Review
Engineering, Biomedical
Yu Zhang, Pan He, Peng Zhang, Xuan Yi, Chunsheng Xiao, Xuesi Chen
Summary: Polypeptides are important biodegradable polymers widely used in drug delivery for cancer treatment. Conjugating anticancer drugs with polypeptides offers advantages in improving pharmacokinetics, enhancing targeting, and controlling drug release, contributing to enhanced therapeutic outcomes with reduced side effects.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Hussein Sabit, Mohamed Abdel-Hakeem, Tahsin Shoala, Shaimaa Abdel-Ghany, Mokhtar Mamdouh Abdel-Latif, Jawaher Almulhim, Mohamed Mansy
Summary: Nanomedicine has gained popularity in cancer treatment due to its advanced targeting and multifunctionality. Nanoparticles can deliver drugs directly to cancer cells, reducing off-target toxicity and increasing efficacy. However, translating nanomedicine from the lab to clinical settings remains challenging.
Article
Engineering, Biomedical
Wenchao Huang, Longshuai Zhang, Jiawei Sun, Yuanzi Sun, Like Gong, Sisi Ge, Xunbin Wei, Weiping Gao
Summary: This study presents intelligent nanoworms with dual-acid-sensitive properties, which can penetrate and release drugs in tumor cells, effectively suppressing tumor growth with better efficacy compared to nanospheres and doxorubicin, and without observed side effects in a mouse model.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Polymer Science
Martin Studenovsky, Anna Rumlerova, Libor Kostka, Tomas Etrych
Summary: The study focuses on the design, synthesis, and physico-chemical properties of polymer-mebendazole nanomedicines for repurposing in cancer therapy, aiming to enhance their bioavailability. Multiple low-molecular-weight mebendazole derivatives and polymer conjugates were successfully synthesized, with potential applications beyond mebendazole to other benzimidazole-based anthelmintics. The methodology described in this study may also be applicable for conjugation of other biologically active compounds containing a heterocyclic N-H group in their molecules.
Article
Chemistry, Multidisciplinary
Michele Anselmi, Adina Borbely, Eduard Figueras, Carmela Michalek, Isabell Kemker, Luca Gentilucci, Norbert Sewald
Summary: The study utilized a hydrophilic beta-glucuronidase-cleavable linker to connect an anticancer drug with a target protein, demonstrating the potential of hydrophilic sugar linkers in reducing cytotoxicity and providing guidance for the development of therapies containing hydrophobic anticancer drugs.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Tiantian Guo, Haiping Zhong, Xingwei Li, Jingqing Mu, Tao Liu, Na Yu, Yang Zhao, Xing-Jie Liang, Shutao Guo
Summary: In this study, we synthesized four dextran-paclitaxel (PTX) conjugates with different drug contents and used them to construct self-assembled nanoparticles. We investigated how PTX content influenced the performance and antitumor efficacy of the nanoparticles. The results showed that nanoparticles with lower PTX content exhibited faster drug release, increased tumor accumulation, and enhanced antitumor efficacy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Natallia V. V. Dubashynskaya, Anton N. N. Bokatyi, Anatoliy V. V. Dobrodumov, Igor V. V. Kudryavtsev, Andrey S. S. Trulioff, Artem A. A. Rubinstein, Arthur D. D. Aquino, Yaroslav A. A. Dubrovskii, Elena S. S. Knyazeva, Elena V. V. Demyanova, Yuliya A. A. Nashchekina, Yury A. A. Skorik
Summary: The growth of microbial multidrug resistance is a problem in modern clinical medicine. Chemical modification of active pharmaceutical ingredients is an attractive strategy to improve their biopharmaceutical properties. Conjugation of antimicrobial drugs with natural polysaccharides provides targeted delivery, controlled drug release, and reduced toxicity. The study synthesized colistin conjugates with succinyl chitosan and found promising results in terms of drug release, antimicrobial activity, and reduction of drug nephrotoxicity and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Corey. A. Stevens, Kuljeet Kaur, Harm-Anton Klok
Summary: Protein-polymer conjugates combine the stability of polymers with the diversity, specificity, and functionality of biomolecules, resulting in hybrid materials with unique properties for drug delivery applications. Engineering amphiphilicity into these bioconjugate materials can lead to phase separation and assembly of high-order structures, with multiple levels of organization and emergence of new properties at each level influenced by lower levels.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Materials Science, Multidisciplinary
Monisha Joy Williams, Sudhaker Raboni Grace, Varnitha Manikantan, Aleyamma Alexander, Govindaraj Sri Varalakshmi, Sivaraj Ramasamy, Archana Sumohan Pillai, Israel V. M. V. Enoch, Dariela Nunez
Summary: In this study, lanthanum-doped carbon dots were developed as a nanocomposite for delivering the anticancer drug camptothecin. The nanocomposite showed promising results as a drug delivery agent, with a high encapsulation efficiency and slow release of the drug.
Article
Biochemistry & Molecular Biology
Natalia Zashikhina, Sergei Gladnev, Vladimir Sharoyko, Viktor Korzhikov-Vlakh, Evgenia Korzhikova-Vlakh, Tatiana Tennikova
Summary: The covalent conjugation of dexamethasone with polymeric carriers is a promising strategy to overcome its limitations. In this study, self-assembling amphiphilic polypeptides were proposed as potential delivery systems for intravitreal delivery. Nanoparticles were prepared using different polypeptides and characterized in terms of size, polydispersity, and zeta potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Dayi Pan, Xiuli Zheng, Miao Chen, Qianfeng Zhang, Zhiqian Li, Zhenyu Duan, Qiyong Gong, Zhongwei Gu, Hu Zhang, Kui Luo
Summary: Dendron-polymer-based nanoscale drug delivery systems show promise in tumor targeting with low toxicity. The dendronized polymer-doxorubicin hybrid displays improved drug delivery efficiency and pH-responsive drug release, resulting in enhanced therapeutic efficacy and longer blood circulation time in cancer therapy. The biosafety and enhanced therapeutic effects of the dendronized polymer-DOX hybrid make it a promising approach for drug delivery.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Review
Nanoscience & Nanotechnology
Yaoqi Wang, Heming Xia, Binlong Chen, Yiguang Wang
Summary: Polymer-drug conjugates as nanoparticles have gained significant attention in cancer theranostics, but none of them have been approved for clinical chemotherapy. Rational design of nanoparticulate PDCs based on CAPIR cascade is crucial for achieving ideal therapeutic efficacy.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Yuan Zhan, Haiping Wang, Mingji Su, Zhengguang Sun, Yuhong Zhang, Peixin He
Summary: A novel biodegradable hybrid nanogel was developed for multistage delivery of anticancer drug, with the ability to control release through remote heating and function within cells. These nanogels showed high intracellular drug accumulation capacity, indicating their potential as an effective nanoplatform for delivery of therapeutic agents.
JOURNAL OF MATERIALS SCIENCE
(2021)
Review
Pharmacology & Pharmacy
Darius P. Zlotos, Thales Kronenberger, Stefan A. Laufer
Summary: Hormone-dependent cancers, such as certain types of breast cancer, can be treated with anticancer drug conjugates that combine estrogen receptor (ER) ligands with other anticancer agents. These conjugates not only have dual action at anti-cancer targets, but also selectively deliver cytotoxic agents to ER-positive tumor cells, reducing toxicity and adverse effects. They can also overcome resistance to anti-hormonal monotherapy. This review discusses the design, structures, and pharmacological effects of various drug conjugates containing ER ligands linked to diverse anticancer agents.
Review
Biochemistry & Molecular Biology
Natallia V. Dubashynskaya, Anton N. Bokatyi, Yury A. Skorik
Summary: Dexamethasone, a commonly prescribed glucocorticoid, shows a wide spectrum of pharmacological activity. Conjugating it to polymeric carriers helps reduce side effects on non-target organs and achieve controlled release in various target organs, making it potentially effective for anti-tumor therapy.