From peroxisomal disorders to common neurodegenerative diseases - the role of ether phospholipids in the nervous system

The lipidome in major depressive disorder: Shared genetic influence for ether-phosphatidylcholines, a plasma-based phenotype related to inflammation, and disease risk

(2017) E.E.M. Knowles et al.   EUROPEAN PSYCHIATRY

Interaction of plasmenylcholine with free radicals in selected model systems

(2017) A. Broniec et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reduced muscle strength in ether lipid-deficient mice is accompanied by altered development and function of the neuromuscular junction

(2017) Fabian Dorninger et al.   JOURNAL OF NEUROCHEMISTRY

Reduction of Ether-Type Glycerophospholipids, Plasmalogens, by NF-κB Signal Leading to Microglial Activation

(2017) Md. Shamim Hossain et al.   JOURNAL OF NEUROSCIENCE

Polyunsaturated fatty acids and recurrent mood disorders: Phenomenology, mechanisms, and clinical application

(2017) Erik Messamore et al.   PROGRESS IN LIPID RESEARCH

Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy

(2017) Sandra Kleinecke et al.   eLife

Efficacy and Blood Plasmalogen Changes by Oral Administration of Plasmalogen in Patients with Mild Alzheimer's Disease and Mild Cognitive Impairment: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial

(2017) Takehiko Fujino et al.   EBioMedicine

Early Biochemical and Morphological Modifications in the Brain of a Transgenic Mouse Model of Alzheimer's Disease: A Role for Peroxisomes

(2017) AnnaMaria Cimini et al.   JOURNAL OF ALZHEIMERS DISEASE

Plasmalogen biosynthesis is spatiotemporally regulated by sensing plasmalogens in the inner leaflet of plasma membranes

(2017) Masanori Honsho et al.   Scientific Reports

Loss of PAFR prevents neuroinflammation and brain dysfunction after traumatic brain injury

(2017) Xiang-Jie Yin et al.   Scientific Reports

Growth charts for individuals with rhizomelic chondrodysplasia punctata

(2016) Angela L. Duker et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

The biophysical properties of ethanolamine plasmalogens revealed by atomistic molecular dynamics simulations

(2016) Tomasz Rog et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Peroxisomes in brain development and function

(2016) Johannes Berger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Modulation of Hexadecyl-LPA-Mediated Activation of Mast Cells and Microglia by a Chemical Probe for LPA5

(2016) Detlef H. Kozian et al.   CHEMBIOCHEM

Serum ethanolamine plasmalogens improve detection of cognitive impairment among elderly with high excretion levels of urinary myo-inositol: A cross-sectional study

(2016) Ryouta Maeba et al.   CLINICA CHIMICA ACTA

Brain Development and Akt Signaling: the Crossroads of Signaling Pathway and Neurodevelopmental Diseases

(2016) Long Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Unbiased Metabolite Profiling of Schizophrenia Fibroblasts under Stressful Perturbations Reveals Dysregulation of Plasmalogens and Phosphatidylcholines

(2016) Joanne H. Huang et al.   JOURNAL OF PROTEOME RESEARCH

Mechanisms of ephrin–Eph signalling in development, physiology and disease

(2016) Artur Kania et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Clinical and Biochemical Pitfalls in the Diagnosis of Peroxisomal Disorders

(2016) Sacha Ferdinandusse et al.   NEUROPEDIATRICS

Platelet-activating factor attenuation of long-term potentiation in rat hippocampal slices via protein tyrosine kinase signaling

(2016) Benjamin Reiner et al.   NEUROSCIENCE LETTERS

Plasmalogen Augmentation Reverses Striatal Dopamine Loss in MPTP Mice

(2016) Edith Miville-Godbout et al.   PLoS One

Membrane lipidomics in schizophrenia patients: a correlational study with clinical and cognitive manifestations

(2016) C Tessier et al.   Translational Psychiatry

Neuronal Orphan G-Protein Coupled Receptor Proteins Mediate Plasmalogens-Induced Activation of ERK and Akt Signaling

(2016) Md. Shamim Hossain et al.   PLoS One

Sub-Chronic Neuropathological and Biochemical Changes in Mouse Visual System after Repetitive Mild Traumatic Brain Injury

(2016) Radouil Tzekov et al.   PLoS One

HPLC-Based Mass Spectrometry Characterizes the Phospholipid Alterations in Ether-Linked Lipid Deficiency Models Following Oxidative Stress

(2016) Robin Drechsler et al.   PLoS One

Dysfunctional epileptic neuronal circuits and dysmorphic dendritic spines are mitigated by platelet-activating factor receptor antagonism

(2016) Alberto E. Musto et al.   Scientific Reports

Non-targeted lipidomics of CSF and frontal cortex grey and white matter in control, mild cognitive impairment, and Alzheimer’s disease subjects

(2015) Paul L. Wood et al.   ACTA NEUROPSYCHIATRICA

Plasmalogen precursor analog treatment reduces levodopa-induced dyskinesias in parkinsonian monkeys

(2015) Laurent Grégoire et al.   BEHAVIOURAL BRAIN RESEARCH

Homeostasis of phospholipids — The level of phosphatidylethanolamine tightly adapts to changes in ethanolamine plasmalogens

(2015) Fabian Dorninger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Metabolic dysfunctions in multiple sclerosis: implications as to causation, early detection, and treatment, a case control study

(2015) Vijitha K. Senanayake et al.   BMC Neurology

PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cortical dysplasia

(2015) Laura A. Jansen et al.   BRAIN

Erythrocyte phospholipid molecular species and fatty acids of Down syndrome children compared with non-affected siblings

(2015) Allain A. Bueno et al.   BRITISH JOURNAL OF NUTRITION

Ether Lipid Deficiency Does Not Cause Neutropenia or Leukopenia in Mice and Men

(2015) Fabian Dorninger et al.   Cell Metabolism

Peroxisomal Lipid Synthesis Regulates Inflammation by Sustaining Neutrophil Membrane Phospholipid Composition and Viability

(2015) Irfan J. Lodhi et al.   Cell Metabolism

Plasmalogen phospholipids protect internodal myelin from oxidative damage

(2015) Adrienne M. Luoma et al.   FREE RADICAL BIOLOGY AND MEDICINE

A novel type of rhizomelic chondrodysplasia punctata, RCDP5, is caused by loss of the PEX5 long isoform

(2015) Tuva Barøy et al.   HUMAN MOLECULAR GENETICS

Dysregulation of Plasmalogen Homeostasis Impairs Cholesterol Biosynthesis

(2015) Masanori Honsho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PEX7Mutations Cause Congenital Cataract Retinopathy and Late-Onset Ataxia and Cognitive Impairment: Report of Two Siblings and Review of the Literature

(2015) Lorenzo Nanetti et al.   Journal of Clinical Neurology

ACaenorhabditis elegansmodel for ether lipid biosynthesis and function

(2015) Xun Shi et al.   JOURNAL OF LIPID RESEARCH

Discovery and Validation of Plasma Biomarkers for Major Depressive Disorder Classification Based on Liquid Chromatography–Mass Spectrometry

(2015) Xinyu Liu et al.   JOURNAL OF PROTEOME RESEARCH

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Dysfunctional plasmalogen dynamics in the plasma and platelets of patients with schizophrenia

(2015) Paul L. Wood et al.   SCHIZOPHRENIA RESEARCH

Dysfunctional glycosynapses in schizophrenia: Disease and regional specificity

(2015) Paul L. Wood et al.   SCHIZOPHRENIA RESEARCH

Extrinsic plasmalogens suppress neuronal apoptosis in mouse neuroblastoma Neuro-2A cells: importance of plasmalogen molecular species

(2015) Shinji Yamashita et al.   RSC Advances

Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA

(2015) Simon C. Dyall   Frontiers in Aging Neuroscience

Non-targeted lipidomics of CSF and frontal cortex grey and white matter in control, mild cognitive impairment, and Alzheimer’s disease subjects

(2015) Paul L. Wood et al.   ACTA NEUROPSYCHIATRICA

A Peroxisomal Disorder of Severe Intellectual Disability, Epilepsy, and Cataracts Due to Fatty Acyl-CoA Reductase 1 Deficiency

(2014) Rebecca Buchert et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Plasmalogens in the retina: From occurrence in retinal cell membranes to potential involvement in pathophysiology of retinal diseases

(2014) Sarah Saab et al.   BIOCHIMIE

Lipidomic analyses identify injury-specific phospholipid changes 3 mo after traumatic brain injury

(2014) Laila Abdullah et al.   FASEB JOURNAL

Mechanistic Insights into PTS2-mediated Peroxisomal Protein Import

(2014) Markus Kunze et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peripheral nervous system plasmalogens regulate Schwann cell differentiation and myelination

(2014) Tiago Ferreira da Silva et al.   JOURNAL OF CLINICAL INVESTIGATION

Plasma phospholipids identify antecedent memory impairment in older adults

(2014) Mark Mapstone et al.   NATURE MEDICINE

Polyunsaturated fatty acids and their metabolites in brain function and disease

(2014) Richard P. Bazinet et al.   NATURE REVIEWS NEUROSCIENCE

Involvement of Plasmalogens in Post-Natal Retinal Vascular Development

(2014) Sarah Saab et al.   PLoS One

Lipidomics reveals dysfunctional glycosynapses in schizophrenia and the G72/G30 transgenic mouse

(2014) Paul L. Wood et al.   SCHIZOPHRENIA RESEARCH

The global prevalence of dementia: A systematic review and metaanalysis

(2013) Martin Prince et al.   Alzheimers & Dementia

Reduced plasmalogen concentration as a surrogate marker of oxidative stress in elderly septic patients

(2013) Thorolf Brosche et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Topogenesis and Homeostasis of Fatty Acyl-CoA Reductase 1

(2013) Masanori Honsho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer’s disease

(2013) Yoko Tajima et al.   Lipids in Health and Disease

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

(2013) L. E. Hebert et al.   NEUROLOGY

Using Whole-Exome Sequencing to Identify Inherited Causes of Autism

(2013) Timothy W. Yu et al.   NEURON

The neurology of rhizomelic chondrodysplasia punctata

(2013) Annemieke M Bams-Mengerink et al.   Orphanet Journal of Rare Diseases

Plasmalogens Rescue Neuronal Cell Death through an Activation of AKT and ERK Survival Signaling

(2013) Md. Shamim Hossain et al.   PLoS One

Biosynthesis and biological function of sulfoglycolipids

(2013) Koichi HONKE   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Using neurolipidomics to identify phospholipid mediators of synaptic (dys)function in Alzheimer's Disease

(2013) Steffany A. L. Bennett et al.   Frontiers in Physiology

Peroxisome deficient invertebrate and vertebrate animal models

(2013) Paul P. Van Veldhoven et al.   Frontiers in Physiology

The importance of ether-phospholipids: A view from the perspective of mouse models

(2012) Tiago Ferreira da Silva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Functions of plasmalogen lipids in health and disease

(2012) Nancy E. Braverman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Orphan enzymes in ether lipid metabolism

(2012) Katrin Watschinger et al.   BIOCHIMIE

Impaired neurotransmission in ether lipid-deficient nerve terminals

(2012) Alexander Brodde et al.   HUMAN MOLECULAR GENETICS

Association Between Peroxisomal Biogenesis Factor 7 and Autism Spectrum Disorders in a Korean Population

(2012) MyungJa Ro et al.   JOURNAL OF CHILD NEUROLOGY

Defective lipid remodeling of GPI anchors in peroxisomal disorders, Zellweger syndrome, and rhizomelic chondrodysplasia punctata

(2012) Noriyuki Kanzawa et al.   JOURNAL OF LIPID RESEARCH

Peroxisome deficiency but not the defect in ether lipid synthesis causes activation of the innate immune system and axonal loss in the central nervous system

(2012) Astrid Bottelbergs et al.   Journal of Neuroinflammation

Anti-inflammatory/anti-amyloidogenic effects of plasmalogens in lipopolysaccharide-induced neuroinflammation in adult mice

(2012) Masataka Ifuku et al.   Journal of Neuroinflammation

Evidence for Premature Lipid Raft Aging in APP/PS1 Double-Transgenic Mice, a Model of Familial Alzheimer Disease

(2012) Noemí Fabelo et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Disrupted ERK Signaling during Cortical Development Leads to Abnormal Progenitor Proliferation, Neuronal and Network Excitability and Behavior, Modeling Human Neuro-Cardio-Facial-Cutaneous and Related Syndromes

(2012) J. Pucilowska et al.   JOURNAL OF NEUROSCIENCE

Plasma phosphatidylcholine and sphingomyelin concentrations are associated with depression and anxiety symptoms in a Dutch family-based lipidomics study

(2012) Ayşe Demirkan et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus

(2012) Federica Facciotti et al.   NATURE IMMUNOLOGY

Lipid rafts, synaptic transmission and plasticity: Impact in age-related neurodegenerative diseases

(2012) Ana M. Sebastião et al.   NEUROPHARMACOLOGY

Impaired plasmalogens in patients with schizophrenia

(2012) Rima Kaddurah-Daouk et al.   PSYCHIATRY RESEARCH

Plasmalogens Inhibit APP Processing by Directly Affectingγ-Secretase Activity in Alzheimer’s Disease

(2012) Tatjana L. Rothhaar et al.   TheScientificWorldJOURNAL

Peroxisomal alterations in Alzheimer’s disease

(2011) Jianqiu Kou et al.   ACTA NEUROPATHOLOGICA

A Drosophila model for the Zellweger spectrum of peroxisome biogenesis disorders

(2011) F. D. Mast et al.   Disease Models & Mechanisms

Interactions of plasmalogens and their diacyl analogs with singlet oxygen in selected model systems

(2011) Agnieszka Broniec et al.   FREE RADICAL BIOLOGY AND MEDICINE

Functional characterization of novel mutations in GNPAT and AGPS, causing rhizomelic chondrodysplasia punctata (RCDP) types 2 and 3

(2011) Brandon Itzkovitz et al.   HUMAN MUTATION

From brain to food: Analysis of phosphatidylcholins, lyso-phosphatidylcholins and phosphatidylcholin–plasmalogens derivates in Alzheimer's disease human post mortem brains and mice model via mass spectrometry

(2011) Marcus O.W. Grimm et al.   JOURNAL OF CHROMATOGRAPHY A

Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer’s disease

(2011) Marcus O. W. Grimm et al.   JOURNAL OF NEUROCHEMISTRY

In vitro and in vivo plasmalogen replacement evaluations in rhizomelic chrondrodysplasia punctata and Pelizaeus-Merzbacher disease using PPI-1011, an ether lipid plasmalogen precursor

(2011) Paul L Wood et al.   Lipids in Health and Disease

Targeted metabolomic analyses of cellular models of pelizaeus-merzbacher disease reveal plasmalogen and myo-inositol solute carrier dysfunction

(2011) Paul L Wood et al.   Lipids in Health and Disease

Blind sterile 2 (bs2), a hypomorphic mutation in Agps, results in cataracts and male sterility in mice

(2011) R. Liegel et al.   MOLECULAR GENETICS AND METABOLISM

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(2011) Noemi Fabelo et al.   MOLECULAR MEDICINE

Alkyl-Glycerol Rescues Plasmalogen Levels and Pathology of Ether-Phospholipid Deficient Mice

(2011) Pedro Brites et al.   PLoS One

Multi-dimensional mass spectrometry-based shotgun lipidomics and the altered lipids at the mild cognitive impairment stage of Alzheimer's disease

(2010) Xianlin Han   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipid oxidation by hypochlorous acid: chlorinated lipids in atherosclerosis and myocardial ischemia

(2010) David A Ford   Clinical Lipidology

Lipid function at synapses

(2010) Bazbek Davletov et al.   CURRENT OPINION IN NEUROBIOLOGY

Peroxisomes in zebrafish: distribution pattern and knockdown studies

(2010) Olga Krysko et al.   HISTOCHEMISTRY AND CELL BIOLOGY

The Role of Plasmalogen in the Oxidative Stability of Neutral Lipids and Phospholipids

(2010) Guang Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Posttranslational Regulation of Fatty Acyl-CoA Reductase 1, Far1, Controls Ether Glycerophospholipid Synthesis

(2010) Masanori Honsho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered brain phospholipid and acylcarnitine profiles in propionic acid infused rodents: further development of a potential model of autism spectrum disorders

(2010) Raymond H. Thomas et al.   JOURNAL OF NEUROCHEMISTRY

Circulating plasmalogen levels and Alzheimer Disease Assessment Scale–Cognitive scores in Alzheimer patients

(2010) Paul Wood   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Membrane plasmalogen composition and cellular cholesterol regulation: a structure activity study

(2010) Rishikesh Mankidy et al.   Lipids in Health and Disease

Combined deficiency of peroxisomal β-oxidation and ether lipid synthesis in mice causes only minor cortical neuronal migration defects but severe hypotonia

(2010) Olga Krysko et al.   MOLECULAR GENETICS AND METABOLISM

Studies on Plasmalogen-Selective Phospholipase A2 in Brain

(2010) Akhlaq A. Farooqui   MOLECULAR NEUROBIOLOGY

Platelet-activating factor-induced synaptic facilitation is associated with increased calcium/calmodulin-dependent protein kinase II, protein kinase C and extracellular signal-regulated kinase activities in the rat hippocampal CA1 region

(2010) S. Moriguchi et al.   NEUROSCIENCE

Old and new generation lipid mediators in acute inflammation and resolution

(2010) Melanie J. Stables et al.   PROGRESS IN LIPID RESEARCH

Cholesterol, regulated exocytosis and the physiological fusion machine

(2009) Matthew A. Churchward et al.   BIOCHEMICAL JOURNAL

Plasmalogens as a marker of elevated systemic oxidative stress in Parkinson's disease

(2009) Charalampos Dragonas et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Plasmalogens in Biological Systems: Their Role in Oxidative Processes in Biological Membranes, their Contribution to Pathological Processes and Aging and Plasmalogen Analysis

(2009) J. Leßig et al.   CURRENT MEDICINAL CHEMISTRY

Structural remodeling of GPI anchors during biosynthesis and after attachment to proteins

(2009) Morihisa Fujita et al.   FEBS LETTERS

Defects in myelination, paranode organization and Purkinje cell innervation in the ether lipid-deficient mouse cerebellum

(2009) Andre Teigler et al.   HUMAN MOLECULAR GENETICS

Drosophila models of peroxisomal biogenesis disorder: peroxins are required for spermatogenesis and very-long-chain fatty acid metabolism

(2009) Haiyang Chen et al.   HUMAN MOLECULAR GENETICS

Unique Ligand Selectivity of the GPR92/LPA5Lysophosphatidate Receptor Indicates Role in Human Platelet Activation

(2009) Jesica R. Williams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Pex7 hypomorphic mouse model for plasmalogen deficiency affecting the lens and skeleton

(2009) Nancy Braverman et al.   MOLECULAR GENETICS AND METABOLISM

MAP'ing CNS Development and Cognition: An ERKsome Process

(2009) Ivy S. Samuels et al.   NEURON

Peroxisome dependency of alkyl-containing GPI-anchor biosynthesis in the endoplasmic reticulum

(2009) N. Kanzawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid- 42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism

(2009) S. D. Ryan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma fatty acid profiles in autism: A case-control study

(2009) M.M. Wiest et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Isolation and characterization of mutant animal cell line defective in alkyl-dihydroxyacetonephosphate synthase: Localization and transport of plasmalogens to post-Golgi compartments

(2008) Masanori Honsho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Plasmalogens participate in very-long-chain fatty acid-induced pathology

(2008) P. Brites et al.   BRAIN

The opposing effects of n−3 and n−6 fatty acids

(2007) Gerd Schmitz et al.   PROGRESS IN LIPID RESEARCH