Article
Multidisciplinary Sciences
Anissa Fries, Fanny Saidoune, Francois Kuonen, Isabelle Dupanloup, Nadine Fournier, Ana Cristina Guerra de Souza, Muzlifah Haniffa, Feiyang Ma, Johann E. Gudjonsson, Lennart Roesner, Yang Li, Thomas Werfel, Curdin Conrad, Raphael Gottardo, Robert L. Modlin, Jeremy Di Domizio, Michel Gilliet
Summary: This study establishes the role of interleukin 26 (IL-26) in the generation of IL-17A producing Th17 CD4(+) T cells, indicating its involvement in the pathogenic response of psoriasis. IL-26-producing cells infiltrate psoriatic skin and promote their own differentiation into IL17A-producing T(H)17 cells through epithelial crosstalk involving paracrine production of TGF-& beta;1.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Nerea Cuesta-Gomez, Laura Medina-Ruiz, Gerard J. Graham, John D. M. Campbell
Summary: Mesenchymal stromal cells (MSC) are potential cellular therapeutics for psoriasis, a chronic inflammatory skin and joint disease. MSC adoptive cellular therapy can modulate the immune response and suppress the hyperactivation of effector T cells underlying the disease. In this study, we investigated the therapeutic potential of bone marrow and adipose tissue-derived MSCs in a psoriasis-like inflammation model. We found that both unlicensed and licensed MSCs accelerated the healing of psoriatic lesions, but unlicensed MSCs were more efficient in resolving skin inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Yongyi Bai, Jingrong Wang, Ying Chen, Tingting Lv, Xiaojian Wang, Chunlei Liu, Hao Xue, Kunlun He, Lan Sun
Summary: The study identified oncologic miR-182 as a new regulator of pulmonary artery hypertension (PAH) targeting Myadm, and suggested that the balance between the BMP and TGF-beta signalling pathways is disrupted in PAH. Hypoxia triggers pathological progression in PAH by downregulating BMP/SMAD1/5/8 expression and enhancing TGF-beta/SMAD2/3 signalling pathway. miR-182 gain-of-function inhibits the progression in PAH, while loss-of-function increases the pathological progression. The study also indicated a crosstalk between endothelial cells and smooth muscle cells in the BMP-TGF-beta pathway associated with NOS3/NO/cGMP.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Article
Allergy
Stephane Esnault, Mehdi Khosravi, Elizabeth A. Kelly, Lin Ying Liu, Yury A. Bochkov, Matthew C. Tattersall, Nizar N. Jarjour
Summary: After allergen challenge, IL-6 trans-signalling proteins showed increased activity in the airways, potentially leading to augmented inflammation and tissue damage. Different cell types expressed IL-6R subunits and could contribute to the production of sIL-6R, while bronchial fibroblasts activated by IL-6 trans-signalling produced increased levels of chemokines. These findings suggest a role for IL-6 trans-signalling in exacerbating inflammation and lung dysfunction in asthma.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Article
Physics, Multidisciplinary
Hemn M. Rasool, Sarbaz H. A. Khoshnaw
Summary: This study used mathematical approaches and computational simulations to simplify cell signalling pathway models, reducing the number of elements in IL-6 and IL-10 signalling pathways, and demonstrated their predictability and accuracy in modeling dynamics.
Review
Immunology
Gaetano Zizzo, Antonio Tamburello, Laura Castelnovo, Antonella Laria, Nicola Mumoli, Paola Maria Faggioli, Ilario Stefani, Antonino Mazzone
Summary: IL-6 inhibitors have shown significant efficacy in treating COVID-19 patients, particularly in severe cases. Identifying baseline characteristics of patients and determining the optimal window for treatment based on specific biomarkers are crucial for successful outcomes in disease management.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Lih-Fhung Hiew, Chi-Him Poon, Heng-Ze You, Lee-Wei Lim
Summary: Research on TGF-beta/Smad signaling has shown its significance in neurogenesis and its potential impact on neuropsychiatric disorders. The relationship between TGF-beta/Smad signaling and neurogenesis in response to stressors suggests a role in stress response regulation and behavioral outcomes of mood disorders. Modifications to these signaling pathways have been found to have diverse effects on neurogenesis, highlighting the complexity of the interactions involved.
Article
Oncology
Marco Carlo Merlano, Matteo Paccagnella, Nerina Denaro, Andrea Abbona, Danilo Galizia, Dario Sangiolo, Loretta Gammaitoni, Erika Fiorino, Silvia Minei, Paolo Bossi, Lisa Licitra, Ornella Garrone
Summary: This study found that IL-6 and TGF-beta play a prognostic role in head and neck cancer patients with poor clinical characteristics. Nivolumab treatment positively modulates some Th1 cytokines, but it does not correlate with the outcome.
Review
Immunology
Stefan Rose-John, Brendan J. Jenkins, Christoph Garbers, Jens M. Moll, Juergen Scheller
Summary: This review discusses the discovery of the IL-6 trans-signalling pathway and the development of biologics that specifically inhibit this pathway. Targeting IL-6 trans-signalling can decrease disease-promoting activities of IL-6 without blocking its protective actions.
NATURE REVIEWS IMMUNOLOGY
(2023)
Review
Oncology
Valeria Ramundo, Giuliana Giribaldi, Elisabetta Aldieri
Summary: Metabolic changes in the tumor microenvironment play a critical role in cancer by affecting signaling pathways that control cellular metabolism. The deregulation of cancer metabolism is closely related to oxidative stress control and the involvement of cytokines like transforming growth factor beta (TGF-beta) in tumorigenesis and cancer progression. The crosstalk between TGF-beta and oxidative stress contributes significantly to tumorigenesis and cancer invasiveness by affecting redox imbalance and cellular metabolism.
Review
Oncology
Roberta Angioni, Ricardo Sanchez-Rodriguez, Antonella Viola, Barbara Molon
Summary: Metabolic reprogramming in the tumor microenvironment is crucial for cancer progression and metastasis, with TGF-beta playing a central role in driving immune suppression and tolerogenic cell accumulation.
Article
Cell Biology
Mark Esposito, Cao Fang, Katelyn C. Cook, Nana Park, Yong Wei, Chiara Spadazzi, Dan Bracha, Ramesh T. Gunaratna, Gary Laevsky, Christina J. DeCoste, Hannah Slabodkin, Clifford P. Brangwynne, Ileana M. Cristea, Yibin Kang
Summary: Intracellular signaling involves a diverse array of molecular players and spatial segregation mechanisms, with liquid-liquid phase separation identified as a distinct mechanism. DACT1 induced by TGF-beta forms protein condensates in the cytoplasm to repress Wnt signaling, impacting breast and prostate cancer bone metastasis through its role in sequestering CK2.
NATURE CELL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Tao Huang, JingWen Huang, ZhaoHong Liao, HaiQiang Lan, XiaoTing Jian, RuiCai Gu, Jun Ouyang, Jijie Hu, Hua Liao
Summary: This study found that the intrinsic TGF-beta signaling in muscle cells plays a role in mediating muscle inflammatory response. Activation of the specific TGF-beta signaling pathway contributes to the production of IL-6 in muscle cells and directs muscle-specific Th17 and Treg cell responses.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Orthopedics
R. Wiegertjes, N. G. M. Thielen, A. P. M. van Caam, M. van Laar, H. M. van Beuningen, M. I. Koenders, P. L. E. M. van Lent, P. M. van der Kraan, F. A. J. van de Loo, E. N. Blaney Davidson
Summary: The study indicates that aging leads to increased expression of IL-6 receptor and enhanced IL-6-induced p-STAT3 signaling in articular cartilage, which may be caused by age-related loss of protective TGF-β3 signaling and suppression of IL-6R. This mechanism could contribute to age-related osteoarthritis development.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Neurosciences
Faezeh-sadat Khorram, Ali Mehdipour, Amir Moghadam-Ahmadi, Habib Farahmand, Azadeh Askari, Seyed Mohsen Moosavi, Ahmad Shabanizadeh, Masoumeh Parsi, Mohammad Kazemi Arababadi
Summary: This study showed that brain MRI without contrast can increase protein levels of IL-6 in the peripheral serum, but has no effect on IL-10, IL-17A, and TGF-beta levels. Participants with mild anxiety had higher IL-6 mRNA levels after MRI compared to those without anxiety.
