Hyperactive mTOR and MNK1 phosphorylation of eIF4E confer tamoxifen resistance and estrogen independence through selective mRNA translation reprogramming

Embryonic transcription factor SOX9 drives breast cancer endocrine resistance

(2017) Rinath Jeselsohn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acquired Tamoxifen Resistance in MCF-7 Breast Cancer Cells Requires Hyperactivation of eIF4F-Mediated Translation

(2017) Dedra H. Fagan et al.   Hormones & Cancer

mTOR inhibitors counteract tamoxifen-induced activation of breast cancer stem cells

(2015) Govindasamy-Muralidharan Karthik et al.   CANCER LETTERS

Targeting the eIF4F Translation Initiation Complex: A Critical Nexus for Cancer Development

(2015) J. Pelletier et al.   CANCER RESEARCH

Differential Requirements for eIF4E Dose in Normal Development and Cancer

(2015) Morgan L. Truitt et al.   CELL

Subnuclear domain proteins in cancer cells support the functions of RUNX2 in the DNA damage response

(2015) S. Yang et al.   JOURNAL OF CELL SCIENCE

Eukaryotic Translation Initiation Factor 4E Is a Feed-Forward Translational Coactivator of Transforming Growth Factor β Early Protransforming Events in Breast Epithelial Cells

(2015) Lindsey Decarlo et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting the translation machinery in cancer

(2015) Mamatha Bhat et al.   NATURE REVIEWS DRUG DISCOVERY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Runx2 contributes to the regenerative potential of the mammary epithelium

(2015) Nicola Ferrari et al.   Scientific Reports

Acquired Resistance to Endocrine Treatments Is Associated with Tumor-Specific Molecular Changes in Patient-Derived Luminal Breast Cancer Xenografts

(2014) P. Cottu et al.   CLINICAL CANCER RESEARCH

RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland

(2014) L. McDonald et al.   Disease Models & Mechanisms

A molecular model for the mechanism of acquired tamoxifen resistance in breast cancer

(2014) Ping Fan et al.   EUROPEAN JOURNAL OF CANCER

RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

(2014) Andrew L. Wolfe et al.   NATURE

eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies

(2014) Lise Boussemart et al.   NATURE

Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3

(2014) N Robichaud et al.   ONCOGENE

The Oncogenic STP Axis Promotes Triple-Negative Breast Cancer via Degradation of the REST Tumor Suppressor

(2014) Kristen L. Karlin et al.   Cell Reports

Genomic occupancy of Runx2 with global expression profiling identifies a novel dimension to control of osteoblastogenesis

(2014) Hai Wu et al.   GENOME BIOLOGY

Overcoming acquired resistance to anticancer therapy: focus on the PI3K/AKT/mTOR pathway

(2013) Howard A. Burris   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The p53-Estrogen Receptor Loop in Cancer

(2013) C. Berger et al.   CURRENT MOLECULAR MEDICINE

Tamoxifen resistance: From bench to bedside

(2013) Marjolein Droog et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Dual mTORC1/2 inhibition in a preclinical xenograft tumor model of endometrial cancer

(2013) Sharmilee Bansal Korets et al.   GYNECOLOGIC ONCOLOGY

Calcitriol reduces thrombospondin-1 and increases vascular endothelial growth factor in breast cancer cells: Implications for tumor angiogenesis

(2013) Janice García-Quiroz et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Activation of Akt, mTOR, and the estrogen receptor as a signature to predict tamoxifen treatment benefit

(2012) Josefine Bostner et al.   BREAST CANCER RESEARCH AND TREATMENT

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

The translational landscape of mTOR signalling steers cancer initiation and metastasis

(2012) Andrew C. Hsieh et al.   NATURE

The RUNX family in breast cancer: relationships with estrogen signaling

(2012) N-O Chimge et al.   ONCOGENE

DNA damage and eIF4G1 in breast cancer cells reprogram translation for survival and DNA repair mRNAs

(2012) M. Badura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex

(2012) Atsushi Sato et al.   Nature Communications

Therapeutic Inhibition of MAP Kinase Interacting Kinase Blocks Eukaryotic Initiation Factor 4E Phosphorylation and Suppresses Outgrowth of Experimental Lung Metastases

(2011) B. W. Konicek et al.   CANCER RESEARCH

Translational Control by the Eukaryotic Ribosome

(2011) Ivan Topisirovic et al.   CELL

Phosphatidylinositol 3-Kinase and Antiestrogen Resistance in Breast Cancer

(2011) Todd W. Miller et al.   JOURNAL OF CLINICAL ONCOLOGY

Everolimus in Postmenopausal Hormone-Receptor–Positive Advanced Breast Cancer

(2011) José Baselga et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms of Endocrine Resistance in Breast Cancer

(2010) C. Kent Osborne et al.   Annual Review of Medicine

Runx2 in normal tissues and cancer cells: A developing story

(2010) Karen Blyth et al.   BLOOD CELLS MOLECULES AND DISEASES

MCF-7 breast cancer cells selected for tamoxifen resistance acquire new phenotypes differing in DNA content, phospho-HER2 and PAX2 expression, and rapamycin sensitivity

(2010) Euphemia Leung et al.   CANCER BIOLOGY & THERAPY

The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survival

(2010) Matthew J. Wheater et al.   CANCER BIOLOGY & THERAPY

Genetic Dissection of the Oncogenic mTOR Pathway Reveals Druggable Addiction to Translational Control via 4EBP-eIF4E

(2010) Andrew C. Hsieh et al.   CANCER CELL

High Levels of Hsp90 Cochaperone p23 Promote Tumor Progression and Poor Prognosis in Breast Cancer by Increasing Lymph Node Metastases and Drug Resistance

(2010) N. E. Simpson et al.   CANCER RESEARCH

Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor–positive human breast cancer

(2010) Todd W. Miller et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitotic Raptor Promotes mTORC1 Activity, G2/M Cell Cycle Progression, and Internal Ribosome Entry Site-Mediated mRNA Translation

(2010) F. Ramirez-Valle et al.   MOLECULAR AND CELLULAR BIOLOGY

Adaptive changes results in activation of alternate signaling pathways and resistance to aromatase inhibitor resistance

(2010) Gauri Sabnis et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

mTOR signaling and drug development in cancer

(2010) Janet Dancey   Nature Reviews Clinical Oncology

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Eukaryotic Initiation Factor 4E Binding Protein Family of Proteins: Sentinels at a Translational Control Checkpoint in Lung Tumor Defense

(2009) Y. Y. Kim et al.   CANCER RESEARCH

Ectopic Runx2 Expression in Mammary Epithelial Cells Disrupts Formation of Normal Acini Structure: Implications for Breast Cancer Progression

(2009) J. Pratap et al.   CANCER RESEARCH

mTOR/S6K1 and MAPK/RSK signaling pathways coordinately regulate estrogen receptor α serine 167 phosphorylation

(2009) Rachel L. Yamnik et al.   FEBS LETTERS

Regulation of Protein Synthesis by Ionizing Radiation

(2009) S. Braunstein et al.   MOLECULAR AND CELLULAR BIOLOGY

An oestrogen-receptor-α-bound human chromatin interactome

(2009) Melissa J. Fullwood et al.   NATURE

Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer

(2009) Deborah Silvera et al.   NATURE CELL BIOLOGY

Tamoxifen Resistance in Breast Tumors Is Driven by Growth Factor Receptor Signaling with Repression of Classic Estrogen Receptor Genomic Function

(2008) S. Massarweh et al.   CANCER RESEARCH

Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells

(2008) Andrea Bianchini et al.   CARCINOGENESIS

eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy

(2008) Francisco Ramírez-Valle et al.   JOURNAL OF CELL BIOLOGY

MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages

(2007) Robert M. Rowlett et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY