Epigenetic germline inheritance in mammals: looking to the past to understand the future

Transgenerational epigenetics: Integrating soma to germline communication with gametic inheritance

(2017) Abhay Sharma   MECHANISMS OF AGEING AND DEVELOPMENT

Adipose-derived circulating miRNAs regulate gene expression in other tissues

(2017) Thomas Thomou et al.   NATURE

A guide to designing germline-dependent epigenetic inheritance experiments in mammals

(2017) Johannes Bohacek et al.   NATURE METHODS

A Matter of Time: Small RNAs Regulate the Duration of Epigenetic Inheritance

(2017) Leah Houri-Zeevi et al.   TRENDS IN GENETICS

MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression

(2017) Yun Teng et al.   Nature Communications

SpermBase: A Database for Sperm-Borne RNA Contents

(2016) A. Schuster et al.   BIOLOGY OF REPRODUCTION

tRNA fragments: novel players in intergenerational inheritance

(2016) Katharina Gapp et al.   CELL RESEARCH

Resetting Epigenetic Memory by Reprogramming of Histone Modifications in Mammals

(2016) Hui Zheng et al.   MOLECULAR CELL

Transgenerational transmission and modification of pathological traits induced by prenatal immune activation

(2016) U Weber-Stadlbauer et al.   MOLECULAR PSYCHIATRY

Epigenetic germline inheritance of diet-induced obesity and insulin resistance

(2016) Peter Huypens et al.   NATURE GENETICS

Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications

(2016) Qi Chen et al.   NATURE REVIEWS GENETICS

Dysregulation of a family of short noncoding RNAs, tsRNAs, in human cancer

(2016) Yuri Pekarsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early-life nutrition modulates the epigenetic state of specific rDNA genetic variants in mice

(2016) Michelle L. Holland et al.   SCIENCE

Transgenerational inheritance: Models and mechanisms of non-DNA sequence-based inheritance

(2016) E. A. Miska et al.   SCIENCE

Elevated paternal glucocorticoid exposure alters the small noncoding RNA profile in sperm and modifies anxiety and depressive phenotypes in the offspring

(2016) A K Short et al.   Translational Psychiatry

High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring

(2016) Thais de Castro Barbosa et al.   Molecular Metabolism

Sperm microRNA Content Is Altered in a Mouse Model of Male Obesity, but the Same Suite of microRNAs Are Not Altered in Offspring’s Sperm

(2016) Tod Fullston et al.   PLoS One

Characterisation of mouse epididymosomes reveals a complex profile of microRNAs and a potential mechanism for modification of the sperm epigenome

(2016) Jackson N. Reilly et al.   Scientific Reports

The protein and transcript profiles of human semen

(2015) Meritxell Jodar et al.   CELL AND TISSUE RESEARCH

Mitochondrial dysfunction in oocytes of obese mothers: transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitors

(2015) L. L. Wu et al.   DEVELOPMENT

Genetic and Epigenetic Variation, but Not Diet, Shape the Sperm Methylome

(2015) Jeremy M. Shea et al.   DEVELOPMENTAL CELL

Environmentally induced epigenetic transgenerational inheritance of sperm epimutations promote genetic mutations

(2015) Michael K Skinner et al.   Epigenetics

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

(2015) Sonia A. Melo et al.   NATURE

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

Efficient and quantitative high-throughput tRNA sequencing

(2015) Guanqun Zheng et al.   NATURE METHODS

ARM-seq: AlkB-facilitated RNA methylation sequencing reveals a complex landscape of modified tRNA fragments

(2015) Aaron E Cozen et al.   NATURE METHODS

Molecular insights into transgenerational non-genetic inheritance of acquired behaviours

(2015) Johannes Bohacek et al.   NATURE REVIEWS GENETICS

The effects of chromatin organization on variation in mutation rates in the genome

(2015) Kateryna D. Makova et al.   NATURE REVIEWS GENETICS

Technologies to probe functions and mechanisms of long noncoding RNAs

(2015) Ci Chu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress

(2015) Ali B. Rodgers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The small RNA content of human sperm reveals pseudogene-derived piRNAs complementary to protein-coding genes

(2015) Lorena Pantano et al.   RNA

Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

(2015) Q. Chen et al.   SCIENCE

Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

(2015) U. Sharma et al.   SCIENCE

Environmentally induced epigenetic transgenerational inheritance of disease susceptibility

(2015) Eric E. Nilsson et al.   Translational Research

Transgenerational epigenetic inheritance requires a much deeper analysis

(2015) Abhay Sharma   TRENDS IN MOLECULAR MEDICINE

Technologies to probe functions and mechanisms of long noncoding RNAs

(2015) Ci Chu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Breeding scheme and maternal small RNAs affect the efficiency of transgenerational inheritance of a paramutation in mice

(2015) Shuiqiao Yuan et al.   Scientific Reports

Pre-reproductive maternal enrichment influences rat maternal care and offspring developmental trajectories: behavioral performances and neuroplasticity correlates

(2015) Debora Cutuli et al.   Frontiers in Behavioral Neuroscience

Transgenerational Inheritance of Diet-Induced Genome Rearrangements in Drosophila

(2015) John C. Aldrich et al.   PLoS Genetics

RNA-mediated paternal heredity of diet-induced obesity and metabolic disorders

(2015) Valérie Grandjean et al.   Scientific Reports

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Transgenerational Epigenetic Inheritance: Myths and Mechanisms

(2014) Edith Heard et al.   CELL

Neonatal Insulin Action Impairs Hypothalamic Neurocircuit Formation in Response to Maternal High-Fat Feeding

(2014) Merly C. Vogt et al.   CELL

Pre-gestational vs gestational exposure to maternal obesity differentially programs the offspring in mice

(2014) Isaac E. Sasson et al.   DIABETOLOGIA

Transgenerationally inherited piRNAs trigger piRNA biogenesis by changing the chromatin of piRNA clusters and inducing precursor processing

(2014) Adrien Le Thomas et al.   GENES & DEVELOPMENT

Environmental epigenetic inheritance through gametes and implications for human reproduction

(2014) Yanchang Wei et al.   HUMAN REPRODUCTION UPDATE

Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

(2014) Katharina Gapp et al.   NATURE NEUROSCIENCE

The role of genomic imprinting in biology and disease: an expanding view

(2014) Jo Peters   NATURE REVIEWS GENETICS

Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions

(2014) L. Vojtech et al.   NUCLEIC ACIDS RESEARCH

High Fat Diet and In Utero Exposure to Maternal Obesity Disrupts Circadian Rhythm and Leads to Metabolic Programming of Liver in Rat Offspring

(2014) Sarah J. Borengasser et al.   PLoS One

Pesticide Methoxychlor Promotes the Epigenetic Transgenerational Inheritance of Adult-Onset Disease through the Female Germline

(2014) Mohan Manikkam et al.   PLoS One

Defining functional DNA elements in the human genome

(2014) M. Kellis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism

(2014) E. J. Radford et al.   SCIENCE

Epigenetic Control of the Genome—Lessons from Genomic Imprinting

(2014) Bjorn Adalsteinsson et al.   Genes

Transgenerational inheritance of non-genetically determined phenotypes

(2013) Michelle L. Holland et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Genome differentiation in a species pair of coregonine fishes: an extremely rapid speciation driven by stress-activated retrotransposons mediating extensive ribosomal DNA multiplications

(2013) Radka Symonová et al.   BMC EVOLUTIONARY BIOLOGY

Mutation in Folate Metabolism Causes Epigenetic Instability and Transgenerational Effects on Development

(2013) Nisha Padmanabhan et al.   CELL

Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content

(2013) Tod Fullston et al.   FASEB JOURNAL

The presence, role and clinical use of spermatozoal RNAs

(2013) Meritxell Jodar et al.   HUMAN REPRODUCTION UPDATE

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Paternal Stress Exposure Alters Sperm MicroRNA Content and Reprograms Offspring HPA Stress Axis Regulation

(2013) A. B. Rodgers et al.   JOURNAL OF NEUROSCIENCE

Richness of human gut microbiome correlates with metabolic markers

(2013) Emmanuelle Le Chatelier et al.   NATURE

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

Environmentally Induced Epigenetic Transgenerational Inheritance of Altered Sertoli Cell Transcriptome and Epigenome: Molecular Etiology of Male Infertility

(2013) Carlos Guerrero-Bosagna et al.   PLoS One

Epididymosomes, prostasomes, and liposomes: their roles in mammalian male reproductive physiology

(2013) Robert Sullivan et al.   REPRODUCTION

RNA–Mediated Epigenetic Heredity Requires the Cytosine Methyltransferase Dnmt2

(2013) Jafar Kiani et al.   PLoS Genetics

piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans

(2012) Alyson Ashe et al.   CELL

A novel class of tRNA-derived small RNAs extremely enriched in mature mouse sperm

(2012) Hongying Peng et al.   CELL RESEARCH

Maternal High-Fat Diet During Gestation or Suckling Differentially Affects Offspring Leptin Sensitivity and Obesity

(2012) B. Sun et al.   DIABETES

Erratum: Corrigendum: Multigenerational epigenetic adaptation of the hepatic wound-healing response

(2012) Müjdat Zeybel et al.   NATURE MEDICINE

Understanding transgenerational epigenetic inheritance via the gametes in mammals

(2012) Lucia Daxinger et al.   NATURE REVIEWS GENETICS

Epigenetic Inheritance of Disease and Disease Risk

(2012) Johannes Bohacek et al.   NEUROPSYCHOPHARMACOLOGY

Genomic Hypomethylation in the Human Germline Associates with Selective Structural Mutability in the Human Genome

(2012) Jian Li et al.   PLoS Genetics

Major Chromosomal Breakpoint Intervals in Breast Cancer Co-Localize with Differentially Methylated Regions

(2012) Man-Hung Tang et al.   Frontiers in Oncology

Transgenerational effects of infantile adversity and enrichment in male and female rats

(2011) Micah Leshem et al.   DEVELOPMENTAL PSYCHOBIOLOGY

Maternal Obesity Promotes a Proinflammatory Signature in Rat Uterus and Blastocyst

(2011) Kartik Shankar et al.   ENDOCRINOLOGY

Exploiting CpG Hypermutability to Identify Phenotypically Significant Variation Within Human Protein-Coding Genes

(2011) Hua Ying et al.   Genome Biology and Evolution

What does it take to make a developmentally competent mammalian egg?

(2011) M. Zuccotti et al.   HUMAN REPRODUCTION UPDATE

Cleavage of rRNA ensures translational cessation in sperm at fertilization

(2011) G.D. Johnson et al.   MOLECULAR HUMAN REPRODUCTION

MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins

(2011) Kasey C. Vickers et al.   NATURE CELL BIOLOGY

Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma

(2011) J. D. Arroyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role for piRNAs and Noncoding RNA in de Novo DNA Methylation of the Imprinted Mouse Rasgrf1 Locus

(2011) T. Watanabe et al.   SCIENCE

Inheritable Effect of Unpredictable Maternal Separation on Behavioral Responses in Mice

(2011) Isabelle C. Weiss et al.   Frontiers in Behavioral Neuroscience

Long-lasting and transgenerational effects of an environmental enrichment on memory formation

(2010) Junko A. Arai et al.   BRAIN RESEARCH BULLETIN

Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

(2010) Benjamin R. Carone et al.   CELL

Maternal Diet-Induced Obesity Alters Mitochondrial Activity and Redox Status in Mouse Oocytes and Zygotes

(2010) Natalia Igosheva et al.   PLoS One

Epigenetic Transgenerational Actions of Vinclozolin on Promoter Regions of the Sperm Epigenome

(2010) Carlos Guerrero-Bosagna et al.   PLoS One

Functional delivery of viral miRNAs via exosomes

(2010) D. M. Pegtel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic transgenerational actions of environmental factors in disease etiology

(2010) Michael K. Skinner et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The miR-124-Sox9 paramutation: RNA-mediated epigenetic control of embryonic and adult growth

(2009) V. Grandjean et al.   DEVELOPMENT

Distinctive chromatin in human sperm packages genes for embryo development

(2009) Saher Sue Hammoud et al.   NATURE

RNA Induction and Inheritance of Epigenetic Cardiac Hypertrophy in the Mouse

(2008) Kay D. Wagner et al.   DEVELOPMENTAL CELL

RNAs as extracellular signaling molecules

(2008) Marcel E Dinger et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY