Review
Cell Biology
Jessica L. Fletcher, Kalina Makowiecki, Carlie L. Cullen, Kaylene M. Young
Summary: Oligodendrocytes play a crucial role in adding myelin sheaths to neurons, supporting axon health, and modulating neuronal function throughout cortical development and adulthood. They also have a lifelong impact on learning and memory, highlighting the importance of myelination in sustaining neural circuits and functions.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Wen Liu, Aaron R. Rohlman, Ryan Vetreno, Fulton T. Crews
Summary: The study found that adolescent binge drinking affects adult OL markers in PFC regions, while also impacting OPC marker expression; furthermore, these effects could lead to lasting changes in PFC function.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Clinical Neurology
Stefano C. Previtali
Summary: Nerve development requires coordinated events and steps, abnormalities during which may lead to peripheral neuropathy. This review focuses on the molecular mechanisms involved in radial sorting of axons, summarizing reported pathways and their interactions, as well as discussing how disruptions of these pathways can result in human neuropathies.
Article
Multidisciplinary Sciences
Xiaoqing Zhu, Yicheng Guo, Chu Chu, Dahai Liu, Kui Duan, Yu Yin, Chenyang Si, Yu Kang, Junjun Yao, Xuewei Du, Junliang Li, Shumei Zhao, Zongyong Ai, Qingyuan Zhu, Weizhi Ji, Yuyu Niu, Tianqing Li
Summary: This study found that BRN2 is a conserved gene that plays a key role in primate brain development. Through gene knockout experiments in cynomolgus monkeys, it was found that the absence of BRN2 leads to embryonic death before midgestation and has negative effects on brain development. Further analysis revealed that BRN2 is responsible for controlling the specification and differentiation of ganglionic eminences. Additionally, the study also found that BRN2 has a similar function in retinal ganglion cells of cynomolgus monkeys and humans.
Article
Multidisciplinary Sciences
Guyu Qin, Eun-Sil Park, Xueqing Chen, Sen Han, Dongxi Xiang, Fang Ren, Gang Liu, Huidong Chen, Guo-Cheng Yuan, Zhe Li
Summary: Epithelial ovarian cancer (EOC) can originate from either fallopian tube epithelial (FTE) or ovarian surface epithelial (OSE) cells, but they exhibit different latencies and disease outcomes. Single cell RNA-sequencing revealed that FTE secretory stem/progenitor cells resemble mammary luminal progenitors, while OSE cells resemble basal cells. Additionally, an FT stromal subpopulation may serve as a niche for FTE cells, while Lgr5(+) OSE cells may self-sustain as their own niche. The differences in intrinsic expression programs and niche organizations of FTE and OSE cells may contribute to the development of EOCs.
Article
Multidisciplinary Sciences
Jordan A. Munroe, Mubarak H. Syed, Chris Q. Doe
Summary: This study focuses on the mechanism of exiting quiescence in Drosophila brain neuroblasts, particularly type II neuroblasts. Researchers found that Insulin-like growth factor II mRNA-binding protein (Imp) plays an important role in the exit from quiescence in type II neuroblasts.
Article
Biology
Nadine Goldhammer, Jiyoung Kim, Rene Villadsen, Lone Ronnov-Jessen, Ole William Petersen
Summary: Single cell sequencing reveals heterogeneity in breast myoepithelial cells based on CD200 expression, with CD200-low cells exhibiting multipotency and CD200-high cells showing bipotency. This heterogeneity may have implications for the development and prevention of breast cancer.
COMMUNICATIONS BIOLOGY
(2022)
Article
Developmental Biology
Li He, Jennifer Jones, Weiguo He, Bryan C. Bjork, Jiayu Wen, Qi Dai
Summary: PRDM16 is a crucial transcriptional regulator that promotes the transition from early to late phase of neurogenesis in the mouse neocortex. It regulates a subset of genes involved in neuronal specification, cell cycle regulation, and neuronal migration by limiting chromatin accessibility of permissive enhancers. This study provides evidence to support the temporal shift in gene expression program of neural progenitors to achieve neural cell diversity.
Article
Clinical Neurology
Giuseppina Natale, Micol Colella, Maria De Carluccio, Daniele Lelli, Alessandra Paffi, Filippo Carducci, Francesca Apollonio, Daniela Palacios, Maria Teresa Viscomi, Micaela Liberti, Veronica Ghiglieri
Summary: This study reveals that intermittent theta-burst stimulation (iTBS) has specific effects on astrocytes, improving motor performance in rats with Parkinson's disease. Furthermore, numerical dosimetry and biological findings allow us to predict electrical stimulation induced in different brain areas and associate it with functional and molecular changes.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
TrangKimberly Thu Nguyen, Chad R. Camp, Juleva K. Doan, Stephen F. Traynelis, Steven A. Sloan, Randy A. Hall
Summary: GPR37L1, an astrocyte-specific G-protein coupled receptor, plays a crucial role in astrocyte maturation. Studies have shown that Gpr37L1 knockout mice have less mature astrocytic genes and exhibit altered morphology in astrocytes. This research highlights the mechanism of GPR37L1 in regulating astrocyte biology and maturation.
Article
Cell & Tissue Engineering
Sun-Li Cai, Yao-Shun Yang, Yan-Fu Ding, Shu-Hua Yang, Xi-Zheng Jia, Yun-Wen Gu, Chris Wood, Xue-Ting Huang, Jin-Shu Yang, Wei-Jun Yang
Summary: This study reveals the existence of long-lived deep quiescent NSCs in the adult murine brain and their role in brain development. SETD4, an epigenetic determinant of cellular quiescence, plays an important role in maintaining the quiescent state of NSCs. The findings suggest that SETD4 has a dual role in the maintenance and activation of NSCs, regulating neurogenesis.
Editorial Material
Developmental Biology
Alex Eve
Summary: Tom Nowakowski, an Assistant Professor at UCSF, utilizes single-cell sequencing technologies to investigate neurodevelopment. He is a Chan Zuckerberg Biohub Investigator and a Next Generation Leader at the Allen Institute for Brain Science. During our Zoom meeting, he discussed his career, transitioning into a group leader role, and his future plans.
Review
Neurosciences
Artem Sinegubov, Daria Andreeva, Nikita Burzak, Maria Vasyutina, Lada Murashova, Vyacheslav Dyachuk
Summary: This review highlights the heterogeneity of peripheral glial cell populations, covering the origin of the first glial precursors from neural crest cells to the diversity of embryonic glia and adult glial populations. The communication of glial cells with axons of neurons and potential therapeutic strategies for neurodiseases are also discussed.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Sitong Yang, Jingjing Ma, Han Zhang, Laiqiang Chen, Yuxuan Li, Mingtian Pan, Hongcheng Zhu, Jun Liang, Dajian He, Shihua Li, Xiao-Jiang Li, Xiangyu Guo
Summary: Huntington's disease (HD) is characterized by late-onset neurodegeneration caused by expanded CAG repeats in the huntingtin gene (HTT). This study investigated whether mutant HTT affects the development of glial cells during early brain development. The results showed that the numbers of astrocytes and oligodendrocytes in postnatal HD KI mice were not significantly altered compared to wild type (WT) mice, but myelin protein expression was reduced at 3 months of age. These findings suggest that cytoplasmic mutant HTT mediates myelination defects in the early stages of HD without impacting glial cell differentiation and maturation.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Aline Timmermann, Dario Tascio, Ronald Jabs, Anne Boehlen, Catia Domingos, Magdalena Skubal, Wenhui Huang, Frank Kirchhoff, Christian Henneberger, Andras Bilkei-Gorzo, Gerald Seifert, Christian Steinhaeuser
Summary: NG2 glia is a unique type of macroglial cells in the CNS that receive synaptic input from neurons. Dysfunction in NG2 glia has been found to improve spatial memory but has no effect on social memory. Loss of the K+ channel Kir4.1 in NG2 glia leads to enhanced synaptic depolarizations and expression of myelin basic protein in the hippocampus. Targeted deletion of the K+ channel in NG2 glia impairs long-term potentiation at CA3-CA1 synapses, which can be rescued by extracellular application of a TrkB receptor agonist. These findings highlight the importance of proper NG2 glia function in brain function and behavior.
Article
Genetics & Heredity
Mariana Malvicini, Jorge B. Aquino, Guillermo Mazzolini
CURRENT GENE THERAPY
(2015)
Article
Biotechnology & Applied Microbiology
Mariana Malvicini, Esteban Fiore, Valentina Ghiaccio, Flavia Piccioni, Miguel Rizzo, Lucila Olmedo Bonadeo, Mariana Garcia, Marcelo Rodriguez, Juan Bayo, Estanislao Peixoto, Catalina Atorrasagasti, Laura Alaniz, Jorge Aquino, Pablo Matar, Guillermo Mazzolini
Article
Cell & Tissue Engineering
Esteban J. Fiore, Juan M. Bayo, Mariana G. Garcia, Mariana Malvicini, Rodrigo Lloyd, Flavia Piccioni, Manglio Rizzo, Estanislao Peixoto, M. Beatriz Sola, Catalina Atorrasagasti, Laura Alaniz, Maria A. Camilletti, Monica Enguita, Jesus Prieto, Jorge B. Aquino, Guillermo Mazzolini
STEM CELLS AND DEVELOPMENT
(2015)
Article
Cell & Tissue Engineering
Esteban J. Fiore, Guillermo Mazzolini, Jorge B. Aquino
STEM CELL REVIEWS AND REPORTS
(2015)
Article
Cell & Tissue Engineering
Esteban Fiore, Mariana Malvicini, Juan Bayo, Estanislao Peixoto, Catalina Atorrasagasti, Romina Sierra, Marcelo Rodriguez, Sofia Gomez Bustillo, Mariana G. Garcia, Jorge B. Aquino, Guillermo Mazzolini
STEM CELL RESEARCH & THERAPY
(2016)
Review
Cell & Tissue Engineering
Jorge B. Aquino
STEM CELLS AND DEVELOPMENT
(2017)
Article
Biochemistry & Molecular Biology
E. Peixoto, C. Atorrasagasti, J. B. Aquino, R. Militello, J. Bayo, E. Fiore, F. Piccioni, E. Salvatierra, L. Alaniz, M. G. Garcia, R. Bataller, F. Corrales, M. Gidekel, O. Podhajcer, M. I. Colombo, G. Mazzolini
Article
Gastroenterology & Hepatology
Fernando J. Barreyro, Silvia Holod, Paola V. Finocchietto, Alejandra M. Camino, Jorge B. Aquino, Alejandra Avagnina, Maria C. Carreras, Juan J. Poderoso, Gregory J. Gores
LIVER INTERNATIONAL
(2015)
Article
Neurosciences
Graciela Lujan Mazzone, Atiyeh Mohammadshirazi, Jorge Benjamin Aquino, Andrea Nistri, Giuliano Taccola
Summary: Correct operation of neuronal networks depends on the interplay between synaptic excitation and inhibition processes leading to a dynamic state termed balanced network. In the spinal cord, balanced network activity is fundamental for the expression of locomotor patterns necessary for rhythmic activation of limb extensor and flexor muscles. The role of GABA A receptors at synaptic and extrasynaptic level to modulate network excitability offers a pharmacological target for symptom control.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Developmental Biology
Jorge B. Aquino, Romina Sierra, Laura A. Montaldo
Summary: The origin and renewal of vascular endothelial cells primarily depend on local resident cells and endothelial progenitor cells. Research shows that some cells can generate endothelial-like cells, with mesenchymal stromal progenitors being a source. Different subpopulations of bone marrow stromal cells exhibit unexpected heterogeneity.
DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jaspreet Kaur, Graciela L. Mazzone, Jorge B. Aquino, Andrea Nistri
Summary: The study found that high dose nicotine was neurotoxic to central and ventral spinal neurons, while low dose nicotine protected neurons and activated the Wnt1 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Developmental Biology
Antonella S. Rios, Ana Paula De Vincenti, Mailin Casadei, Jorge B. Aquino, Pablo R. Brumovsky, Gustavo Paratcha, Fernanda Ledda
Summary: The transcription factor Etv4 plays a crucial role in the development and function of peptidergic sensory neurons. It is regulated by NGF and is involved in the expression of genes associated with extracellular matrix remodeling. Etv4-null mice show reduced sensitivity to noxious stimuli and a decrease in the expression of the pain-transducing ion channel TRPV1.
Review
Neurosciences
Maximiliano Borda, Jorge B. Aquino, Graciela L. Mazzone
Summary: This review article discusses therapeutic strategies for inducing myelin repair and improving multiple sclerosis (MS), including the application of different cell types and new strategies combining cell-based treatment with other applications. The treatments using different cell sources yielded different results in experimental models and have their own advantages and disadvantages.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Medicine, General & Internal
Esteban Fiore, Eduardo Picazo, Jorge Aquino, Guillermo Mazzolini
MEDICINA-BUENOS AIRES
(2017)