Understanding capsid assembly and genome packaging for adeno-associated viruses

Cryo-electron Microscopy Reconstruction and Stability Studies of the Wild Type and the R432A Variant of Adeno-associated Virus Type 2 Reveal that Capsid Structural Stability Is a Major Factor in Genome Packaging

(2016) Lauren M. Drouin et al.   JOURNAL OF VIROLOGY

OneBac 2.0:Sf9 Cell Lines for Production of AAV5 Vectors with Enhanced Infectivity and Minimal Encapsidation of Foreign DNA

(2015) Mario Mietzsch et al.   HUMAN GENE THERAPY

Structure of neurotropic adeno-associated virus AAVrh.8

(2015) Sujata Halder et al.   JOURNAL OF STRUCTURAL BIOLOGY

Advanced Characterization of DNA Molecules in rAAV Vector Preparations by Single-stranded Virus Next-generation Sequencing

(2015) Emilie Lecomte et al.   Molecular Therapy-Nucleic Acids

The structure of AAVrh32.33, a novel gene delivery vector

(2014) Kyle Mikals et al.   JOURNAL OF STRUCTURAL BIOLOGY

Defining the Stoichiometry and Cargo Load of Viral and Bacterial Nanoparticles by Orbitrap Mass Spectrometry

(2014) Joost Snijder et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enhanced Transgene Expression from Recombinant Single-Stranded D-Sequence-Substituted Adeno-Associated Virus Vectors in Human Cell LinesIn Vitroand in Murine HepatocytesIn Vivo

(2014) Chen Ling et al.   JOURNAL OF VIROLOGY

Optimization of AAV expression cassettes to improve packaging capacity and transgene expression in neurons

(2014) Jun-Hyeok Choi et al.   Molecular Brain

Triple Trans-Splicing Adeno-Associated Virus Vectors Capable of Transferring the Coding Sequence for Full-Length Dystrophin Protein into Dystrophic Mice

(2013) Taeyoung Koo et al.   HUMAN GENE THERAPY

Structural Insights into Adeno-Associated Virus Serotype 5

(2013) L. Govindasamy et al.   JOURNAL OF VIROLOGY

Oversized AAV Transductifon Is Mediated via a DNA-PKcs-independent, Rad51C-dependent Repair Pathway

(2013) Matthew L Hirsch et al.   MOLECULAR THERAPY

Intracellular transport of recombinant adeno-associated virus vectors

(2012) M Nonnenmacher et al.   GENE THERAPY

Efficacy of Codelivery of Dual AAV2/5 Vectors in the Murine Retina and Hippocampus

(2012) Arpad Palfi et al.   HUMAN GENE THERAPY

Nuclear translocation of adeno-associated virus type 2 capsid proteins for virion assembly

(2012) R. Popa-Wagner et al.   JOURNAL OF GENERAL VIROLOGY

Impact of VP1-Specific Protein Sequence Motifs on Adeno-Associated Virus Type 2 Intracellular Trafficking and Nuclear Entry

(2012) R. Popa-Wagner et al.   JOURNAL OF VIROLOGY

Properties of the Adeno-Associated Virus Assembly-Activating Protein

(2012) M. Naumer et al.   JOURNAL OF VIROLOGY

Structural Insight into the Unique Properties of Adeno-Associated Virus Serotype 9

(2012) M. A. DiMattia et al.   JOURNAL OF VIROLOGY

Optimizing Promoters for Recombinant Adeno-Associated Virus-Mediated Gene Expression in the Peripheral and Central Nervous System Using Self-Complementary Vectors

(2011) Steven J. Gray et al.   HUMAN GENE THERAPY

DNA-Binding Activity of Adeno-Associated Virus Rep Is Required for Inverted Terminal Repeat-Dependent Complex Formation with Herpes Simplex Virus ICP8

(2011) M. Alex et al.   JOURNAL OF VIROLOGY

The Assembly-Activating Protein Promotes Capsid Assembly of Different Adeno-Associated Virus Serotypes

(2011) F. Sonntag et al.   JOURNAL OF VIROLOGY

Phase 1 Gene Therapy for Duchenne Muscular Dystrophy Using a Translational Optimized AAV Vector

(2011) Dawn E Bowles et al.   MOLECULAR THERAPY

Structure–function analysis of receptor-binding in adeno-associated virus serotype 6 (AAV-6)

(2011) Qing Xie et al.   VIROLOGY

Structural Characterization of the Dual Glycan Binding Adeno-Associated Virus Serotype 6

(2010) R. Ng et al.   JOURNAL OF VIROLOGY

Little Vector, Big Gene Transduction: Fragmented Genome Reassembly of Adeno-associated Virus

(2010) Matthew L Hirsch et al.   MOLECULAR THERAPY

Gene Therapy of mdx Mice With Large Truncated Dystrophins Generated by Recombination Using rAAV6

(2010) Guy L Odom et al.   MOLECULAR THERAPY

A viral assembly factor promotes AAV2 capsid formation in the nucleolus

(2010) F. Sonntag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of adeno-associated virus serotype 3B (AAV-3B): Insights into receptor binding and immune evasion

(2010) Thomas F. Lerch et al.   VIROLOGY

Effect of Genome Size on AAV Vector Packaging

(2009) Zhijian Wu et al.   MOLECULAR THERAPY

Manufacturing and characterizing AAV-based vectors for use in clinical studies

(2008) J F Wright   GENE THERAPY

Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice

(2008) Mariacarmela Allocca et al.   JOURNAL OF CLINICAL INVESTIGATION

Heparin binding induces conformational changes in Adeno-associated virus serotype 2

(2008) Hazel C. Levy et al.   JOURNAL OF STRUCTURAL BIOLOGY

Undetectable Transcription of cap in a Clinical AAV Vector: Implications for Preformed Capsid in Immune Responses

(2008) Bernd Hauck et al.   MOLECULAR THERAPY

A Hybrid Vector System Expands Adeno-associated Viral Vector Packaging Capacity in a Transgene-independent Manner

(2007) Arkasubhra Ghosh et al.   MOLECULAR THERAPY