Sulfated glycosaminoglycans in protein aggregation diseases

Structural requirements of glycosaminoglycans for facilitating amyloid fibril formation of human serum amyloid A

(2016) Hiroka Takase et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Enzymatic remodeling of heparan sulfate: a therapeutic strategy for systemic and localized amyloidoses?

(2016) Kazuchika Nishitsuji et al.   Neural Regeneration Research

D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile

(2016) Sophie Valleix et al.   Nature Communications

Iowa Mutant Apolipoprotein A-I (ApoA-IIowa) Fibrils Target Lysosomes

(2016) Hirokazu Kameyama et al.   Scientific Reports

Microglial Keratan Sulfate Epitope Elicits in Central Nervous Tissues of Transgenic Model Mice and Patients with Amyotrophic Lateral Sclerosis

(2015) Tahmina Foyez et al.   AMERICAN JOURNAL OF PATHOLOGY

The polyphenol (−)-epigallocatechin-3-gallate prevents apoA-IIowaamyloidosisin vitroand protects human embryonic kidney 293 cells against amyloid cytotoxicity

(2015) Hiroyuki Nakajima et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer’s disease-related tau pathology

(2015) Julia Elisa Sepulveda-Diaz et al.   BRAIN

Heparan Sulfate Proteoglycans Are Important for Islet Amyloid Formation and Islet Amyloid Polypeptide-induced Apoptosis

(2015) Marie E. Oskarsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular Interaction and Cytotoxicity of the Iowa Mutation of Apolipoprotein A-I (ApoA-IIowa) Amyloid Mediated by Sulfate Moieties of Heparan Sulfate

(2015) Kaori Kuwabara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microglia and neuroprotection

(2015) Zhihong Chen et al.   JOURNAL OF NEUROCHEMISTRY

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

(2015) Renato V. Iozzo et al.   MATRIX BIOLOGY

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

New Roles of Glycosaminoglycans in α-Synuclein Aggregation in a Cellular Model of Parkinson Disease

(2015) Sonia Lehri-Boufala et al.   PLoS One

Divergent effect of glycosaminoglycans on the in vitro aggregation of serum amyloid A

(2014) J. Javier Aguilera et al.   BIOCHIMIE

Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity

(2014) J. Guan et al.   EMBO Molecular Medicine

Differential Effects on Light Chain Amyloid Formation Depend on Mutations and Type of Glycosaminoglycans

(2014) Luis M. Blancas-Mejía et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of Heparanase Lowers the Amyloid Burden in Amyloid-β Precursor Protein Transgenic Mice

(2014) Charlotte B. Jendresen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Postmortem findings in a case of variant Creutzfeldt-Jakob disease treated with intraventricular pentosan polysulfate

(2014) P. K. Newman et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Protein aggregation in amyotrophic lateral sclerosis

(2013) Anna M. Blokhuis et al.   ACTA NEUROPATHOLOGICA

Heparanase Regulates Secretion, Composition, and Function of Tumor Cell-derived Exosomes

(2013) Camilla A. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KSGal6ST Is Essential for the 6-Sulfation of Galactose within Keratan Sulfate in Early Postnatal Brain

(2013) Hitomi Hoshino et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Ablation of Keratan Sulfate Accelerates Early Phase Pathogenesis of ALS

(2013) Kenichi Hirano et al.   PLoS One

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

(2013) H. C. Christianson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biophysical Insights into How Surfaces, Including Lipid Membranes, Modulate Protein Aggregation Related to Neurodegeneration

(2013) Kathleen A. Burke et al.   Frontiers in Neurology

Heparan Sulfate Subdomains that are Degraded by Sulf Accumulate in Cerebral Amyloid ß Plaques of Alzheimer's Disease

(2012) Tomomi Hosono-Fukao et al.   AMERICAN JOURNAL OF PATHOLOGY

Heparan Sulfate Biosynthesis

(2012) Johan Kreuger et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Heparin Inhibits Membrane Interactions and Lipid-Induced Fibrillation of a Prion Amyloidogenic Determinant

(2011) Ehud Bazar et al.   CHEMBIOCHEM

Mechanism of Amylin Fibrillization Enhancement by Heparin

(2011) Suman Jha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-  Uptake

(2011) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

RB4CD12 epitope expression and heparan sulfate disaccharide composition in brain vasculature

(2011) Tomomi Hosono-Fukao et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Protease-resistant PrP and PrP oligomers in the brain in human prion diseases after intraventricular pentosan polysulfate infusion

(2011) Hiroyuki Honda et al.   NEUROPATHOLOGY

Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein

(2011) F. Noborn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transmembrane Signaling Proteoglycans

(2010) John R. Couchman   Annual Review of Cell and Developmental Biology

Sulf-2: an extracellular modulator of cell signaling and a cancer target candidate

(2010) Steven D Rosen et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Modulation of Aβ42 fibrillogenesis by glycosaminoglycan structure

(2010) Juan José Valle-Delgado et al.   FASEB JOURNAL

Heparan sulfate mediates amyloid-beta internalization and cytotoxicity

(2010) Elina Sandwall et al.   GLYCOBIOLOGY

Role of Glycosaminoglycan Sulfation in the Formation of Immunoglobulin Light Chain Amyloid Oligomers and Fibrils

(2010) Ruiyi Ren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipoprotein Lipase Is a Novel Amyloid β (Aβ)-binding Protein That Promotes Glycosaminoglycan-dependent Cellular Uptake of Aβ in Astrocytes

(2010) Kazuchika Nishitsuji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Abnormal post-translational and extracellular processing of brevican in plaque-bearing mice over-expressing APPsw

(2010) Joanne M. Ajmo et al.   JOURNAL OF NEUROCHEMISTRY

Glypican-1 facilitates prion conversion in lipid rafts

(2010) Nigel M. Hooper   JOURNAL OF NEUROCHEMISTRY

N-Acetylglucosamine 6-O-Sulfotransferase-1-Deficient Mice Show Better Functional Recovery after Spinal Cord Injury

(2010) Z. Ito et al.   JOURNAL OF NEUROSCIENCE

Glycosaminoglycan Sulphation Affects the Seeded Misfolding of a Mutant Prion Protein

(2010) Victoria A. Lawson et al.   PLoS One

Less protease-resistant PrP in a patient with sporadic CJD treated with intraventricular pentosan polysulphate

(2009) T. Terada et al.   ACTA NEUROLOGICA SCANDINAVICA

Sulfation of heparan sulfate associated with amyloid-β plaques in patients with Alzheimer’s disease

(2009) Ilona B. Bruinsma et al.   ACTA NEUROPATHOLOGICA

Amyloid β induces cellular relocalization and production of agrin and glypican-1

(2009) Nienke M. Timmer et al.   BRAIN RESEARCH

Heparan sulfate promotes the aggregation of HDL-associated serum amyloid A: evidence for a proamyloidogenic histidine molecular switch

(2009) Elena Elimova et al.   FASEB JOURNAL

Direct detection of HSulf-1 and HSulf-2 activities on extracellular heparan sulfate and their inhibition by PI-88

(2009) Md Motarab Hossain et al.   GLYCOBIOLOGY

Amyloid Formation by the Model Protein Muscle Acylphosphatase is Accelerated by Heparin and Heparan Sulphate Through a Scaffolding-based Mechanism

(2009) N. Motamedi-Shad et al.   JOURNAL OF BIOCHEMISTRY

Functional Consequences of the Subdomain Organization of the Sulfs

(2009) Renhong Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetic Analysis of Amyloid Formation in the Presence of Heparan Sulfate

(2009) Neda Motamedi-Shad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Continuous intraventricular infusion of pentosan polysulfate: Clinical trial against prion diseases

(2009) Yoshio Tsuboi et al.   NEUROPATHOLOGY

Aggregation and cytotoxic properties towards cultured cerebrovascular cells of Dutch-mutated Aβ40 (DAβ1-40) are modulated by sulfate moieties of heparin

(2009) Nienke M. Timmer et al.   NEUROSCIENCE RESEARCH

Identification of an Intracellular Site of Prion Conversion

(2009) Zrinka Marijanovic et al.   PLoS Pathogens

Cathepsin D Is the Main Lysosomal Enzyme Involved in the Degradation of α-Synuclein and Generation of Its Carboxy-Terminally Truncated Species†

(2008) Daniel Sevlever et al.   BIOCHEMISTRY

Cerebral Amyloid Angiopathy and Parenchymal Amyloid Deposition in Transgenic Mice Expressing the Danish Mutant Form of Human BRI2

(2008) Ruben Vidal et al.   BRAIN PATHOLOGY

Intraventricular pentosan polysulphate in human prion diseases: an observational study in the UK

(2008) I. Bone et al.   EUROPEAN JOURNAL OF NEUROLOGY

Sulfated Polysaccharides Promote the Assembly of Amyloid β1–42 Peptide into Stable Fibrils of Reduced Cytotoxicity

(2008) Ramona Bravo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two Faces of Chondroitin Sulfate Proteoglycan in Spinal Cord Repair: A Role in Microglia/Macrophage Activation

(2008) Asya Rolls et al.   PLOS MEDICINE