Targeted localized use of therapeutic antibodies: a review of non-systemic, topical and oral applications

Intratumoral Immunization: A New Paradigm for Cancer Therapy

(2014) A. Marabelle et al.   CLINICAL CANCER RESEARCH

The Expanding Role of Therapeutic Antibodies

(2014) Simonetta Salemi et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease

(2014) Raja Atreya et al.   NATURE MEDICINE

A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life

(2014) Enas A. S. Attia et al.   WOUND REPAIR AND REGENERATION

Treatment of Corneal Neovascularization Using Anti-VEGF Bevacizumab

(2014) Deli Krizova et al.   Journal of Ophthalmology

Local CTLA4 blockade effectively restrains experimental pancreatic adenocarcinoma growth in vivo

(2014) Linda C Sandin et al.   OncoImmunology

Anti-Tumor Necrosis Factor Therapy Is Associated With Infections after Abdominal Surgery in Crohn's Disease Patients

(2013) Ali Syed et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Opportunistic Infections With Anti-Tumor Necrosis Factor-α Therapy in Inflammatory Bowel Disease: Meta-Analysis of Randomized Controlled Trials

(2013) Alexander C Ford et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Controlled Local Delivery of CTLA-4 Blocking Antibody Induces CD8+ T-Cell-Dependent Tumor Eradication and Decreases Risk of Toxic Side Effects

(2013) M. F. Fransen et al.   CLINICAL CANCER RESEARCH

Intratumoral Anti-CTLA-4 Therapy: Enhancing Efficacy While Avoiding Toxicity

(2013) A. Marabelle et al.   CLINICAL CANCER RESEARCH

Cyclodextrin-based hydrogels toward improved wound dressings

(2013) Eva Pinho et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Attenuation of flightless I improves wound healing and enhances angiogenesis in a murine model of type 1 diabetes

(2013) Nadira Ruzehaji et al.   DIABETOLOGIA

Assessment of the efficacy of polyclonal intravenous immunoglobulin G (IVIG) against the infectivity of clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) in vitro and in vivo

(2013) N. Farag et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Combating multidrug-resistant Gram-negative bacterial infections

(2013) Ze-Qi Xu et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Anti-Rotavirus Protein Reduces Stool Output in Infants With Diarrhea: A Randomized Placebo-Controlled Trial

(2013) Shafiqul A. Sarker et al.   GASTROENTEROLOGY

AVX-470

(2013) Kailash C. Bhol et al.   INFLAMMATORY BOWEL DISEASES

Depleting tumor-specific Tregs at a single site eradicates disseminated tumors

(2013) Aurélien Marabelle et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapid improvement of refractory pyoderma gangrenosum with infliximab gel in a patient with ulcerative colitis

(2013) Niels Teich et al.   Journal of Crohns & Colitis

Use of a new functional dual coating (FDC) assay to measure low toxin levels in serum and food samples following an outbreak of human botulism

(2013) R. G. A. Jones et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Progress in intra-articular therapy

(2013) Christopher H. Evans et al.   Nature Reviews Rheumatology

Penetration of a Topically Administered Anti–Tumor Necrosis Factor Alpha Antibody Fragment into the Anterior Chamber of the Human Eye

(2013) Michael A. Thiel et al.   OPHTHALMOLOGY

An Empirical Approach towards the Efficient and Optimal Production of Influenza-Neutralizing Ovine Polyclonal Antibodies Demonstrates That the Novel Adjuvant CoVaccine HT™ Is Functionally Superior to Freund's Adjuvant

(2013) Natalie E. Stevens et al.   PLoS One

Cancer Immunotherapy

(2013) J. Couzin-Frankel   SCIENCE

Locally Delivered CD40 Agonist Antibody Accumulates in Secondary Lymphoid Organs and Eradicates Experimental Disseminated Bladder Cancer

(2013) L. C. Sandin et al.   Cancer Immunology Research

NICE clinical guideline (CG152): the management of Crohn's disease in adults, children and young people

(2012) J. F. Mayberry et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Subconjunctival bevacizumab induces regression of corneal neovascularisation: a pilot randomised placebo-controlled double-masked trial

(2012) Constantinos Petsoglou et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Immunoglobulins in Defense, Pathogenesis, and Therapy of Fungal Diseases

(2012) Arturo Casadevall et al.   Cell Host & Microbe

Effectiveness and Safety of Local Adalimumab Injection in Patients With Fistulizing Perianal Crohn’s Disease

(2012) Francesco Tonelli et al.   DISEASES OF THE COLON & RECTUM

Oral tolerance induction in humans

(2012) Tim Meyer et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Eudragit®: a technology evaluation

(2012) Seema Thakral et al.   Expert Opinion on Drug Delivery

Topical Neutralization of Interleukin-17 during Experimental Pseudomonas aeruginosa Corneal Infection Promotes Bacterial Clearance and Reduces Pathology

(2012) Tanweer S. Zaidi et al.   INFECTION AND IMMUNITY

Topically Applied Flightless I Neutralizing Antibodies Improve Healing of Blistered Skin in a Murine Model of Epidermolysis Bullosa Acquisita

(2012) Zlatko Kopecki et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Marketed therapeutic antibodies compendium

(2012) Janice M. Reichert   mAbs

Corneal Neovascularization and the Utility of Topical VEGF Inhibition: Ranibizumab (Lucentis) Vs Bevacizumab (Avastin)

(2012) William Stevenson et al.   Ocular Surface

Randomized placebo-controlled clinical trial of immunoglobulin Y as adjunct to standard supportive therapy for rotavirus-associated diarrhea among pediatric patients

(2012) Shofiqur Rahman et al.   VACCINE

Egg Yolk Antibodies for Passive Immunity

(2012) Jennifer Kovacs-Nolan et al.   Annual Review of Food Science and Technology

Ocular Distribution, Spectrum of Activity, andIn VivoViral Neutralization of a Fully Humanized Anti-Herpes Simplex Virus IgG Fab Fragment following Topical Application

(2011) Marianne Berdugo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Induction of Immunological Tolerance by Oral Anti-CD3

(2011) Andre Pires da Cunha et al.   Clinical & Developmental Immunology

Intralesional Infliximab in Noninfectious Cutaneous Granulomas: Three Cases of Necrobiosis Lipoidica

(2011) C. Barde et al.   DERMATOLOGY

Oral immunoglobulin induces mononuclear cell apoptosis in patients suffering from idiopathic chronic pain syndrome: Results from a pilot study

(2011) A.M. Waaga-Gasser et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Development of Antidrug Antibodies Against Adalimumab and Association With Disease Activity and Treatment Failure During Long-term Follow-up

(2011) Geertje M. Bartelds   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Neutralization ofClostridium difficileToxin A with Single-domain Antibodies Targeting the Cell Receptor Binding Domain

(2011) Greg Hussack et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Local effects of intra-articular injection of anti-rabbit tumor necrosis factor alpha monoclonal antibody in antigen-induced arthritis of the rabbit temporomandibular joint

(2011) Taishi Ohtani et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Antibody-based therapeutics to watch in 2011

(2011) Janice M. Reichert   mAbs

Antibodies in infectious diseases: polyclonals, monoclonals and niche biotechnology

(2011) Jody D. Berry et al.   New Biotechnology

Is there a role for oral human immunoglobulin in the treatment for norovirus enteritis in immunocompromised patients?

(2011) Diana F. Florescu et al.   PEDIATRIC TRANSPLANTATION

Specific Egg Yolk Immunoglobulin as a New Preventive Approach for Shiga-Toxin-Mediated Diseases

(2011) Paola Neri et al.   PLoS One

Tumor necrosis factor-alpha (TNF-α) is a therapeutic target for impaired cutaneous wound healing

(2011) Gillian S. Ashcroft et al.   WOUND REPAIR AND REGENERATION

Clinical Pharmacokinetics of Therapeutic Monoclonal Antibodies

(2010) Ron J. Keizer et al.   CLINICAL PHARMACOKINETICS

A paradigm shift in enteric coating: Achieving rapid release in the proximal small intestine of man

(2010) Fang Liu et al.   JOURNAL OF CONTROLLED RELEASE

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anti-TNF therapy is associated with an increased risk of serious infections in patients with rheumatoid arthritis especially in the first 6 months of treatment: updated results from the British Society for Rheumatology Biologics Register with special emphasis on risks in the elderly

(2010) J. B. Galloway et al.   RHEUMATOLOGY

Toxin-Specific Antibodies for the Treatment of Clostridium difficile: Current Status and Future Perspectives

(2010) Greg Hussack et al.   Toxins

Anti-inflammatory and cartilage-protecting effects of an intra-articularly injected anti-TNF  single-chain Fv antibody (ESBA105) designed for local therapeutic use

(2009) D M Urech et al.   ANNALS OF THE RHEUMATIC DISEASES

Therapeutic antibodies: successes, limitations and hopes for the future

(2009) Patrick Chames et al.   BRITISH JOURNAL OF PHARMACOLOGY

A novel double-coating approach for improved pH-triggered delivery to the ileo-colonic region of the gastrointestinal tract

(2009) Fang Liu et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Orally administered L. lactis secreting an anti-TNF Nanobody demonstrate efficacy in chronic colitis

(2009) K Vandenbroucke et al.   Mucosal Immunology

Treatment of erosive osteoarthritis of the hands by intra-articular infliximab injections: a pilot study

(2009) Antonella Fioravanti et al.   RHEUMATOLOGY INTERNATIONAL

High-level expression of Camelid nanobodies in Nicotiana benthamiana

(2009) Yi-Hui Audrey Teh et al.   TRANSGENIC RESEARCH

Emerging treatments for complex perianal fistula in Crohn’s disease

(2009) Carlos Taxonera et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Immunogenicity negatively influences the outcome of adalimumab treatment in Crohn’s disease

(2008) R. L. WEST et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Monoclonal Antibody Pharmacokinetics and Pharmacodynamics

(2008) W Wang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Good effect of IgY againstPseudomonas aeruginosainfections in cystic fibrosis patients

(2008) Elin Nilsson et al.   PEDIATRIC PULMONOLOGY

Two cases of Norwalk virus enteritis following small bowel transplantation treated with oral human serum immunoglobulin

(2008) Diana F. Florescu et al.   PEDIATRIC TRANSPLANTATION

Interplay Between Intestinal pH, Transit Time and Feed Status on the In Vivo Performance of pH Responsive Ileo-Colonic Release Systems

(2008) Valentine C. Ibekwe et al.   PHARMACEUTICAL RESEARCH

A randomized, double-blind study comparing Clostridium difficile immune whey and metronidazole for recurrent Clostridium difficile-associated diarrhoea: Efficacy and safety data of a prematurely interrupted trial

(2008) Eero Mattila et al.   SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES

Treatment of inflammatory bowel disease: A review of medical therapy

(2008) Patricia L Kozuch et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Kinetics of Whole Serum and Prepurified IgG Digestion by Pepsin for F(ab')2 Manufacture

(2003) Rihab Boushaba et al.   BIOTECHNOLOGY PROGRESS

Single-domain antibody fragments with high conformational stability

(2002) Mireille Dumoulin et al.   PROTEIN SCIENCE