Targeting β-amyloid plaques and oligomers: development of near-IR fluorescence imaging probes

Amyloid-β Deposits Target Efficient Near-Infrared Fluorescent Probes: Synthesis, in Vitro Evaluation, and in Vivo Imaging

(2016) Hualong Fu et al.   ANALYTICAL CHEMISTRY

Defining the earliest pathological changes of Alzheimer's disease

(2016) James C. Vickers et al.   Current Alzheimer Research

Tau Biology and Tau-Directed Therapies for Alzheimer’s Disease

(2016) Lidia Bakota et al.   DRUGS

Amyloid cascade in Alzheimer's disease: Recent advances in medicinal chemistry

(2016) Tarek Mohamed et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tau-directed approaches for the treatment of Alzheimer’s disease: focus on leuco-methylthioninium

(2016) Davide Seripa et al.   Expert Review of Neurotherapeutics

Tau-directed approaches for the treatment of Alzheimer’s disease: focus on leuco-methylthioninium

(2016) Davide Seripa et al.   Expert Review of Neurotherapeutics

Soluble amyloid beta oligomers block the learning-induced increase in hippocampal sharp wave-ripple rate and impair spatial memory formation

(2016) Olivier Nicole et al.   Scientific Reports

2015 Alzheimer's disease facts and figures

(2015)   Alzheimers & Dementia

Development of fluorescent probes that bind and stain amyloid plaques in Alzheimer’s disease

(2015) Seung-Jin Jung et al.   ARCHIVES OF PHARMACAL RESEARCH

Imaging of β-amyloid plaques by near infrared fluorescent tracers: a new frontier for chemical neuroscience

(2015) Matteo Staderini et al.   CHEMICAL SOCIETY REVIEWS

PET and SPECT Radiotracers for Alzheimer’s Disease

(2015) Killian Oukoloff et al.   CURRENT MEDICINAL CHEMISTRY

Diagnostic accuracy of 18F amyloid PET tracers for the diagnosis of Alzheimer’s disease: a systematic review and meta-analysis

(2015) Elizabeth Morris et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Compounds for imaging amyloid-β deposits in an Alzheimer’s brain: a patent review

(2015) Peiyu Tu et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Highly Sensitive Near-Infrared Fluorophores for in Vivo Detection of Amyloid-β Plaques in Alzheimer’s Disease

(2015) Hualong Fu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel cyanine dyes and homodimeric styryl dyes as fluorescent probes for assessment of lactic acid bacteria cell viability

(2015) Rositsa Tropcheva et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Chemical Fluorescent Probe for Detection of Aβ Oligomers

(2015) Chai Lean Teoh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Essential Role of Soluble Aβ Oligomers in Alzheimer’s Disease

(2015) Zi-Xuan Wang et al.   MOLECULAR NEUROBIOLOGY

Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer’s disease

(2015) Xueli Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's disease

(2015) Colin L. Masters et al.   Nature Reviews Disease Primers

A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease

(2014) Xueli Zhang et al.   CHEMICAL COMMUNICATIONS

Target-Triggered NIR Emission with a Large Stokes Shift for the Detection and Imaging of Cysteine in Living Cells

(2014) Chunchang Zhao et al.   Chemistry-An Asian Journal

Smart Near-Infrared Fluorescence Probes with Donor–Acceptor Structure for in Vivo Detection of β-Amyloid Deposits

(2014) Mengchao Cui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lessons from immunotherapy for Alzheimer disease

(2014) Yan-Jiang Wang   Nature Reviews Neurology

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Designing BODIPY-based probes for fluorescence imaging of β-amyloid plaques

(2014) Fazli Sozmen et al.   RSC Advances

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

The global prevalence of dementia: A systematic review and metaanalysis

(2013) Martin Prince et al.   Alzheimers & Dementia

Aza-BODIPY: Improved synthesis and interaction with soluble Aβ1–42 oligomers

(2013) Laramie P. Jameson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Past and Recent Progress of Molecular Imaging Probes for β-Amyloid Plaques in the Brain

(2013) Mengchao Cui   CURRENT MEDICINAL CHEMISTRY

Design and Synthesis of Curcumin Analogues for in Vivo Fluorescence Imaging and Inhibiting Copper-Induced Cross-Linking of Amyloid Beta Species in Alzheimer’s Disease

(2013) Xueli Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and evaluation of thioflavin-T analogs as potential imaging agents for amyloid plaques

(2013) Soon Jae Jung et al.   MEDICINAL CHEMISTRY RESEARCH

BODIPY-Based Molecular Probe for Imaging of Cerebral β-Amyloid Plaques

(2012) Masahiro Ono et al.   ACS Chemical Neuroscience

Cerebrospinal Fluid Levels ofβ-Amyloid 1-42, but Not of Tau, Are Fully Changed Already 5 to 10 Years Before the Onset of Alzheimer Dementia

(2012) Peder Buchhave   ARCHIVES OF GENERAL PSYCHIATRY

Synthesis and evaluation of pyridylbenzofuran, pyridylbenzothiazole and pyridylbenzoxazole derivatives as 18F-PET imaging agents for β-amyloid plaques

(2012) Britt-Marie Swahn et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Bioinorganic Chemistry of Alzheimer’s Disease

(2012) Kasper P. Kepp   CHEMICAL REVIEWS

BODIPY dyes in photodynamic therapy

(2012) Anyanee Kamkaew et al.   CHEMICAL SOCIETY REVIEWS

Aminonaphthalene 2-Cyanoacrylate (ANCA) Probes Fluorescently Discriminate between Amyloid-β and Prion Plaques in Brain

(2012) Kevin Cao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ANCA: A Family of Fluorescent Probes that Bind and Stain Amyloid Plaques in Human Tissue

(2011) Willy M. Chang et al.   ACS Chemical Neuroscience

National estimates of the prevalence of Alzheimer’s disease in the United States

(2011) Ron Brookmeyer et al.   Alzheimers & Dementia

New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs

(2011) Salvatore Salomone et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Aβ Oligomer-Induced Synapse Degeneration in Alzheimer’s Disease

(2011) Kyle C. Wilcox et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Health State Values for Use in the Economic Evaluation of Treatments for Alzheimerʼs Disease

(2011) James Shearer et al.   DRUGS & AGING

Soluble Aβ oligomer production and toxicity

(2011) Megan E. Larson et al.   JOURNAL OF NEUROCHEMISTRY

Clinical amyloid imaging in Alzheimer's disease

(2011) Karl Herholz et al.   LANCET NEUROLOGY

Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils

(2011) Jan Bieschke et al.   Nature Chemical Biology

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Alzheimer's Disease: The Challenge of the Second Century

(2011) D. M. Holtzman et al.   Science Translational Medicine

Fluorescence Molecular Tomography: Principles and Potential for Pharmaceutical Research

(2011) Florian Stuker et al.   Pharmaceutics

Development of dual functional SPECT/fluorescent probes for imaging cerebral β-amyloid plaques

(2010) Masahiro Ono et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Selective Tuning of the HOMO-LUMO Gap of Carbazole-Based Donor-Acceptor-Donor Compounds toward Different Emission Colors

(2010) Huaqiang Zhang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Cerebrospinal fluid and plasma biomarkers in Alzheimer disease

(2010) Kaj Blennow et al.   Nature Reviews Neurology

Thioflavine T interaction with synthetic Alzheimer's disease β-amyloid peptides: Detection of amyloid aggregation in solution

(2010) Harry Levine   PROTEIN SCIENCE

Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport: Fig. 1

(2010) Keith A. Vossel et al.   SCIENCE

Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease

(2010) Oyinkan Sofola et al.   PLoS Genetics

Triazole-containing BODIPY dyes as novel fluorescent probes for soluble oligomers of amyloid Aβ1–42 peptide

(2009) Nicholas W. Smith et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bright, Color-Tunable Fluorescent Dyes in the Vis/NIR Region: Establishment of New “Tailor-Made” Multicolor Fluorophores Based on Borondipyrromethene

(2009) Keitaro Umezawa et al.   CHEMISTRY-A EUROPEAN JOURNAL

Design, Synthesis, and Testing of Difluoroboron-Derivatized Curcumins as Near-Infrared Probes for in Vivo Detection of Amyloid-β Deposits

(2009) Chongzhao Ran et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The role of tau in neurodegeneration

(2009) Tania F Gendron et al.   Molecular Neurodegeneration

Alzheimer's disease, metal ions and metal homeostatic therapy

(2009) Paolo Zatta et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Functional Near-Infrared Fluorescent Probes

(2008) Kazuki Kiyose  et al.   Chemistry-An Asian Journal

Smart optical probes for near-infrared fluorescence imaging of Alzheimer’s disease pathology

(2008) Scott B. Raymond et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Detection of Breast Cancer Microcalcifications Using a Dual-modality SPECT/NIR Fluorescent Probe

(2008) Kumar R. Bhushan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Optical properties of amyloid stained by Congo red: History and mechanisms

(2008) Alexander J. Howie et al.   MICRON

The Chemistry of Fluorescent Bodipy Dyes: Versatility Unsurpassed

(2007) Gilles Ulrich et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION