LRRK2 interacts with ATM and regulates Mdm2–p53 cell proliferation axis in response to genotoxic stress

Inhibitor treatment of peripheral mononuclear cells from Parkinson’s disease patients further validates LRRK2 dephosphorylation as a pharmacodynamic biomarker

(2016) G. Perera et al.   Scientific Reports

P53 and aging: A fresh look at an old paradigm

(2016) Masha V. Poyurovsky et al.   Aging-US

F-box protein 7 mutations promote protein aggregation in mitochondria and inhibit mitophagy

(2015) Zhi Dong Zhou et al.   HUMAN MOLECULAR GENETICS

Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21WAF1/CIP1 expression

(2015) Dong Hwan Ho et al.   Molecular Brain

Higher Frequency of Certain Cancers inLRRK2G2019S Mutation Carriers With Parkinson Disease

(2015) Ilir Agalliu et al.   JAMA Neurology

DNA Damage and Its Links to Neurodegeneration

(2014) Ram Madabhushi et al.   NEURON

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7

(2014) Ruth Chia et al.   Nature Communications

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Shared Predispositions of Parkinsonism and Cancer

(2012) Seth A. Kareus et al.   ARCHIVES OF NEUROLOGY

Phosphorylation of LRRK2: from kinase to substrate

(2012) Evy Lobbestael et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Expression, purification and preliminary biochemical and structural characterization of the leucine rich repeat namesake domain of leucine rich repeat kinase 2

(2012) Renée Vancraenenbroeck et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

EGFR-dependent phosphorylation of leucine-rich repeat kinase LRRK1 is important for proper endosomal trafficking of EGFR

(2012) Kouki Ishikawa et al.   MOLECULAR BIOLOGY OF THE CELL

Parkinson disease, cancer, and LRRK2: Causation or association?

(2012) O. Bandmann et al.   NEUROLOGY

The LRRK2 G2019S mutation is associated with Parkinson disease and concomitant non-skin cancers

(2012) R. Inzelberg et al.   NEUROLOGY

The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling

(2012) Nicolas Dzamko et al.   PLoS One

Chemoproteomics-Based Design of Potent LRRK2-Selective Lead Compounds That Attenuate Parkinson’s Disease-Related Toxicity in Human Neurons

(2011) Nigel Ramsden et al.   ACS Chemical Biology

Complement 3 and Factor H in Human Cerebrospinal Fluid in Parkinson's Disease, Alzheimer's Disease, and Multiple-System Atrophy

(2011) Yu Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Re-examination of the dimerization state of leucine-rich repeat kinase 2: predominance of the monomeric form

(2011) Genta Ito et al.   BIOCHEMICAL JOURNAL

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2

(2011) Xianming Deng et al.   Nature Chemical Biology

Role of p53 in Neurodegenerative Diseases

(2011) J. Robert Chang et al.   Neurodegenerative Diseases

Meta-analysis of the relationship between Parkinson disease and melanoma

(2011) R. Liu et al.   NEUROLOGY

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization

(2010) Nicolas Dzamko et al.   BIOCHEMICAL JOURNAL

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

(2010) R. Jeremy Nichols et al.   BIOCHEMICAL JOURNAL

A positive role for c-Abl in Atm and Atr activation in DNA damage response

(2010) X Wang et al.   CELL DEATH AND DIFFERENTIATION

New Therapeutic Strategy for Parkinsons and Alzheimers Disease

(2010) E. Esposito et al.   CURRENT MEDICINAL CHEMISTRY

Phosphopeptide Analysis Reveals Two Discrete Clusters of Phosphorylation in the N-Terminus and the Roc Domain of the Parkinson-Disease Associated Protein Kinase LRRK2

(2010) Christian Johannes Gloeckner et al.   JOURNAL OF PROTEOME RESEARCH

A Cytoplasmic ATM-TRAF6-cIAP1 Module Links Nuclear DNA Damage Signaling to Ubiquitin-Mediated NF-κB Activation

(2010) Michael Hinz et al.   MOLECULAR CELL

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

ATM activates p53 by regulating MDM2 oligomerization and E3 processivity

(2009) Qian Cheng et al.   EMBO JOURNAL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Family history of melanoma and Parkinson disease risk

(2009) X. Gao et al.   NEUROLOGY

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

The Involvement of DNA-Damage and -Repair Defects in Neurological Dysfunction

(2008) Avanti Kulkarni et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Parkinson Disease-associated Leucine-rich Repeat Kinase 2 (LRRK2) Is a Dimer That Undergoes Intramolecular Autophosphorylation

(2008) Elisa Greggio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leucine-rich repeat kinase 2 (LRRK2): A key player in the pathogenesis of Parkinson's disease

(2008) Payal N. Gandhi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

ARE PARKINSON DISEASE PATIENTS PROTECTED FROM SOME BUT NOT ALL CANCERS?

(2008) A. J. Strongosky et al.   NEUROLOGY

Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation

(2007) Chao-Kuen Lai et al.   VIROLOGY