Epigallocatechin-3-gallate and related phenol compounds redirect the amyloidogenic aggregation pathway of ataxin-3 towards non-toxic aggregates and prevent toxicity in neural cells and Caenorhabditis elegans animal model

Opposite Structural Effects of Epigallocatechin-3-gallate and Dopamine Binding to α-Synuclein

(2016) Albert Konijnenberg et al.   ANALYTICAL CHEMISTRY

Flavonoids and Their Glycosides as Anti-amyloidogenic Compounds: Aβ1-42 Interaction Studies to Gain New Insights into Their Potential for Alzheimer's Disease Prevention and Therapy

(2016) Cinzia Guzzi et al.   Chemistry-An Asian Journal

How Epigallocatechin-3-gallate and Tetracycline Interact with the Josephin Domain of Ataxin-3 and Alter Its Aggregation Mode

(2015) Marcella Bonanomi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Structural Modifications ofcis-Glycofused Benzopyran Compounds and Their Influence on the Binding to Amyloid-β Peptide

(2015) Cristina Airoldi et al.   Chemistry-An Asian Journal

Enhanced Molecular Mobility of Ordinarily Structured Regions Drives Polyglutamine Disease

(2015) Christopher J. Lupton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins

(2015) Edward Harder et al.   Journal of Chemical Theory and Computation

Examination of Ataxin-3 (atx-3) Aggregation by Structural Mass Spectrometry Techniques: A Rationale for Expedited Aggregation upon Polyglutamine (polyQ) Expansion

(2015) Charlotte A. Scarff et al.   MOLECULAR & CELLULAR PROTEOMICS

Enhancement of flavonoid ability to cross the blood–brain barrier of rats by co-administration with α-tocopherol

(2015) Paola Ferri et al.   Food & Function

Gallic acid interacts with α-synuclein to prevent the structural collapse necessary for its aggregation

(2014) Yanqin Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Natural Compounds against Neurodegenerative Diseases: Molecular Characterization of the Interaction of Catechins from Green Tea with Aβ1-42, PrP106-126, and Ataxin-3 Oligomers

(2014) Erika Sironi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Polyphenols: Well Beyond The Antioxidant Capacity: Gallic Acid and Related Compounds as Neuroprotective Agents: You are What You Eat!

(2014) Maria Daglia et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Gallic acid, one of the components in many plant tissues, is a potential inhibitor for insulin amyloid fibril formation

(2014) Jayaraman Jayamani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The green tea polyphenol (−)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios

(2014) Heike J. Wobst et al.   FEBS LETTERS

Epigallocatechin-3-gallate and tetracycline differently affect ataxin-3 fibrillogenesis and reduce toxicity in spinocerebellar ataxia type 3 model

(2014) Marcella Bonanomi et al.   HUMAN MOLECULAR GENETICS

Epigallocatechin-3-Gallate (EGCG), a Green Tea Polyphenol, Stimulates Hepatic Autophagy and Lipid Clearance

(2014) Jin Zhou et al.   PLoS One

Engineered nanoparticles. How brain friendly is this new guest?

(2014) Francesca A. Cupaioli et al.   PROGRESS IN NEUROBIOLOGY

Structure activity relationship of phenolic acid inhibitors of α-synuclein fibril formation and toxicity

(2014) Mustafa T. Ardah et al.   Frontiers in Aging Neuroscience

New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate

(2014) Hae-Suk Kim et al.   Redox Biology

Different ataxin-3 amyloid aggregates induce intracellular Ca 2+ deregulation by different mechanisms in cerebellar granule cells

(2013) Francesca Pellistri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Natural Compounds against Alzheimer’s Disease: Molecular Recognition of Aβ1-42 Peptide bySalvia sclareoidesExtract and its Major Component, Rosmarinic Acid, as Investigated by NMR

(2013) Cristina Airoldi et al.   Chemistry-An Asian Journal

Temperature profoundly affects ataxin-3 fibrillogenesis

(2012) Alessandra Apicella et al.   BIOCHIMIE

Thermodynamic Analysis of the Molecular Interactions between Amyloid β-Protein Fragments and (−)-Epigallocatechin-3-gallate

(2012) Shi-Hui Wang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

cis-Glyco-fused benzopyran compounds as new amyloid-β peptide ligands

(2011) Cristina Airoldi et al.   CHEMICAL COMMUNICATIONS

Curcumin derivatives as new ligands of Aβ peptides

(2011) Cristina Airoldi et al.   JOURNAL OF BIOTECHNOLOGY

A Major Role for Side-Chain Polyglutamine Hydrogen Bonding in Irreversible Ataxin-3 Aggregation

(2011) Antonino Natalello et al.   PLoS One

Tetracycline prevents Aβ oligomer toxicity through an atypical supramolecular interaction

(2010) Cristina Airoldi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Plant Polyphenols as Dietary Antioxidants in Human Health and Disease

(2010) Kanti Bhooshan Pandey et al.   Oxidative Medicine and Cellular Longevity

Introducing Nanochemoprevention as a Novel Approach for Cancer Control: Proof of Principle with Green Tea Polyphenol Epigallocatechin-3-Gallate

(2009) I. A. Siddiqui et al.   CANCER RESEARCH

Binding of epigallocatechin-3-gallate to transthyretin modulates its amyloidogenicity

(2009) Nelson Ferreira et al.   FEBS LETTERS

Nonspecific Interaction of Prefibrillar Amyloid Aggregates with Glutamatergic Receptors Results in Ca2+Increase in Primary Neuronal Cells

(2008) Francesca Pellistri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of nutrient mixture and black grapes on the pharmacokinetics of orally administered (-)epigallocatechin-3-gallate from green tea extract: a human study

(2008) Sonia Gawande et al.   PHYTOTHERAPY RESEARCH

FTIR reveals structural differences between native β-sheet proteins and amyloid fibrils

(2004) Giorgia Zandomeneghi et al.   PROTEIN SCIENCE