Article
Cell Biology
Hongmei Ding, Fei Jiang, Lifeng Deng, Juan Wang, Ping Wang, Mintao Ji, Jie Li, Weiqiang Shi, Yufang Pei, Jiafu Li, Yue Zhang, Zengli Zhang, Youguo Chen, Bingyan Li
Summary: In this study, a new lncRNA model was developed to predict the prognosis of patients with EC by analyzing differentially expressed lncRNAs from the TCGA database. Eight independent prognostic lncRNAs for EC patients were identified. According to the risk score of these lncRNAs, EC patients could be divided into high-risk and low-risk groups, with the low-risk group having a higher survival rate. Additionally, the lncRNA signature was closely associated with histological subtype, advanced clinical stage, and clinical grade in EC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xinyan Qiu, Jinlan Chen
Summary: Long stress-induced noncoding transcripts 5 (LSINCT5), a long chain non-coding RNA (lncRNA), is abnormally expressed in various cancers and plays an oncogenic role. It exerts its functions by sponging microRNAs, interacting with proteins, participating in cellular signaling, and being regulated by transcription factors. Dysregulated LSINCT5 is associated with poor prognosis in malignant tumors. LSINCT5 has the potential to be a diagnostic and prognostic marker for cancer and can be applied in clinical practice.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Julia Bohosova, Adela Kubickova, Ondrej Slaby
Summary: PVT1 plays a crucial role in RCC development and there is a significant amount of research trying to uncover its cellular mechanisms. This review summarizes the current knowledge on the role of PVT1 in RCC development and its association with clinical behavior. 17 scientific papers analyzed in this review provide robust support for the importance of PVT1 in RCC development and personalized therapy.
Article
Chemistry, Multidisciplinary
Xin Huang, Wei Wu, Doudou Jing, Lingkai Yang, Haoyu Guo, Lutong Wang, Weiyue Zhang, Feifei Pu, Zengwu Shao
Summary: This study demonstrates the potential therapeutic effects of engineered exosomes as targeted delivery vehicles for lncRNA MEG3 in osteosarcoma. The engineered exosomes cRGD-Exo-MEG3 efficiently deliver MEG3 to tumor cells, significantly enhancing its anti-tumor effects.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Immunology
Qin Dang, Zaoqu Liu, Yang Liu, Wenkang Wang, Weitang Yuan, Zhenqiang Sun, Lin Liu, Chengzeng Wang
Summary: This study provides a framework for screening Notch-derived lncRNAs in colorectal cancer (CRC) and identifies clinically significant lncRNAs associated with prognosis. The NLncS model, consisting of six lncRNAs, is shown to be an independent risk factor and a robust biomarker for assessing the prognosis of CRC patients. Patients with high NLncS risk scores exhibit upregulation of immune pathways, strong immunogenicity, CD8+ T-cell infiltration, and potentially higher response rates to CTLA4 blockers, making them suitable candidates for immunotherapy. Additionally, the study identifies dasatinib as a potential agent for high-risk CRC patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Binliang Gan, Youwu He, Yonggang Ma, Linfeng Mao, Chuanjie Liao, Ganlu Deng
Summary: This study identified 32 differentially expressed long non-coding RNAs (lncRNAs), of which 12 were associated with the prognosis of hepatocellular carcinoma (HCC) patients. A prognostic signature comprising 6 prognostic lncRNAs was developed and showed excellent predictive ability. Additionally, a differential m6A regulator, RBMX, was found to be negatively correlated with the hub lncRNA AC115619.1. AC115619.1 was downregulated in HCC tissues compared to normal tissues, and its expression was significantly related to clinicopathological features, survival rate, and drug sensitivity. Overexpression of AC115619.1 inhibited proliferation, migration, and invasion of HCC cells.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Microbiology
Christine Olbjorn, Milada Cvancarova Smastuen, Aina Elisabeth Fossum Moen
Summary: This study explored the fecal microbiota in pediatric patients with treatment-naive IBD and found that the abundance and species of bacteria differed between IBD patients and healthy children. Based on the abundance of bacterial species, diagnostic, phenotype, and prognostic indexes were constructed, which can aid in diagnosing and treating IBD.
Review
Biochemistry & Molecular Biology
Yun Ma, Siqi He, Qiao Xie, Zhihan Tang, Zhisheng Jiang
Summary: Long non-coding RNA (lncRNA) is a biomolecule that regulates important life activities and is closely related to various diseases. In cardiovascular diseases, lncRNAs play a role in regulating the occurrence and development of atherosclerosis by affecting the expression of related genes. Investigating the role of lncRNAs in regulating cardiac gene networks has attracted clinical attention and may be a novel target for atherosclerosis therapy. This paper focuses on lncRNAs related to atherosclerosis, explores their relationship and role in prevention and treatment, and suggests their potential as markers in clinical diagnosis and treatment.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Chengyu Bian, Xinti Sun, Jingjing Huang, Wenhao Zhang, Guang Mu, Ke Wei, Liang Chen, Yang Xia, Jun Wang
Summary: In this study, we found that GT-related lncRNAs have independent prognostic characteristics in LUAD, which can serve as important predictors for predicting patient survival and guiding treatments.
FRONTIERS IN ONCOLOGY
(2022)
Article
Genetics & Heredity
Maria Cristina Munteanu, Sri Nandhini Sethuraman, Mohit Pratap Singh, Jerry Malayer, Ashish Ranjan
Summary: FENDRR is a recently discovered tumor suppressor long non-coding RNA associated with epigenetic modulation of target genes involved in tumor immunity. Its expression levels correlate with the expression of immune activation genes and MHC-I molecules in tumor cells. Modulation of FENDRR expression enhances inflammatory and WNT signaling pathways in tumors, suggesting a potential role in the development of immune-relevant phenotypes and improvement of cancer immunotherapy.
Review
Cell Biology
Omayma Mazouji, Abdelhak Ouhajjou, Roberto Incitti, Hicham Mansour
Summary: Colorectal cancer is one of the most common cancers globally, with solid biopsy being an essential guide for clinical management, but liquid biopsy has shown significant promise as an alternative tool in various CRC clinical applications, such as early detection, treatment decision-making, and monitoring treatment response.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yajun Deng, Wenhua Yuan, Enhui Ren, Zuolong Wu, Guangzhi Zhang, Qiqi Xie
Summary: This study established a methylated lncRNA signature for predicting osteosarcoma patient survival based on comprehensive analysis of DNA methylation and transcriptome data. The signature was validated using Kaplan-Meier and ROC analysis, showing higher prediction accuracy than known biomarkers, and was independent of clinicopathological factors.
Review
Oncology
Zonglei Zhao, Xixiu Wang, Yan Ding, Xuefeng Cao, Xingyuan Zhang
Summary: SMC4 is a member of the ATPase family of chromosomes and is involved in various biological functions such as compression and dissociation of sister chromatids, DNA damage repair, and transcription. It also plays a role in embryonic cell division cycle, immune response regulation, and tumor development. High expression of SMC4 is consistently associated with worse overall survival in tumors.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Fan Zhang, Jiajia Jiang, Hui Qian, Yongmin Yan, Wenrong Xu
Summary: Exosomal circRNA is a novel genetic information molecule that facilitates communication between tumor cells and microenvironmental cells, impacting critical aspects of cancer progression such as immune escape, tumor angiogenesis, metabolism, drug resistance, proliferation, and metastasis. Microenvironmental cells have been found to influence tumor progression and immune escape through the release of exosomal circRNA. Due to their stability, abundance, and widespread distribution, exosomal circRNAs show promise as excellent diagnostic and prognostic biomarkers for liquid biopsy. Additionally, artificially synthesized circRNAs may open up new possibilities for cancer therapy, potentially utilizing nanoparticle or plant exosome delivery strategies.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mariapaola Nitti, Caterina Ivaldo, Nicola Traverso, Anna Lisa Furfaro
Summary: Heme oxygenase 1 (HO-1) plays a crucial role in cancer progression, potentially leading to poor prognosis and treatment failure, with high expression levels often associated with reduced survival rates in tumor specimens.
