Genome-wide TOP2A DNA cleavage is biased toward translocated and highly transcribed loci

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Chemical profiling of the genome with anti-cancer drugs defines target specificities

(2015) Baoxu Pang et al.   Nature Chemical Biology

Topoisomerase II and leukemia

(2014) MaryJean Pendleton et al.   Annals of the New York Academy of Sciences

DNA Break Mapping Reveals Topoisomerase II Activity Genome-Wide

(2014) Laura Baranello et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2·DNA and Top2·RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)

(2014) Rui Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

WTAP is a novel oncogenic protein in acute myeloid leukemia

(2014) H Bansal et al.   LEUKEMIA

Defining functional DNA elements in the human genome

(2014) M. Kellis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The MLL recombinome of acute leukemias in 2013

(2013) C Meyer et al.   LEUKEMIA

BAF complexes facilitate decatenation of DNA by topoisomerase IIα

(2013) Emily C. Dykhuizen et al.   NATURE

Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing

(2013) Nicola Crosetto et al.   NATURE METHODS

Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures

(2013) Catherine Naughton et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transcription-dependent dynamic supercoiling is a short-range genomic force

(2013) Fedor Kouzine et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Gene regulation and priming by topoisomerase IIα in embryonic stem cells

(2013) Sudhir Thakurela et al.   Nature Communications

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

The accessible chromatin landscape of the human genome

(2012) Robert E. Thurman et al.   NATURE

Topoisomerase II is required for the production of long Pol II gene transcripts in yeast

(2012) Ricky S. Joshi et al.   NUCLEIC ACIDS RESEARCH

Model for MLL translocations in therapy-related leukemia involving topoisomerase II -mediated DNA strand breaks and gene proximity

(2012) I. G. Cowell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA cleavage and opening reactions of human topoisomerase II  are regulated via Mg2+-mediated dynamic bending of gate-DNA

(2012) S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Target genes of Topoisomerase II  regulate neuronal survival and are defined by their chromatin state

(2012) V. K. Tiwari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Hierarchical Combination of Factors Shapes the Genome-wide Topography of Yeast Meiotic Recombination Initiation

(2011) Jing Pan et al.   CELL

Topoisomerase II binds nucleosome-free DNA and acts redundantly with topoisomerase I to enhance recruitment of RNA Pol II in budding yeast

(2011) A. S. Sperling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-resolution profiling of γH2AX around DNA double strand breaks in the mammalian genome

(2010) Jason S Iacovoni et al.   EMBO JOURNAL

Reciprocal intronic and exonic histone modification regions in humans

(2010) Jason T Huff et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Histone H3K27ac separates active from poised enhancers and predicts developmental state

(2010) M. P. Creyghton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Numerical Analysis of Etoposide Induced DNA Breaks

(2009) Aida Muslimović et al.   PLoS One

RE: INVITED COMMENTARY: STRESS AND MORTALITY

(2008)   AMERICAN JOURNAL OF EPIDEMIOLOGY

Prospective tracing of MLL-FRYL clone with low MEIS1 expression from emergence during neuroblastoma treatment to diagnosis of myelodysplastic syndrome

(2008) B. W. Robinson et al.   BLOOD

Identification of a potential “hotspot” DNA region in theRUNX1gene targeted by mitoxantrone in therapy-related acute myeloid leukemia with t(16;21) translocation

(2008) Tiziana Ottone et al.   GENES CHROMOSOMES & CANCER

Topoisomerase IIβ Activates a Subset of Neuronal Genes that Are Repressed in AT-Rich Genomic Environment

(2008) Kuniaki Sano et al.   PLoS One