Arl3 and RP2 regulate the trafficking of ciliary tip kinesins

Ciliary entry of KIF17 is dependent on its binding to the IFT-B complex via IFT46–IFT56 as well as on its nuclear localization signal

(2017) Teruki Funabashi et al.   MOLECULAR BIOLOGY OF THE CELL

Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups

(2016) David A. Parfitt et al.   Cell Stem Cell

Unexpected Roles for Ciliary Kinesins and Intraflagellar Transport Proteins

(2016) Niedharsan Pooranachandran et al.   GENETICS

Arf-like Protein 3 (ARL3) Regulates Protein Trafficking and Ciliogenesis in Mouse Photoreceptors

(2016) Christin Hanke-Gogokhia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of ciliary retrograde protein trafficking by the Joubert syndrome proteins ARL13B and INPP5E

(2016) Shohei Nozaki et al.   JOURNAL OF CELL SCIENCE

Unexpected Roles for Ciliary Kinesins and Intraflagellar Transport Proteins

(2016) Niedharsan Pooranachandran et al.   GENETICS

Kinesin family 17 (osmotic avoidance abnormal-3) is dispensable for photoreceptor morphology and function

(2015) Li Jiang et al.   FASEB JOURNAL

A role for Rab23 in the trafficking of Kif17 to the primary cilium

(2015) Y. S. Lim et al.   JOURNAL OF CELL SCIENCE

A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins

(2015) Katja Gotthardt et al.   eLife

An Assay for Clogging the Ciliary Pore Complex Distinguishes Mechanisms of Cytosolic and Membrane Protein Entry

(2014) Daisuke Takao et al.   CURRENT BIOLOGY

Translational read-through of the RP2 Arg120stop mutation in patient iPSC-derived retinal pigment epithelium cells

(2014) Nele Schwarz et al.   HUMAN MOLECULAR GENETICS

The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment

(2014) Mu He et al.   NATURE CELL BIOLOGY

Kif7 keeps cilia tips in shape

(2014) Lotte B. Pedersen et al.   NATURE CELL BIOLOGY

Mutations in ARL2BP, Encoding ADP-Ribosylation-Factor-Like 2 Binding Protein, Cause Autosomal-Recessive Retinitis Pigmentosa

(2013) Alice E. Davidson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The role of primary cilia in the development and disease of the retina

(2013) Gabrielle Wheway et al.   Organogenesis

Positive and Negative Regulation of Gli Activity by Kif7 in the Zebrafish Embryo

(2013) Ashish Kumar Maurya et al.   PLoS Genetics

Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs

(2012) Tokushige Nakano et al.   Cell Stem Cell

Kinesin-2 family in vertebrate ciliogenesis

(2012) C. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of KIF17 distal tip trafficking in zebrafish cone photoreceptors

(2012) Jason R. Bader et al.   VISION RESEARCH

The prenyl-binding protein PrBP/δ: A chaperone participating in intracellular trafficking

(2012) Houbin Zhang et al.   VISION RESEARCH

An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium

(2011) K. J. Wright et al.   GENES & DEVELOPMENT

Localization of retinitis pigmentosa 2 to cilia is regulated by Importin  2

(2011) T. W. Hurd et al.   JOURNAL OF CELL SCIENCE

Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics

(2011) Claudia Dafinger et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional characterization of putative cilia genes by high-content analysis

(2011) Cary K. Lai et al.   MOLECULAR BIOLOGY OF THE CELL

Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo

(2011) Shehab A Ismail et al.   Nature Chemical Biology

KIF7 mutations cause fetal hydrolethalus and acrocallosal syndromes

(2011) Audrey Putoux et al.   NATURE GENETICS

Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions

(2011) Carsten Janke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular Motor KIF17 Is Fundamental for Memory and Learning via Differential Support of Synaptic NR2A/2B Levels

(2011) Xiling Yin et al.   NEURON

Ciliopathies

(2011) Friedhelm Hildebrandt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interaction and Localization of the Retinitis Pigmentosa Protein RP2 and NSF in Retinal Photoreceptor Cells

(2010) Juha M. Holopainen et al.   BIOCHEMISTRY

The retinitis pigmentosa protein RP2 interacts with polycystin 2 and regulates cilia-mediated vertebrate development

(2010) Toby Hurd et al.   HUMAN MOLECULAR GENETICS

The retinitis pigmentosa protein RP2 links pericentriolar vesicle transport between the Golgi and the primary cilium

(2010) R. Jane Evans et al.   HUMAN MOLECULAR GENETICS

KIF17 stabilizes microtubules and contributes to epithelial morphogenesis by acting at MT plus ends with EB1 and APC

(2010) Fanny Jaulin et al.   JOURNAL OF CELL BIOLOGY

The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis

(2010) Yujie Li et al.   JOURNAL OF CELL BIOLOGY

Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-β2 and RanGTP

(2010) John F. Dishinger et al.   NATURE CELL BIOLOGY

Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance

(2010) Andrew Burgess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mammalian Cos2 Homolog Kif7 Plays an Essential Role in Modulating Hh Signal Transduction during Development

(2009) Setsu Endoh-Yamagami et al.   CURRENT BIOLOGY

Different roles for KIF17 and kinesin II in photoreceptor development and maintenance

(2009) Christine Insinna et al.   DEVELOPMENTAL DYNAMICS

Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling

(2009) K. F. Liem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Kinesin Protein Kif7 Is a Critical Regulator of Gli Transcription Factors in Mammalian Hedgehog Signaling

(2009) H. O.-L. Cheung et al.   Science Signaling

Mutations in the Cilia Gene ARL13B Lead to the Classical Form of Joubert Syndrome

(2008) Vincent Cantagrel et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The homodimeric kinesin, Kif17, is essential for vertebrate photoreceptor sensory outer segment development

(2008) Christine Insinna et al.   DEVELOPMENTAL BIOLOGY

Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex

(2008) Stefan Veltel et al.   FEBS LETTERS

The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3

(2008) Stefan Veltel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY