Article
Oncology
Shizhao Cheng, Lei Yang, Xin Dai, Jing Wang, Xingpeng Han
Summary: The incidence of brain metastases in esophageal cancer patients is rare, with a prognosis of only 5 months. Both bone and lung metastases are significant factors for the development and prognosis of brain metastases. Various clinical characteristics, such as age, race, tumor location, histology subtype, and metastases sites, are associated with the occurrence of brain metastases in esophageal cancer patients. The nomogram is a reliable tool for predicting brain metastases.
Article
Oncology
Natalie Kuesters, Katharina Grupp, Julia-Kristin Grass, Kai Bachmann, Tarik Ghadban, Faik G. Uzunoglu, Michael Tachezy, Daniel Perez, Matthias Reeh, Jakob R. Izbicki, Nathaniel Melling
Summary: The role of CD147 as a prognostic factor in esophageal cancer remains controversial. This study found that CD147 expression was not associated with prognosis in both esophageal adenocarcinoma and squamous cell carcinoma.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Weidong Wang, Danhong Dong, Pengfei Yu, Tong Chen, Ruiqi Gao, Jiangpeng Wei, Zhenchang Mo, Haikun Zhou, Qinchuan Yang, Chao Yue, Xisheng Yang, Xiaohua Li, Gang Ji
Summary: This study successfully established an m6A-related lncRNA prognostic risk model for esophageal cancer, which can accurately predict the prognosis of patients. Analysis of ceRNA network, PPI network, as well as GO and KEGG pathways, provided insights into the underlying mechanisms and functions, guiding potential therapeutic strategies. Additionally, immunotherapy responses were found to be better in the low-risk subgroup of patients, showing the potential benefits of checkpoint immunotherapy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Caiyu Guo, Fanye Zeng, Hui Liu, Jianlin Wang, Xue Huang, Judong Luo
Summary: This study established a prognostic model based on eight immune-related genes for predicting the prognosis of esophageal cancer patients.
FRONTIERS IN GENETICS
(2022)
Article
Multidisciplinary Sciences
Mamiko Sato, Satoshi Tamauchi, Kosuke Yoshida, Masato Yoshihara, Yoshiki Ikeda, Nobuhisa Yoshikawa, Hiroaki Kajiyama
Summary: Magnetic resonance imaging (MRI) is used for pretreatment staging in cervical cancer. This study categorized patients into clear and unclear tumor border groups based on MRI images and assessed their prognosis. The unclear tumor border group was associated with higher rates of recurrence, lymphovascular space invasion, lymph node metastasis, and vimentin positivity compared to the clear tumor border group. Although there was no significant difference in recurrence-free survival, the unclear tumor border group had significantly poorer overall survival.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, General & Internal
Chunfang Tian, Haiyan Jing, Caixia Wang, Weibo Wang, Yangang Cui, Jianpeng Chen, Dan Sha
Summary: High TIL density in H&E-stained sections is associated with better overall survival and less aggressive clinicopathological characteristics in patients with gastric cancer. However, TIL density was not correlated with age, gender, Lauren classification, or histological grade.
Article
Immunology
Huimei Wang, Yiping Zhang, Lin Chen, Yufeng Liu, Chen Xu, Dongxian Jiang, Qi Song, Haixing Wang, Liyan Wang, Yu Lin, Yuanmei Chen, Junqiang Chen, Yuanji Xu, Yingyong Hou
Summary: This study found significant differential expression of most of the 23 regulators in ESCA tissues. LASSO regression analysis identified 7 m6A-related factors, and the risk model was associated with biological functions such as base metabolism, DNA repair, and mismatch repair. A nomogram was created to predict the prognosis of ESCA patients, and bioinformatics analysis of human ESCA and normal tissues was performed using qRT-PCR.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Xiaoling Xu, Ding Wang, Na Li, Jiamin Sheng, Mingying Xie, Zichao Zhou, Guoping Cheng, Yun Fan
Summary: Esophageal carcinoma (EC) is a significant cause of cancer-related mortality globally. Studying the tumor microenvironment (TME) and its associations with pathology and prognosis can provide insights into prognostic prediction mechanisms as well as potential targets for immunotherapy in EC treatment. Results from transcriptomic profiles of EC patients revealed TME-related genes, such as allograft inflammatory factor 1 (AIF1), as promising prognostic factors. Additionally, AIF1 was found to impact immune infiltrates and showed a correlation with T-cell immunoreceptor with Ig and ITIM domains (TIGIT) expression. Further mechanistic studies are warranted.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Matteo Zuin, Giulia Capelli, Nicola Gennaro, Cesare Ruffolo, Gaya Spolverato, Salvatore Pucciarelli, Laura Albertoni, Matteo Fassan
Summary: This study evaluated the prognostic implication of a histopathologic sub-classification of pT3 rectal cancer patients, finding that the depth of tumor invasion is an independent risk factor for survival outcomes. The results suggest that introducing a sub-classification of pT3 rectal cancer based on tumor invasion depth should be considered for the TNM staging system.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
Article
Surgery
Maximilian Kloft, Jessica E. Ruisch, Gayatri Raghuram, Jake Emmerson, Matthew Nankivell, David Cunningham, William H. Allum, Ruth E. Langley, Heike I. Grabsch
Summary: This study analyzed the relationship between negative lymph node size and overall survival in esophageal cancer patients. It found that large negative lymph node size is associated with better survival and may serve as a new prognostic biomarker. Further studies are needed to confirm these findings and explore the underlying biological mechanisms.
Review
Cell Biology
Lei Wang, Huiqiong Han, Zehua Wang, Litong Shi, Mei Yang, Yanru Qin
Summary: Esophageal cancer is a common and deadly type of cancer, with current treatment options including surgery, chemotherapy, and radiotherapy. However, the limited efficacy of conventional treatments has led to the exploration of new therapeutic targets, with the tumor microenvironment (TME) emerging as an important focus. Microenvironment-targeting therapies such as immunotherapy and antiangiogenic therapy have shown promise in prolonging survival and improving outcomes for EC patients. Many new drugs and therapies targeting the microenvironment may become future treatment options.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jingjing Dai, Abdusemer Reyimu, Ao Sun, Zaxi Duoji, Wubi Zhou, Song Liang, Suxia Hu, Weijie Dai, Xiaoguang Xu
Summary: A multigene prognostic risk scoring system was constructed using bioinformatics analysis for esophageal cancer (EC) patients. The model, based on gene expression profiles and clinical data, effectively predicted prognosis and had independent prognostic value.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Bing Wen, Dan-Xia Deng, Lian-Di Liao, Zhi-Da Zhang, Ya-Qi Zheng, Ke Dong, Li-Yan Xu, En-Min Li
Summary: In this study, CHAF1A and PCNA were identified as key cell cycle-related proteins leading to the malignant progression of esophageal cancer. These proteins could serve as important prognostic biomarkers and targets for esophageal cancer.
Article
Oncology
Jiangyue Lu, Lehui Du, Xiao Lei, Zhibo Zhang
Summary: This study aimed to determine whether the immune prognostic index (ECIPI), based on hemoglobin (Hb) and neutrophil-to-lymphocyte ratio (NLR), could predict the prognosis in patients with advanced esophageal squamous cell carcinoma (ESCC) receiving programmed cell death-1 (PD-1) inhibitor treatment. The results showed that pretreatment ECIPI was associated with the prognosis in advanced ESCC patients with anti-PD-1 therapy, suggesting that ECIPI may be a useful tool to identify patients likely sensitive to PD-1 inhibitors.
Article
Multidisciplinary Sciences
Qingqing Wang, Xiaoyan Yu, Ningning Yang, Lu Xu, Yunfeng Zhou
Summary: This study identified a novel immune-related eRNA, AC007255.1, in esophageal cancer, which could be a promising prognostic factor. High expression of AC007255.1 was associated with poor survival time, and it showed significant correlations with pathological features and immune infiltration levels.
Review
Pathology
Esther Klaver, Myrtle Van der Wel, Lucas Duits, Roos Pouw, Kees Seldenrijk, Johan Offerhaus, Mike Visser, Fiebo ten Kate, Katharina Biermann, Lodewijk Brosens, Michael Doukas, Clement Huysentruyt, Arend Karrenbeld, Gursah Kats-Ugurlu, Jaap Van der Laan, Ineke van Lijnschoten, Freek Moll, Ariadne Ooms, Jan Tijssen, Sybren Meijer, Jacques Bergman
Summary: This study evaluated the performance of pathologists from Dutch BO expert centres in 80 consecutive LGD reviews, determining their eligibility for an expert panel through independent assessment of digital slides. After group discussions and a second phase of evaluation, remaining aspirant panel members were confirmed to meet the criteria.
JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Gastroenterology & Hepatology
Maarten Struyvenberg, Allon Kahn, David Fleischer, Anne-Fre Swager, Brett Bouma, Eric K. Ganguly, Vani Konda, Charles J. Lightdale, Douglas Pleskow, Amrita Sethi, Michael Smith, Arvind J. Trindade, Michael B. Wallace, Kenneth Wang, Herbert C. Wolfsen, G. J. Tearney, Wouter L. Curvers, Cadman L. Leggett, Jacques J. Bergman
Summary: The study evaluated the accuracy of VLE experts in correctly diagnosing VLE full scans of early neoplasia and NDBE, showing that the experts correctly labeled 73% of neoplastic VLE videos and were consistent with NDBE endoscopic biopsies in 52% of cases. The findings suggest that there is room for improvement in the identification of subtle neoplastic lesions in VLE full scans by experts.
Article
Gastroenterology & Hepatology
Charles E. Gaber, Swathi Eluri, Cary C. Cotton, Paula D. Strassle, Timothy M. Farrell, Jennifer L. Lund, Evan S. Dellon
Summary: This study estimated the incidence, prevalence, and direct medical costs of achalasia in the United States. The results showed that achalasia has a higher epidemiologic and economic burden in the US than previously suggested, with a particularly increasing diagnosis in older patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Annieke W. Gotink, Steffi E. M. van de Ven, Fiebo J. C. ten Kate, Daan Nieboer, Lucia Suzuki, Bas L. A. M. Weusten, Lodewijk A. A. Brosens, Richard van Hillegersberg, Lorenza Alvarez Herrero, Cees A. Seldenrijk, Alaa Alkhalaf, Freek C. P. Moll, Erik J. Schoon, Ineke van Lijnschoten, Thjon J. Tang, Hans van Der Valk, Wouter B. Nagengast, Gursah Kats-Ugurlu, John T. M. Plukker, Martin H. M. G. Houben, Jaap S. van Der Laan, Roos E. Pouw, Jacques J. G. H. M. Bergman, Sybren L. Meijer, Mark I. van Berge Henegouwen, Bas P. L. Wijnhoven, Pieter Jan F. de Jonge, Michael Doukas, Marco J. Bruno, Katharina Biermann, Arjun D. Koch
Summary: This study focused on predicting the risk of lymph node metastasis in patients with pT1b EAC after endoscopic resection or surgery. Factors like submucosal invasion depth, tumor size, and lymphovascular invasion were found to be associated with an increased risk of metastases. The developed prediction model demonstrated good discriminative ability in estimating the probability of post-resection metastases.
Article
Gastroenterology & Hepatology
Anouk Overwater, Sanne N. van Munster, Wouter B. Nagengast, Roos E. Pouw, Jacques J. G. H. M. Bergman, Erik J. Schoon, Bas L. A. M. Weusten
Summary: The 180-degree cryoballoon technology showed feasibility, safety, and effectiveness in the treatment of Barrett's esophagus neoplasia, with a high technical success rate of 96%. The initial dose resulted in a median BE regression of 94% without serious adverse events, and the overall regression rate was 80%.
Article
Gastroenterology & Hepatology
Geltrude Mingrone, Annieke C. G. van Baar, Jacques Deviere, David Hopkins, Eduardo Moura, Cintia Cercato, Harith Rajagopalan, Juan Carlos Lopez-Talavera, Kelly White, Vijeta Bhambhani, Guido Costamagna, Rehan Haidry, Eduardo Grecco, Manoel Galvao Neto, Guruprasad Aithal, Alessandro Repici, Bu'Hussain Hayee, Amyn Haji, A. John Morris, Raf Bisschops, Manil D. Chouhan, Naomi S. Sakai, Deepak L. Bhatt, Arun J. Sanyal, J. J. G. H. M. Bergman
Summary: Hydrothermal duodenal mucosal resurfacing (DMR) is a safe outpatient endoscopic procedure that can improve glycemic control and liver fat content in patients with type 2 diabetes (T2D), particularly in those with high fasting plasma glucose levels.
Article
Gastroenterology & Hepatology
Sanne van Munster, Esther Nieuwenhuis, Bas L. A. M. Weusten, Lorenza Alvarez Herrero, Auke Bogte, Alaa Alkhalaf, B. E. Schenk, Erik J. Schoon, Wouter Curvers, Arjun D. Koch, Steffi Elisabeth Maria van de Ven, Pieter Jan Floris de Jonge, Tjon J. Tang, Wouter B. Nagengast, Frans T. M. Peters, Jessie Westerhof, Martin H. M. G. Houben, Jacques J. G. H. M. Bergman, Roos E. Pouw
Summary: The study investigated the short-term and long-term outcomes of radiofrequency ablation (RFA) +/- endoscopic resection (ER) for early neoplasia in Barrett's esophagus patients in the Netherlands. The results showed that in a centralized care setting, this treatment approach is effective with low recurrence rates, supporting the use of more lenient follow-up intervals and emphasizing careful endoscopic inspection.
Article
Gastroenterology & Hepatology
Shweta Bhatia, Cary C. Cotton, Erin Kim, Hannah Angle, Ariel E. Watts, Swathi Eluri, Nicholas J. Shaheen
Summary: This study found that the proportion of female authors in high-impact gastroenterology journals has significantly increased over the past 20 years, especially in the role of first authors. However, the growth rate of female last authors is slower, indicating that gender disparities still exist. Future interventions should focus on the transition from first to last authorship to reduce gender inequality in GI research.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Surgery
Anouk Overwater, Bas L. A. M. Weusten, Jelle P. Ruurda, Richard van Hillegersberg, Roel J. Bennink, Bart de Keizer, Sybren L. Meijer, Lodewijk A. A. Brosens, Roos E. Pouw, Jacques J. G. H. M. Bergman, Mark I. van Berge Henegouwen, Suzanne S. Gisbertz
Summary: This study evaluated the feasibility and safety of SNNS using a hybrid tracer in patients with high-risk T1b EAC, showing that all patients could identify and resect SNs, with high concordance between preoperative and intraoperative detection. Indocyanine green fluorescence appears to be valuable for detecting peritumoral SNs.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Annefleur Koopen, Julia Witjes, Koen Wortelboer, Soumia Majait, Andrei Prodan, Evgeni Levin, Hilde Herrema, Maaike Winkelmeijer, Steven Aalvink, Jacques J. G. H. M. Bergman, Stephan Havik, Bolette Hartmann, Han Levels, Per-Olof Bergh, Jamie van Son, Manon Balvers, Diogo Mendes Bastos, Erik Stroes, Albert K. Groen, Marcus Henricsson, Ellis Marleen Kemper, Jens Holst, Christopher M. Strauch, Stanley L. Hazen, Fredrik Backhed, Willem M. De Vos, Max Nieuwdorp, Elena Rampanelli
Summary: The study shows that A. soehngenii can improve insulin sensitivity in patients with metabolic syndrome by stimulating intestinal GLP-1 production and REG1B expression. Further research is needed to understand the specific pathways involved in REG1B induction and its role in insulin sensitivity.
Article
Gastroenterology & Hepatology
Charles E. Gaber, Cary C. Cotton, Swathi Eluri, Jennifer L. Lund, Timothy M. Farrell, Evan S. Dellon
Summary: This study suggests that achalasia may be associated with autoimmune conditions and viral infections. Autoimmune diseases and certain viral infections may increase the risk of achalasia.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Surgery
Kiki Fockens, Jeroen de Groof, Joost van der Putten, Tsevelnorov Khurelbaatar, Hisashi Fukuda, Takahito Takezawa, Yoshimasa Miura, Hiroyuki Osawa, Hironori Yamamoto, Jacques Bergman
Summary: This study demonstrates that the use of linked color imaging (LCI) next to white-light endoscopy (WLE) can improve the accuracy of identification and biopsy placement for both expert and non-expert endoscopists in early gastric cancer (EGC) cases.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Oncology
Sofie P. G. Henckens, Eliza R. C. Hagens, Mark I. van Berge Henegouwen, Sybren L. Meijer, Wietse J. Eshuis, Suzanne S. Gisbertz
Summary: This study investigates the impact of lymph node yield after transthoracic esophagectomy on lymph node metastasis, complications, and survival in patients with esophageal adenocarcinoma. The results demonstrate that a lymph node yield of 31 or higher is associated with an increased number of positive lymph nodes, improved disease-free survival, and overall survival, without increasing morbidity.
Article
Gastroenterology & Hepatology
Pieter de Groot, Tanja Nikolic, Silvia Pellegrini, Valeria Sordi, Sultan Imangaliyev, Elena Rampanelli, Nordin Hanssen, Ilias Attaye, Guido Bakker, Gaby Duinkerken, Antoinette Joosten, Andrei Prodan, Evgeni Levin, Han Levels, Bartjan Potter van Loon, Arianne van Bon, Catherina Brouwer, Sytze van Dam, Suat Simsek, Daniel van Raalte, Frank Stam, Victor Gerdes, Roel Hoogma, Martin Diekman, Martin Gerding, Cees Rustemeijer, Bernadette de Bakker, Joost Hoekstra, Aeilko Zwinderman, Jacques Bergman, Frits Holleman, Lorenzo Piemonti, Willem De Vos, Bart Roep, Max Nieuwdorp
Summary: This study found that fecal microbiota transplantation can help delay disease progression and protect pancreatic function in patients with type 1 diabetes. Certain plasma metabolites and bacterial strains are associated with preserved residual beta cell function. The gut microbiome plays a crucial role in the pathophysiology of T1D.