Article
Engineering, Biomedical
Wenchao Huang, Longshuai Zhang, Jiawei Sun, Yuanzi Sun, Like Gong, Sisi Ge, Xunbin Wei, Weiping Gao
Summary: This study presents intelligent nanoworms with dual-acid-sensitive properties, which can penetrate and release drugs in tumor cells, effectively suppressing tumor growth with better efficacy compared to nanospheres and doxorubicin, and without observed side effects in a mouse model.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Applied
Zhilang Xu, Die Yang, Tao Long, Lun Yuan, Shi Qiu, Defu Li, Changdao Mu, Liming Ge
Summary: pH-responsive nanoparticles based on modified hydroxyethyl starch have been developed as an effective drug delivery system for cancer chemotherapy. These nanoparticles can accumulate in tumors and selectively release drugs in the acidic microenvironment, providing a sustained release of the drug.
CARBOHYDRATE POLYMERS
(2022)
Article
Materials Science, Multidisciplinary
Roberto Bernasconi, Emanuele Mauri, Arianna Rossetti, Stefano Rimondo, Raffaella Suriano, Marinella Levi, Alessandro Sacchetti, Salvador Pane, Luca Magagnin, Filippo Rossi
Summary: Targeted drug delivery is a promising approach that utilizes stimuli-responsive materials to control drug release with spatial and temporal precision. This study describes coating magnetically controlled microdevices with functionalized alginate-based hydrogels for drug release at specific pH values, showcasing the potential for spatially and temporally controlled release. The functional microtransporters hold promise for in-vivo applications, particularly in environments with pH differences like the digestive tract.
MATERIALS & DESIGN
(2021)
Review
Engineering, Biomedical
Hyeongmok Park, Gurusamy Saravanakumar, Jinseong Kim, Junha Lim, Won Jong Kim
Summary: The tumor microenvironment (TME) sensitive nano-carriers show promise in enhancing tumor therapy and imaging, utilizing the characteristics of the TME for targeted delivery. Smart nano-carriers responding to multiple stimuli within the TME have been designed for a more desirable drug release control.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Physical
Mengna Zhang, Shujing Zhang, Kun Zhang, Zongyuan Zhu, Yalei Miao, Yudian Qiu, Panke Zhang, Xubo Zhao
Summary: A novel strategy was proposed to enhance the functionality of polymer-based nanostructures through the design of medicated hydrophobic chains, improving the efficiency of drug delivery systems and the suppression against cancer cells.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Review
Chemistry, Multidisciplinary
Can Lei, Xiu-Ran Liu, Quan-Bing Chen, You Li, Jia-Li Zhou, Ling-Yue Zhou, Tao Zou
Summary: The combined utilization of albumin and HA as nanocarriers offers numerous advantages, including efficient targeting, reducible particle size, and pH and/or hyaluronidase sensitive drug release, contributing significantly to drug delivery systems.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Materials Science, Multidisciplinary
Leilei Chen, Jun Xu, Yi Wang, Rongqin Huang
Summary: A facile one-step solvothermal reaction was used to achieve the homogeneously incorporation of ultra-small and monodispersed MoS2 nanodots in mesoporous silica nanospheres (MSN), forming UsMSND@MSN with good biocompatibility. The well-dispersed UsMSND in MSN showed great potential as a non-toxic contrast agent for sensitive in vivo CT imaging in various tumors, promising a good strategy for cancer imaging and therapy.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
B. H. Jaswanth Gowda, Mohammed Gulzar Ahmed, Mohammad Ali Abdullah Almoyad, Shadma Wahab, Waleed H. Almalki, Prashant Kesharwani
Summary: Nanosponges, with their unique sponge-like structure, offer a promising solution for drug delivery in cancer therapy. By utilizing their interconnected voids and mesh-like network, nanosponges enable efficient drug loading and controlled release, overcoming the limitations of conventional methods. They show potential in both cancer treatment and diagnosis, and are considered versatile carrier systems.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Miaobo Pan, Gabriela Moran Cruz, Chloe Grazon, Djamila Kechkeche, Ludivine Houel Renault, Gilles Clavier, Rachel Meallet-Renault
Summary: pH is a fundamental parameter for describing the quality of aqueous solutions. We have developed a ratiometric fluorescent platform that can monitor pH in both solutions and surfaces. By grafting pH-sensitive fluorescent nanoparticles onto a silanized glass surface, we were able to accurately measure pH and monitor the growth of Escherichia coli through optical measurements within the physiological pH range.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Natallia V. V. Dubashynskaya, Anton N. N. Bokatyi, Anatoliy V. V. Dobrodumov, Igor V. V. Kudryavtsev, Andrey S. S. Trulioff, Artem A. A. Rubinstein, Arthur D. D. Aquino, Yaroslav A. A. Dubrovskii, Elena S. S. Knyazeva, Elena V. V. Demyanova, Yuliya A. A. Nashchekina, Yury A. A. Skorik
Summary: The growth of microbial multidrug resistance is a problem in modern clinical medicine. Chemical modification of active pharmaceutical ingredients is an attractive strategy to improve their biopharmaceutical properties. Conjugation of antimicrobial drugs with natural polysaccharides provides targeted delivery, controlled drug release, and reduced toxicity. The study synthesized colistin conjugates with succinyl chitosan and found promising results in terms of drug release, antimicrobial activity, and reduction of drug nephrotoxicity and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Fan Li, Yan Liang, Miaochen Wang, Xing Xu, Fen Zhao, Xu Wang, Yong Sun, Wantao Chen
Summary: The pH cascade-responsive micellar nanoplatform with nucleus-targeted ability effectively combines synergistic chemo-photodynamic therapy for cancer treatment. The novel multifunctional nanoplatform demonstrates high anticancer efficacy both in vitro and in vivo, making it a promising candidate for synergistic anticancer therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Polymer Science
Martin Studenovsky, Anna Rumlerova, Libor Kostka, Tomas Etrych
Summary: The study focuses on the design, synthesis, and physico-chemical properties of polymer-mebendazole nanomedicines for repurposing in cancer therapy, aiming to enhance their bioavailability. Multiple low-molecular-weight mebendazole derivatives and polymer conjugates were successfully synthesized, with potential applications beyond mebendazole to other benzimidazole-based anthelmintics. The methodology described in this study may also be applicable for conjugation of other biologically active compounds containing a heterocyclic N-H group in their molecules.
Article
Biochemistry & Molecular Biology
Haibin Zhang, Zhiyang Gu, Wenya Li, Lili Guo, Litong Wang, Lan Guo, Saibo Ma, Baoqin Han, Jing Chang
Summary: Oral drug delivery is the most preferred mode of treatment due to its convenience and non-invasiveness. However, delivering protein drugs orally has been a challenge. This study developed a novel OCMC/SA nanohydrogel that solves this problem, with high drug loading capacity and passive drug targeting function.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Felicia Roffo, Alfonso Maria Ponsiglione, Paolo Antonio Netti, Enza Torino
Summary: An innovative hybrid nanocarrier based on lipid-polymer coupling was proposed and validated for theranostics and multimodal imaging applications. The nanocarrier, prepared using Microfluidics, consists of a core-shell structure with a lipid bilayer enveloping a polymeric chitosan core, capable of co-encapsulating different compounds. The hybrid nanocarriers exhibit monodispersity, structural integrity in different environmental conditions, and high biocompatibility, making them suitable for MRI and Optical applications.
Article
Chemistry, Multidisciplinary
Marie Piantino, Masahiko Nakamoto, Michiya Matsusaki
Summary: Efficient and selective drug delivery systems (DDS) in cancer therapy remain a major challenge. A recent study introduced a molecular block (MB) therapy targeting the cancer cell microenvironment, which induced cancer cell death through self-aggregation and cell membrane disruption. The optimized MB showed increased sensitivity to the cancer microenvironment and avoided off-target accumulation in the bloodstream, making it a promising approach for improved cancer cell targeting.
Article
Nanoscience & Nanotechnology
Zhen Li, Qingqing Yin, Binlong Chen, Zenghui Wang, Yue Yan, Tong Qi, Wei Chen, Qiang Zhang, Yiguang Wang
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2019)
Article
Materials Science, Biomaterials
Yulin Mo, Hongliang Du, Binlong Chen, Dechun Liu, Qingqing Yin, Yue Yan, Zenghui Wang, Fangjie Wan, Tong Qi, Yaoqi Wang, Qiang Zhang, Yiguang Wang
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2019)
Article
Pharmacology & Pharmacy
Dong Mei, Binlong Chen, Bing He, Haibin Liu, Zhiqiang Lin, Jialiang Lin, Xiaoyan Zhang, Ning Sun, Libo Zhao, Xiaoling Wang, Qiang Zhang
ACTA PHARMACEUTICA SINICA B
(2019)
Article
Engineering, Biomedical
Tong Qi, Binlong Chen, Zenghui Wang, Hongliang Du, Dechun Liu, Qingqing Yin, Bangyuan Liu, Qiang Zhang, Yiguang Wang
Article
Chemistry, Multidisciplinary
Dechun Liu, Binlong Chen, Yulin Mo, Zenghui Wang, Tong Qi, Qiang Zhang, Yiguang Wang
Article
Chemistry, Multidisciplinary
Yue Yan, Binlong Chen, Zenghui Wang, Qingqing Yin, Yaoqi Wang, Fangjie Wan, Yulin Mo, Bo Xu, Qiang Zhang, Siling Wang, Yiguang Wang
Summary: The study highlights the importance of regulating the tumor microenvironment to enhance the therapeutic efficacy of active-targeted nanophotosensitizers, with normalization of tumor vasculature and photoablation of stromal cells improving tumor accumulation and cancer cell accessibility of the nanoparticles. This sequential regulation strategy significantly enhances the antitumor efficacy of active-targeted nanoparticles, providing a basis for accelerating their clinical translation.
Article
Nanoscience & Nanotechnology
Binlong Chen, Ye Yang, Yaoqi Wang, Yue Yan, Zenghui Wang, Qingqing Yin, Qiang Zhang, Yiguang Wang
Summary: The SPR-SOSG nanosensor has been developed to specifically illuminate singlet oxygen in endocytic organelles through encoding SOSG into pH-sensitive micelles, achieving more than 10-fold amplification of the singlet oxygen signal.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Zenghui Wang, Heming Xia, Binlong Chen, Yaoqi Wang, Qingqing Yin, Yue Yan, Ye Yang, Mingmei Tang, Jianxiong Liu, Ruiyang Zhao, Wenzhe Li, Qiang Zhang, Yiguang Wang
Summary: A novel type of near-infrared nanoparticles integrating chemiluminescence technology and signal amplification strategy has been developed for accurate identification of metastatic sentinel lymph nodes in animal tumor models, showing excellent imaging capability for early detection.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Yaoqi Wang, Zenghui Wang, Binlong Chen, Qingqing Yin, Meijie Pan, Heming Xia, Bo Zhang, Yue Yan, Zhujun Jiang, Qiang Zhang, Yiguang Wang
Summary: The study engineered sequential pH/redox-responsive nanoparticles to activate the immune microenvironment of tumors and lymph nodes, enhancing the antitumor immune response and providing a potential candidate for synergistic cancer chemo-immunotherapy.
Article
Multidisciplinary Sciences
Qingqing Yin, Anni Pan, Binlong Chen, Zenghui Wang, Mingmei Tang, Yue Yan, Yaoqi Wang, Heming Xia, Wei Chen, Hongliang Du, Meifang Chen, Chuanxun Fu, Yanni Wang, Xia Yuan, Zhihao Lu, Qiang Zhang, Yiguang Wang
Summary: The authors developed a binary ratiometric nanoreporter that quantifies intracellular nanoparticle uptake and predicts nanotherapeutic responses. This technology accurately quantifies the internalisation of nanoparticles in tumor cells, enabling the prediction of therapeutic responses and personalized cancer therapy.
NATURE COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Anpu Yang, Yanan Sun, Bochen Lyu, Binlong Chen, Zhipu Fan, Minghui Li, Yao Zhao, Jijun Fu, Bing He, Hua Zhang, Xueqing Wang, Wenbing Dai, Qiang Zhang
Summary: This study demonstrates the high potential of the PCT nanodispersion in tumor combined therapy by simply associating three readily available materials (single-walled carbon nanohorns, zinc phthalocyanine, and surfactant TPGS) together. The PCT exhibits promising photothermal and photodynamic effects, effectively destroying tumor cells in vitro and inhibiting the growth and metastasis of tumors in vivo.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Binlong Chen, Yue Yan, Ye Yang, Guang Cao, Xiao Wang, Yaoqi Wang, Fangjie Wan, Qingqing Yin, Zenghui Wang, Yunfei Li, Letong Wang, Bo Xu, Fuping You, Qiang Zhang, Yiguang Wang
Summary: The authors in this paper engineer a library of ultra-pH-sensitive nanophotosensitizers that can target specific endocytic organelles and induce pyroptotic cancer cell death in a controlled manner. By spatiotemporally targeting distinct stages of endosomal maturation, they achieve tunable cellular pyroptosis. The nanotuner platform demonstrates enhanced antitumor efficacy and minimized systemic side effects in various gasdermin-E-positive human cancers.
NATURE NANOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Yue Yan, Binlong Chen, Qingqing Yin, Zenghui Wang, Ye Yang, Fangjie Wan, Yaoqi Wang, Mingmei Tang, Heming Xia, Meifang Chen, Jianxiong Liu, Siling Wang, Qiang Zhang, Yiguang Wang
Summary: This study developed a pH/light dual-responsive nanoparticle that can accurately quantify the distribution of nanoparticles inside and outside tumors, and determine the contribution of extracellularly distributed nanophotosensitizer to therapeutic efficacy.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Mingmei Tang, Binlong Chen, Heming Xia, Meijie Pan, Ruiyang Zhao, Jiayi Zhou, Qingqing Yin, Fangjie Wan, Yue Yan, Chuanxun Fu, Lijun Zhong, Qiang Zhang, Yiguang Wang
Summary: This study reports the development of pH-gated nanoparticles that selectively target and reprogram immunosuppressive macrophages in tumors, improving antigen cross-presentation and promoting immune response and tumor regression.
NATURE COMMUNICATIONS
(2023)