Review
Biochemistry & Molecular Biology
Blassan P. George, Rahul Chandran, Heidi Abrahamse
Summary: Cancer chemoprevention involves using external agents to slow down or suppress cancer growth, and the occurrence of global cancer types varies depending on factors such as environmental, lifestyle, and genetic factors. Developed countries can prevent cancer with advanced treatment modalities, while developing countries often see it as a painful death sentence.
Article
Plant Sciences
Marcelo Augusto Altieri, Luis Manuel Sarmiento-Machado, Guilherme Ribeiro Romualdo, Nelci Antunes de Moura, Luis Fernando Barbisan
Summary: The study found that dietary capsaicin can reduce the development of urothelial lesions in rats, demonstrating a protective effect.
PLANT FOODS FOR HUMAN NUTRITION
(2023)
Article
Plant Sciences
Maria Stephanie Cid-Gallegos, Cristian Jimenez-Martinez, Xariss M. Sanchez-Chino, Eduardo Madrigal-Bujaidar, Veronica R. Vasquez-Garzon, Rafael Baltierrez-Hoyos, Isela Alvarez-Gonzalez
Summary: This study evaluates the chemopreventive effect of chickpea on colon carcinogenesis in a mice model. The results show that a 20% chickpea diet significantly reduces tumors and biomarkers of proliferation and inflammation in AOM/DSS-induced colon cancer mice. Both diets of 10% and 20% chickpea exert a chemopreventive effect.
Article
Oncology
Cody J. Schmidlin, Aryatara Shakya, Matthew Dodson, Eli Chapman, Donna D. Zhang
Summary: NRF2 plays a complex role in cancer by regulating genes involved in cell function and survival, and its activation mode determines its effects in cancer. The discovery of pharmacological modulators targeting NRF2 provides potential breakthroughs in cancer treatment.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Plant Sciences
Bushra Ansari, Michael Aschner, Yaseen Hussain, Thomas Efferth, Haroon Khan
Summary: The research focuses on evaluating the inhibitory effects of naringin in citrus fruits on colorectal cancer, as well as its potential mechanistic pathways, including multiple signaling pathways such as NF-Kappa B/IL-6/STAT3, PI3K/AKT/mTOR, apoptosis, NF-Kappa B-COX-2-iNOS, and beta-catenin pathways.
Article
Nutrition & Dietetics
Juan Manuel Garcia-Cordero, Nikte Y. Martinez-Palma, Eduardo Madrigal-Bujaidar, Cristian Jimenez-Martinez, Eduardo Madrigal-Santillan, Jose A. Morales-Gonzalez, Rogelio Paniagua-Perez, Isela Alvarez-Gonzalez
Summary: The study demonstrated the powerful in vivo antioxidant, antigenotoxic, and chemopreventive potential of phaseolin, which effectively reduced oxidative stress and damage induced by AOM.
Review
Biochemistry & Molecular Biology
Nuray Erin, Arpad Szallasi
Summary: Both sensory neurons and immune cells express TRPV1, which can induce neurogenic inflammation and modify tumor growth and metastasis. TRPV1 is also found in various immune cells, and the effects of TRPV1 agonists and antagonists depend on the cell type(s) activated and/or inhibited. A comprehensive understanding of TRPV1 activity on immune cells and nerve endings is necessary to predict the outcome of therapies targeting TRPV1 channels. This review focuses on the neuro-immune modulation of cancer growth and metastasis caused by TRPV1 activation and discusses the potential use of TRPV1 modulators in cancer therapy.
Article
Biochemistry & Molecular Biology
Ga-Eun Lee, Cheol-Jung Lee, Hyun-Jung An, Han Chang Kang, Hye Suk Lee, Joo Young Lee, Sei-Ryang Oh, Sung-Jun Cho, Dae Joon Kim, Yong-Yeon Cho
Summary: Fargesin inhibits cancer cell growth by suppressing cell cycle transition and EGF-induced cell transformation through multiple signaling pathways, including CDK/cyclin and Rb-E2F pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Samuel E. Weinberg, Le Yu Sun, Allison L. Yang, Jie Liao, Guang Yu Yang
Summary: Chronic inflammation is a common risk factor for human cancer, including colon cancer. Patients with inflammatory bowel disease have a significantly increased risk for colorectal carcinoma. Inositol and its phosphates play important roles in cancer prevention through cellular metabolic and signal transduction pathways.
Article
Chemistry, Multidisciplinary
Qi Jiang, Mengchun Chen, Xuewei Yang, Deli Zhuge, Qingqing Yin, Dongyan Tian, Li Li, Xufei Zhang, Wenbin Xu, Shuangshuang Liu, Fan Li, Cuiye Weng, Yijing Lin, Haonan Wang, Dapang Rao, Yiming Chen, Qiangjun Cai, Linzhi Yan, Ledan Wang, Fang Wang, Xiaosheng Lu, Bin Wen, Yingzheng Zhao, Feng Zhang, Weiliang Xia, Haiyan Zhu, Yijie Chen
Summary: Researchers have developed a biomimetic nanoparticle that can enhance the effectiveness of chemotherapy drugs for cancer treatment while reducing their toxicity. This nanoparticle can selectively target healthy tissue and prevent the drug from damaging healthy cells, enabling higher drug doses to be delivered to tumor tissue without toxicity. The nanoparticle also activates the immune system to attack tumors. In mouse tumor models, pretreatment with this nanoparticle followed by high-dose chemotherapy significantly prolonged survival.
Article
Gastroenterology & Hepatology
Yi Bao, Jianning Zhai, Huarong Chen, Chi Chun Wong, Cong Liang, Yanqiang Ding, Dan Huang, Hongyan Gou, Danyu Chen, Yasi Pan, Wei Kang, Ka Fai To, Jun Yu
Summary: YTHDF1 plays a crucial role in the tumour immune microenvironment of colorectal cancer by regulating the m(6)A-p65-CXCL1/CXCR2 pathway, affecting anti-tumour immune response, and serving as a potential target for immune checkpoint blockade therapy.
Article
Nutrition & Dietetics
Jiaqiang Deng, Lili Zhao, Xieyong Yuan, Yan Li, Junyang Shi, Hua Zhang, Yuxuan Zhao, Liping Han, Huani Wang, Yan Yan, Hong Zhao, Haojie Wang, Fangdong Zou
Summary: BBR has preventive effects in colon carcinogenesis by inhibiting inflammation and tumor proliferation, and maintaining intestinal homeostasis.
Article
Agriculture, Dairy & Animal Science
J. G. Liu, W. G. Xia, W. Chen, K. F. M. Abouelezz, D. Ruan, S. Wang, Y. N. Zhang, X. B. Huang, K. C. Li, C. T. Zheng, J. P. Deng
Summary: The study found that dietary supplementation of capsaicin under ad libitum feeding conditions can increase feed intake and improve egg production performance in laying ducks, possibly by activating the calcium signaling pathway and improving redox status.
Article
Agronomy
Shengnan Li, Zedong Wu, Chunhong Liu, Lianxue Fan, Yongheng He, Ke Lu, Dajun Liu, Guojun Feng
Summary: The CsGSH2 gene in cucumber is involved in the detoxification process of Propamocarb, and overexpression of CsGSH2 can reduce Propamocarb residues and phytotoxicity, while enhancing cucumber's antioxidant capacity.
Article
Immunology
Jose Manuel Correia da Costa, Maria Joao Gouveia, Gabriel Rinaldi, Paul J. Brindley, Julio Santos, Lucio Lara Santos
Summary: Helminthiases are highly prevalent in developing countries and chronic infection with some parasitic worms is associated with carcinogenesis. Understanding parasite-host interactions and mechanisms of carcinogenesis is crucial for developing novel control strategies. Chemotherapy and immunotherapy are potential therapeutic options, with a focus on targeting both the parasite and associated pathologies to combat the cancer-causing effects of helminth infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)