Interleukin 6-dependent genomic instability heralds accelerated carcinogenesis following liver regeneration on a background of chronic hepatitis

Spontaneous Hepatocellular Carcinoma after the Combined Deletion of Akt Isoforms

(2016) Qi Wang et al.   CANCER CELL

MicroRNA-122 regulates polyploidization in the murine liver

(2016) Shu-hao Hsu et al.   HEPATOLOGY

Hepatocellular carcinoma

(2016) Josep M. Llovet et al.   Nature Reviews Disease Primers

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

IL-6 as a keystone cytokine in health and disease

(2015) Christopher A Hunter et al.   NATURE IMMUNOLOGY

New molecular therapies for hepatocellular carcinoma

(2015) S. Torrecilla et al.   Clinics and Research in Hepatology and Gastroenterology

Causes of Genome Instability

(2013) Andrés Aguilera et al.   Annual Review of Genetics

Inflammation-induced hepatocellular carcinoma is dependent on CCR5 in mice

(2013) Neta Barashi et al.   HEPATOLOGY

Hypertrophy and Unconventional Cell Division of Hepatocytes Underlie Liver Regeneration

(2012) Yuichiro Miyaoka et al.   CURRENT BIOLOGY

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

Aspects of liver pathology in adult patients with MDR3/ABCB4 gene mutations

(2012) Dominique Wendum et al.   VIRCHOWS ARCHIV

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

(2010) Eek Joong Park et al.   CELL

Early hepatocyte DNA synthetic response posthepatectomy is modulated by IL-6 trans-signaling and PI3K/AKT activation

(2010) Yael Nechemia-Arbely et al.   JOURNAL OF HEPATOLOGY

Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells

(2010) M. Fenech et al.   MUTAGENESIS

Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks

(2010) H. Barash et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA lesions sequestered in micronuclei induce a local defective-damage response

(2009) Mariona Terradas et al.   DNA REPAIR

The effects of surgery on tumor growth: a century of investigations

(2008) R. Demicheli et al.   ANNALS OF ONCOLOGY

The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation

(2008) Sanae Haga et al.   HEPATOLOGY