Metal-free radical C–H methylation of pyrimidinones and pyridinones with dicumyl peroxide

Copper-Catalyzed Coupling of Indoles with Dimethylformamide as a Methylenating Reagent

(2016) Fan Pu et al.   ADVANCED SYNTHESIS & CATALYSIS

Phenyltrimethylammonium Salts as Methylation Reagents in the Nickel-Catalyzed Methylation of C−H Bonds

(2016) Takeshi Uemura et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct regioselective Csp2–H trifluoromethylation of pyrimidinones and pyridinones

(2016) Pei-Zhi Zhang et al.   TETRAHEDRON

Recent Advances in Transition Metal-Catalyzed Methylation Reactions

(2015) Guobing Yan et al.   ADVANCED SYNTHESIS & CATALYSIS

Iron-Catalyzed Directed Alkylation of Alkenes and Arenes with Alkylzinc Halides

(2015) Laurean Ilies et al.   ADVANCED SYNTHESIS & CATALYSIS

Iron-Catalyzed C(sp2)H and C(sp3)H Methylations of Amides and Anilides

(2015) Karolina Graczyk et al.   CHEMISTRY-A EUROPEAN JOURNAL

Copper-Catalyzed Radical Methylation/C–H Amination/Oxidation Cascade for the Synthesis of Quinazolinones

(2015) Yajie Bao et al.   JOURNAL OF ORGANIC CHEMISTRY

Iron-Catalyzed Directed C(sp2)–H and C(sp3)–H Functionalization with Trimethylaluminum

(2015) Rui Shang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal-free methylation of a pyridine N-oxide C–H bond by using peroxides

(2015) Gang Li et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A novel 11C-labeled thymidine analog, [11C]AZT, for tumor imaging by positron emission tomography

(2015) Tsuyoshi Tahara et al.   EJNMMI Research

Manganese(iii)-mediated direct Csp2–H radical trifluoromethylation of coumarins with sodium trifluoromethanesulfinate

(2014) Xiao-Hui Cao et al.   CHEMICAL COMMUNICATIONS

The carbomethylation of arylacrylamides leading to 3-ethyl-3-substituted indolin-2-one by cascade radical addition/cyclization

(2014) Qiang Dai et al.   CHEMICAL COMMUNICATIONS

Metal-Free Multicomponent Syntheses of Pyridines

(2014) Christophe Allais et al.   CHEMICAL REVIEWS

tert-Butyl Peroxybenzoate-Promoted α-Methylation of 1,3-Dicarbonyl Compounds

(2014) Songjin Guo et al.   JOURNAL OF ORGANIC CHEMISTRY

C–H Methylation of Heteroarenes Inspired by Radical SAM Methyl Transferase

(2014) Jinghan Gui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Free-Radical Cascade Methylation/Cyclization of N-Arylacrylamides and Isocyanides with Dicumyl Peroxide

(2014) Zhengbao Xu et al.   ORGANIC LETTERS

Profound Methyl Effects in Drug Discovery and a Call for New CH Methylation Reactions

(2013) Heike Schönherr et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium(I)-Catalyzed Redox-Economic Cross-Coupling of Carboxylic Acids with Arenes Directed by N-Containing Groups

(2013) Fei Pan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium-Catalyzed Ketone Methylation Using Methanol Under Mild Conditions: Formation of α-Branched Products

(2013) Louis K. M. Chan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of pyrazole encompassing 2-pyridone derivatives as antibacterial agents

(2013) Nisheeth C. Desai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Controlled Oxygen Release from Pyridone Endoperoxides Promotes Cell Survival under Anoxic Conditions

(2013) Sebastian Benz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Copper-Catalyzed Methyl Esterification Reactions via C–C Bond Cleavage

(2013) Yan Zhu et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium-Catalyzed Picolinamide-Directed Alkylation of Unactivated C(sp3)–H Bonds with Alkyl Iodides

(2013) Shu-Yu Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereoselective Synthesis of β-Alkylated α-Amino Acids via Palladium-Catalyzed Alkylation of Unactivated Methylene C(sp3)–H Bonds with Primary Alkyl Halides

(2013) Shu-Yu Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DMF as Carbon Source: Rh-Catalyzed α-Methylation of Ketones

(2013) Yang Li et al.   ORGANIC LETTERS

Copper-Catalyzed N-Methylation of Amides and O-Methylation of Carboxylic Acids by Using Peroxides as the Methylating Reagents

(2013) Qinqin Xia et al.   ORGANIC LETTERS

Mild Palladium-Catalyzed C–H Alkylation Using Potassium Alkyltrifluoroborates in Combination with MnF3

(2013) Sharon R. Neufeldt et al.   ORGANIC LETTERS

Palladium-Catalyzed CH Oxidation of Isoquinoline N-Oxides: Selective Alkylation with Dialkyl Sulfoxides and Halogenation with Dihalo sulfoxides

(2012) Bo Yao et al.   ADVANCED SYNTHESIS & CATALYSIS

Direct Arylation/Alkylation/Magnesiation of Benzyl Alcohols in the Presence of Grignard Reagents via Ni-, Fe-, or Co-Catalyzed sp3 C–O Bond Activation

(2012) Da-Gang Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cu(OAc)2-Catalyzed Tandem Blaise/Pinner-Type Reaction for One-Pot Synthesis of Pyrimidin-4-ones

(2012) Yu Sung Chun et al.   ORGANIC LETTERS

Synthesis and biological evaluation of novel 5-alkyl-2-arylthio-6-((3,4-dihydroquinolin-1(2H)-yl)methyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

(2011) Jing Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Substituted N -aryl-6-pyrimidinones: A new class of potent, selective, and orally active p38 MAP kinase inhibitors

(2011) Balekudru Devadas et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ionic Liquid Catalyzed 4,6-Disubstituted-3-Cyano-2-Pyridone Synthesis Under Solvent-Free Conditions

(2011) Sunil S. Chavan et al.   CATALYSIS LETTERS

The Methylation Effect in Medicinal Chemistry

(2011) Eliezer J. Barreiro et al.   CHEMICAL REVIEWS

Palladium-Catalyzed Coupling of Arene C–H Bonds with Methyl- and Arylboron Reagents Assisted by the Removable 2-Pyridylsulfinyl Group

(2011) José A. Romero-Revilla et al.   JOURNAL OF ORGANIC CHEMISTRY

Vilsmeier Reaction of 3-Aminopropenamides: One-Pot Synthesis of Pyrimidin-4(3H)-ones

(2011) Rui Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Evaluation of α-Pyrones and Pyrimidones as Photoaffinity Probes for Affinity-Based Protein Profiling

(2011) Oliver A. Battenberg et al.   JOURNAL OF ORGANIC CHEMISTRY

Expedient Synthesis ofN-Acyl Anthranilamides and β-Enamine Amides by the Rh(III)-Catalyzed Amidation of Aryl and Vinyl C–H Bonds with Isocyanates

(2011) Kevin D. Hesp et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cobalt-Catalyzed Coupling of Alkyl Grignard Reagent with Benzamide and 2-Phenylpyridine Derivatives through Directed C–H Bond Activation under Air

(2011) Quan Chen et al.   ORGANIC LETTERS

Substrate-controlled chemoselective synthesis and potent cytotoxic activity of novel 5,6,7-triarylpyrido[2,3-d]pyrimidin-4-one derivatives

(2010) Feng Shi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

1,4-Diaza-bicyclo[2,2,2]octane as a Novel and Efficient Catalyst for the Synthesis of 3,4,6-Trisubstituted 2-Pyridone Derivatives

(2010) Majid M. Heravi et al.   CHINESE JOURNAL OF CHEMISTRY

One-Pot Synthesis of 4,6-Diaryl-2-oxo(imino)-1,2-dihydropyridine-3-carbonitrile; a New Scaffold for p38α MAP Kinase Inhibition

(2010) Aya M. Serry et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Titanium(IV) Isopropoxide Mediated Synthesis of Pyrimidin-4-ones

(2010) Joshi M. Ramanjulu et al.   ORGANIC LETTERS

Enzymology of Purine and Pyrimidine Antimetabolites Used in the Treatment of Cancer

(2009) William B. Parker   CHEMICAL REVIEWS

Discovery of colon tumor cell growth inhibitory agents through a combinatorial approach

(2009) Ashraf H. Abadi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

6,6′-Dimethyl-2,2′-bipyridine-4-ester: A pivotal synthon for building tethered bipyridine ligands

(2009) Fabien Havas et al.   TETRAHEDRON

A facile synthesis of pyrimidin-4-ones

(2009) Cheng Guo   TETRAHEDRON LETTERS

Palladium-Catalyzed Methylation of Aryl C−H Bond by Using Peroxides

(2008) Yuhua Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

One‐Pot Synthesis of 4,6‐Diaryl‐2‐oxo‐1,2‐dihydropyridine‐3‐carbonitriles via Three‐Component Cyclocondensation under Solvent‐Free Conditions

(2008) Liangce Rong et al.   SYNTHETIC COMMUNICATIONS