Neurodegenerative drug discovery: building on the past, looking to the future

Pharmacological tools based on imidazole scaffold proved the utility of PDE10A inhibitors for Parkinson’s disease

(2017) Ana M García et al.   Future Medicinal Chemistry

New (benz)imidazolopyridino tacrines as nonhepatotoxic, cholinesterase inhibitors for Alzheimer disease

(2017) Houssem Boulebd et al.   Future Medicinal Chemistry

Natural antioxidants in hybrids for the treatment of neurodegenerative diseases: a successful strategy?

(2017) Sandra Gunesch et al.   Future Medicinal Chemistry

Modulating 5-HT4 and 5-HT6 receptors in Alzheimer’s disease treatment

(2017) Julien Lalut et al.   Future Medicinal Chemistry

Synthesis and biological assessment of racemic benzochromenopyrimidinetriones as promising agents for Alzheimer's disease therapy

(2017) Youssef Dgachi et al.   Future Medicinal Chemistry

Melatonin as a versatile molecule to design novel multitarget hybrids against neurodegeneration

(2017) Eva Ramos et al.   Future Medicinal Chemistry

Dual inhibitors of cholinesterases and monoamine oxidases for Alzheimer’s disease

(2017) Damijan Knez et al.   Future Medicinal Chemistry

Chalcone-based carbamates for Alzheimer’s disease treatment

(2017) Angela Rampa et al.   Future Medicinal Chemistry

Inhibition of amyloid oligomerization into different supramolecular architectures by small molecules: mechanistic insights and design rules

(2017) Sayanti Brahmachari et al.   Future Medicinal Chemistry

Multitarget Drug Design Strategy: Quinone–Tacrine Hybrids Designed To Block Amyloid-β Aggregation and To Exert Anticholinesterase and Antioxidant Effects

(2014) Eugenie Nepovimova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

Polypharmacology in a Single Drug: Multitarget Drugs

(2013) M. L. Bolognesi   CURRENT MEDICINAL CHEMISTRY

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Revisiting the cholinergic hypothesis in the development of Alzheimer's disease

(2011) Laura A. Craig et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS