Arf-like Protein 3 (ARL3) Regulates Protein Trafficking and Ciliogenesis in Mouse Photoreceptors

A Phosphoinositide Code for Primary Cilia

(2015) Fubito Nakatsu   DEVELOPMENTAL CELL

Mistrafficking of prenylated proteins causes retinitis pigmentosa 2

(2015) Houbin Zhang et al.   FASEB JOURNAL

Heterotrimeric Kinesin-2 (KIF3) Mediates Transition Zone and Axoneme Formation of Mouse Photoreceptors

(2015) Li Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins

(2015) Katja Gotthardt et al.   eLife

Membrane Protein Transport in Photoreceptors: The Function of PDE 

(2014) W. Baehr   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Molecular views of Arf-like small GTPases in cilia and ciliopathies

(2013) Qing Zhang et al.   EXPERIMENTAL CELL RESEARCH

A HomozygousPDE6DMutation in Joubert Syndrome Impairs Targeting of Farnesylated INPP5E Protein to the Primary Cilium

(2013) Sophie Thomas et al.   HUMAN MUTATION

Temporal deletion of Arl13b reveals that a mispatterned neural tube corrects cell fate over time

(2012) C.-Y. Su et al.   DEVELOPMENT

Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119

(2012) Shehab A Ismail et al.   EMBO JOURNAL

Inositol polyphosphate 5-phosphatases; new players in the regulation of cilia and ciliopathies

(2012) Sarah E. Conduit et al.   FEBS LETTERS

ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting

(2012) M. C. Humbert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arl3 and RP2 mediated assembly and traffic of membrane associated cilia proteins

(2012) Nele Schwarz et al.   VISION RESEARCH

Stages of ciliogenesis and regulation of ciliary length

(2011) Prachee Avasthi et al.   DIFFERENTIATION

An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium

(2011) K. J. Wright et al.   GENES & DEVELOPMENT

Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo

(2011) Shehab A Ismail et al.   Nature Chemical Biology

UNC119 is required for G protein trafficking in sensory neurons

(2011) Houbin Zhang et al.   NATURE NEUROSCIENCE

The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis

(2010) Yujie Li et al.   JOURNAL OF CELL BIOLOGY

Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport inCaenorhabditis elegans

(2010) Sebiha Cevik et al.   JOURNAL OF CELL BIOLOGY

Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait

(2010) Alan F. Wright et al.   NATURE REVIEWS GENETICS

Trafficking of Membrane Proteins to Cone But Not Rod Outer Segments Is Dependent on Heterotrimeric Kinesin-II

(2009) P. Avasthi et al.   JOURNAL OF NEUROSCIENCE

INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse

(2009) Monique Jacoby et al.   NATURE GENETICS

Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies

(2009) Stephanie L Bielas et al.   NATURE GENETICS

Mutations in the Cilia Gene ARL13B Lead to the Classical Form of Joubert Syndrome

(2008) Vincent Cantagrel et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex

(2008) Stefan Veltel et al.   FEBS LETTERS

Trafficking of Membrane-Associated Proteins to Cone Photoreceptor Outer Segments Requires the Chromophore 11-cis-Retinal

(2008) H. Zhang et al.   JOURNAL OF NEUROSCIENCE

The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3

(2008) Stefan Veltel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Leber congenital amaurosis: Genes, proteins and disease mechanisms

(2008) Anneke I. den Hollander et al.   PROGRESS IN RETINAL AND EYE RESEARCH