Review
Cell Biology
Mark Tomas Mc Auley
Summary: Ageing is a biological process characterized by physical decline and increased risk of mortality over time, with recent evidence linking epigenetic mechanisms like DNA methylation to age-related diseases. Evolutionary theory provides insights into how genes impact fitness at different ages, and how DNA methylation changes are associated with age onset pathology.
AGEING RESEARCH REVIEWS
(2021)
Review
Cardiac & Cardiovascular Systems
Veronique Regnault, Pascal Challande, Florence Pinet, Zhenlin Li, Patrick Lacolley
Summary: This review provides an update on the mechanisms of vascular cell senescence, connecting selected proteins in biological networks through a computational approach. It discusses the potential of senolytic drugs in treating age-related vascular diseases, as well as the feedback controls between identified networks.
CARDIOVASCULAR RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Lorna W. Harries
Summary: The human genome produces a wide range of proteins and non-coding RNAs through the coordinated processes of mRNA processing and metabolism. Dysfunctional RNA processing and metabolism have been implicated in cellular senescence and may be a key contributor to aging.
Article
Biology
Thibaut Renard, Baptiste Martinet, Natalia De Souza Araujo, Serge Aron
Summary: Epigenetic alterations are a primary hallmark of aging, and this study found that such changes occur not only in mammals but also play a crucial role in insects. By using a hypomethylating agent, the researchers extended the average lifespan of bumblebees and induced differential methylation of genes associated with aging. Additionally, they discovered that the overexpression of the longevity gene sirt1 was positively correlated with lifespan.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Brian T. Joyce, Tao Gao, Kalsea Koss, Yinan Zheng, Andres Cardenas, Jonathan Heiss, Allan Just, Kai Zhang, Linda van Horn, Norrina Bai Allen, Philip Greenland, Sheldon Cohen, Penny Gordon-Larsen, Colter Mitchell, Sara McLanahan, Lisa Schneper, Daniel Notterman, Sheryl L. Rifas-Shiman, Emily Oken, Marie-France Hivert, Robert Wright, Andrea Baccarelli, Donald Lloyd-Jones, Lifang Hou
Summary: This study examines the relationship between individual, parental, and neighborhood socioeconomic status and epigenetic age acceleration (EAA), and finds that paternal education is associated with EAA.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Anaelle Bailly, Ollivier Milhavet, Jean-Marc Lemaitre
Summary: Cell reprogramming techniques, including RNA-based strategies, have shown great potential in treating various diseases and improving healthspan and longevity.
Article
Biochemistry & Molecular Biology
Benjamin Mayne, Walter Mustin, Vandanaa Baboolal, Francesca Casella, Katia Ballorain, Mathieu Barret, Mathew A. Vanderklift, Anton D. Tucker, Darren Korbie, Simon Jarman, Oliver Berry
Summary: This study presents the development of an epigenetic clock that can predict the age of marine turtles from skin biopsies. The method, based on DNA methylation levels, was highly accurate and has the potential to provide key life history information through a nonlethal and inexpensive approach, transforming marine turtle management.
MOLECULAR ECOLOGY RESOURCES
(2022)
Review
Biotechnology & Applied Microbiology
Nasrullah, Abrar Hussain, Sagheer Ahmed, Mahmood Rasool, Abdul Jabbar Shah
Summary: DNA methylation is a process of adding methyl groups to the DNA molecule, which can alter the function of DNA. The importance and role of DNA methylation vary across different organisms, with mammals showing a strong relationship between DNA methylation and diseases such as cancer and placental development.
Article
Biochemistry & Molecular Biology
Genfu Yagi, Huiyuan Qi, Kana Arai, Yuki F. Kita, Kazunobu Kogi, Tadamichi Morisaka, Motoi Yoshioka, Miho Inoue-Murayama
Summary: Age is crucial for studying the life history of wild animals but often requires invasive methods. This study developed a non-invasive method to estimate the age of dolphins using DNA methylation rate from fecal samples, achieving high accuracy.
MOLECULAR ECOLOGY RESOURCES
(2023)
Article
Clinical Neurology
Marie-Laure Ancelin, Isabelle Jaussent, Karen Ritchie, Alain Besset, Joanne Ryan, Yves Dauvilliers
Summary: This study examines the association between BDNF variants and promoter I methylation with sleep disturbances in older adults. The results show that wake time after sleep onset (WASO) is associated with four SNPs in participants not taking psychotropic drugs, while the associations are either not significant or in the reverse direction in participants taking drugs. Higher BDNF methylation levels are found in participants with long WASO, and this varies depending on psychotropic drug use.
JOURNAL OF SLEEP RESEARCH
(2023)
Review
Cell Biology
Jack Crouch, Maria Shvedova, Rex Jeya Rajkumar Samdavid Thanapaul, Vladimir Botchkarev, Daniel Roh
Summary: Senescence is a complex cellular stress response that leads to loss of proliferative capacity and changes in secretory pattern. Transcriptional regulation of multiple genes and epigenetic alterations to DNA and chromatin play crucial roles in the induction and maintenance of senescence. This review highlights the changes in chromatin, DNA methylation, histone alterations, and the specific epigenetic regulation of the senescence-associated secretory phenotype (SASP).
Article
Cell Biology
Philip Vlummens, Stefaan Verhulst, Kim De Veirman, Anke Maes, Eline Menu, Jerome Moreaux, Hugues De Boussac, Nicolas Robert, Elke De Bruyne, Dirk Hose, Fritz Offner, Karin Vanderkerken, Ken Maes
Summary: In this study, bio-informatic tools were used to identify novel targets associated with high-risk myeloma. Protein arginine methyltransferase 5 (PRMT5) was identified as a promising target. The PRMT5 inhibitor EPZ015938 effectively reduced the growth of myeloma cells and induced apoptosis. PRMT5 was found to be involved in regulating alternative splicing, DNA repair, and PI3K/mTOR signaling, and was associated with important genes in MM disease. These findings suggest that PRMT5 could be a potential therapeutic target for myeloma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Natalia Slawinska, Renata Krupa
Summary: Cells can become senescent in response to stress, which can be beneficial in some cases like suppressing tumour development or promoting tissue repair, but may also contribute to the ageing process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Yousra Hamdan, Loubna Mazini, Gabriel Malka
Summary: Exosomes are key players in intercellular communication and regulate various biological processes such as cell development, growth, repair, and immunomodulation. Exosome-derived miRNAs play a crucial role in age-related diseases and longevity but further research is needed to understand their underlying mechanisms.
Article
Cardiac & Cardiovascular Systems
Abel Martin Garrido, Anuradha Kaistha, Anna K. Uryga, Sebnem Oc, Kirsty Foote, Aarti Shah, Alison Finigan, Nichola Figg, Lina Dobnikar, Helle Jorgensen, Martin Bennett
Summary: The study suggests that traditional markers of cell senescence, such as p16, have significant limitations in identifying and removing senescent cells in atherosclerosis. Research indicates that genetic and pharmacological senolysis have variable effects on atherosclerosis, and may promote inflammation and non-specific effects respectively. New senolytic drugs and studies on senescence in atherosclerosis may require more specific and lineage-restricted markers before attributing their effects entirely to senolysis.
CARDIOVASCULAR RESEARCH
(2022)
Editorial Material
Biology
Jose R. Pineda, Iker Badiola, Gaskon Ibarretxe
Article
Biochemistry & Molecular Biology
Daniela Gerovska, Patricia Garcia-Gallastegi, Jean Descarpentrie, Olatz Crende, Maria Casado-Andres, Ander Martin, Jokin Eguia, Abdel-Majid Khatib, Marcos J. Arauzo-Bravo, Iker Badiola
Summary: Colon cancer remains a major health issue globally, and evidence suggests cancer stem cells may play a crucial role in its development, with proprotein convertases possibly playing a role in regulating malignant phenotypes. Targeting proprotein convertases could be a new potential therapeutic strategy for colon cancer, given their impact on cell proliferation, differentiation, and chemoresistance.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Daniela Gerovska, Patricia Garcia-Gallastegi, Olatz Crende, Joana Marquez, Gorka Larrinaga, Maite Unzurrunzaga, Marcos J. Arauzo-Bravo, Iker Badiola
Summary: Cancer is closely related to aging, with tumor cells being the main driver of cancer progression, but the cells and matrix of the tumor microenvironment (TME) also play crucial roles in disease advancement. Epigenetic changes, including miRNA dysregulation, are essential for phenotypic changes in the TME during cancer progression. Specific miRNAs related to the aging process, called geromiRs, are significantly downregulated in the liver TME during colon cancer colonization, suggesting a link between aging-related miRNA dysregulation and cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Jean Descarpentrie, Marcos J. Arauzo-Bravo, Zongsheng He, Alexia Francois, Alvaro Gonzalez, Patricia Garcia-Gallastegi, Iker Badiola, Serge Evrard, Simon Pernot, John W. M. Creemers, Abdel-Majid Khatib
Summary: This study reveals that the malignant phenotype of colorectal cancer stem cells can be repressed by inhibition of the proprotein convertase Furin, leading to reduced expression of stem cell markers LGR5 and Nanog, as well as dysregulated expression of several calcium regulators. Targeting Furin may provide a potential therapeutic approach for colorectal cancer stem cells.
Article
Biology
Nerea Garcia-Urkia, Jon Luzuriaga, Veronica Uribe-Etxebarria, Igor Irastorza, Francisco Javier Fernandez-San-Argimiro, Beatriz Olalde, Nerea Briz, Fernando Unda, Gaskon Ibarretxe, Iratxe Madarieta, Jose Ramon Pineda
Summary: Obesity has a negative impact on human lifespan and is a significant public health issue worldwide. However, the development of in vitro 3D adipose tissue models is limited and expensive. In this study, we designed and produced 3D solid foams using a mixture of collagen and decellularized adipose tissue to mimic the in vivo adipose microenvironment. We demonstrated that these foams are compatible with dental pulp stem cell culture and can support adipocyte differentiation.
Article
Public, Environmental & Occupational Health
Aitor Zabala, Francisco Javier Martin-Arregui, Jon Sagazola, Francisco Javier Santaolalla, Francisco Santaolalla
Summary: The aim of this study is to evaluate the implementation of a screening program for the early diagnosis of head and neck tumors. The study included 324 asymptomatic patients who had major or minor risk factors. The results showed that 9.6% of the patients had overlooked some symptoms before inclusion, and 1.2% were diagnosed with tumors, while 4.6% were diagnosed with pre-neoplastic lesions.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Biochemistry & Molecular Biology
Elham Mehranzadeh, Olatz Crende, Iker Badiola, Patricia Garcia-Gallastegi
Summary: Protein convertases (PCs) play a crucial role in cell signaling and immune escape of tumors. Furin (PC3) is a key enzyme involved in tumor immune evasion.
Editorial Material
Biotechnology & Applied Microbiology
Gaskon Ibarretxe
BIOENGINEERING-BASEL
(2022)
Review
Biochemistry & Molecular Biology
Veronica Uribe-Etxebarria, Jose Ramon Pineda, Patricia Garcia-Gallastegi, Alice Agliano, Fernando Unda, Gaskon Ibarretxe
Summary: The dental pulp of permanent human teeth contains stem cells known as Dental Pulp Stem Cells (DPSCs), which have the ability to differentiate into multiple cell lineages. The pluripotency core factors expressed by these cells, as well as the involvement of signaling pathways like Notch and Wnt, contribute to their stemness maintenance. Utilizing recombinant proteins, pharmacological modulators, serum-free media, and appropriate scaffolds, researchers can optimize the potency of DPSCs without genetic modification. This review highlights the mechanisms and regulatory pathways responsible for maintaining stemness in DPSCs, drawing interesting parallels with pluripotent stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biotechnology & Applied Microbiology
Gaskon Ibarretxe
BIOENGINEERING-BASEL
(2023)
Article
Cell & Tissue Engineering
J. Luzuriaga, P. Garcia-Gallastegui, N. Garcia-Urkia, Jr. Pineda, I. Irastorza, F-J Fernandez-San-Argimiro, B. Olalde, F. Unda, I Madarieta, G. Ibarretxe
Summary: 3D cell culture systems based on biological scaffold materials from animal and human tissues show promising applications in cell therapy and personalised medicine. The extracellular matrix from white adipose tissue is a potential biomaterial for tissue engineering. Porcine ECM scaffolds effectively support the osteogenic differentiation of human dental pulp stem cells, while human ECM scaffolds are more suitable for adipogenesis.
EUROPEAN CELLS & MATERIALS
(2022)
Article
Education & Educational Research
Borja Herrero de la Parte, Maria Santaolalla-Sanchez, Francisco Javier Santaolalla-Sanchez, Ignacio Garcia-Alonso, Francisco Santaolalla, Ana Sanchez del Rey
Summary: This paper introduces the organizational model of a student-promoted and student-managed surgical congress and discusses its role in promoting transversal competencies among students. Findings from the survey show that the congress was well-received and highly rated by attendees, and the organizers demonstrated a significant increase in transversal competences throughout the process.
EDUCATION SCIENCES
(2021)
Article
Surgery
A. Carreras, M. I. Martinez-Torre, M. Zabaleta, A. Sanchez-del-Rey, F. Santaolalla, P. Diaz-de-Cerio
Summary: The research aims to investigate whether involvement of the anterior commissure in early stage glottis cancer is an independent risk factor for recurrence and mortality. The study found that patients with anterior commissure involvement had a higher rate of local recurrence, mortality, lower disease-free survival, and overall survival.
INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY
(2021)