article reviews different therapeutic options and suggests that immunomodulation and predictive biomarkers may be promising solutions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Alisha T. Tolani, Marcelle Cedars, Lydia B. Zablotska, Paolo F. Rinaudo
Summary: This study compared the metabolic differences between children conceived by assisted reproductive technologies (ART) and non-in vitro fertilization fertility treatments (NIFT) and children conceived spontaneously. The results showed that there were no metabolic differences between NIFT-conceived children and spontaneously conceived children, but there were small metabolic differences between ART-conceived children and spontaneously conceived children.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Pharmacology & Pharmacy
Li Li, Na Ning, Jian-an Wei, Qiu-Ling Huang, Yue Lu, Xiu-fei Pang, Jing-jing Wu, Jie-bin Zhou, Jie-wen Zhou, Guo-an Luo, Ling Han
Summary: Zishen Yutai Pills (ZYP) is a safe and well quality-controlled traditional Chinese medicine preparation with promising effects in reproduction, including prevention of miscarriage and increasing pregnancy rates during in vitro fertilization-embryo transfer (IVF-ET). This study used metabonomics method to analyze plasma samples from a clinical trial comparing ZYP and placebo groups, identifying potential metabolites and enriched pathways to explore the underlying mechanisms of ZYP combined with IVF-ET in treating infertility.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Agriculture, Dairy & Animal Science
Carolina Acevedo, Jennifer P. Barfield
Summary: To conserve the important species of bison in Europe and North America, conservation efforts have focused on establishing sustainable herds through the use of assisted reproductive technologies (ARTs). These technologies facilitate the transfer of genetics and offer protection against future losses of genetic diversity. Research on ART for bison has made progress, but there are still opportunities for improvement and expanding their impact on bison conservation.
Review
Agriculture, Dairy & Animal Science
Carolina Acevedo, Jennifer P. Barfield
Summary: Bison are important species ecologically and culturally, and conservation efforts are focused on building sustainable herds using assisted reproductive technologies. This review discusses the current state of ART in American bison and European bison, highlighting the potential for genetic conservation and the need for further improvement and expansion of these technologies.
Article
Multidisciplinary Sciences
Kwadwo Asante-Afari, David Teye Doku, Eugene K. M. Darteh
Summary: This study explores the experiences of 40 women in Ghana who have successfully given birth through the use of assisted reproductive technologies. The findings reveal that childless women face hostility but having a child brings social recognition and transition to motherhood is characterized by excitement, high self-esteem, and acceptance into spouses' families.
Article
Obstetrics & Gynecology
Manish Banker, Silke Dyer, Georgina M. Chambers, Osamu Ishihara, Markus Kupka, Jacques de Mouzon, Fernando Zegers-Hochschild, G. David Adamson
Summary: The report provides data on the utilization, effectiveness, and safety of assisted reproductive technology (ART) globally in 2013, showing an increase in ART cycles and changes in trends such as a rise in the proportion of older women undergoing non-donor ART. Further efforts are needed to improve the quality and consistency of reporting ART data by registries.
FERTILITY AND STERILITY
(2021)
Article
Cardiac & Cardiovascular Systems
Maria C. Magnus, Abigail Fraser, Siri E. Haberg, Kristiina Rono, Liv Bente Romundstad, Christina Bergh, Anne Laerke Spangmose, Anja Pinborg, Mika Gissler, Ulla-Britt Wennerholm, Bjorn Olav Asvold, Deborah A. Lawlor, Signe Opdahl
Summary: This study examines the associations between different combinations of aerobic and muscle strengthening activity with mortality rates. The findings suggest that balanced levels of aerobic activity and muscle strengthening may reduce the risk of mortality.
Review
Food Science & Technology
Nan Wang, Lu Chen, Kangle Yi, Baizhong Zhang, Chunjin Li, Xu Zhou
Summary: Reproductive issues are a growing global concern, and there is increasing interest in understanding the relationship between microbiota and reproductive health. Stable microbiota communities exist in various parts of the reproductive system, and dysbiosis can have detrimental effects on gamete quality, embryo development, and disease susceptibility. A healthy microbiota, on the other hand, can protect against pathogens, improve reproductive potential, and reduce adverse pregnancy outcomes. This review explores the effects and mechanisms of microbiota on reproduction, factors influencing microbiota composition, and potential applications in reproductive disorder treatment and detection.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Cardiac & Cardiovascular Systems
Maria C. Magnus, Abigail Fraser, Siri E. Haberg, Kristiina Rono, Liv Bente Romundstad, Christina Bergh, Anne Laerke Spangmose, Anja Pinborg, Mika Gissler, Ulla-Britt Wennerholm, Bjorn Olav Asvold, Deborah A. Lawlor, Signe Opdahl
Summary: A study using nationwide data from Denmark, Finland, Norway, and Sweden found that women who gave birth after assisted reproductive technologies (ART) did not have an increased risk of cardiovascular disease (CVD) compared to those who conceived without ART during a median follow-up of 11 years. Longer-term studies are needed to further investigate the association between ART and higher risk of CVD.
Article
Reproductive Biology
Ayumi Hasegawa, Keiji Mochida, Shogo Matoba, Kimiko Inoue, Daiki Hama, Masayo Kadota, Noriko Hiraiwa, Atsushi Yoshiki, Atsuo Ogura
Summary: This study developed assisted reproductive technologies for wild-derived Mus spretus mice, enabling efficient production of embryos and successful interspecies embryo transfer into laboratory mice, demonstrating the potential for safe preservation and utilization of strains in research settings.
BIOLOGY OF REPRODUCTION
(2021)
Article
Surgery
Richmond T. Bergner, Sarah Onida, Rahul Velineni, Konstantina Spagou, Manjit S. Gohel, Marielle Bouschbacher, Serge Bohbot, Joseph Shalhoub, Elaine Holmes, Alun H. Davies
Summary: The study aimed to identify potential biomarkers predictive of healing or failure to heal in venous leg ulceration. It found that serum biofluids could differentiate between healing and nonhealing patients, and the ratio of carnitine to ceramide could differentiate between healing phenotypes with 100% sensitivity, 79% specificity, and 91% accuracy. This metabolic signature has potential applications for disease prognostication and development of targeted therapies for venous leg ulceration.
Article
Obstetrics & Gynecology
Timothy Bracewell-Milnes, Aleena Hossain, Benjamin P. Jones, Raef Faris, Jaya Parikh, James Nicopoullos, Mark Johnson, Meen-Yau Thum
Summary: This study shows that egg sharing does not compromise the chances of donors or recipients achieving a live birth. However, participants may occasionally require additional ovarian stimulation cycles. Egg sharing is a practical option to allow more women access to IVF.
Article
Pathology
Lucy M. V. Gee, Ben Barron-Millar, Jack Leslie, Claire Richardson, Marco Y. W. Zaki, Saimir Luli, Rachel A. Burgoyne, Rainie I. T. Cameron, Graham R. Smith, John G. Brain, Barbara Innes, Laura Jopson, Jessica K. Dyson, Katherine R. C. McKay, Alexandros Pechlivanis, Elaine Holmes, Rolando Berlinguer-Palmini, Stella Victorelli, George F. Mells, Richard N. Sandford, Jeremy Palmer, John A. Kirby, Christos Kiourtis, Joao Mokochinski, Zoe Hall, Thomas G. Bird, Lee A. Borthwick, Christopher M. Morris, Peter S. Hanson, Diana Jurk, Elizabeth A. Stoll, Fiona E. N. LeBeau, David E. J. Jones, Fiona Oakley
Summary: Patients with cholestatic liver disease can experience cognitive impairments, but the underlying cellular mechanisms are poorly understood. This study used a rodent model and human neuronal cell cultures to explore the neurocognitive symptoms and potential therapies. The results showed that obeticholic acid, a second-line anti-cholestatic agent, could normalize memory function and reverse neuronal senescence.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Gastroenterology & Hepatology
Francesca M. Trovato, Rabiya Zia, Florent Artru, Salma Mujib, Ellen Jerome, Anna Cavazza, Muireann Coen, Ian Wilson, Elaine Holmes, Phillip Morgan, Arjuna Singanayagam, Christine Bernsmeier, Salvatore Napoli, William Bernal, Julia Wendon, Rosa Miquel, Krishna Menon, Vishal C. Patel, John Smith, Stephen R. Atkinson, Evangelos Triantafyllou, Mark J. W. McPhail
Summary: A metabolome study found that ALF patients have dysregulated metabolism and immune responses, potentially mediated by the LPC-ATX-LPA pathway.
JOURNAL OF HEPATOLOGY
(2023)
Article
Immunology
Helene Ruffieux, Aimee L. Hanson, Samantha Lodge, Nathan G. Lawler, Luke Whiley, Nicola Gray, Tui H. Nolan, Laura Bergamaschi, Federica Mescia, Lorinda Turner, Aloka de Sa, Victoria S. Pelly, Prasanti Kotagiri, Nathalie R. Kingston, John Bradley, Elaine Holmes, Julien K. Wist, Jeremy A. Nicholson, Paul Lyons, Kenneth G. C. Smith, Sylvia Richardson, Glenn Bantug, Christoph Hess
Summary: We analyzed detailed longitudinal phenotyping data from 215 individuals with varying disease severities to understand the biology behind individual patient responses to SARS-CoV-2 infection. Our findings revealed distinct profiles of 'systemic recovery', including the progression and resolution of inflammatory, immune cell, metabolic, and clinical responses. We identified strong correlations between innate immune cell numbers, kynurenine metabolites, and lipid metabolites, which have implications for homeostasis restoration, risk of death, and long COVID.
Article
Obstetrics & Gynecology
Sughashini Murugesu, Mikaela Maria Charalambides, Benjamin P. Jones, Srdjan Saso, Raef Faris, Jaya Parikh, James Nicopoullos, Meen-Yau Thum, Timothy Bracewell-Milnes
Summary: This study aimed to assess the motivations and treatment experiences of women undergoing social egg freezing and understand the impact of the COVID-19 pandemic. The findings showed that the majority of women decided to undergo social egg freezing due to concerns about age-related fertility decline. The process of social egg freezing can be stressful and women may have concerns about it.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Chemistry, Applied
Sung-Tong Chin, Gerhard Hoerlendsberger, Kok Wai Wong, Sirui Li, Sze How Bong, Luke Whiley, Julien Wist, Reika Masuda, Johan Greeff, Elaine Holmes, Jeremy K. Nicholson, Ruey Leng Loo
Summary: In this study, a one-step isopropanol method and a two-step methyl-tert-butyl ether method were compared for extracting lipid species in chicken egg yolks before LC-MS/MS analysis. The isopropanol method showed high reproducibility in extracting 937 lipid species from 20 major lipid subclasses. Machine learning techniques successfully differentiated cage, barn, and free-range eggs with high accuracy. The lipid profiles of these eggs were found to be characteristic and could be used for verifying the provenance of conventional chicken eggs.
Review
Agriculture, Multidisciplinary
David Felipe Garcia Mendez, Janeth Sanabria, Julien Wist, Elaine Holmes
Summary: Since the early 1980s, researchers have developed in vitro models of the human gastrointestinal system for studying the gut microbiome ecology. Simulating all features and conditions of the gastrointestinal system using a bioreactor is a significant challenge. Despite advances in simulating functionalities such as temperature and pH control, more work is needed to make the models closer to in vivo conditions. In this review, the impact of key operational parameters on gut microbial ecology is discussed, highlighting the advantages and limitations of current bioreactor systems.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemical Research Methods
Monique J. Ryan, Alanah Grant-St James, Nathan G. Lawler, Mark W. Fear, Edward Raby, Fiona M. Wood, Garth L. Maker, Julien Wist, Elaine Holmes, Jeremy K. Nicholson, Luke Whiley, Nicola Gray
Summary: This study presents an optimized comprehensive targeted workflow for plasma and serum lipid quantification, which combines stable isotope internal standard dilution, automated sample preparation, and ultrahigh performance liquid chromatography-tandem mass spectrometry with rapid polarity switching. The method is robust to common sources of analytical variation and is suitable for large-scale, multibatch applications in precision medicine.
JOURNAL OF PROTEOME RESEARCH
(2023)
Review
Obstetrics & Gynecology
Erna Bayar, Nicola J. Williams, Amel Alghrani, Sughashini Murugesu, Srdjan Saso, Timothy Bracewell-Milnes, Meen-Yau Thum, James Nicopoullos, Philippa Sangster, Ephia Yasmin, J. Richard Smith, Stephen Wilkinson, Allan Pacey, Benjamin P. P. Jones
Summary: Medical care for transgender people should include attention to reproductive aspirations and planning, considering the impact of hormonal therapy and gender affirmation procedures on fertility. Counselling and discussions about fertility preservation should be conducted prior to treatment. This review article explores the reproductive desires of transgender women and the potential options for fertility preservation.
Article
Obstetrics & Gynecology
L. S. Kasaven, A. Mitra, P. Ostrysz, E. Theodorou, S. Murugesu, J. Yazbek, T. Bracewell-Milnes, J. Ben Nagi, B. P. Jones, S. Saso
Summary: The study explores the knowledge, perceptions, and attitudes of women in the UK towards age-related fertility decline and elective oocyte cryopreservation. The awareness of OC for ARFD has improved compared to previous studies, but there are still knowledge gaps regarding miscarriage rates, financial costs, and optimal age for OC.
HUMAN REPRODUCTION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Joram M. Posma, Isabel Garcia Perez, Ibrahim Karaman, He Gao, Queenie Chan, Martha Daviglus, Linda Van Horn, Elaine Holmes, Jeremy K. Nicholson, Paul Elliott
JOURNAL OF HYPERTENSION
(2023)
Retraction
Food Science & Technology
Isabel Garcia-Perez, Joram M. Posma, Edward S. Chambers, John C. Mathers, John Draper, Manfred Beckmann, Jeremy K. Nicholson, Elaine Holmes, Gary Frost
Article
Emergency Medicine
Eva Kierath, Monique Ryan, Elaine Holmes, Jeremy K. Nicholson, Mark W. Fear, Fiona M. Wood, Luke Whiley, Nicola Gray
Summary: Background: Non-severe paediatric burns can result in poor long-term health outcomes, even in cases with good acute burn-related outcomes. The mechanisms underlying this transition from non-severe burn to sustained negative long-term health impacts remain unknown. This study aimed to investigate the role of plasma lipidome changes in reflecting underlying changes in health status and linking to long-term health after burn trauma in children. Methods: The lipidome was analyzed in children who had previously experienced a non-severe burn, compared to non-injured controls. Results: The analysis revealed significantly higher concentrations of lysophosphatidylethanolamines and phosphatidylethanolamines, and significantly lower concentrations of myristic, palmitic, and palmitoleic acids in the plasma of burn-injured children compared to controls. Conclusion: Long-term changes in the lipid profile may provide insight into the mechanisms underlying poor long-term health after non-severe burn injury. Further investigation is needed to understand the relationship between long-term pathology and lipidomic changes for clinical intervention to reduce the long-term health burden post-burn trauma.
Article
Biophysics
Jose Ivan Serrano-Contreras, John C. Lindon, Gary Frost, Elaine Holmes, Jeremy K. Nicholson, Isabel Garcia-Perez
Summary: NMR spectroscopy is an important technique in metabolic profiling, but metabolite identification is often hindered by peak overlap. Recently developed pure shift NMR spectroscopy has the potential to simplify complex proton NMR spectra and aid metabolite identification. In this study, two complementary approaches to spectral simplification were evaluated, and both methods were found to improve resolution of resonances and enhance metabolite identification. These methods are easy to implement and the strong coupling artifacts contain latent connectivity information that can be used to enhance metabolite identification.
NMR IN BIOMEDICINE
(2023)