USP19 suppresses cellular type I interferon signaling by targeting TRAF3 for deubiquitination

The BECN1-USP19 axis plays a role in the crosstalk between autophagy and antiviral immune responses

(2016) Jun Cui et al.   Autophagy

USP19 modulates autophagy and antiviral immune responses by deubiquitinating Beclin‐1

(2016) Shouheng Jin et al.   EMBO JOURNAL

Manipulation of viral infection by deubiquitinating enzymes: new players in host–virus interactions

(2016) Zhiwen Gu et al.   Future Microbiology

2C Proteins of Enteroviruses Suppress IKKβ Phosphorylation by Recruiting Protein Phosphatase 1

(2016) Qian Li et al.   JOURNAL OF VIROLOGY

New MAPS for misfolded proteins

(2016) Norbert Volkmar et al.   NATURE CELL BIOLOGY

Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting

(2015) Nathalie Bédard et al.   FASEB JOURNAL

TLR and RLR Signaling Are Reprogrammed in Opposite Directions after Detection of Viral Infection

(2015) Christian Hotz et al.   JOURNAL OF IMMUNOLOGY

Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway

(2015) Sowmya Pattabhi et al.   JOURNAL OF VIROLOGY

Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6

(2015) Dandan Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enterovirus 2Apro Targets MDA5 and MAVS in Infected Cells

(2014) Q. Feng et al.   JOURNAL OF VIROLOGY

The Innate Immune Sensor LGP2 Activates Antiviral Signaling by Regulating MDA5-RNA Interaction and Filament Assembly

(2014) Annie M. Bruns et al.   MOLECULAR CELL

TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination

(2014) J. Yan et al.   Journal of Molecular Cell Biology

HSCARG Negatively Regulates the Cellular Antiviral RIG-I Like Receptor Signaling Pathway by Inhibiting TRAF3 Ubiquitination via Recruiting OTUB1

(2014) Yanyan Peng et al.   PLoS Pathogens

The Ubiquitin-Conjugating System: Multiple Roles in Viral Replication and Infection

(2014) Arianna Calistri et al.   Cells

Induction of Siglec-G by RNA Viruses Inhibits the Innate Immune Response by Promoting RIG-I Degradation

(2013) Weilin Chen et al.   CELL

USP3 inhibits type I interferon signaling by deubiquitinating RIG-I-like receptors

(2013) Jun Cui et al.   CELL RESEARCH

Characterization of the Deubiquitinating Activity of USP19 and Its Role in Endoplasmic Reticulum-associated Degradation

(2013) Jin-Gu Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

USP4 Positively Regulates RIG-I-Mediated Antiviral Response through Deubiquitination and Stabilization of RIG-I

(2013) L. Wang et al.   JOURNAL OF VIROLOGY

Ubiquitin-Specific Protease 25 Regulates TLR4-Dependent Innate Immune Responses Through Deubiquitination of the Adaptor Protein TRAF3

(2013) B. Zhong et al.   Science Signaling

Enterovirus 71 Protease 2Apro Targets MAVS to Inhibit Anti-Viral Type I Interferon Responses

(2013) Bei Wang et al.   PLoS Pathogens

Viral and host factors that contribute to pathogenicity of enterovirus 71

(2012) Hsing-I Huang et al.   Future Microbiology

Cleavage of Interferon Regulatory Factor 7 by Enterovirus 71 3C Suppresses Cellular Responses

(2012) Xiaobo Lei et al.   JOURNAL OF VIROLOGY

Enterovirus 71 Disrupts Interferon Signaling by Reducing the Level of Interferon Receptor 1

(2012) J. Lu et al.   JOURNAL OF VIROLOGY

Viral immune modulators perturb the human molecular network by common and unique strategies

(2012) Andreas Pichlmair et al.   NATURE

Structural Insights into RNA Recognition by RIG-I

(2011) Dahai Luo et al.   CELL

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

The USP19 Deubiquitinase Regulates the Stability of c-IAP1 and c-IAP2

(2011) Yide Mei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin-specific Protease 19 (USP19) Regulates Hypoxia-inducible Factor 1α (HIF-1α) during Hypoxia

(2011) Mikael Altun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enterovirus 71 2C Protein Inhibits TNF- -Mediated Activation of NF- B by Suppressing I B Kinase   Phosphorylation

(2011) Z. Zheng et al.   JOURNAL OF IMMUNOLOGY

Host Factors in Enterovirus 71 Replication

(2011) S.-R. Shih et al.   JOURNAL OF VIROLOGY

Cleavage of the Adaptor Protein TRIF by Enterovirus 71 3C Inhibits Antiviral Responses Mediated by Toll-Like Receptor 3

(2011) X. Lei et al.   JOURNAL OF VIROLOGY

A Non-Mouse-Adapted Enterovirus 71 (EV71) Strain Exhibits Neurotropism, Causing Neurological Manifestations in a Novel Mouse Model of EV71 Infection

(2011) W. X. Khong et al.   JOURNAL OF VIROLOGY

The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling

(2010) Rui Chen et al.   CELL RESEARCH

Virus-triggered Ubiquitination of TRAF3/6 by cIAP1/2 Is Essential for Induction of Interferon-β (IFN-β) and Cellular Antiviral Response

(2010) Ai-Ping Mao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The 3C Protein of Enterovirus 71 Inhibits Retinoid Acid-Inducible Gene I-Mediated Interferon Regulatory Factor 3 Activation and Type I Interferon Responses

(2010) X. Lei et al.   JOURNAL OF VIROLOGY

Virology, epidemiology, pathogenesis, and control of enterovirus 71

(2010) Tom Solomon et al.   LANCET INFECTIOUS DISEASES

Clinical features, diagnosis, and management of enterovirus 71

(2010) Mong How Ooi et al.   LANCET NEUROLOGY

The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates

(2009) Gerco C Hassink et al.   EMBO REPORTS

Regulation of Virus-triggered Signaling by OTUB1- and OTUB2-mediated Deubiquitination of TRAF3 and TRAF6

(2009) Shu Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

USP19 Deubiquitinating Enzyme Supports Cell Proliferation by Stabilizing KPC1, a Ubiquitin Ligase for p27Kip1

(2008) Y. Lu et al.   MOLECULAR AND CELLULAR BIOLOGY