Article
Environmental Sciences
Xiaoping Zhou, Guoliang Wang, Xiaoya An, Jun Wu, Kai Fan, Lina Xu, Cheng Li, Yuhua Xue
Summary: Microplastics, a global environmental pollutant, are widely found in water bodies and daily products. The effects of microplastics on ocular surface health are still unclear. This study revealed that polystyrene microplastics could cause dysfunction of the ocular surface in mice, leading to dry eye symptoms and inflammation.
ENVIRONMENTAL POLLUTION
(2022)
Article
Chemistry, Multidisciplinary
Swapnali Londhe, Shagufta Haque, Sanchita Tripathy, Sreedhar Bojja, Chitta Ranjan Patra
Summary: The advancement of nanotechnology has led to the experimental development of silver nitroprusside nanoparticles (AgNNPs) for breast cancer therapy, which showed positive results in in vitro and in vivo experiments. AgNNPs exhibited biocompatibility with normal cell lines and cytotoxicity against cancer cell lines. They also demonstrated anti-angiogenic behavior and inhibited orthotopic breast tumor growth in mice. The possible molecular mechanisms for their anti-cancer activity were investigated. AgNNPs have the potential to be used as a generalized nanomedicine for breast and other cancers after proper biosafety evaluation in the future.
Review
Biochemistry & Molecular Biology
Humna Sajjad, Anila Sajjad, Rida Tul Haya, Muhammad Mustajab Khan, Muhammad Zia
Summary: Copper oxide nanoparticles have unique properties and are widely used in various fields. However, their applications also bring about potential toxicity risks. It is important to study the toxicity mechanisms and potential impacts of copper oxide nanoparticles to ensure their safe usage.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Food Science & Technology
Jinling Cui, Shutao Yin, Chong Zhao, Lihong Fan, Hongbo Hu
Summary: This study demonstrated that the co-exposure of patulin and cadmium resulted in synergistic cytotoxicity in liver or renal cells in vitro and enhanced liver toxicity in vivo. The synergistic toxicity was attributed to boosted ROS generation and mediated by p53/JNK1 activation promoting a second-round ROS production through a positive feedback loop. These findings extend toxicological knowledge about patulin and cadmium, which may aid in more precise risk assessments of these food contaminants.
Article
Environmental Sciences
Karoline Felisbino, Nathalia Kirsten, Shayane da Silva Milhorini, Isabela Saragioto Marcal, Karina Bernert, Rafaela Schiessl, Leticia Nominato-Oliveira, Izonete Cristina Guiloski
Summary: This study evaluated the acute toxicity, teratogenic effects, oxidative stress, and neurotoxicity of Dicamba in zebrafish embryos. The results showed that Dicamba could cause developmental delay, teratogenic effects, and oxidative stress. These findings highlight the potential risks of Dicamba exposure during embryonic development and the need for further studies.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Yunlong Meng, Keyuan Zhong, Suping Chen, Yong Huang, You Wei, Juan Wu, Juan Liu, Zhaopeng Xu, Jing Guo, Fasheng Liu, Huiqiang Lu
Summary: The study revealed that exposure to Pendimethalin can reduce heart rate, survival rate, and body length of zebrafish embryos, causing various malformations and affecting antioxidant enzyme activity and the expression of genes related to cardiac development.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Gastroenterology & Hepatology
Macarena Pozo-Morales, Ines Garteizgogeascoa, Camille Perazzolo, Juhoon So, Donghun Shin, Sumeet Pal Singh
Summary: This study successfully observed the changes in hepatocyte calcium dynamics by taking advantage of the transparency of zebrafish larvae. The presence of calcium oscillations, waves, and spikes in vivo were demonstrated, and it was found that calcium waves are related to nutrition intake and negatively regulate starvation-induced lipid droplet accumulation.
Article
Environmental Sciences
Siyu Xia, Xinhong Zhu, Yuepei Yan, Tao Zhang, Guoliang Chen, Daoxi Lei, Guixue Wang
Summary: This study revealed the neurotoxic and developmental toxicity of antimony on zebrafish embryos, primarily affecting neurotransmitter systems and oxidative stress, thereby altering behavior. The findings advance the understanding of antimony-induced neurotoxicity, environmental issues, and health hazards.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Toxicology
Jia Liu, Shubin Yang, Laien Zhao, Feng Jiang, Jianchao Sun, Shengjun Peng, Ruikang Zhao, Yanmei Huang, Xiaoxuan Fu, Rongrui Luo, Yu Jiang, Zelin Li, Nan Wang, Tengzheng Fang, Zhuhong Zhang
Summary: This study explored the ocular toxicity of montmorillonite (Mt) and its underlying mechanisms. Different types of Mt caused cytotoxicity in corneal cells, with sodium montmorillonite (Na-Mt) showing the highest toxicity. Na-Mt induced reactive oxygen species generation and activated the p38 signaling pathway, contributing to its cytotoxicity.
PARTICLE AND FIBRE TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Hui Zhu, Chunyi Lu, Fei Gao, Zhixiang Qian, Yu Yin, Shidong Kan, Daijie Chen
Summary: The study evaluated the preventive effects of Se-enriched Bifidobacterium longum DD98 on CPT-11-induced intestinal and hepatic toxicities, both in vitro and in vivo. Results indicate that Se-B. longum DD98 can protect against CPT-11-induced damages by regulating cell viability, oxidative stress, pro-inflammatory cytokines, tight-junction proteins, and gut microbiota composition. It shows potential as a promising adjuvant therapeutic agent in combination with CPT-11 for cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Andras Acs, Xinyue Liang, Illes Bock, Jeffrey Griffitts, Bence Ivanovics, Erna Vasarhelyi, Arpad Ferincz, Zsolt Pirger, Bela Urbanyi, Zsolt Csenki
Summary: The study evaluated the chronic effects of the anticonvulsant drug carbamazepine (CBZ) and progesterone (P4) on zebrafish at environmentally relevant concentrations. The results indicated a synergistic effect of CBZ and P4, highlighting the potential risk to fish reproduction if these pharmaceuticals co-occur.
Article
Environmental Sciences
Xianglin Cao, Chenyang Rao, Han Cui, Dandan Sun, Lulu Li, Suqi Guo, Jiameng Zhou, Rongjie Yuan, Shuai Yang, Jianjun Chen
Summary: This study analyzed the toxic effects of glyphosate (GLY) on juvenile common carp and an epithelioma papulosum cyprinid (EPC) cell line. The results showed that GLY induced liver inflammation and oxidative damage in common carp, as well as changes in the physical barrier of the intestine. In EPC cells, GLY led to oxidative DNA damage, mitochondrial dysfunction, and reactive oxygen species production. These findings not only highlight the negative effects of GLY on common carp, but also provide valuable insights into the cytotoxicity mechanism and comprehensive toxicity of GLY.
Article
Environmental Sciences
Shanshan Guo, Yaqing Wu, Wenhua Li, Peng Xiao
Summary: This study aimed to investigate the toxicity of tralomethrin in zebrafish. Results showed that tralomethrin exposure caused cardiovascular dysplasia and dysfunction, as well as developmental abnormalities and oxidative stress in embryos. The dysregulation of crucial genes responsible for cardiovascular development was also observed. These findings highlight the cardiovascular and developmental toxicity of tralomethrin in zebrafish, and their significance for assessing the environmental risk of tralomethrin in aquatic ecosystems.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Bolin Lian, Yuanyuan Li, Qilei Yang, Lanlan Xie, Qian Zhang, Yanjie Liu, Xiuhua Zhao, Shujun Li
Summary: Ph-PS, prepared by absorption method, showed improved dissolution rate and antioxidant ability compared to free Ph. The in vitro release study demonstrated higher release amount and faster release rate of Ph from Ph-PS. Additionally, in the zebrafish model, Ph-PS exhibited better reduction of ROS generation and lipid peroxidation than free Ph.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Environmental
Nayoung Min, Hahyun Park, Taeyeon Hong, Garam An, Gwonhwa Song, Whasun Lim
Summary: This study evaluated the developmental toxicity of the herbicide prometryn in zebrafish embryos, revealing that it shortened body length, induced organ development defects, reactive oxygen species accumulation, and cell death. It was also found to interfere with mitochondrial function and energy metabolism.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Darko Makovec, Nina Krizaj, Anton Meden, Goran Drazic, Hana Ursic, Rok Kostanjsek, Martin Sala, Saso Gyergyek
Summary: Two different morphologies of ferroelectric bismuth titanate nanoparticles, nanoplatelets and nanowires, were synthesized by changing the concentration of NaOH during hydrothermal treatment. The nanoplatelets exhibit the characteristic Aurivillius-type layered-perovskite crystal structure, while the nanowires exhibit an entirely new orthorhombic structure. The nanowire structure is a metastable polymorph that transforms into the Aurivillius structure with annealing at temperatures above 500 degrees C.
Article
Chemistry, Physical
Tina Dukic, Leonard Jean Moriau, Luka Pavko, Mitja Kostelec, Martin Prokop, Francisco Ruiz-Zepeda, Martin Sala, Goran Drazic, Matija Gatalo, Nejc Hodnik
Summary: This research provides a study on the stability of carbon-supported intermetallic Pt-alloy electrocatalysts and determines the effects of temperature and potential window on metal dissolution. The findings contradict the commonly accepted hypothesis that Pt dissolution is not significantly affected by temperature, and highlight the critical role of temperature in governing Pt stability and metal retention in Pt-alloy electrocatalysts. Additionally, the study shows that the rate of Pt redeposition increases with temperature, providing insight into the temperature-dependent kinetics of Pt stability.
Article
Multidisciplinary Sciences
Gregory S. Herbert, Stephen P. Geiger, Stephen G. Hesterberg, Nicole Seiden, Jaime A. Rogers, Ryan M. Harke, Martin Sala, Kaydee J. West, Ethan A. Goddard
Summary: The Florida Horse Conch, one of the largest marine gastropods in the world, is facing decline due to overexploitation. To effectively manage its population, more data on commercial and recreational harvest intensities is needed, as well as an understanding of its intrinsic capacity to recover. A study using stable oxygen and carbon isotope sclerochronology reveals that the horse conch has slow growth rates and females mature relatively late in life.
Review
Chemistry, Analytical
Monika Ogrizek, Ana Kroflic, Martin Sala
Summary: Particulate matter (PM) is the major threat to our health among all environmental pollutants, and its regular monitoring is required. To determine the concentrations of toxic metals and other elements in PM, microwave digestion inductively coupled plasma mass spectrometry (MW/ICPMS) and X-ray fluorescence (XRF) techniques are commonly used. This review paper critically assesses these two techniques as well as three others for element determination in PM deposited on filter media, and identifies XRF and LA-ICPMS as two promising surface techniques for the analysis of PM deposits.
TRENDS IN ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2022)
Article
Plant Sciences
Servane Bigot, Paula Pongrac, Martin Sala, Johannes T. T. van Elteren, Juan-Pablo Martinez, Stanley Lutts, Muriel Quinet
Summary: This study compared the salt resistance of tomato and Solanum chilense during the reproductive phase and found that S. chilense exhibited higher salt tolerance. Differences in element distribution and transport in flowers may contribute to this disparity.
Article
Chemistry, Multidisciplinary
Philipp A. Heizmann, Hien Nguyen, Miriam von Holst, Andreas Fischbach, Mitja Kostelec, Francisco Javier Gonzalez Lopez, Marjan Bele, Luka Pavko, Tina Dukic, Martin Sala, Francisco Ruiz-Zepeda, Carolin Klose, Matija Gatalo, Nejc Hodnik, Severin Vierrath, Matthias Breitwieser
Summary: The design of stable and finely dispersed platinum or platinum alloy nanoparticles on the carbon support is crucial for controlling the performance of PEM fuel cells. In this study, a PtCo/C catalyst with intermetallic structures is synthesized and shows significantly narrowed particle size distribution compared to commercial benchmark catalysts. The improved dispersion of PtCo particles leads to an increase in electrochemically active surface area and a more efficient usage of precious metal, resulting in enhanced performance of PEM fuel cells.
Article
Chemistry, Analytical
Dino Metarapi, Andreas Schweikert, Ana Jerse, Martin Schaier, Johannes T. van Elteren, Gunda Koellensperger, Sarah Theiner, Martin Sala
Summary: Laser ablation in combination with ICP-TOFMS allows non-targeted multi-element imaging and screening unexpected elements in a sample. However, quantification is limited due to the preparation of calibration standards. This study presents a workflow for semiquantitative analysis using gelatin micro droplet standards, which was evaluated on gelatin samples and real-world bioimaging samples.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Johannes T. van Elteren, Dino Metarapi, Kristina Mervic, Martin Sala
Summary: This study aims to investigate the potential benefits of adapting the ablating grid in laser ablation inductively coupled plasma mass spectrometry, specifically in a single pulse mapping mode. The study focuses on improving surface sampling accuracy, depth-related sampling control, post-ablation surface smoothness, and image quality. Computational modeling was used to optimize square or round ablation grids, and an online application was developed for users to experiment with different grid designs and assess resulting surface characteristics.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Luka Suhadolnik, Marjan Bele, Miha Cekada, Primoz Jovanovic, Nik Maselj, Anja Loncar, Goran Drazic, Martin Sala, Nejc Hodnik, Janez Kovac, Tiziano Montini, Michele Melchionna, Paolo Fornasiero
Summary: A versatile approach for producing cluster- and single atom-based thin-film electrode composites is described in this article. The TiOxNy-Ir catalyst developed in this study was prepared from sputtered Ti-Ir alloy with 0.8 +/- 0.2 at % Ir in alpha-Ti solid solution. The prepared catalyst exhibited high oxygen evolution reaction activity and has potential applications in electrocatalysis. The article provides a detailed description of the new method and a high-performance thin film catalyst, along with suggestions for future development in this field.
CHEMISTRY OF MATERIALS
(2023)
Article
Environmental Sciences
Monika Ogrizek, Ana Kroflic, Tomas Vaculovic, Marketa Hola, Martin Sala
Summary: Airborne particles, known as particulate matter (PM), are a major environmental pollutant that can cause damage to human health. Monitoring the PM concentration and toxicants is important, and current methods produce toxic chemical waste. Laser ablation inductively coupled plasma mass spectroscopy (LA-ICPMS) is a potential sustainable alternative. In this study, the performance of two laser systems (LA213 and LA193) was evaluated for direct analysis of PM, and LA213 proved to be suitable and more affordable for air-quality monitoring purposes.
AIR QUALITY ATMOSPHERE AND HEALTH
(2023)
Article
Chemistry, Physical
Luka Pavko, Matija Gatalo, Tina Dukic, Francisco Ruiz-Zepeda, Angelja Kjara Surca, Martin Salad, Nik Maselj, Primoz Jovanovic, Marjan Bele, Matjaz Finsgar, Bostjan Genorio, Nejc Hodnik, Miran Gaberscek
Summary: This study evaluates the durability of carbon support materials for Pt alloy nanoparticles and finds that the total amount of oxygen functionalities, the type of oxygen functionalities, and sp2 carbon content play a crucial role in carbon support durability. The findings are confirmed with direct online measurements of carbon corrosion via an advanced in-situ technique.
Article
Chemistry, Multidisciplinary
Tatjana Radovanovic Vukajlovic, Christian Philipp, Phillip Eder, Martin Sala, Vid Simon Selih, Andreja Vanzo, Katja Suklje, Klemen Lisjak, Melita Sternad Lemut, Reinhard Eder, Guillaume Antalick
Summary: This study aimed to improve the understanding of 2-AAP formation in white wines and investigated the varietal effect on its formation and the role of antioxidants and transition metal ions in this process. The surveys found that Muscat and Riesling wines showed higher concentrations of 2-AAP than Chardonnay and other regional varieties. The presence of Cu limited the formation of 2-AAP while Fe and Mn tended to promote its formation. The study highlights the importance of further research on varietal effects and the complex interactions involving metal ions and antioxidants in 2-AAP production.
APPLIED SCIENCES-BASEL
(2023)
Article
Materials Science, Textiles
Anja Verbic, Katja Brencic, Gregor Primc, Miran Mozetic, Martin Sala, Marija Gorjanc
Summary: This article introduces a green in situ synthesis method of ZnO on PET fabrics using pomegranate peel extract. The PET surface was activated by environmentally friendly oxygen plasma, and compared with alkali treatment using wood ash extract. Both treatments slightly reduced the fabric's breaking strength and elongation. The ZnO particles were successfully synthesized on alkali- and plasma-treated PET, resulting in enhanced UV protection.
FIBERS AND POLYMERS
(2023)
Article
Chemistry, Multidisciplinary
Miha Ravbar, Ajda Kuncic, Lev Matoh, Sonja Smole Mozina, Martin Sala, Andraz Suligoj
Summary: In this study, zinc oxide nanoparticles were synthesized using ethanolic extracts from the roots of Japanese knotweed. The research demonstrated the synergistic effect of polyphenolic components in the extracts on crystallite growth and antimicrobial activity of the nanoparticles.
Article
Chemistry, Analytical
Ana Jerse, Kristina Mervic, Johannes Teun van Elteren, Vid Simon Selih, Martin Sala
Summary: Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has made significant improvements in reducing analysis time, increasing spatial resolution, and improving sensitivity. However, quantification and accurate analysis remain challenging. This study focuses on the influence of laser fluence, beam size, and aerosol transport on quantification in single pulse LA-ICP-MS analysis. The findings suggest that the right selection of laser fluence and beam size is critical for reliable quantification.
